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Organic Chemistry: A Survival Guide For Students, Ethan C. Levine 2012 Northeastern University

Organic Chemistry: A Survival Guide For Students, Ethan C. Levine

Anton Geiler

This project reviews material from undergraduate Organic Chemistry I and II. It is meant to function as a supplement to the textbook and lecture material for the course as it is taught in universities throughout the United States. Complex ideas are broken down into simpler ones. Material is presented in conversational language, using as little scientific jargon as possible.


Establishment Of An Efficient Method For The Synthesis Of Srh, An Important Molecule In Bacterial Quorum Sensing, Emily Showell-Rouse, Ruoyi Liu 2012 The University of San Francisco

Establishment Of An Efficient Method For The Synthesis Of Srh, An Important Molecule In Bacterial Quorum Sensing, Emily Showell-Rouse, Ruoyi Liu

Creative Activity and Research Day - CARD

Quorum sensing (QS) is a process of bacterial communication that regulates the expression of virulence genes in many bacteria. The study of QS, could lead to new treatments for bacterial diseases. Interspecies bacterial communication utilizes the signaling molecule autoinducer-2 (AI-2). The LuxS enzyme converts S-ribosyl-L-homocysteine (SRH) into 4(S),5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2. LuxS inhibitors could prevent QS by halting conversion of SRH. We have developed an efficient synthesis of SRH from D-ribose and L-homocystine. This procedure provides us with both a supply of SRH for biochemical assays and a foundation for the synthesis of SRH ...


Mesoionic Compounds, Mark Gordon 2012 Olivet Nazarene University

Mesoionic Compounds, Mark Gordon

Student Scholarship - Chemistry

A poster presentation defining what mesoionic compounds are, describing their uses in the medical field and beyond, and providing examples of common mesoionic compounds.


Progress Towards The Total Synthesis Of Amphidinolide C, Nicholas A. Morra 2012 The University of Western Ontario

Progress Towards The Total Synthesis Of Amphidinolide C, Nicholas A. Morra

Electronic Thesis and Dissertation Repository

A second generation catalyst for the Mukaiyama oxidative cyclization for the formation of trans-THF rings is described. Co(nmp)2, displays increased stability to the reaction conditions, resulting in lower catalyst loadings, lower reaction temperatures, and significantly higher purity and yields of the products. Three procedures have been developed with this new water-soluble catalyst that greatly simplifies the post-reaction purification, making this procedure the premier method of forming trans-THF rings.

This new catalyst has been applied towards the total synthesis of the potently bioactive macrocycle, Amphidinolide C. Herein we report the successful synthesis of several fragments of the ...


Improved Synthesis Of The Longtailed Mealybug Pheromone, Johanna M. Bakonyi 2012 Johanna Bakonyi

Improved Synthesis Of The Longtailed Mealybug Pheromone, Johanna M. Bakonyi

Master's Theses

No abstract provided.


Synthesis Of (±)-Quebrachamine, Tetrahydroisoquinocarbazoles, And Progress Towards Biselide A And E, Barbora Morra 2012 The University of Western Ontario

Synthesis Of (±)-Quebrachamine, Tetrahydroisoquinocarbazoles, And Progress Towards Biselide A And E, Barbora Morra

Electronic Thesis and Dissertation Repository

A variety of methodologies developed in our research group have inspired the three separate projects reported. First, the total synthesis of (±)-quebrachamine was performed in 13 steps and 17.8% overall yield. Highlights of the synthesis include an efficient preparation of a functionalized indole core via a [3+2] annulation cycloaddition reaction between a functionalized nitrile and donor-acceptor cyclopropane and a photo induced 9-membered ring closure.

Secondly, we have reported the most efficent and highest yielding route to several tetrahydroisoquinocarbazoles, where the core was prepared in six steps from tryptophol in 51% overall yield. This work highlights for the first ...


Enantioselective Biotransformation Of Prochiral Ketone Via Daucus Carota, Ryan Smith, Charlie Knox, Elizabeth Davis 2012 Stephen F Austin State University

Enantioselective Biotransformation Of Prochiral Ketone Via Daucus Carota, Ryan Smith, Charlie Knox, Elizabeth Davis

Undergraduate Research Conference

Biotransformations of prochiral ketones can be performed using plant cells. The benefits of using plant cells include low cost, environmentally sound procedures compared to conventional chemical processes, and the stereospecific nature of the reaction.1,2 Benzofuran-2-yl methyl ketone was reduced to (- )-benzofuran-2-yl-ethanol after incubation with carrots in water. The reaction was enantioselective in that it produced the S-isomer as indicated by optical activity. Currently, attempts to isolate the carrot enzyme and antimicrobial studies of the (-)-benzofuran-2-yl-ethanol product are underway.


I. Synthesis Of Β-Sitosterol And Phytosterol Esters; Ii. New Methodology For Singlet Oxygen Generation From 1,1-Dihydroperoxides, Jiliang Hang 2012 University of Nebraska-Lincoln

I. Synthesis Of Β-Sitosterol And Phytosterol Esters; Ii. New Methodology For Singlet Oxygen Generation From 1,1-Dihydroperoxides, Jiliang Hang

Student Research Projects, Dissertations, and Theses - Chemistry Department

Phytosterols are steroid compounds structurally similar with cholesterol and vary in the nature of carbon side chain. β-Sitosterol is commercially available in preparative amount only as mixtures with other phytosterols. New semipreparative synthesis of pure β-sitosterol and sidechain-modified phytosterols is discussed in this dissertation. This new synthesis is achieved via a temporary masking of the stigmasterol 5,6-alkene as an epoxide. Following performance of the desired modification, the alkene is regenerated through a mild deoxygenation. Preparation of phytosterol esters for cholesterol metabolism study is also discussed in this dissertation.

Singlet oxygen (1O2) is the lowest excited state of ...


A Dynamic Programming Approach To Sequence Alignments, Jeffery Allen 2012 Carroll College, Helena, MT

A Dynamic Programming Approach To Sequence Alignments, Jeffery Allen

Mathematics, Engineering and Computer Science Undergraduate Theses

Using a created a program in MatLab, several amino acid sequences can be aligned with one another so they can be examined for biological significance. Sequence alignments are used to determine similarities in proteins and from this information, make inferences on protein functionality. The program accomplishes this by setting a cost for gaps in a sequence or substitution of one amino acid for another. A dynamic programming algorithm called the Needleman & Wunsch Algorithm is used to find several possible global pairwise alignments. These pairwise alignments are used to form a multiple sequence alignment, which compares a number of like sequences ...


The Influence Of Surface Plasmons On Excited State Dynamics In Ptcda, Natalia A. Azarova 2012 University of Colorado at Boulder

The Influence Of Surface Plasmons On Excited State Dynamics In Ptcda, Natalia A. Azarova

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Organic thin film solar cells can be paired with nanostructured substrates to overcome the issue of narrow spectral absorption in a thin-film configuration. The nanostructured surface acts not only as an effective scattering back reflector to increase the light path within the absorbing thin film but also affords plasmonic activity. The interface between the metal and the absorbing chromophore supports surface plasmon modes. The associated strong electromagnetic field can potentially couple with excitations of the chromophore, altering its exciton dynamics. Such a plasmon-exciton coupling can lead to control over excitation processes, namely singlet fission. Singlet fission is a sharing of ...


Design And Synthesis Of Polycyclic Aromatic Hydrocarbons For Emission And Through-Space Charge Delocalization Studies, Vijay Vyas 2012 Marquette University

Design And Synthesis Of Polycyclic Aromatic Hydrocarbons For Emission And Through-Space Charge Delocalization Studies, Vijay Vyas

Dissertations (2009 -)

Over the past decades, a variety of pi-conjugated organic materials have been explored as potential charge transport materials in conducting layers of photovoltaic devices. The performance of these devices critically depend on the efficiency with which the charge carriers (electrons and/or holes) move within the pi-conjugated materials present in their hole and electron conducting layers before their collection at the electrode. Hence, a large amount of research effort is devoted not only to the preparation of new pi-conjugated organic molecules for charge transport applications but also in understanding the nature of charge transport along the molecule (intra-chain) as well ...


Rhodium-Catalyzed Hydroboration Of 1,1-Disubstituted Alkenes, Scott A. Pettibone 2012 University of Nebraska-Lincoln

Rhodium-Catalyzed Hydroboration Of 1,1-Disubstituted Alkenes, Scott A. Pettibone

Student Research Projects, Dissertations, and Theses - Chemistry Department

Enantioselective rhodium-catalyzed hydroboration is becoming an increasingly important asymmetric transformation of alkenes based upon the utility of the organo boranate ester intermediate. The newly acquired asymmetric C-B bond can be converted to C-O, C-N, C-C bonds and the organo borante can be coupled to SP2 hybridized halogen bonds, all with retention of configuration. Catalyzed hydroboration of 1,1-disubstituted alkenes are an especially challenging substrate class for this enantioselective transformation. The difficulty for catalysts to distinguish between the two enantiotopic faces of the olefin is one of the major issues that have to be overcome to achieve a desirable level of ...


Design, Synthesis And Study Of Polycyclic Aromatic Hydrocarbons And Their Cation Radicals, Tushar Navale 2012 Marquette University

Design, Synthesis And Study Of Polycyclic Aromatic Hydrocarbons And Their Cation Radicals, Tushar Navale

Dissertations (2009 -)

The unifying theme of most of optoelectronic devices revolves around the charge carrier mobility of the organic materials used in the conductive layers, which is a measure of how easily the electron/hole moves in a particular pi conjugated organic material. When pi conjugated materials are incorporated in these devices, molecules are generally layered in random orientation. Consequently, the efficiency of charge transport in the conducting layers of these devices is governed not only by the intramolecular electron/hole transport through the backbone of the molecule but also by the intermolecular electron/hole transport between the molecules and hence packing ...


Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. McTeague 2012 Trinity College

Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague

Senior Theses and Projects

Previous research within the Curran group has demonstrated that ferrocene may be used as an organometallic constraint to induce the formation of α-helices in short peptides which traditionally possess undefined conformations. Through strategic placement of lysine residues at the i and i+3 positions within the peptide, such a constraint was accomplished via the crosslinking of the lysine side chains to ferrocene dicarboxylic acid chloride in solution phase synthesis. The aim of this work was to develop a method for solid phase peptide synthesis (SPPS) for the synthesis of these ferrocene-constrained helices. In particular, we seek to develop a method ...


Nmr Structure And Dynamics Of A Designed Water-Soluble Transmembrane Domain Of Nicotinic Acetylcholine Receptor, Tanxing Cui, David Mowrey, Vasyl Bondarenko, Tommy Tillman, Dejian Ma, Elizabeth Landrum, Jose Manuel Perez Aguilar, Jing He, Wei Wang, Jeffery G. Saven, Roderic G. Eckenhoff, Pei Tang, Yan Xu 2012 University of Pennsylvania

Nmr Structure And Dynamics Of A Designed Water-Soluble Transmembrane Domain Of Nicotinic Acetylcholine Receptor, Tanxing Cui, David Mowrey, Vasyl Bondarenko, Tommy Tillman, Dejian Ma, Elizabeth Landrum, Jose Manuel Perez Aguilar, Jing He, Wei Wang, Jeffery G. Saven, Roderic G. Eckenhoff, Pei Tang, Yan Xu

Departmental Papers (Chemistry)

The nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide range of pathophysiological conditions, for which rational drug designs often require receptor structures at atomic resolution. Recent proof-of-concept studies demonstrated a water-solubilization approach to structure determination of membrane proteins by NMR (Slovic et al., PNAS, 101: 1828–1833, 2004; Ma et al., PNAS, 105: 16537–42, 2008). We report here the computational design and experimental characterization of WSA, a water-soluble protein with ~ 83% sequence identity to the transmembrane (TM) domain of the nAChR α1 subunit. Although the design was based on a low-resolution structural template, the resulting ...


Microarray Analysis As A Strategy To Identify And Characterize Glycome Regulatory, John F. Rakus 2012 Marshall University

Microarray Analysis As A Strategy To Identify And Characterize Glycome Regulatory, John F. Rakus

Chemistry Faculty Research

Glycosylation involves the post-translational addition of carbohydrates to protein molecules and is an intricate and indispensable biochemical process. Study of this complicated network of interactions is hindered by the lack of a coding template analogous to the genetic code, and by the vast structural complexity inherent to carbohydrate polymers. We use lectins (non-enzymatic carbohydrate-binding proteins of non-immunological origin) as microarray probes to identify carbohydrate features expressed on cellular surfaces. Specifically, we utilized lectin microarray technology to investigate the differences in carbohydrates expressed by the cell lines of the Nation Cancer Institute’s NCI-60 panel. Our investigation identified tissue-specific expression differences ...


Room Temperature Syntheses Of Entirely Diverse Substituted Β-Fluorofurans, Li Yan, Kraig A. Wheeler, Roman Dembinski 2012 Oakland University

Room Temperature Syntheses Of Entirely Diverse Substituted Β-Fluorofurans, Li Yan, Kraig A. Wheeler, Roman Dembinski

Kraig A. Wheeler

Synthesis of highly substituted 3-fluorofurans is reported. The sequence began with preparation of tertbutyldimethylsilyl alk-1-en-3-yn-1-yl ethers from 1,4-disubstituted alk-3-yn-1-ones. Subsequent fluorination of alkenynyl silyl ethers with Selectfluor gave 2-fluoroalk-3-yn-1-ones in almost quantitative yield. Subsequent 5-endo-dig cyclizations using chlorotriphenylphosphine gold(I)/silver trifluoromethanesulfonate (5/5 mol%), N-bromo- or N-iodosuccinimide and gold(I) chloride/zinc bromide (5/20 mol%), all at room temperature, provided a facile method for the generation of substituted 3-fluoro-, 3-bromo-4-fluoro-, and 3-fluoro-4-iodofurans in good yields. Also, 2,2-difluoroalk-3-yn-1-ones were prepared by fluorination of alk-3-yn-1-ones under organocatalytic conditions. The structures of (Z)-tertbutyldimethylsilyl but-1-en-3-yn-1-yl ether, 3-bromo-4-fluorofuran, and 3-fluoro-4- ...


Room Temperature Syntheses Of Entirely Diverse Substituted Β-Fluorofurans, Li Yan, Kraig A. Wheeler, Roman Dembinski 2012 Oakland University

Room Temperature Syntheses Of Entirely Diverse Substituted Β-Fluorofurans, Li Yan, Kraig A. Wheeler, Roman Dembinski

Faculty Research and Creative Activity

Synthesis of highly substituted 3-fluorofurans is reported. The sequence began with preparation of tertbutyldimethylsilyl alk-1-en-3-yn-1-yl ethers from 1,4-disubstituted alk-3-yn-1-ones. Subsequent fluorination of alkenynyl silyl ethers with Selectfluor gave 2-fluoroalk-3-yn-1-ones in almost quantitative yield. Subsequent 5-endo-dig cyclizations using chlorotriphenylphosphine gold(I)/silver trifluoromethanesulfonate (5/5 mol%), N-bromo- or N-iodosuccinimide and gold(I) chloride/zinc bromide (5/20 mol%), all at room temperature, provided a facile method for the generation of substituted 3-fluoro-, 3-bromo-4-fluoro-, and 3-fluoro-4-iodofurans in good yields. Also, 2,2-difluoroalk-3-yn-1-ones were prepared by fluorination of alk-3-yn-1-ones under organocatalytic conditions. The structures of (Z)-tertbutyldimethylsilyl but-1-en-3-yn-1-yl ether, 3-bromo-4-fluorofuran, and 3-fluoro-4- ...


The Synthesis And Biological Evaluation Of Tamandarin B Analogs, Kenneth Lassen 2012 University of Pennsylvania

The Synthesis And Biological Evaluation Of Tamandarin B Analogs, Kenneth Lassen

Kenneth Lassen

The tamandarin and didemnins are a class of cyclodepsipeptides that have shown a wide range of biological activity. The didemnins have demonstrated antitumor, antiviral and immunosuppressive activity at low nano- and femtomolar levels. Didemnin B was the first marine natural product to enter clinical trials in humans in the United States. The structures of tamandarins A and B were reported in 2000 and possess almost identical structure and biological activity to didemnin B. These compounds have shown impressive biological activity and some progress has been made in establishing structure-activity relationships. However, their molecular mechanism of action is still unclear. The ...


Dalton, David R.: Foundations Of Organic Chemistry: Unity And Diversity Of Structures, Pathways & Reactions (Book Review), Jeffrey H. Glans 2012 Sacred Heart University

Dalton, David R.: Foundations Of Organic Chemistry: Unity And Diversity Of Structures, Pathways & Reactions (Book Review), Jeffrey H. Glans

Chemistry & Physics Faculty Publications

Book review by Jeffrey Glans.

Dalton, David R. Foundations of Organic Chemistry: Unity and Diversity of Structures, Pathways & Reactions. Hoboken, NJ: Wiley, 2011.

ISBN 9780470479087


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