Utilizing Polymer Topology In Peptide-Based Block Copolymers: Unique Aqueous Assembly And Responsive Behavior, 2013 University of Southern Mississippi
Utilizing Polymer Topology In Peptide-Based Block Copolymers: Unique Aqueous Assembly And Responsive Behavior, Jacob Griffin Ray
This document details work in the area of amphiphilic polypeptide-based block copolymers that are able to self-assemble into well-defined nanostructures in aqueous solution. The main focus of this work is to understand the impacts of polymer topology on self-assembly behavior and response to external stimulus, particularly pH. Poly(L-lysine) and poly(L-glutamic acid) are two pH-responsive, hydrophilic polypeptides that possess the unique property of undergoing α-helix to random coil secondary structure transitions with pH, and this responsiveness can lead to global morphology changes such as changes in aggregate size or even morphology transitions. These polypeptides are synthesized via ring opening ...
Dynamic Bioactive Stimuli-Responsive Polymeric Surfaces, 2013 University of Southern Mississippi
Dynamic Bioactive Stimuli-Responsive Polymeric Surfaces, Heather Marie Pearson
This dissertation focuses on the design, synthesis, and development of antimicrobial and anticoagulant surfaces of polyethylene (PE), polypropylene (PP), and poly(tetrafluoroethylene) (PTFE) polymers. Aliphatic polymeric surfaces of PE and PP polymers functionalized using click chemistry reactions by the attachment of –COOH groups via microwave plasma reactions followed by functionalization with alkyne moieties. Azide containing ampicillin (AMP) was synthesized and subsequently clicked into the alkyne prepared PE and PP surfaces. Compared to non-functionalized PP and PE surfaces, the AMP clicked surfaces exhibited substantially enhanced antimicrobial activity against Staphylococcus aureus bacteria. To expand the biocompatibility of polymeric ...
Polymers For Dna Binding, 2013 Seton Hall University
Polymers For Dna Binding, Sue Yuan Li
Seton Hall University Dissertations and Theses (ETDs)
Fused Arenes-Based Molecular And Polymeric Materials For Organic Field Effect Transistors, 2013 Western Kentucky University
Fused Arenes-Based Molecular And Polymeric Materials For Organic Field Effect Transistors, Harista Irugulapati
Masters Theses & Specialist Projects
In the past decade, tremendous progress has been made in organic field effect
transistors. Fused oligothiophenes and anthracene molecules are fascinating
macromolecules having unique optoelectronic properties. These compounds are successfully employed as active components in optoelectronic devices including field effect transistors. Our goal is to design and synthesize conjugated molecular materials, which are highly functionalized through structural modifications in order to enhance their electronic, photonic, and morphological properties. The main desire is to synthesize novel organic fused-arenes having efficient charge carrier mobilities, as well as to optimize optical properties for organic field effect transistors (OFETs). Novel series of fused arene ...
Tuning Sol-Gel Phase Diagrams Of Doubly Thermosensitive Hydrophilic Diblock Copolymers In Water, 2013 University of Tennessee, Knoxville
Tuning Sol-Gel Phase Diagrams Of Doubly Thermosensitive Hydrophilic Diblock Copolymers In Water, Naixiong Jin
This dissertation presents the synthesis of stimuli-responsive hydrophilic diblock copolymers and the study of their behavior in water under various conditions. The polymers were made by “living”/controlled radical polymerization. Chapter 1 presents a background of this dissertation. Chapters 2-4 describe a family of doubly thermosensitive diblock copolymers with a small amount of carboxylic acid groups incorporated into either one or both blocks. The lower critical solution temperature (LCST) of the weak acid-containing block increases with increasing pH due to the ionization of carboxylic acid. Chapter 5 presents the preparation of pH-sensitive diblock copolymer micelle-embedded agarose hydrogels.
Chapter 2 describes ...
Direct Chain-End Functionalization Of Living Polyisobutylene With Phenoxyalkyl(Meth)Acrylates, 2013 University of Southern Mississippi
Direct Chain-End Functionalization Of Living Polyisobutylene With Phenoxyalkyl(Meth)Acrylates, Conor Patrick Roche
This volume describes efforts toward the synthesis and employment of phenoxyalkyl (meth)acrylates, which were used to end-quench 1sobutylene polymers m1tiated from 2-chloro-2,4,4-tnmethylpentane (TMPCl), and 5-tert-butyl-1 ,3-d1(1-chlorol- methylethyl)benzene (bDCC), respectively, at -70 °C in 40/60 (v/v) hexane/methyl chlonde. The quencher/cham end molar rat10s typically ranged from 2.5-4, while the ratio of Lewis ac1d/cham end was vaned from approximately 3 5-6 In all cases, alkylation occurred exclusively at the para position of the quencher and no cham degradat10n was observed, even at high concentrations of TiC14 and long reaction times. Prellmmary ...
Mechanistic Insights Into Ring-Opening And Decarboxylation Of 2-Pyrones In Liquid Water And Tetrahydrofuran, 2013 University of Wisconsin - Madison
Mechanistic Insights Into Ring-Opening And Decarboxylation Of 2-Pyrones In Liquid Water And Tetrahydrofuran, Mei Chia, M. Ali Haider, Gerald Pollock Iii, George A. Kraus, Matthew Neurock, James A. Dumesic
2-Pyrones, such as triacetic acid lactone, are a promising class of biorenewable platform chemicals that provide access to an array of chemical products and intermediates. We illustrate through the combination of results from experimental studies and first-principle density functional theory calculations that key structural features dictate the mechanisms underlying ring-opening and decarboxylation of 2-pyrones, including the degree of ring saturation, the presence of C═C bonds at the C4═C5 or C5═C6 positions within the ring, as well as the presence of a β-keto group at the C4 position. Our results demonstrate that 2-pyrones undergo a range of reactions ...
Carbon Nitride And Conjugated Polymer Composite Materials, 2013 The University of Western Ontario
Carbon Nitride And Conjugated Polymer Composite Materials, Josh Byers
Electronic Thesis and Dissertation Repository
The semiconductor and photovoltaic properties of carbon nitride (CNx) thin films prepared using a reactive magnetron sputtering technique were investigated both individually and as composites with the organic conjugated polymers polybithiophene (PBT) and poly(3-hextlthiophene) (P3HT). At low nitrogen content, the film structure was dominated by graphitic sp2 percolation networks, whereas at higher nitrogen contents CNx films started to demonstrate semiconductor properties, as evidenced by the occurrence of photoconductivity and the development of a space charge region. When CNx was deposited onto a PBT substrate, it was found to function as an acceptor material improving the photocurrent generation both ...
Carboxylic Acid Functionalized Butyl Rubber: From Synthesis To Applications, 2013 The University of Western Ontario
Carboxylic Acid Functionalized Butyl Rubber: From Synthesis To Applications, Matthew John Mceachran
Electronic Thesis and Dissertation Repository
Butyl Rubber (RB) is a copolymer of isobutylene (IB) with small percentages of isoprene (IP). Typically these IP units serve as sites for the covalent cross-linking of the rubber, but they can also serve as sites to further functionalize RB. These modifications can expand the potential applications of RB. This thesis describes the synthesis of carboxylic acid functionalized RB and some properties and applications of these materials.
Fluorescent Ratiometric Indicators Based On Cu(Ii)-Induced Changes In Poly(Nipam) Microparticle Volume, 2013 Worcester Polytechnic Institute
Fluorescent Ratiometric Indicators Based On Cu(Ii)-Induced Changes In Poly(Nipam) Microparticle Volume, Shawn Burdette, John Osambo, W.Rudolf Seitz, Daniel Kennedy, Roy Planalp, Aaron Jones, Randy Jackson
Shawn C. Burdette
Microparticles consisting of the thermal responsive polymer N-isopropyl acrylamide (polyNIPAM), a metal ion-binding ligand and a fluorophore pair that undergoes fluorescence resonance energy transfer (FRET) have been prepared and characterized. Upon the addition of Cu(II), the microparticles swell or contract depending on whether charge is introduced or neutralized on the polymer backbone. The variation in microparticle morphology is translated into changes in emission of each fluorophore in the FRET pair. By measuring the emission intensity ratio between the FRET pair upon Cu(II) addition, the concentration of metal ion in solution can be quantified. This ratiometric fluorescent indicator is ...
Total Synthesis Of Paracaseolide A, 2013 Iowa State University
Total Synthesis Of Paracaseolide A, Tezcan Guney, George A. Kraus
The total synthesis of paracaseolide A, a valuable cell-cycle progression inhibitor, was accomplished in 8 steps from known compounds, with 6.6% overall yield. The synthetic strategy creates strong potential for diversification.
Synthesis And Characterization Of Cuo Nanosheets In Polyvinylpyrrolidone By Quick Precipitation Method, 2013 university putra malaysia
Synthesis And Characterization Of Cuo Nanosheets In Polyvinylpyrrolidone By Quick Precipitation Method, Mahdi Shahmiri
In this project, CuO nanosheets were grown successfully in polyvinylpyrrolidone (PVP) by a simple and quick chemical method in the absence of templates. Copper nitrate, PVP and sodium hydroxide were used as copper precursor, stabilizer and accelerator, respectively. The products were characterized by X-ray diffraction (XRD), UV–vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy dispersive analysis of X-rays (EDAX), transmission electron microscopy (TEM) and Fourier transform infrared (FT-IR) spectroscopy. The result of the XRD and EDAX confirmed the formation of pure single-phase CuO. Generation of the CuO nanosheets and nanorods were confirmed by UV–visible spectra. FE-SEM depicted ...
Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, 2013 Michigan Technological University
Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, Xiaochu Ding
Dissertations, Master's Theses and Master's Reports - Open
This dissertation is related to the studies of functionalized nanoparticles for self-assembly and as controlled drug delivery system. The whole topic is composed of two parts. In the first part, the research was conducted to design and synthesize a new type of ionic peptide-functionalized copolymer conjugates for self-assembly into nanoparticle fibers and 3D scaffolds with the ability of multi-drug loading and governing the release rate of each drug for tissue engineering. The self-assembly study confirmed that such peptide-functionalized amphiphilic copolymers underwent different self-assembly behavior. The bigger nanoparticles were more easily assembled into nanoparticle fibers and 3D scaffolds with larger pore ...
Hideki Shirakawa: Synthesized Counductive Polymers, 2013 Parkland College
Hideki Shirakawa: Synthesized Counductive Polymers, Erika Rosenberger
Natural Sciences Poster Sessions
Hideki Shirakawa discovered how to create polyacteylene thin films by accidentally adding extra Zieglar-Natta catalyst. this led him to discovering conductive polymers by using a technique called chemical doping, which oxydizes polyacetylene. This is a project for the Natural Sciences Poster Session at Parkland College.
Fluorinated Arene, Imide And Unsaturated Pyrrolidinone Based Donor Acceptor Conjugated Polymers: Synthesis, Structure-Property And Device Studies, Arawwawala Don T. Liyanage
Theses and Dissertations--Chemistry
FLUORINATED ARENE, IMIDE AND LACTAM-FUNCTIONALIZED DONOR ACCEPTOR CONJUGATED POLYMERS: SYNTHESIS, STRUCTURE-PROPERTY AND DEVICE STUDIES
After the discovery of doped polyacetylene, organic semiconductor materials are widely studied as high impending active components in consumer electronics. They have received substantial consideration due to their potential for structural tailoring, low cost, large area and mechanically flexible alternatives to common inorganic semiconductors. To acquire maximum use of these materials, it is essential to get a strong idea about their chemical and physical nature. Material chemist has an enormous role to play in this novel area, including development of efficient synthetic methodologies and control the ...
Evaluating Chalcogen Heteroatoms In Conjugated Polymers For Organic Electronics, 2013 Iowa State University
Evaluating Chalcogen Heteroatoms In Conjugated Polymers For Organic Electronics, Brandon Michael Kobilka
Graduate Theses and Dissertations
In recent years, alternating electron-donating and electron-acceptor (D-A) conjugated copolymers are among the best materials being used to fabricate high-efficiency bulk-heterojunction organic photovoltaics (BHJ-OPVs). Thiophene and thiophene-based aromatic molecules are typically used in the design and construction of these materials due to their ability to impart good film-forming and charge transport properties as well as their synthetic robustness. Among thiophene-based molecules benzo[1,2-b:4,5-b']dithiophene (BDT) has been incorporated into numerous, high-efficiency OPVs. This dissertation reports on the synthesis and characterization of the analogous oxygen- and selenium-containing functionalized benzodifuran (BDF) and benzodiselenophene (BDSe) and their incorporation ...
Multifunctional Nanomaterials Of Dna Block Copolymers: Synthesis, Self- Assembly, Thermodynamic Studies And Biomedical Applications, 2013 University of Pennsylvania
Multifunctional Nanomaterials Of Dna Block Copolymers: Synthesis, Self- Assembly, Thermodynamic Studies And Biomedical Applications, Xi-Jun Chen
Publicly Accessible Penn Dissertations
Oligonucleotide-conjugated bio-hybrid nanomaterials with a dense DNA layer on the surface have been shown to possess extraordinary selectivity and sensitivity for DNA detection as well as promising results as delivery agents, as demonstrated with the exceptional example of polyvalent oligonucleotide-conjugated gold nanoparticles. However, progress in this field has been slowed, since achieving high DNA density functionalization on the nanoparticle surface for materials other than gold is a major challenge. In this body of work, we have developed a general system to conjugate a dense layer of DNA on the surface of nanoparticles by the self-assembly of DNA block copolymer. These ...
Raft Microemulsion Polymerization With Surface-Active Chain Transfer Agent, 2013 Iowa State University
Raft Microemulsion Polymerization With Surface-Active Chain Transfer Agent, Ibrahim Adnan El-Hedok
Graduate Theses and Dissertations
The work described in this dissertation focuses on enhancing the polymer nanoparticle synthesis using RAFT (reversible-addition fragmentation chain transfer) in microemulsion polymerization in order to achieve predetermined molecular weight with narrow molecular weight polydispersity.
The hypothesis is that the use of an amphiphilic chain transfer agent (surface-active CTA) will confine the CTA to the surface of the particle and thermodynamically favor partitioning of the CTA between micelles and particles throughout the polymerization. Thus, the CTA diffusion from micelles to polymer particles would be minimized and the breadth of the CTA per particle distribution would remain low.
We report the successful ...
Hierarchical Assemblies Of Soft Matters From Polymers And Liquid Crystals On Structured Surfaces, 2013 University of Pennsylvania
Hierarchical Assemblies Of Soft Matters From Polymers And Liquid Crystals On Structured Surfaces, Apiradee Honglawan
Publicly Accessible Penn Dissertations
Hierarchical, multifunctional materials hold important keys to numerous advanced technologies, including electronics, optics, and medicine. This thesis encompasses generation of hierarchical structures with novel morphologies and functions through self-assembly directed by lithographically fabricated templates. Here, two soft materials, amphiphilic random copolymers of photopolymerized acryloyl chloride (ranPAC) and smectic-A liquid crystal (SmA-LC) molecule, 4'(5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-heptadecaflu-orododecyloxy)-biphenyl-4-carboxylic acid ethyl ester, are synthesized as model systems to investigate the governing principles at the topographic surface/interface.
The ranPAC can self-organize into nanomicelles with high regularity and stability ...
A Rheology Model Of Soft Elastomeric Capacitor For Weigh-In-Motion Application, 2013 Iowa State University
A Rheology Model Of Soft Elastomeric Capacitor For Weigh-In-Motion Application, Venkata Dharmateja Kollipara
Graduate Theses and Dissertations
As a result of fast growing industry, there is an increase in traffic congestion and deterioration of transportation inventory. Real-time traffic characterisation could be used to amoliorate the efficiency of our transportation system. Weigh-In-Motion (WIM) systems offer the advantages of vehicle classification, speed measurement, in addition to weight measurement while vehicles are moving. In this thesis, state-of-the-art WIM systems are discussed and limitations of current technologies are identified. A Soft Elastomeric Capacitor (SEC) that works as a large scale surface strain gauge is introduced to address the limitations in existing techniques and investigated for its applicability as a WIM sensor ...