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255 full-text articles. Page 2 of 8.

3d Maldi Mass Spectrometry Imaging Of A Single Cell: Spatial Mapping Of Lipids In The Embryonic Development Of Zebrafish, Maria Emilia Dueñas, Jeffrey J. Essner, Young Jin Lee 2017 Iowa State University

3d Maldi Mass Spectrometry Imaging Of A Single Cell: Spatial Mapping Of Lipids In The Embryonic Development Of Zebrafish, Maria Emilia Dueñas, Jeffrey J. Essner, Young Jin Lee

Ames Laboratory Accepted Manuscripts

The zebrafish ( Danio rerio ) has been widely used as a model vertebrate system to study lipid metabolism, the roles of lipids in diseases, and lipid dynamics in embryonic development. Here, we applied high-spatial resolution matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) to map and visualize the three-dimensional spatial distribution of phospholipid classes, phosphatidylcholine (PC), phosphatidylethanolamines (PE), and phosphatidylinositol (PI), in newly fertilized individual zebrafish embryos. This is the first time MALDI-MSI has been applied for three dimensional chemical imaging of a single cell. PC molecular species are present inside the yolk in addition to the blastodisc, while PE ...


High-Throughput Selective Capture Of Single Circulating Tumor Cells By Dielectrophoresis At A Wireless Electrode Array, Robbyn Anand, Min Li 2017 Iowa State University

High-Throughput Selective Capture Of Single Circulating Tumor Cells By Dielectrophoresis At A Wireless Electrode Array, Robbyn Anand, Min Li

Chemistry Publications

We demonstrate continuous high-throughput selective capture of circulating tumor cells by dielectrophoresis at arrays of wireless electrodes (bipolar electrodes, BPEs). The use of BPEs removes the requirement of ohmic contact to individual array elements, thus enabling otherwise unattainable device formats. Capacitive charging of the electrical double layer at opposing ends of each BPE allows an AC electric field to be transmitted across the entire device. Here, two such designs are described and evaluated. In the first design, BPEs interconnect parallel microchannels. Pockets extruding from either side of the microchannels volumetrically control the number of cells captured at each BPE tip ...


Evolution Of Cu2o Morphology During Copper Corrosion In The Presence Of Gamma-Radiation, Arielle M. Jean 2017 The University of Western Ontario

Evolution Of Cu2o Morphology During Copper Corrosion In The Presence Of Gamma-Radiation, Arielle M. Jean

Electronic Thesis and Dissertation Repository

In this work, experiments were carried out in order to develop a mechanistic understanding of the corrosion of copper metal in limited water volumes under gamma-radiation. When exposed to gamma-radiation, water decomposes into chemically reactive oxidizing and reducing species. Under a continuous radiation flux, the concentrations of the radiolytically produced oxidants eventually reach a pseudo-steady state that can influence the corrosion kinetics of metallic surfaces.

The evolution of the surface morphology during water droplet corrosion of copper in the presence of gamma-radiation was investigated as a function of irradiation time and pH. The oxide growth kinetics were studied by measuring ...


Development Of Neurotensin-Based Radiopharmaceuticals For Neurotensin-Receptor-1-Positive Tumors Targeting, Yinnong Jia 2017 University of Nebraska Medical Center

Development Of Neurotensin-Based Radiopharmaceuticals For Neurotensin-Receptor-1-Positive Tumors Targeting, Yinnong Jia

Theses & Dissertations

The neurotensin receptor 1 (NTR1) is overexpressed in many cancers, due to its role as a growth pathway. These NTR1-positive cancers include pancreatic, colon, prostate and breast cancers. In the radiopharmaceutical field, the overexpression of NTR1 in cancer has prompted the development of NTR1-targeted diagnostics and therapeutics. The neurotensin (NT) peptide exhibits low nanomolar affinity for NTR1 and has been the paradigm for NTR1-targeted agents. Since the 1980’s, radiolabeled NT analogs have been developed and evaluated for targeting NTR1-positive cancers. Since native NT is rapidly degraded in vivo by a variety of peptidases, a tremendous amount of effort has ...


Ion Separations: Achieving Selectivity Through Rational Design In Solvent Extraction And Crystallization Systems, Neil Justin Williams 2017 University of Tennessee, Knoxville

Ion Separations: Achieving Selectivity Through Rational Design In Solvent Extraction And Crystallization Systems, Neil Justin Williams

Doctoral Dissertations

The selective separation of ions from aqueous solutions has been a difficult challenge to address in the separation sciences. The difficulties associated with selective separations of ions are due to a multitude of chemical and physical differences between them. Additionally, the term ions encompass both positively charged cations and their counter parts the negatively charge anions. The work covered in this dissertation discusses the difficulties encountered during the selective separation of both oxoanions and cations. Apart from the Introduction Chapter 1 and Conclusion Chapter 10, the selective separations oxoanions and cations will be discussed separately with the dissertation being divided ...


Improved Sample Utilization In Thermal Ionization Mass Spectrometry Isotope Ratio Measurements: Refined Development Of Porous Ion Emitters For Nuclear Forensic Applications, Matthew Louis Baruzzini 2017 University of Tennessee, Knoxville

Improved Sample Utilization In Thermal Ionization Mass Spectrometry Isotope Ratio Measurements: Refined Development Of Porous Ion Emitters For Nuclear Forensic Applications, Matthew Louis Baruzzini

Doctoral Dissertations

The precise and accurate determination of isotopic composition in nuclear forensic samples is vital for assessing origin, intended use and process history. Thermal ionization mass spectrometry (TIMS) is widely accepted as the gold standard for high performance isotopic measurements and has long served as the workhorse in the isotopic ratio determination of nuclear materials. Nuclear forensic and safeguard specialists have relied heavily on such methods for both routine and atypical efforts. Despite widespread use, TIMS methods for the assay of actinide systems continue to be hindered by poor ionization efficiency, often less than tenths of a percent; the majority of ...


Thermodynamic Characterization And Isothermal Separability Of Heavy Fission Product Chelates For Post-Detonation Nuclear Forensic Analysis, Steven Adam Stratz 2017 University of Tennessee, Knoxville

Thermodynamic Characterization And Isothermal Separability Of Heavy Fission Product Chelates For Post-Detonation Nuclear Forensic Analysis, Steven Adam Stratz

Doctoral Dissertations

Nuclear terrorism, one of the most critical threats to national security, exhibits complexities that do not exist with similar threats from sanctioned state actors. Responding to a domestic nuclear terrorism strike is difficult when the original source of the weapon may be unknown, given that terrorist organizations (at the time of writing) do not themselves have nuclear technology sufficient to design and build nuclear weapons. Consequently, the development of forensic techniques to help source and characterize nuclear weapons after detonation has recently become an area of interest. This relatively new field of science, known as post-detonation nuclear forensics, aims to ...


Synthesis, Characterization And Biological Studies Of Technetium-99m And Rhenium-188 Peptides, Vanessa Anne Sanders 2017 University of Nevada, Las Vegas

Synthesis, Characterization And Biological Studies Of Technetium-99m And Rhenium-188 Peptides, Vanessa Anne Sanders

UNLV Theses, Dissertations, Professional Papers, and Capstones

Radiopharmaceuticals are very powerful diagnostic tools for evaluation of a host of medical conditions. These drugs are labeled with radioactive isotopes, which are utilized to create pictures of areas of interest through absorption of the drug. They are currently in high demand due to their ability to image areas that traditional imaging devices cannot. The radioisotope 99mTc, with a half-life of 6.01 hours and a 140 keV gamma emission, is central to many radiopharmaceutical compounds. This isotope is easily obtained from a 99Mo-99mTc generator, through beta decay and column chromatography separations. Very little technetium, less than 6 ng, is ...


Development Of Nuclear Underground Engineered Test Surrogates For Technical Nuclear Forensics Exploitation, Robert Boone Gilbreath 2017 University of Tennessee, Knoxville

Development Of Nuclear Underground Engineered Test Surrogates For Technical Nuclear Forensics Exploitation, Robert Boone Gilbreath

Masters Theses

A method for formulation and production of Nuclear UnderGround Engineered Test Surrogates (NUGETS) based on notional improvised nuclear device (IND) detonations in an underground environment analogous to the Nevada National Security Site (NNSS) is presented. Extensive statistical analyses of precursory geochemical and geophysical characteristics are combined with an augmented surrogate debris cooling technique and predictive IND contributions from the ORIGEN Fallout Analysis Tool. Precursory and resultant elemental compositions, cooling curve calculations, and visual comparison of NUGETS to genuine underground debris are reported. Application of NUGETS methodology to future studies in urban, underground post-detonation technical nuclear forensic (TNF) analysis is suggested.


Solvent Suppression In Dnp Enhanced Solid State Nmr, Jayasubba Reddy Yarava, Sachin Rama Chaudhari, Aaron J. Rossini, Anne Lesage, Lyndon Emsley 2017 Ecole Polytechnique Fédérale de Lausanne (EPFL)

Solvent Suppression In Dnp Enhanced Solid State Nmr, Jayasubba Reddy Yarava, Sachin Rama Chaudhari, Aaron J. Rossini, Anne Lesage, Lyndon Emsley

Chemistry Publications

We show how DNP enhanced solid-state NMR spectra can be dramatically simplified by suppression of solvent signals. This is achieved by (i) exploiting the paramagnetic relaxation enhancement of solvent signals relative to materials substrates, or (ii) by using short cross-polarization contact times to transfer hyperpolarization to only directly bonded carbon-13 nuclei in frozen solutions. The methods are evaluated for organic microcrystals, surfaces and frozen solutions. We show how this allows for the acquisition of high-resolution DNP enhanced proton-proton correlation experiments to measure inter-nuclear proximities in an organic solid.


Energy Efficient Process Heating: Insulation And Thermal Mass, Kevin Carpenter, J. Kelly Kissock 2017 Energy & Resource Solutions

Energy Efficient Process Heating: Insulation And Thermal Mass, Kevin Carpenter, J. Kelly Kissock

J. Kelly Kissock

Open tanks and exterior surfaces of process heating equipment lose heat to the surroundings via convection, radiation, and/or evaporation. A practical way of reducing heat loss is by insulating or covering the surfaces. This paper presents methods to quantify heat loss and energy savings from insulating hot surfaces and open tanks. The methods include radiation and evaporation losses, which are ignored by simplified methods. In addition, thermal mass, such as refractory, conveyor and racking equipment, acts as a heat sink and increases heating energy use in process heating applications. This paper presents lumped capacitance and finite-difference methods for estimating ...


Electrochemical And Modelling Studies On Simulated Spent Nuclear Fuel Corrosion Under Permanent Waste Disposal Conditions, Nazhen Liu 2017 The University of Western Ontario

Electrochemical And Modelling Studies On Simulated Spent Nuclear Fuel Corrosion Under Permanent Waste Disposal Conditions, Nazhen Liu

Electronic Thesis and Dissertation Repository

The safety assessment models for the deep geological disposal of spent nuclear fuel require a fundamental understanding of the corrosion of spent fuel in a failed waste container. The overall research goal of this project is to investigate the corrosion of simulated spent fuel under permanent disposal conditions, using both model simulations and experimental investigations. A model for fuel corrosion has been expanded to determine the relative importance of radiolytic hydrogen and hydrogen from corrosion of the steel vessel in suppressing fuel corrosion. It was shown that, for CANDU (CANada Deuterium Uranium) fuel with moderate in-reactor burnup, only micromolar concentrations ...


Chemical Imaging Of Cyanoacrylate‐Fumed Fingerprints By Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging, Kelly C. O'Neill, Paige Hinners, Young Jin Lee 2017 Iowa State University

Chemical Imaging Of Cyanoacrylate‐Fumed Fingerprints By Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging, Kelly C. O'Neill, Paige Hinners, Young Jin Lee

Chemistry Conference Papers, Posters and Presentations

For new techniques to be incorporated into forensic science, they must be compatible with current practices. Here, cyanoacrylate fuming, a common development technique for latent fingerprints, is studied for its compatibility with matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) for chemical imaging of latent fingerprints. Half of a fingerprint was fumed while the other half was not; then, the changes in chemical composition and signal intensity were compared with MALDI‐MS imaging. No evidence was found that fingerprint compounds are chemically altered by fuming or their signal intensities affected. The only exceptions were significant signal loss for quaternary ...


Irene Joliot-Curie, Erick J. Klein 2017 Parkland College

Irene Joliot-Curie, Erick J. Klein

Natural Sciences Poster Sessions

This poster for the Natural Sciences Poster Session at Parkland College features chemist Irene Joliot-Curie, one of four women, including her mother, Marie Curie, who have won the Nobel Prize for Chemistry. Joliot-Curie, with her husband Frederic Joliot-Curie won the prize in 1935 for their discovery of artificial radioactivity.


Letter From The Editor, 2016 University of Tennessee, Knoxville

Letter From The Editor

International Journal of Nuclear Security

No abstract provided.


Nuclear Power: Black Sky Liability Or Black Sky Asset?, Sherrell R. Greene 2016 Advanced Technology Insights, LLC (ATI)

Nuclear Power: Black Sky Liability Or Black Sky Asset?, Sherrell R. Greene

International Journal of Nuclear Security

Ready access to abundant electricity is a key enabler of modern life. During the past decade the vulnerability of Critical Infrastructure sectors in the U.S. to a variety of natural hazards and man-made threats has become increasingly apparent. The electrical infrastructure (the “Grid”) is the foundation for all other critical civil infrastructures upon which our society depends. Therefore, protection of the Grid is an energy security, homeland security, and national security issue of highest importance. Geomagnetic disturbances (GMD) induced by solar coronal mass ejections (CMEs), electromagnetic pulse (EMP) attacks, and cyber attacks are three events having the potential to ...


Prospects For Cooperation On Tackling Nuclear And Radiological Terrorism In South Asia: India–Pakistan Nuclear Detection Architecture, Muhammad Umer Khan 2016 Middlebury Institute of International Studies (MIIS)

Prospects For Cooperation On Tackling Nuclear And Radiological Terrorism In South Asia: India–Pakistan Nuclear Detection Architecture, Muhammad Umer Khan

International Journal of Nuclear Security

No abstract provided.


Janus Realized: The Use Of Social Media As A Means Of Transparency Nuclear Communication To The Public, Frances Bachstein 2016 University of Tennessee, Knoxville

Janus Realized: The Use Of Social Media As A Means Of Transparency Nuclear Communication To The Public, Frances Bachstein

International Journal of Nuclear Security

No abstract provided.


Table Of Contents, 2016 University of Tennessee, Knoxville

Table Of Contents

International Journal of Nuclear Security

No abstract provided.


Evaluation Of Covert Plutonium Production From Unconventional Uranium Sources, Ondrej Chvala, Steven Skutnik, Tyrone Christopher Harris, Emily Anne Frame 2016 University of Tennessee

Evaluation Of Covert Plutonium Production From Unconventional Uranium Sources, Ondrej Chvala, Steven Skutnik, Tyrone Christopher Harris, Emily Anne Frame

International Journal of Nuclear Security

The potential for a relatively non-advanced nation to covertly acquire a significant quantity of weapons-grade plutonium using a gas-cooled, natural uranium-fueled reactor based on relatively primitive early published designed is evaluated in this article. The economic and technical issues that would influence the design decisions of a covert 239Pu production program are considered.

Several unconventional uranium acquisition approaches were explored. Methods for extracting uranium from enrichment tails, seawater, and coal ash sources were considered. The evaluation indicated that uranium extraction from coal ash or insitu leaching from underground deposits could be performed in economical manner that might be difficult ...


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