Antimicrobial Activity Of D-Lenolate®, 2010 University of Nevada Las Vegas
Antimicrobial Activity Of D-Lenolate®, Andy Phui
UNLV Theses, Dissertations, Professional Papers, and Capstones
Olive trees are one of the most important fruit trees in the Mediterranean. Although not validated by research, olive leaves are traditionally believed to fight off fever and infections. It has been shown that olive leaf extracts possess antimicrobial activity. Olive leaf extracts contain polyphenols. One of the major phenolic compounds is oleuropein. Oleuropein and other polyphenols have been shown to exhibit antimicrobial activity. East Park Research (EPR) developed an extraction process that they claim does not alter the chemical composition of the olive leaves. The extract is known by the commercial name d-lenolate®. Studies have provided evidence that d-lenolate ...
Development Of A Scanning Angle Total Internal Reflection Raman Spectrometer, 2010 Iowa State University
Development Of A Scanning Angle Total Internal Reflection Raman Spectrometer, Kristopher J. Mckee, Emily A. Smith
A scanning angle total internal reflection (SATIR) Raman spectrometer has been developed for measuring interfacial phenomena with chemical specificity and high axial resolution perpendicular to the interface. The instrument platform is an inverted optical microscope with added automated variable angle optics to control the angle of an incident laser on a prism/sample interface. These optics include two motorized translation stages, the first containing a focusing lens and the second a variable angle galvanometer mirror. The movement of all instrument components is coordinated to ensure that the same sample location and area are probed at each angle. At angles greater ...
The Reaction Of A Water Soluble Platinum Compound With Methionine And Derivatives, 2010 Western Kentucky University
The Reaction Of A Water Soluble Platinum Compound With Methionine And Derivatives, Yueh Ying Liao
Masters Theses & Specialist Projects
Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine are dominant; at lower Pt: methionine ratios, a bis-methionine product is ...
Solid Supported Synthesis Of Secondary Amines Via Staudinger And Microwave Aza-Wittig Reactions, 2010 Butler University
Solid Supported Synthesis Of Secondary Amines Via Staudinger And Microwave Aza-Wittig Reactions, Kyle Thomas Holsinger
Undergraduate Honors Thesis Collection
Amine bond formation is a major topic in organic chemistry and is widely applied to the formation of medicinal compounds. Current studies have analyzed the benefits of microwave irradiation and solid supported reagents in order to improve reaction conditions and both synthetic and environmental costs. In the synthesis of amines, we investigate the combined use of microwave irradiation and solid supported reagents in the aza-Wittig and reductive amination reaction.
Nmr Resonance Assignment Of The Therapeutic Rna Aptamer Macugen In Complex With Its In Vivo Target, The Heparin Binding Domain Of Vegf165, 2010 University of Colorado, Boulder
Nmr Resonance Assignment Of The Therapeutic Rna Aptamer Macugen In Complex With Its In Vivo Target, The Heparin Binding Domain Of Vegf165, Andrew Eric Libby
Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)
Aptamers consist of nucleic acids that are selected from an in vitro library in order to bind a specific target or catalyze a reaction. Many aptamer-ligand structures have been solved in recent years to characterize the molecular mechanisms that explain the high affinity and specificity observed in these interactions. To this end, NMR resonance assignment experiments were performed as a necessary first step to calculating the solution structure of a therapeutically-active RNA aptamer, Macugen, bound to its in vivo target, the heparin binding domain (HBD) of vascular endothelial growth factor 165 (VEGF165). Though the resonance assignment of Macugen is challenging ...
Targeting Base Excision Repair Suggests A New Therapeutic Strategy Of Fludarabine For The Treatment Of Chronic Lymphocytic Leukemia, 2010 Cleveland State University
Targeting Base Excision Repair Suggests A New Therapeutic Strategy Of Fludarabine For The Treatment Of Chronic Lymphocytic Leukemia, A. D. Bulgar, M. Snell, J. R. Donze, E. B. Kirkland, Lan Li, Shuming Yang, Yan Xu, S. L. Gerson, Lili Liu
Chemistry Faculty Publications
No abstract provided.
Improved Arene Fluorination Methodology For I(Iii) Salts, 2010 University of Nebraska-Lincoln
Improved Arene Fluorination Methodology For I(Iii) Salts, Bijia Wang, Linlin Qin, Kiel D. Neumann, Shriharsha Uppaluri, Ronald Cerny, Stephen G. Dimagno
Ronald Cerny Publications
The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to “scale down” to the conditions used typically for radiotracer synthesis.
New 2-Aminoethylimidazole-Based Dicarboxylic Acid Receptor Derived From Cholestane, 2009 Kyungpook National University
New 2-Aminoethylimidazole-Based Dicarboxylic Acid Receptor Derived From Cholestane, Jyoti Ramesh Jadhav, Md Wasi Ahmad, Hong Seok Kim
Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)
A new facial amphiphile cholestane-based receptor 1 containing a 2-imidazolylethylamino moiety at the 3a and 7a positions of cholestane was synthesized. Recognition selectivity of the new receptor 1 with various dicarboxylic acids was assessed by 1H NMR titration. Maleic acid showed the highest binding constant among all the tested acids