Biocompatible, Responsive Polysoaps Via Raft Copolymerization For The Delivery Of Model Cancer Therapeutics, 2018 The University of Southern Mississippi
Biocompatible, Responsive Polysoaps Via Raft Copolymerization For The Delivery Of Model Cancer Therapeutics, Mason Dearborn
Many chemotherapeutic drugs are small, hydrophobic molecules that require water-soluble, biocompatible nanocarriers for enhanced vascular circulation. Existing polymeric carriers either conjugate the drug along a copolymer backbone or sequester drugs within a protected interior domain to be delivered to specific sites in the body. Such therapeutic systems must overcome a myriad of hurdles, beginning with complex, multi-step syntheses, followed by other inherent barriers that limit the efficiency of drug delivery at the targeted site. This work aims to circumvent a number of these issues using biocompatible, stimuli-responsive polysoaps that are capable of unimeric micelle formation, hydrophobic drug delivery, and triggered ...
Synthesis Of A Silsesquioxane Based Supramolecular Polymer, 2018 Bowling Green State University
Synthesis Of A Silsesquioxane Based Supramolecular Polymer, Rachel Bianculli
Research toward smart materials, specifically self-healing polymers, is an expanding topic within the materials science field. These materials rely heavily on dynamic crosslinking that is achieved by inducing different degrees of hydrogen bonding, van der Waals forces, etc. This work, demonstrated by research previously done within the Ostrowski research group, shows how coordination bonds of transition metals have been shown to create light activated, self-healing properties. Work done with these light-activated chromium (III) complexes with a poly(butylyene-co-ethylene) backbone have shown how metal—ligand coordination geometries can tune mechanical properties of the polymeric material. However, these materials suffer from being ...
Characterization Of Nylon-12 In A Novel Additive Manufacturing Technology, And The Rheological And Spectroscopic Analysis Of Peg-Starch Matrix Interactions, Garrett Michael Craft
Graduate Theses and Dissertations
In this work differential scanning calorimetry, dynamic mechanical analysis, Fourier-Transformed Infrared Spectroscopy [FT-IR] and polarized light microscopy will be employed to characterize polymeric systems. The first chapter broadly covers polymer synthesis and important characterization methods.
In the second chapter, a polyamide (PA12) will be sintered via a novel additive manufacturing (AM) technology developed here at USF termed LAPS (Large Area Projection Sintering). LAPS uses extended sintering timespans to ensure complete melting and densification of the polymer powder over the entire two-dimensional area of the part’s footprint. Further, it allows for the printed layer to crystallize and shrink in its ...
Characterization Of Polymers Containing Ferrocene And Imidazole With Density Functional Theory, 2018 Pittsburg State University
Characterization Of Polymers Containing Ferrocene And Imidazole With Density Functional Theory, Eric Mullins
Electronic Thesis Collection
Electrochemical and UV-Vis studies on these polymers in the presence of aqueous solutions containing metal ions have revealed significant modifications in the electrochemical properties and absorption spectra. These modifications in electrochemical properties could be attributed to the ability of the imidazole to coordinate with metal ions, increasing its electron deficiency and enhancing oxidization of the nearby ferrocene moiety if it is in close proximity with imidazole. However, the mechanism of interaction between the imidazole and metal ions, as well as the equilibrium geometry of the resulting polymer-metal ion complex is unknown.
In this thesis, density functional theory (DFT) was used ...
Synthesis And Evaluation Of Acetylcholine Molecularly Imprinted Polymers, 2018 Trinity College, Hartford Connecticut
Synthesis And Evaluation Of Acetylcholine Molecularly Imprinted Polymers, Nathaniel Donald Thiemann
Polymers imprinted with acetylcholine during synthesis were prepared in order to evaluate their potential for implementation as a novel recognition element in acetylcholine biosensors. Biosensors, such as the glucose monitor, are used to rapidly detect and quantify a target analyte. Acetylcholine biosensors have already been produced using enzymatic recognition elements, but they are currently expensive and plagued by short viability. Molecularly imprinted polymers are not only cheap and durable, but have also been successfully used as a recognition element in biosensors for other analytes. Therefore, computational tools were used to rationally design acetylcholine molecularly imprinted polymers. Three chemicals, itaconic acid ...
Photo-Controlled Release Of Zinc Ions In Aqueous Solution With Simultaneous Fluorescence Detection, 2018 College of William and Mary
Photo-Controlled Release Of Zinc Ions In Aqueous Solution With Simultaneous Fluorescence Detection, Tyler Larson
Undergraduate Honors Theses
We created a system consisting of a highly fluorescent conjugated polymer nanoparticle paired with a photo-release dye. Upon irradiation at the maximum absorbance of the nanoparticle, it non-radiatively transfers its energy to the dye through the process of FRET (Fluorescence Resonance Energy Transfer), exciting the dye, which then releases a biologically relevant ion, zinc. This system enhances the photo-release process, making it kinetically faster and more efficient. The photo-event is accompanied by a change in fluorescence of the dye, allowing for simultaneous detection of photo-release. This thesis outlines nanoparticle synthesis using the reprecipitation method, synthesis of the zinc releasing dye ...
Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, 2018 Michigan Technological University
Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee
Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhe-sion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized poly- mers. Specifically, we reviewed recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface ...
Higher Energy Gap Control Of Fluorescence In Conjugated Polymers, 2018 Louisiana State University and Agricultural and Mechanical College
Higher Energy Gap Control Of Fluorescence In Conjugated Polymers, Chien-Hung Chiang
LSU Doctoral Dissertations
Chemo- and biosensors based on fluorescent conjugated polymer benefit from greater detection sensitivity due to amplification of the electronic perturbations produced by analyte binding. This amplification stems from the exciton-transporting properties of conjugated polymers. A conventional design paradigm relies on the analyte binding events which generate sites of lower energy relative to the polymer energy: either fluorescence quenching sites (turn-off sensors) or bathochromically shifted fluorophores (turn-on sensors). In both type sensors, the excitons migrate to the lower-energy site created by analyte binding.
This dissertation primarily focused the investigation of an alternative paradigm when analyte binding creates higher energy gap sites ...
Understanding The Functional Group-Dependent Self-Assembly And Cellular Entry Of Cationic Conjugated Polymer Nanoparticles, 2018 Florida International University
Understanding The Functional Group-Dependent Self-Assembly And Cellular Entry Of Cationic Conjugated Polymer Nanoparticles, Prakash Manandhar
FIU Electronic Theses and Dissertations
Highly fluorescent conjugated polymers (CPs) are an important class of biomaterials used for various biological applications including labelling, sensing, and delivery of biological substances. Synthetic versatility and tunable emission make CPs a superior class of biomaterials. Understanding the structure-function relationship of CPs plays a vital role in designing high performing biomaterials. The cationic CPs are self-assembled to conjugated polymer nanoparticles (CPNs) in an aqueous environment due to their amphiphilicity. The physical and biophysical properties of CPNs are highly dependent on the chemical functionality and backbone structure of CPs. Modulation of the surface property and backbone structure of CPNs play an ...
Synthesis, Characterization, And Assessment Of Cationic Polypeptoids Toward Gene Delivery And Development Of Air Stable N-Substituted N-Thiocarboxyanhydrides, 2018 Louisiana State University and Agricultural and Mechanical College
Synthesis, Characterization, And Assessment Of Cationic Polypeptoids Toward Gene Delivery And Development Of Air Stable N-Substituted N-Thiocarboxyanhydrides, Jessica Michelle Simpson
LSU Doctoral Dissertations
Peptoids are a class of peptidomimetic polymers, which have attracted much attention over the years. Due to their structural similarity to peptides, this group of polymers affords good biocompatibility making them of interest for biomedical applications. This dissertation is largely about the design, synthesis, and characterization of cationic polypeptoids for biological applications, particularly nonviral gene delivery. The dissertation will also cover the development, characterization, and polymerization behavior of a new, air stable N-thiocarboxyanhydride (NTA) monomer.
Introducing functionality, such as small biomolecules and organic compounds can provide distinctive properties to the polymers. Chapter 1 introduces gene therapy and concepts pertinent ...
Computational Investigation Of The Ring-Opening Homo- And Co-Polymerizations Of Lactide And Ε-Caprolactone, 2018 Pepperdine University
Computational Investigation Of The Ring-Opening Homo- And Co-Polymerizations Of Lactide And Ε-Caprolactone, Diego Garcia, Benjamin Wilson, Joe Fritsch
Seaver College Research And Scholarly Achievement Symposium
The mechanism for the ring-opening polymerization of lactide and ε-caprolactone is presented here with an aluminum-centered catalyst featuring a tridentate ligand and two alkoxide initiating ligands. In each homopolymerization, the addition of electron-withdrawing groups on the tridentate ligand lowers the activation energy of the reaction by increasing the electrophilicity of the central Aluminum. We further investigated the polymerizations by comparing the energy difference between copolymerization and homopolymerization following the initial ring opening as well as the potential for dual polymer chains from the insertion of both initiating ligand. Single chain polymerization is favored in every case, due to lower bond ...
Synthesis Of Dimeric Zinc Complexes For Use As Ring Opening Polymerization Catalysts, 2018 Pepperdine University
Synthesis Of Dimeric Zinc Complexes For Use As Ring Opening Polymerization Catalysts, Kyle D. Brooks, Arnlold Rheingold, David B. Green, Joe Fritsch
Seaver College Research And Scholarly Achievement Symposium
No abstract provided.
Synthesis And Characterization Of Covalent Adaptable Networks Comprised Of Dynamic Imine And Aminal Covalent Bonds, 2018 Louisiana State University and Agricultural and Mechanical College
Synthesis And Characterization Of Covalent Adaptable Networks Comprised Of Dynamic Imine And Aminal Covalent Bonds, Albert Chao
LSU Doctoral Dissertations
The dissertation is about the design, synthesis and characterization of materials comprised of covalent adaptable networks (CANs). There are three chapters within this dissertation.
Chapter 1 contains a short overview of conventional thermosets and thermoplastics. A new strategy of combining advantages from thermosets and thermoplastics is utilizing dynamic covalent chemistry (DCC) for material design. Dynamic covalent bonds are able to undergo dynamic exchange which allow the material to adapt to a new state when under stimuli such as stress or strain. Material comprised of such reversible networks is called covalent adaptable networks (CANs). These types of reversible covalent bonds followed ...
Polymers Course For Small Colleges And Universities, 2018 Bowling Green State University - Main Campus
Polymers Course For Small Colleges And Universities, Joseph Furgal
Chemistry Faculty Publications
This article describes the course design and teaching methodology for a polymer chemistry and applications lecture class specifically aimed at small college and university instruction. This intermediate course for advanced undergraduates and masters level graduate students focuses on teaching the basics of polymer history, synthesis and characterization with connections to the core chemistry curriculum in a small class size environment and without a textbook. Furthermore, an extensive overview of the applications of polymeric materials gives students a connection to real life applications. The course includes polymer case studies, informational lessons on real world objects made of polymers, and demonstrations. Student ...
Functional Emulsions Via Thiol-Ene Chemistry, 2018 The University of Southern Mississippi
Functional Emulsions Via Thiol-Ene Chemistry, Douglas Amato
Polymer particles (micro to nano) with tunable functionality have emerged as a promising and viable technology platform for applications including coatings, cosmetics, nanomedicine, and imaging. Unfortunately, the lengthy polymerization time and lack of intrinsic functionality in the monomers used to fabricate particles is an industrial challenge. Thiol-ene chemistry cirmcumvents these limitations with very rapid polymerization kinetics, high reaction yields, with supressed side reactions and inherent functionality. This dissertation demonstrates the utility of thiol-ene/yne polymerization in miniemulsion and microfluidics to generate functional materials in a one-pot-method. The functionality is typically generated via off-stoichiometry thiol-ene (OSTE) resins which allow for either ...
Triazole-Based Polymers Via Photo-Initiated Copper-Catalyzed Azide-Alkyne Cycloaddition, 2018 University of Colorado at Boulder
Triazole-Based Polymers Via Photo-Initiated Copper-Catalyzed Azide-Alkyne Cycloaddition, Han Byul Song
Chemical & Biological Engineering Graduate Theses & Dissertations
Conventional thermosetting photopolymers are ubiquitous in a wide array of industrial applications such as UV coatings and adhesives, 3D printed objects, and dental composites, and these reactions are largely based on acrylate or methacrylate chain-growth free radical photopolymerizations. Despite the significant demand for (meth-) acrylate-based thermosets, problematic characteristics that are inherent in the nature of this polymerization still persist especially in bioapplications. For instance, incomplete conversion of monomers upon early gelation and vitrification in heterogenous networks containing hydrolytically labile ester functionalities, considerable shrinkage stress developed during polymerization, and brittleness of these highly crosslinked (meth-) acrylate-based polymers hinder both the biological ...
Direct Measurement Of Rupture Force Of Single Triazole Molecule By Atomic Force Microscope And Solid Phase Synthesis Of Monodisperse Polyethylene Glycols, 2018 Michigan Technological University
Direct Measurement Of Rupture Force Of Single Triazole Molecule By Atomic Force Microscope And Solid Phase Synthesis Of Monodisperse Polyethylene Glycols, Ashok Khanal
Dissertations, Master's Theses and Master's Reports
This dissertation includes two topics, which are related to each other: (1) Rupture force measurement of single triazole molecule by atomic force microscope (AFM) and (2) Solid phase stepwise synthesis of polyethylene glycols (PEGs).
The reaction of an alkyne and an azide to form a 1,2,3- triazole has found wide applications. However, the stability of triazole under mechanical stress is unclear. We investigated the cycloreversion at the single molecular level using atomic force microscopy. A mica surface functionalized with a molecule containing a 1,2,3-triazole moiety in the middle and an activated ester at the end was ...
Synthesis Of Ordered, Phase-Separated, Organic And Metal-Containing Ionic Liquid-Based Block Copolymers Via Controlled Radical Polymerization, 2018 University of Colorado at Boulder
Synthesis Of Ordered, Phase-Separated, Organic And Metal-Containing Ionic Liquid-Based Block Copolymers Via Controlled Radical Polymerization, Zhangxing Shi
Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)
Polymerized ionic liquids (PILs) are a class of polyelectrolytes that contain an ionic liquid (IL) moiety in each monomer repeating unit that are connected through a polymeric backbone. Since ILs are small-molecule liquid materials with a unique combination of properties (e.g., negligible vapor pressure, high thermal stability, ion conductivity, high solubility for certain light gases, etc.), the development of ordered, phase-separated polymeric systems containing PIL segments has considerable implications with respect to a range of transport-dependent, energy-based technology applications. The work presented in this thesis was focused on the synthesis of two IL-based block copolymer (BCPs) platforms: (1) a ...
Synthesis, Characterization And Evaluation Of Photo/ Thermal Base Generators For Thiol-Michael Addition Polymerization Reactions, 2018 University of Colorado at Boulder
Synthesis, Characterization And Evaluation Of Photo/ Thermal Base Generators For Thiol-Michael Addition Polymerization Reactions, Xinpeng Zhang
Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)
The focus of this thesis is to develop effective methodologies to achieve spatiotemporal control over the thiol-Michael addition reaction and to enhance the fundamental understanding of this reaction as well as to broaden its applicable range. With the attributes of quantitative reaction yield, rapid reaction rate, and the ability to be conducted at mild reaction conditions, thiol-Michael click reaction acts as a powerful tool for material synthesis, bio-conjugation and polymer functionalization. Firstly, the control of the thiol-Michael addition polymerization was achieved by the development of two visible light sensitive photobase generators, namely Coumarin-TMG and MNPPOC-TMG. By measuring the photolytic efficiency ...
Synthesis And Catalytic Testing Of A Proline Functionalized Amphiphilic Block Copolymer, 2018 Eastern Michigan University
Synthesis And Catalytic Testing Of A Proline Functionalized Amphiphilic Block Copolymer, Eric Firestone
Master's Theses and Doctoral Dissertations
Catalysts are reagents used to reduce the amount of energy that a reaction needs to execute, allowing it to proceed at a higher rate while not being consumed. The use of catalyst functionalized amphiphilic copolymer allows easier recovery of the catalyst at the end of the synthesis and allows for the reaction. In water, under appropriate conditions, the amphiphilic block copolymers will form micelles and allow the reaction to occur on the interior of the micelle. The synthesis of amphiphilic copolymer with a hydrophobic O-methacryloyl-trans-4- hydroxy-L-proline and methyl methacrylate end and a hydrophilic acrylic acid end was characterized. The polymer ...