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Relatin Dissolved Oxygen Concentration To Fish Distribution In Jarecki Lake, Adam Sutton 2010 University of Nebraska at Lincoln

Relatin Dissolved Oxygen Concentration To Fish Distribution In Jarecki Lake, Adam Sutton

Environmental Studies Undergraduate Student Theses

Abstract Water temperature and dissolved oxygen (DO) profiles were measured once every month from mid July to mid February in a relatively deep sand-pit lake in southeast Nebraska. These profiles showed depleted DO concentrations below the thermocline during summer stratification indicating areas fish will likely avoid in summer months. Colder temperatures in fall caused complete mixing of the water column allowing fish to inhabit all depths of the lake. An inverse temperature stratification occurred directly below the ice during winter months as ice cover cooled the surface water to below 4 degrees Celsius. Ice cover also blocked air – water oxygen ...


Herbicides And Amphibian Populations, Zach Shirk 2010 University of Nebraska - Lincoln

Herbicides And Amphibian Populations, Zach Shirk

Environmental Studies Undergraduate Student Theses

Amphibians are a unique class of species that are found worldwide except Antarctica and Greenland. They range in size from a few millimeters to over six feet long. Amphibian’s habitats are as various as their size, but one thing in common is that amphibians require an aquatic location to breed. Amphibians live in deserts, mountain prairies, rain forest, wetlands, and almost everywhere in between. Amphibians are an integrated part of most natural ecosystems across the world. Amphibians are a critical part of many food chains; they provide the important link between secondary and tertiary consumers. Amphibians are indicator species ...


Synthesis Of Cifidabco And Mannose Co-Functionalized G(4)-Pamam Dendrimer For Use In Antibiotics, Harrison VanKoten 2010 Carroll College, Helena, MT

Synthesis Of Cifidabco And Mannose Co-Functionalized G(4)-Pamam Dendrimer For Use In Antibiotics, Harrison Vankoten

Chemistry and Physics Undergraduate Theses

Synthesis of C16DABCO and mannose co-functionalized G(4)-PAMAM dendrimer is expected to yield a useful antimicrobial that is effective in binding to mannose specific lectins on bacterial fimbriae. Thus far, mannose has been attached to the dendrimer with near complete functionalization. C16DABCO and mannose cofunctionalized G(4)-PAMAM dendrimer have been synthesized, but not in sufficient quantities to allow examination of its the antibacterial properties. Future work includes optimizing the final synthesis and performing toxicity studies.


Computational Design And Elaboration Of A De Novo Heterotetrameric Α-Helical Protein That Selectively Binds An Emissive Abiological (Porphinato)Zinc Chromophore, H Christopher Fry, Andreas Lehmann, Jeffery G. Saven, William F. DeGrado, Michael J. Therien 2010 University of Pennsylvania

Computational Design And Elaboration Of A De Novo Heterotetrameric Α-Helical Protein That Selectively Binds An Emissive Abiological (Porphinato)Zinc Chromophore, H Christopher Fry, Andreas Lehmann, Jeffery G. Saven, William F. Degrado, Michael J. Therien

Departmental Papers (Chemistry)

The first example of a computationally de novo designed protein that binds an emissive abiological chromophore is presented, in which a sophisticated level of cofactor discrimination is pre-engineered. This heterotetrameric, C(2)-symmetric bundle, A(His):B(Thr), uniquely binds (5,15-di[(4-carboxymethyleneoxy)phenyl]porphinato)zinc [(DPP)Zn] via histidine coordination and complementary noncovalent interactions. The A(2)B(2) heterotetrameric protein reflects ligand-directed elements of both positive and negative design, including hydrogen bonds to second-shell ligands. Experimental support for the appropriate formulation of [(DPP)Zn:A(His):B(Thr)](2) is provided by UV/visible and circular dichroism spectroscopies ...


Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, Ram Mohan, Scott Krabbe, Veronica Angeles 2010 Illinois Wesleyan University

Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, Ram Mohan, Scott Krabbe, Veronica Angeles

Scholarship

A bismuth bromide-catalyzed (10.0 mol %) multicomponent reaction involving the allylation of THF- and THP-ethers, followed by in situ derivatization with acetic anhydride to generate highly functionalized esters has been developed under solvent-free conditions. To the best of our knowledge, this is the first report of a catalytic procedure for the allylation of THF- and THP-ethers to yield ring-opened products.


2-(3-Nitrophenoxy)Quinoxaline, Hairul Anuar Bin Tajuddin 2010 University of Malaya

2-(3-Nitrophenoxy)Quinoxaline, Hairul Anuar Bin Tajuddin

Hairul Anuar Bin Tajuddin

In the title molecule, C(14)H(9)N(3)O(3), the dihedral angle between the quinoxaline and benzene rings is 77.13 (9)degrees. The molecule is twisted about the ether-benzene O-C bond, with a C-O-C-C torsion angle of -102.8 (2)degrees. In the crystal, molecules are linked by C-H center dot center dot center dot O hydrogen bonds, forming layers in the ab plane, with one nitro O atom accepting two such interactions. The layers stack along the c-axis direction via weak C-H center dot center dot center dot pi interactions.


A Mild And Chemoselective Method For The Deprotection Of Tert-Butyldimethylsilyl (Tbdms) Ethers Using Iron(Iii) Tosylate As A Catalyst, Ram Mohan, Jason Bothwell, Veronica Angeles, James Carolan, Margaret Olson 2010 Illinois Wesleyan University

A Mild And Chemoselective Method For The Deprotection Of Tert-Butyldimethylsilyl (Tbdms) Ethers Using Iron(Iii) Tosylate As A Catalyst, Ram Mohan, Jason Bothwell, Veronica Angeles, James Carolan, Margaret Olson

Scholarship

The most common method for the deprotection ofTBDMS ethers utilizes stoichiometric amounts of tetrabutylammonium fluoride, n-Bu4N+F(TBAF), which is highly corrosive and toxic. We have developed a mild and chemoselective method for the deprotection ofTBDMS, TES, and TIPS ethers using iron(III) tosylate as a catalyst. Phenolic TBDMS ethers, TBDPS ethers and the BOC group are not affected under these conditions. Iron(III) tosylate is an inexpensive, commercially available, and non-corrosive reagent.


Iron(Iii) Tosylate-Catalyzed Deprotection Of Aromatic Acetals In Water, Ram Mohan, Margaret Olson, James Carolan, Michael Chiodo, Phillip Lazzara 2010 Illinois Wesleyan University

Iron(Iii) Tosylate-Catalyzed Deprotection Of Aromatic Acetals In Water, Ram Mohan, Margaret Olson, James Carolan, Michael Chiodo, Phillip Lazzara

Scholarship

The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0–5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.


In Your Element: Green Bismuth, Ram Mohan 2010 Illinois Wesleyan University

In Your Element: Green Bismuth, Ram Mohan

Scholarship

No abstract provided.


Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone, Kasinath Sana 2010 Wayne State University

Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone, Kasinath Sana

Wayne State University Dissertations

ABSTRACT

DEVELOPMENT AND APPLICATIONS OF THIOACIDS IN PEPTIDE CHEMISTRY AND EXPLORATION OF METHODS TOWARD THE STEREOCHEMICAL ELUCIDATION AND SYNTHESIS OF VIRGINEONE

by

KASINATH SANA

December 2010

Advisor: David Crich

Major: Chemistry

Degree: Doctor of Philosophy

This dissertation describes investigations toward the development of methods for the synthesis of peptidyl thioacids and thioesters, with particular emphasis on applications in peptide chemistry, and the exploration of methods toward the assignment of the relative and absolute configuration of virgineone and its total synthesis.

The first part of chapter one introduces the general characteristics and reactivity of thioacids, and describes their potential for application ...


Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, LuAnne M. McNulty, John Magers, Paul Morgan 2010 Butler University

Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, Luanne M. Mcnulty, John Magers, Paul Morgan

Scholarship and Professional Work - LAS

The ability to use computer-based technology is an essential skill set for students majoring in chemistry. This exercise details the introduction of appropriate uses for this technology in the organic chemistry series. The incorporation of chemically appropriate online resources (module 1), scientific databases (module 2), and the use of a chemical drawing program (module 3) are detailed here.


Structure-Reactivity Relationships Of L-Proline Derived Spirolactams And A-Methyl Prolinamide Organocatalysts In The Asymmetric Michael Addition Reaction Of Aldehydes To Nitroolefins., Fintan Kelleher, Sinead Kelly, John Watts, Vickie McKee 2010 Institute of Technology, Tallaght

Structure-Reactivity Relationships Of L-Proline Derived Spirolactams And A-Methyl Prolinamide Organocatalysts In The Asymmetric Michael Addition Reaction Of Aldehydes To Nitroolefins., Fintan Kelleher, Sinead Kelly, John Watts, Vickie Mckee

Articles

L-Proline derived spirolactams and a-methyl prolinamides act as organocatalysts for the asymmetric conjugate addition of aldehydes to nitroolefins in excellent yields, with good diastereoselectivity and enantioselectivity. Furthermore, low catalyst loadings (5 mol%) and a low aldehyde molar excess (1.5 molar equivalents) were achieved.


10,12-Dimethylpteridino[6,7-F][1,10]- Phenanthroline-11,13(10h,12h)-Dione– Chloroform (1/1), Waynie Olaprath, Jennifer Rodin, Kraig A. Wheeler, Mark E. McGuire 2010 Eastern Illinois University

10,12-Dimethylpteridino[6,7-F][1,10]- Phenanthroline-11,13(10h,12h)-Dione– Chloroform (1/1), Waynie Olaprath, Jennifer Rodin, Kraig A. Wheeler, Mark E. Mcguire

Kraig A. Wheeler

In the title co-crystal, C18H12N6O2_CHCl3, intramolecular Cl3C—H_ _ _N hydrogen-bonding interactions occur between a single CHCl3 and both N atoms at the 1,10-positions on the phenanthroline portion of the molecule. The interplanar distance between inversion-related molecules is 3.241 (2) A ° .


10,12-Dimethylpteridino[6,7-F][1,10]- Phenanthroline-11,13(10h,12h)-Dione– Chloroform (1/1), Waynie Olaprath, Jennifer Rodin, Kraig A. Wheeler, Mark E. McGuire 2010 Eastern Illinois University

10,12-Dimethylpteridino[6,7-F][1,10]- Phenanthroline-11,13(10h,12h)-Dione– Chloroform (1/1), Waynie Olaprath, Jennifer Rodin, Kraig A. Wheeler, Mark E. Mcguire

Faculty Research and Creative Activity

In the title co-crystal, C18H12N6O2_CHCl3, intramolecular Cl3C—H_ _ _N hydrogen-bonding interactions occur between a single CHCl3 and both N atoms at the 1,10-positions on the phenanthroline portion of the molecule. The interplanar distance between inversion-related molecules is 3.241 (2) A ° .


The Synthesis Of Unnatural Morphine Derivatives As Glial Activation Inhibitors And The Synthesis Of Corticosterone-Glucuronide, Morin Mae Frick 2010 University of Colorado Boulder

The Synthesis Of Unnatural Morphine Derivatives As Glial Activation Inhibitors And The Synthesis Of Corticosterone-Glucuronide, Morin Mae Frick

Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)

A novel, non-neuronal mechanism to explain the development of opioid tolerance and dependance has been described. This mechanism involves the activation of spinal cord glia. Glia are important contributors to the creation of enhanced pain states via the release of neuroexcitatory and proinflammatory substances. Data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Inhibiting glial activation could therefore increase the clinical utility of analgesic drugs. The synthesis of advanced intermediates for the development of a series of novel morphinan-like structures that are potential glial activation inhibitors will be discussed.

Corticosterone displays an intense ...


2,3-Bis(Bromomethyl)-1,4-Diphenylbenzene, Jonathan B. Briggs, Mikael D. Jazdzyk, Glen P. Miller 2010 University of New Hampshire

2,3-Bis(Bromomethyl)-1,4-Diphenylbenzene, Jonathan B. Briggs, Mikael D. Jazdzyk, Glen P. Miller

Chemistry Scholarship

In the title compound, C(20)H(16)Br(2), the terminal phenyl groups are twisted away from the central ring by approximately 55 and -125 degrees (average of four dihedral angles each), respectively. The crystal structure is stabilized by a combination of interMolecular and intraMolecular interactions including interMolecular pi-pi stacking interactions [C atoms of closest contact = 3.423 ( 5) angstrom].


Solid Supported Synthesis Of Secondary Amines Via Staudinger And Microwave Aza-Wittig Reactions, Kyle Thomas Holsinger 2010 Butler University

Solid Supported Synthesis Of Secondary Amines Via Staudinger And Microwave Aza-Wittig Reactions, Kyle Thomas Holsinger

Undergraduate Honors Thesis Collection

Amine bond formation is a major topic in organic chemistry and is widely applied to the formation of medicinal compounds. Current studies have analyzed the benefits of microwave irradiation and solid supported reagents in order to improve reaction conditions and both synthetic and environmental costs. In the synthesis of amines, we investigate the combined use of microwave irradiation and solid supported reagents in the aza-Wittig and reductive amination reaction.


Development Of Novel Ahr Antagonists, Hyosung Lee 2010 University of Kentucky

Development Of Novel Ahr Antagonists, Hyosung Lee

University of Kentucky Doctoral Dissertations

Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR ...


Synthesis Of Functionalized Gpi Anchors And Related Glycoconjugates, Benjamin M. Swarts 2010 Wayne State University

Synthesis Of Functionalized Gpi Anchors And Related Glycoconjugates, Benjamin M. Swarts

Wayne State University Dissertations

This dissertation is divided into two chapters describing the background, significance, and synthesis of GPI anchors and GPI-anchored molecules. GPI anchors are a class of complex glycolipids with the primary purpose of attaching cell surface proteins/glycoproteins to the cell membrane. The first chapter is focused on the synthesis of functionalized GPI anchors, and begins with an introductory look at the discovery, structure, biosynthesis, and biological functions of GPIs. Then, after surveying progress and achievements in GPI synthesis, including discussion about current strategic shortcomings in the field that prevent the chemical synthesis of various GPI derivatives, our approach to accessing ...


Transition Metal-Mediated Higher-Order Cycloaddition Reactions: Application To The Total Synthesis Of Complex Natural Products, Bilal Abou Aleiwi 2010 Wayne State University

Transition Metal-Mediated Higher-Order Cycloaddition Reactions: Application To The Total Synthesis Of Complex Natural Products, Bilal Abou Aleiwi

Wayne State University Dissertations

ABSTRACT

TRANSITION METAL-MEDIATED HIGHER-ORDER CYCLOADDITION REACTIONS: APPLICATION TO THE TOTAL SYNTHESIS OF COMPLEX NATURAL PRODUCTS

by

BILAL ABOU ALEIWI

October 2010

Advisor: Dr. James H. Rigby

Major: Chemistry (Organic)

Degree: Doctor of Philosophy

Chromium (0)-mediated [6ð + 2ð] and [6ð + 2ð + 2ð] cycloaddition reactions between cyclic trienes and alkynes is reported. The development, investigation and the application of these reactions in the total synthesis of complex ring systems and natural products is described. Two natural products, namely, ∆ 9(12) -Capnellene and Echinopines A and B were targeted.

An investigation led to the successful development of a methodology to form the ...


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