Open Access. Powered by Scholars. Published by Universities.®

Organic Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2,822 Full-Text Articles 3,906 Authors 589,517 Downloads 153 Institutions

All Articles in Organic Chemistry

Faceted Search

2,822 full-text articles. Page 6 of 78.

Synthesis And Evaluation Of 1,2,4-Oxadiazolidinones: The Search For A Potential Non-Β-Lactam Β-Lactamase Inhibitors., Chimdi Eke Kalu 2019 East Tennessee State University

Synthesis And Evaluation Of 1,2,4-Oxadiazolidinones: The Search For A Potential Non-Β-Lactam Β-Lactamase Inhibitors., Chimdi Eke Kalu

Electronic Theses and Dissertations

β-lactam antibiotics have been the most widely used drug of choice to combat infectious disease caused by bacteria. Unfortunately, their effectiveness is drastically threatened by bacterial β-lactamases. β-lactamases is responsible for the resistance to most antibiotic drugs. For decades, β-lactam β-lactamases inhibitors have been used to reduce bacterial resistance; however, in this study 1,2,4-oxadiazolidinone derivatives as a non-β-lactam β-lactamases inhibitor against TEM-1 and P99 β-lactamases. The significance of oxadiazolidinone is the prominent five-membered ring scaffold in its structure, which is configurationally stable and present in other biologically active compounds such as linezolid and avibactam. Oxadiazolidinones were synthesized by ...


Synthetic Methods And Biological Applications Of Nitrogen Heterocycles To Compounds Of Biological Interest., Jarrid Ronnebaum 2019 University of Louisville

Synthetic Methods And Biological Applications Of Nitrogen Heterocycles To Compounds Of Biological Interest., Jarrid Ronnebaum

Electronic Theses and Dissertations

Thalidomide analogues were synthesized utilizing optimized click conditions from 3-azidoglutarimide and an array of arylacetylenes or N-ethynyl/N-propargyl phthalimide derivatives. The intermediate, 3-azidoglutarimde, was pivotal and yielded a new and scalable synthesis. The reaction conditions utilized a copper sulfate/sodium ascorbate system in aqueous tetrahydrofuran to propagate the dipolar cycloaddition reactions between the azidoglutarimide and the alkynyl coupling partners. The first explored substrates were substituted arylalkynes to optimize the click reaction. Arylalkynes selected were to exhibit similar electron deficient rings to mimic phthalimide. Along with the synthesis of click thalidomide analogues, click analogue of the antiangiogenic and more ...


Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding - Sample Problems, Candace M. Lawrence 2019 Xavier University of Louisiana

Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding - Sample Problems, Candace M. Lawrence

Course Modules

Sample Problems for Organic Chemistry I Module 1.


Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding - Sample B- Answer Key, Candace M. Lawrence 2019 Xavier University of Louisiana

Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding - Sample B- Answer Key, Candace M. Lawrence

Course Modules

Sample B Answer Key to Organic Chemistry I Drill Module 1.


Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding, Candace M. Lawrence 2019 Xavier University of Louisiana

Organic Chemistry I Drill (Chem 2210d) - 1st Module - Bonding, Candace M. Lawrence

Course Modules

A Review of General Chemistry: Electrons, Bonds and Molecular Properties.


Preparation Of Enantioenriched Alkyltin Species And Their Application In Stereospecific Transformations, Glenn O. Ralph 2019 The Graduate Center, City University of New York

Preparation Of Enantioenriched Alkyltin Species And Their Application In Stereospecific Transformations, Glenn O. Ralph

All Dissertations, Theses, and Capstone Projects

Organometallic reagents containing the tin-carbon bond are used extensively in modern synthetic chemistry for the formation of new bonds to carbon. Over recent decades, transition metal catalyzed cross coupling reactions between two C(sp2) centers have been widely developed. However, the introduction of a C(sp3) center complicates the catalytic cycle, and opens unproductive chemical pathways which lead to isomerization, elimination, and racemization. Our lab has developed a modified-Stille reaction to combat the deleterious effects of β-hydride elimination. Our protocol enables unactivated 2° alkyl organotin nucleophiles to undergo efficient cross coupling reactions with C(sp2) electrophiles, avoiding ...


An Investigation Of Alkylboron Transmetallation In Palladium-Catalyzed Suzuki Reactions, Benjamin Murray 2019 The Graduate Center, City University of New York

An Investigation Of Alkylboron Transmetallation In Palladium-Catalyzed Suzuki Reactions, Benjamin Murray

All Dissertations, Theses, and Capstone Projects

Through the past 40 years, carbon-carbon cross-coupling reactions have greatly enhanced the ability of chemists to synthesize C(sp2)-C(sp2) bonds and more recently C(sp2)-C(sp3) bonds. In particular, the Suzuki reaction has proven to be invaluable with its high yields, good functional group tolerance, and low toxicity of reagents. One of the component steps of the catalytic cycle of this reaction is transmetallation, in which the nucleophilic species transfers its organic component to the metal center (generally palladium). The mechanism of transfer from primary alkylboron nucleophiles was studied in the 1990's ...


Mild Synthesis Of Perylene Tetracarboxylic Monoanhydrides With Potential Applications In Organic Optoelectronics, Xizhe Zhao 2019 The Graduate Center, City University of New York

Mild Synthesis Of Perylene Tetracarboxylic Monoanhydrides With Potential Applications In Organic Optoelectronics, Xizhe Zhao

All Dissertations, Theses, and Capstone Projects

Perylene tetracarboxylic derivatives are considered good n-type semi-conductors. In past decades, there has been extensive study on their synthesis and electronic properties. Because of the high electron affinity, the ability to form π-π stacks, they have been widely utilized in organic photovoltaic solar cells, field-effect transistors and light-emitting diodes. Many of those applications prefer unsymmetrically substituted perylene tetracarboxylic derivatives. Perylene monoanhydrides are the most versatile intermediates for the preparation of unsymmetrically substituted perylene tetracarboxylic derivatives. In this thesis, I focused on introducing new synthesis methods for perylene monoanhydrides with labile functional group and their potential applications in organic optoelectronics.

In ...


Molecular Machines: Synthesis, Modeling, And Applications, Syd Kotar 2019 Chapman University

Molecular Machines: Synthesis, Modeling, And Applications, Syd Kotar

Student Scholar Symposium Abstracts and Posters

While some of the smallest, most useful machines known to science are the biological molecules that keep living organisms alive, there is a growing advancement of the creation of artificial molecules that have the same function and are more efficient. Molecular machines were invented in 1983 when scientists in France created a machine formed of two interlinked molecular rings. In 2016, the Nobel prize in chemistry was awarded to Feringa, Stoddart, and Sauvage who finally documented molecular machines and put them into energy‐filled states in which their movements could be controlled. From this, molecular machines became known as a ...


Heavy-Atom Tunneling In The Planar Bond Shifting Of [16]Annulene, Philip Lampkin, Jon Shezaf 2019 The University of San Francisco

Heavy-Atom Tunneling In The Planar Bond Shifting Of [16]Annulene, Philip Lampkin, Jon Shezaf

Creative Activity and Research Day - CARD

Mid-sized annulenes are known to undergo rapid π-bond shifting. Given that heavy­atom tunneling plays a role in planar bond shifting of cyclobutadiene, we computationally explored the contribution of heavy­ atom tunneling to the planar bond shifting in the major (CTCTCTCT) and minor (CTCTTCTT) isomers of [16]annulene. (U)M06-2X/cc-pVDZ calculations yield bond-shifting barriers of ca. 10 kcal/mol. The results also reveal extremely narrow barrier widths, suggesting a high probability of tunneling for these bond-shifting reactions. Rate constants were calculated using canonical variational transition state theory (CVT) as well as with small curvature tunneling (SCT) contributions, via direct ...


Forming Carbon-Carbon Bonds Via Photo-Oxidation, Joseph Pesa, John Rowley 2019 Carroll College

Forming Carbon-Carbon Bonds Via Photo-Oxidation, Joseph Pesa, John Rowley

Carroll College Student Undergraduate Research Festival

1-(2-thienyl)-pyrene has been viewed to form a carbon-carbon bond when oxidized. We investigated a palladium catalyzed reaction leading to the dimerization of a furan. However, ostensibly a similar reaction can occur in the absence of palladium but the presence of a photocurrent substantial enough to push an electron to an excited state, leaving a hole in it’s previous orbital. After this occurs, this molecule can find another of the same nature and complete the desired carbon-carbon bond. In creating this bond, we will have synthesized a “solar fuel” that can store energy in a stable bond using ...


Investigating Oxidation Of Alcohols With (Nh4)2cr2o7 In Washed Sand, Emily Toy, John Lepore 2019 SUNY Geneseo

Investigating Oxidation Of Alcohols With (Nh4)2cr2o7 In Washed Sand, Emily Toy, John Lepore

Papers, Posters, and Recordings

The oxidation of alcohols to aldehydes and ketones is among the important class of reactions in organic chemistry. Classical methods used to oxidize primary and secondary alcohols into aldehydes and ketones utilize chromium-based reagents such as pyridinum chlorochromate (PCC) and sodium dichromate (Na2Cr2O7). There has been an increasing interest throughout the years to use supported reagents in tandem with these reactions, particularly with silica gel. Despite the abundance of reported reactions carried out in silica gel in the literature, it is surprising that little is known about using sand as the medium for solid support ...


Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage 2019 Olivet Nazarene University

Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage

Scholar Week 2016 - present

The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.


Synthesis And Optimization Of Novel Poly-(Β-Amino Ester) Polymer For Gene-Delivery, Maria Montes 2019 Kansas State University Libraries

Synthesis And Optimization Of Novel Poly-(Β-Amino Ester) Polymer For Gene-Delivery, Maria Montes

Kansas State University Undergraduate Research Conference

Gene delivery is one of the most promising methods to treat multiple diseases through the alteration of a genetic code to enhance or inhibit gene expression (NIH). The potential for gene delivery to be used as a treatment for cancerous cells is the beginning for advanced personalized healthcare. Current methods for cancer are costly, nonspecific, and come with major side effects that lowers quality of life in cancer patients. Previous studies have demonstrated Poly-(β-amino ester) (PBAE) to be biodegradable, non-toxic, and capable to deliver payloads in a targeted manner. For this study, PBAE was synthesized and characterized by Nuclear ...


Copper Binding Of Heterocyclic Compounds Is Vital For Novel Drugs Against Gram-Positive Bacteria, Azriel Minjarez-Almeida 2019 Kansas State University Libraries

Copper Binding Of Heterocyclic Compounds Is Vital For Novel Drugs Against Gram-Positive Bacteria, Azriel Minjarez-Almeida

Kansas State University Undergraduate Research Conference

Azzy Minjarez1, Man Zhang1, Anjana Delpe-Acharige1, Kayla Eschliman1, Olaf Kutsch2, Stefan H. Bossmann1

1: Department of Chemistry, Kansas State University

2: Department of Medicine, University of Alabama at Birmingham

Copper Binding of Heterocyclic Compounds Is Vital For Novel Drugs Against Resistant Gram-positive Bacteria

Multidrug resistant bacteria are capable of developing resistance to a majority of available antibiotics making them an imminent threat. Thus, synthesizing novel drug candidates is vital. The average adult contains 50-80 mg of copper within the body, which assist the immune system. Efflux pumps of bacterial cells are the primary defense mechanism, which recognize and remove copper ...


Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova 2019 Andrews University

Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova

Honors Theses

HPLC methodology was developed to determine the concentrations and ratios of D to L amino acids in emu and ostrich eggshells treated with heat at different temperatures . We aimed to determine an internal standard and how ratios were affected under different conditions. An HPLC method was determined that gave consistent retention times and satisfactory enantioseparation . Calibration curves for each amino acid were developed from single and multi-amino acid containing dilution series producing a model that most closely replicates the eggshell-extracted amino acids.


Studies Into The Synthesis Of Alkyne Dienophiles With N6 - Ruthenium Arene Complex Substituents, Alexander Moses 2019 Carroll College

Studies Into The Synthesis Of Alkyne Dienophiles With N6 - Ruthenium Arene Complex Substituents, Alexander Moses

Chemistry and Physics Undergraduate Theses

In organic chemistry, η6-metal arene complexes constitute a class of valuable intermediates in organic synthesis due to the metals ability to act as a strong electron withdrawing group.1-9 While known for being an electron withdrawing group, little research regarding their ability to accelerate the Diels-Alder (DA) reaction - which is known to be accelerated by electron-withdrawing dienophile substituents -has been done. Previous work by the Hitt research group has strongly suggested that the DA reaction can be accelerated by an alkene dienophile with a η6 -ruthenium arene substituent.10 However, the effects of using an alkyne dienophile with a η6 ...


Dentin Biomodification Potency Of Proanthocyanidins, David J. Ryker 2019 Taylor University

Dentin Biomodification Potency Of Proanthocyanidins, David J. Ryker

Student Scholarship: Chemistry

No abstract provided.


A Chemical Overview Of Opioid Receptors And Their Agonists, Noah Kuszak 2019 Taylor University

A Chemical Overview Of Opioid Receptors And Their Agonists, Noah Kuszak

Student Scholarship: Chemistry

This work is a brief overview of the three main opioid receptors and some current research of the ways we can change the agonists and how they affect the opioid receptor pathway.


Drug Improvement And Design Involving G-Protein Coupled Receptors, Gabriel Saliba 2019 Taylor University

Drug Improvement And Design Involving G-Protein Coupled Receptors, Gabriel Saliba

Student Scholarship: Chemistry

No abstract provided.


Digital Commons powered by bepress