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Medicinal-Pharmaceutical Chemistry Commons

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774 full-text articles. Page 19 of 33.

Lamictal, Jessica L. Sherman-Corbett 2015 Parkland College

Lamictal, Jessica L. Sherman-Corbett

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Lamictal, a medication used as therapy for seizure disorders and bipolar disorders in adults.


The Link Between Adhd And Chemical Exposures, Lily Rong 2015 Parkland College

The Link Between Adhd And Chemical Exposures, Lily Rong

Natural Sciences Poster Sessions

A part of the Natural Sciences Poster Session at Parkland College, this poster investigates the relationship of Attention Deficit Hyperactivity Disorder to exposures to perfluorinated compounds (PFCs) and polychlorinated biphenyls (PCBs).


Zyban, Shawna R. Meadows 2015 Parkland College

Zyban, Shawna R. Meadows

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Zyban, or bupropion hydrochloride, a medication used to treat depression and seasonal affective disorder.


Orap, Sophie A. Catlin 2015 Parkland College

Orap, Sophie A. Catlin

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Orap, a medication used in the treatment of Tourette's syndrome.


Kapvay, Russell E. Anderson 2015 Parkland College

Kapvay, Russell E. Anderson

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Kapvay, or Clonidine Hydrochloric, a medication used to manage hypertension and in the treatment of severe pain.


Ketoconozole, Jeremy M. Wood 2015 Parkland College

Ketoconozole, Jeremy M. Wood

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Ketoconazole, or Nizoral, an antifungal medication used in the treatment of animals.


Paxil, Allyson M. Hadfield 2015 Parkland College

Paxil, Allyson M. Hadfield

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Paxil, a medication used to treat depression, obsessive-compulsive disorders, panic attacks and anxiety disorders.


Cordarone, Miriana McCombe 2015 Parkland College

Cordarone, Miriana Mccombe

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Cordarone, or amiodarone hydrochloride, a medication used for the treatment of ventricular arrhythmias and supraventricular arrhythmias.


Design, Synthesis, And Pharmacological Evaluation Of Three Series Of Lobelane Analogs As Inhibitors Of The Vesicular Monoamine Transporter (Vmat2), John P. Culver 2015 University of Kentucky

Design, Synthesis, And Pharmacological Evaluation Of Three Series Of Lobelane Analogs As Inhibitors Of The Vesicular Monoamine Transporter (Vmat2), John P. Culver

Theses and Dissertations--Pharmacy

Methamphetamine (METH) abuse is a serious problem in the United States and worldwide. The reward experienced by METH users is due to the increase in extracellular dopamine (DA) concentrations caused by an interaction between METH and the DA transporter (DAT) as well as the Vesicular Monoamine Transporter-2 (VMAT2). The reward felt by users of METH leads to further use of the drug and subsequent abuse. The current project examined the ability of three novel series of lobelane analogs to interact with a binding site on the Vesicular Monoamine Transporter-2 (VMAT2) in an attempt to inhibit the effects of METH. Lobelane ...


A Comparison Of Energy-Resolved Vibrational Activation/Dissociation Characteristics Of Protonated And Sodiated High Mannose N-Glycopeptides, Forouzan Aboufazeli, Venkata Kolli, Eric D. Dodds 2015 University of Nebraska-Lincoln

A Comparison Of Energy-Resolved Vibrational Activation/Dissociation Characteristics Of Protonated And Sodiated High Mannose N-Glycopeptides, Forouzan Aboufazeli, Venkata Kolli, Eric D. Dodds

Faculty Publications -- Chemistry Department

Fragmentation of glycopeptides in tandem mass spectrometry (MS/MS) plays a pivotal role in site-specific protein glycosylation profiling by allowing specific oligosaccharide compositions and connectivities to be associated with specific loci on the corresponding protein. Although MS/MS analysis of glycopeptides has been successfully performed using a number of distinction dissociation methods, relatively little is known regarding the fragmentation characteristics of glycopeptide ions with various charge carriers. In this study, energy-resolved vibrational activation/ dissociation was examined via collision-induced dissociation for a group of related high mannose tryptic glycopeptides as their doubly protonated, doubly sodiated, and hybrid protonated sodium adduct ions ...


The Importance Of Context: An Exploration Of Factors Influencing The Adoption Of Student-Centered Teaching Among Chemistry, Biology, And Physics Faculty, Travis J. Lund, Marilyne Stains 2015 Oregon Institute of Technology

The Importance Of Context: An Exploration Of Factors Influencing The Adoption Of Student-Centered Teaching Among Chemistry, Biology, And Physics Faculty, Travis J. Lund, Marilyne Stains

Faculty Publications -- Chemistry Department

Background: Research at the secondary and postsecondary levels has clearly demonstrated the critical role that individual and contextual characteristics play in instructors’ decision to adopt educational innovations. Although recent research has shed light on factors influencing the teaching practices of science, technology, engineering, and mathematics (STEM) faculty, it is still not well understood how unique departmental environments impact faculty adoption of evidence-based instructional practices (EBIPs) within the context of a single institution. In this study, we sought to characterize the communication channels utilized by STEM faculty, as well as the contextual and individual factors that influence the teaching practices of ...


Application Of Scanning Angle Raman Spectroscopy For Determining The Location Of Buried Polymer Interfaces With Tens Of Nanometer Precision, Craig A. Damin, Vy H.T. Nguyen, Auguste S. Niyibizi, Emily A. Smith 2015 Iowa State University and Ames Laboratory

Application Of Scanning Angle Raman Spectroscopy For Determining The Location Of Buried Polymer Interfaces With Tens Of Nanometer Precision, Craig A. Damin, Vy H.T. Nguyen, Auguste S. Niyibizi, Emily A. Smith

Chemistry Publications

Near-infrared scanning angle (SA) Raman spectroscopy was utilized to determine the interface location in bilayer films (a stack of two polymer layers) of polystyrene (PS) and polycarbonate (PC). Finite-difference-time-domain (FDTD) calculations of the sum square electric field (SSEF) for films with total bilayer thicknesses of 1200–3600 nm were used to construct models for simultaneously measuring the film thickness and the location of the buried interface between the PS and PC layers. Samples with total thicknesses of 1320, 1890, 2300, and 2750 nm and varying PS/PC interface locations were analyzed using SA Raman spectroscopy. Comparing SA Raman spectroscopy and ...


Responsive Supramolecular Assemblies Based On Amphiphilic Polymers And Hybrid Materials, Longyu Li 2015 University of Massachusetts - Amherst

Responsive Supramolecular Assemblies Based On Amphiphilic Polymers And Hybrid Materials, Longyu Li

Doctoral Dissertations

The design and synthesis of responsive supramolecular assemblies are of great interest due to their applications in a variety of areas such as drug delivery and sensing. We have developed a facile method to prepare self-crosslinking disulfide-based nanogels derived from an amphiphilic random copolymer containing a hydrophilic oligo-(ethylene glycol)-based side-chain functionality and a hydrophobic pyridyl disulfide functional group. This thesis first provides a concept of studying the influence of Hofmeister ions on the size and guest encapsulation stability of a polymeric nanogel. The size and core density of nanogel can be fine-tuned through the addition of both chaotropes ...


Stability Of Lidocaine Tested By Forced Degradation And Its Interactions With Serum Albumin, Lindsay Nichols 2015 San Luis Obispo High School

Stability Of Lidocaine Tested By Forced Degradation And Its Interactions With Serum Albumin, Lindsay Nichols

STAR (STEM Teacher and Researcher) Presentations

A concern for future long-term manned space expeditions is the ability to treat illnesses with appropriate pharmaceuticals. However, pharmaceuticals degrade faster in space than on Earth presumably due to an abundance of space radiation. The stability of Lidocaine was investigated because it is a common pain reliever currently used on the International Space Station. One of the most common proteins in blood is serum albumin, which acts as a carrier to distribute drugs throughout the body. It is important to know how well the drug binds to serum albumin so that the rate of distribution of Lidocaine-bound protein in blood ...


Structural And Optical Properties Of Cobalt Slanted Nanopillars Conformally Coated With Few-Layer Graphene, Peter M. Wilson, Alexey Lipatov, Daniel Schmidt, Eva Schubert, Mathias Schubert, Alexander Sinitskii, Tino Hofmann 2015 University of Nebraska—Lincoln

Structural And Optical Properties Of Cobalt Slanted Nanopillars Conformally Coated With Few-Layer Graphene, Peter M. Wilson, Alexey Lipatov, Daniel Schmidt, Eva Schubert, Mathias Schubert, Alexander Sinitskii, Tino Hofmann

Faculty Publications -- Chemistry Department

Optical characterization of anisotropic multicomponent nanostructures is generally not a trivial task, since the relation between a material’s structural properties and its permittivity tensor is nonlinear. In this regard, an array of slanted cobalt nanopillars that are conformally coated with few-layer graphene is a particularly challenging object for optical characterization, as it has a complex anisotropic geometry and comprises several materials with different topologies and filling fractions. Normally, a detailed characterization of such complex nanostructures would require a combination of several microscopic and spectroscopic techniques. In this letter, we demonstrate that the important structural parameters of these graphene-coated sculptured ...


Recyclable Magnetite Nanoparticle Catalyst For One-Pot Conversion Of Cellobiose To 5-Hydroxymethylfurfural In Water, Anuja Bhalkikar, Zane C. Gernhart, Chin Li Cheung 2015 University of Nebraska - Lincoln

Recyclable Magnetite Nanoparticle Catalyst For One-Pot Conversion Of Cellobiose To 5-Hydroxymethylfurfural In Water, Anuja Bhalkikar, Zane C. Gernhart, Chin Li Cheung

Faculty Publications -- Chemistry Department

Environmentally benign and easily recoverable magnetite nanoparticles (Fe3O4 NPs) were demonstrated to catalyze the one-pot conversion of cellobiose, a glucose disaccharide, to 5-hydroxymethylfurfural (5-HMF).Theconversion was achieved in water under hydrothermal conditions.The catalytic activity of Fe3O4 NPs surpassed those of iron (II) and iron (III) chlorides in this reaction. Optimized cellobiose conversion reactions catalyzed with Fe3O4 NPs gave the highest 5-HMF yields of 23.4 ± 0.6% at 160C for 24 hours. After three reuses, the Fe3O4 NP catalyst retained its catalytic activity with similar 5-HMF ...


Research-Based Implementation Of Peer Instruction: A Literature Review, Trisha Vickrey, Kaitlyn Rosploch, Reihaneh Rahmanian, Matthew Pilarz, Marilyne Stains 2015 University of Nebraska-Lincoln

Research-Based Implementation Of Peer Instruction: A Literature Review, Trisha Vickrey, Kaitlyn Rosploch, Reihaneh Rahmanian, Matthew Pilarz, Marilyne Stains

Faculty Publications -- Chemistry Department

Current instructional reforms in undergraduate science, technology, engineering, and mathematics (STEM) courses have focused on enhancing adoption of evidence-based instructional practices among STEM faculty members. These practices have been empirically demonstrated to enhance student learning and attitudes. However, research indicates that instructors often adapt rather than adopt practices, unknowingly compromising their effectiveness. Thus, there is a need to raise awareness of the research-based implementation of these practices, develop fidelity of implementation protocols to understand adaptations being made, and ultimately characterize the true impact of reform efforts based on these practices. Peer instruction (PI) is an example of an evidence-based instructional ...


New Insight Into The Helium-Induced Damage In Max Phase Ti3Alc2 By First-Principles Studies, Yiguo Xu, Xiaojing Bai, Xianhu Zha, Qing Huang, Jian He, Kan Luo, Yuhong Zhou, Timothy C. Germann, Joseph S. Francisco, Shiyu Du 2015 Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang

New Insight Into The Helium-Induced Damage In Max Phase Ti3Alc2 By First-Principles Studies, Yiguo Xu, Xiaojing Bai, Xianhu Zha, Qing Huang, Jian He, Kan Luo, Yuhong Zhou, Timothy C. Germann, Joseph S. Francisco, Shiyu Du

Faculty Publications -- Chemistry Department

In the present work, the behavior of He in the MAX phase Ti3AlC2 material is investigated using first-principle methods. It is found that, according to the predicted formation energies, a single He atom favors residing near the Al plane in Ti3AlC2. The results also show that Al vacancies are better able to trap He atoms than either Ti or C vacancies. The formation energies for the secondary vacancy defects near an Al vacancy or a C vacancy are strongly influenced by He impurity content. According to the present results, the existence of trapped He atoms in primary Al vacancy can ...


Few-Layer Titanium Trisulfide (Tis3) Field-Effect Transistors, Alexey Lipatov, Peter M. Wilson, Mikhail Shekhirev, Jacob D. Teeter, Ross Netusil, Alexander Sinitskii 2015 University of Nebraska-Lincoln

Few-Layer Titanium Trisulfide (Tis3) Field-Effect Transistors, Alexey Lipatov, Peter M. Wilson, Mikhail Shekhirev, Jacob D. Teeter, Ross Netusil, Alexander Sinitskii

Faculty Publications -- Chemistry Department

Titanium trisulfide (TiS3) is a promising layered semiconductor material. Several-mm-long TiS3 whiskers can be conveniently grown by the direct reaction of titanium and sulfur. In this study, we exfoliated these whiskers using the adhesive tape approach and fabricated few-layer TiS3 field-effect transistors (FETs). The TiS3 FETs showed an n-type electronic transport with roomtemperature field-effect mobilities of 18-24 cm2V-1s-1 and ON/OFF ratios up to 300. We demonstrate that TiS3 is compatible with the conventional atomic layer deposition (ALD) procedure for Al2O3. ALD of alumina on TiS3 FETs ...


Energetics, Structure, And Rovibrational Spectroscopic Properties Of The Sulfurous Anions Sno− And Osn−, Ryan C. Fortenberry, Joseph S. Francisco 2015 Georgia Southern University

Energetics, Structure, And Rovibrational Spectroscopic Properties Of The Sulfurous Anions Sno− And Osn−, Ryan C. Fortenberry, Joseph S. Francisco

Faculty Publications -- Chemistry Department

The SNO and OSN anions are shown in this work to be very stable negatively charged species in line with other recent work [T. Trabelsi et al., J. Chem. Phys. 143, 164301 (2015)]. Utilizing established quartic force field techniques, the structural and rovibrational data for these anions are produced. The SNO anion is less linear and has weaker bonds than the corresponding neutral radical giving much smaller rotational constants.OSN is largely unchanged in these regards with inclusion of the additional electron.The S–N bond is actually stronger,and the rotational constants of OSN versus OSN are similar. The ...


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