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Medicinal-Pharmaceutical Chemistry Commons

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Monitoring And Evaluation Of Terni (Central Italy) Air Quality Through Spatially Resolved Analyses, Lorenzo Massimi, Martina Ristorini, Marta Eusebio, Darla Florendo, Adeola Adeyemo, David Brugnoli, Silvia Canepari 2017 Department of Chemistry, Sapienza University of Rome, Piazzale Also Moro, Roma, Italy

Monitoring And Evaluation Of Terni (Central Italy) Air Quality Through Spatially Resolved Analyses, Lorenzo Massimi, Martina Ristorini, Marta Eusebio, Darla Florendo, Adeola Adeyemo, David Brugnoli, Silvia Canepari

Conference Papers

A study of spatial variability of PM10 elemental components was conducted in Terni city (Central Italy), situated in an intramountain depression characterized by the presence of several particulate matter emission sources. The meteorological conditions of the Terni basin limit the dispersion and enhance the accumulation of atmospheric pollutants. Thanks to the utilization of new smart samplers, used for the first time and working in parallel at 23 sampling sites, spatially resolved data were obtained. Localizations of the samplers were chosen in order to evaluate the impact of different local PM10 sources. Chemical composition of the samples was determined in combination ...


Nanoparticle As Supramolecular Platform For Delivery And Bioorthogonal Catalysis, Gulen Yesilbag Tonga 2017 University of Massachusetts Amherst

Nanoparticle As Supramolecular Platform For Delivery And Bioorthogonal Catalysis, Gulen Yesilbag Tonga

Doctoral Dissertations

Nanoparticles (NPs) are being investigated widely for many applications including imaging, drug delivery, therapeutics, materials, and catalysis due to their unique and tunable physical and chemical properties. Among NPs, gold nanoparticles (AuNPs) have attracted great attention due to ease of synthesis and surface functionalization, inertness of the core, biocompatibility, and functional versatility. Introducing supramolecular chemistry into the nanoparticle-based platforms brings out controllable properties, dynamic self assembly processes, and adjustable performance. My research has focused on the synthesis of AuNPs bearing different surface functionalities and their host-guest interactions with synthetic small molecules or commercially available hydrophobic catalysts for delivery and therapeutic ...


Nortriptyline Hyrdochloride, Israel R. Gomez Raffoul 2017 Parkland College

Nortriptyline Hyrdochloride, Israel R. Gomez Raffoul

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Nortriptyline Hydrochloride, trade names Acetexa, Allegron, Aventyl, Noritren, Nortrilen, Sensaval, and Vividyl, used to treat endogenous drpression. Unlabeled uses include treatment of nocturnal enuresis in children, ADJD, and diabetic neuropathy.


Clozaril, Gillian Jones 2017 Parkland College

Clozaril, Gillian Jones

Natural Sciences Poster Sessions

This is a poster presented at the Natural Sciences Poster Session at Parkland College, which provides the chemical makeup, dosage, and the body's response to Clozaril (Clozapine, Fazaclo, Versacloz) an atypical antipsychotic used to manage schizophrenia and schizoaffective disorder as well as bipolar disorder, dementia-related behavior disorders, and tremors.


Benazepril Hydrochloride, Tuan A. Nguyen 2017 Parkland College

Benazepril Hydrochloride, Tuan A. Nguyen

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Benazepril Hydrochloride, trade names Briem, Cibacen, Fortekor, and Iotensin, used to treat mild to moderate hypertension.


Sertraline Hydrochloride, Michelle L. Fehr 2017 Parkland College

Sertraline Hydrochloride, Michelle L. Fehr

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Sertraline Hydrochloride, trade name Zoloft, used to treat the symptoms of depression, obsessive compulsive disorder, panic disorder, social anxiety disorder, premenstual dysphoric disorder, generalized anxiety, and post-traumatic stress disorder.


Citalopram Hydrobromide, Maria Parks 2017 Parkland College

Citalopram Hydrobromide, Maria Parks

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Citalopram Hydrobromide, trade name Celexa, used to treat depression.


Prednisone, Donna K. Broderick 2017 Parkland College

Prednisone, Donna K. Broderick

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Predinisone, trade name Deltasone, Apo-Prednisone, Meticorton, Orasone, Panasol, Panasal, Prenicen-M Sterapred, Winred, an adrenal corticosteroid used to treat a variety of symptoms.


Zoloft/Sertraline Hcl, Loretta Banks 2017 Parkland College

Zoloft/Sertraline Hcl, Loretta Banks

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Sertraline Hydrochloride, trade name Zoloft, used to treat the symptoms of depression, obsessive compulsive disorder, panic disorder, social anxiety disorder, premenstual dysphoric disorder, generalized anxiety, and post-traumatic stress disorder.


Naloxone Therapy In Opioid Overdose Patients: Intranasal Or Intravenous?, Leiah Carney 2017 Parkland College

Naloxone Therapy In Opioid Overdose Patients: Intranasal Or Intravenous?, Leiah Carney

Natural Sciences Poster Sessions

This slide presentation for the Natural Science Poster Session at Parkland College describes the chemical makeup and effect of Naloxone, an opioid antagonist used in the treatment opioid overdose and summarizes a study comparing intravenous and intranasal delivery methods. Concludes that although there are conflicting studies, evidence supports intranasal delivery.


Lunesta, Mary Kreie 2017 Parkland College

Lunesta, Mary Kreie

Natural Sciences Poster Sessions

This poster, presented at the Natural Sciences Poster Session at Parkland College, provides the chemical makeup, dosage, and effects of Eszopiclone, trade name Lunesta, used to treat insomnia.


A Potential Improved Anti-Hiv Drug: Using A Bivalent Design To Increase Specificity And Potency, Theo Koelsch 2017 University of Colorado Boulder

A Potential Improved Anti-Hiv Drug: Using A Bivalent Design To Increase Specificity And Potency, Theo Koelsch

Undergraduate Honors Theses

In this thesis, the synthesis of a potentially improved HIV entry inhibitor is presented. HIV has infected millions of people, and yet there is no fully effective treatment for the infection and the subsequent, high mortality disease AIDS. This is due in large part to the virus’s rapid development of resistance to any drug used to treat the infection. The best way to combat this is to use multiple drugs with different inhibition targets and so prevent the virus from developing resistance. In order to contribute to the effective treatment of HIV infection, it is therefore important to develop ...


Phage Display To Identify Functional Resistance Mutations To Rigosertib, Nedim Filipovic 2017 Claremont McKenna College

Phage Display To Identify Functional Resistance Mutations To Rigosertib, Nedim Filipovic

CMC Senior Theses

In vitro protein selection has had major impacts in the field of protein engineering. Traditional screens assay individual proteins for specific function. Selection, however, analyzes a pool of mutants and yields the best variants. Phage display, a successful selection technique, also provides a reliable link between variant phenotype and genotype. It can also be coupled with high throughput sequencing to map protein mutations; potentially highlighting vital mutations in variants. We propose to apply this technique to cancer therapy. RAF, a serine/threonine kinase, is critical for cell regulation in mammals. RAF can be activated by oncogenic RAS, found in over ...


Analytical Methods To Support Design And Optimization Of Protein Drug Conjugate: Focusing On Haptoglobin-Hemoglobin Complex As A Drug Carrier, Shengsheng Xu 2017 University of Massachusetts Amherst

Analytical Methods To Support Design And Optimization Of Protein Drug Conjugate: Focusing On Haptoglobin-Hemoglobin Complex As A Drug Carrier, Shengsheng Xu

Doctoral Dissertations

Acquired immunodeficiency syndrome (AIDS) remains one of the most serious public health challenges and a significant cause of mortality for certain populations. Despite the large number of antiretrovirals (mostly nucleotide and nucleoside analogs) developed in the past two decades, the inability of small molecule therapeutics to target HIV reservoirs directly creates a significant obstacle to their effective utilization. Indeed, achieving the desired therapeutic effect in the absence of the effective targeted delivery must rely on dosage escalation, which frequently causes severe toxicity. This problem may be solved by conjugation of antiretroviral agents to endogenous proteins (e.g., hemoglobin haptoglobin complex ...


Analysis Of Novel Cyanide Antidote Dimethyl Trisulfide For Pharmacokinetic Studies, And Sulfur Mustard Metabolites For Identification Of Biomarker Of Inhaled Dose, Erica Manandhar 2017 South Dakota State University

Analysis Of Novel Cyanide Antidote Dimethyl Trisulfide For Pharmacokinetic Studies, And Sulfur Mustard Metabolites For Identification Of Biomarker Of Inhaled Dose, Erica Manandhar

Electronic Theses and Dissertations

Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current FDA approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate, is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS is not currently available from any matrix, one will be vital for the approval of DMTS as a therapeutic agent against cyanide poisoning. Hence, a stir bar sorptive extraction (SBSE) gas chromatography – mass spectrometry (GC-MS) method was developed and validated for ...


Target Based Design And Synthesis Of Heterocycles In The Potential Treatment Of Cancer And Opportunistic Infection, Shruti Choudhary 2017 Duquesne University

Target Based Design And Synthesis Of Heterocycles In The Potential Treatment Of Cancer And Opportunistic Infection, Shruti Choudhary

Electronic Theses and Dissertations

Dose limiting toxicity and development of multidrug resistance by the tumors are the major limitations of current cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Among the various classes of such agents, the colchicine site binding agents are particularly important as they circumvent the Pgp and β-III tubulin mediated clinical resistance. These resistance mechanisms, when manifested, are a major reason for the failure of clinically used agents such as taxanes and vinca alkaloids. A series of monocyclic pyrimidine analogs were designed and synthesized as colchicine site ...


Fluorogenic Protein Labeling Using A Genetically Encoded Unstrained Alkene, X. Shang, X. Song, C. Faller, R. Lai, H. Li, Ronald Cerny, Wei Niu, Jiantao Guo 2017 University of Nebraska-Lincoln

Fluorogenic Protein Labeling Using A Genetically Encoded Unstrained Alkene, X. Shang, X. Song, C. Faller, R. Lai, H. Li, Ronald Cerny, Wei Niu, Jiantao Guo

Faculty Publications -- Chemistry Department

We developed a new fluorogenic bioorthogonal reaction that is based on the inverse electron-demand Diels–Alder reaction between styrene (an unstrained alkene) and a simple tetrazine. The reaction forms a new fluorophore with no literature precedent. We have identified an aminoacyl-tRNA synthetase/tRNA pair for the efficient and site-specific incorporation of a styrene-containing amino acid into proteins in response to amber nonsense codon. Fluorogenic labeling of purified proteins and intact proteins in live cells were demonstrated. The fluorogenicity of the styrene–tetrazine reaction can be potentially applied to the study of protein folding and function under physiological conditions with low ...


A Surface-Stabilized Ozonide Triggers Bromide Oxidation At The Aqueous Solution-Vapour Interface, Luca Artiglia, Jacinta Edebeli, Fabrizio Orlando, Shuzhen Chen, Ming-Tao Lee, Pablo Corral Arroyo, Anina Gilgen, Thorsten Bartels-Rausch, Armin Kleibert, Mario Vazdar, Marcelo Andrea Carignano, Joseph S. Francisco, Paul B. Shepson, Ivan Gladich, Markus Ammann 2017 Paul Scherrer Institut

A Surface-Stabilized Ozonide Triggers Bromide Oxidation At The Aqueous Solution-Vapour Interface, Luca Artiglia, Jacinta Edebeli, Fabrizio Orlando, Shuzhen Chen, Ming-Tao Lee, Pablo Corral Arroyo, Anina Gilgen, Thorsten Bartels-Rausch, Armin Kleibert, Mario Vazdar, Marcelo Andrea Carignano, Joseph S. Francisco, Paul B. Shepson, Ivan Gladich, Markus Ammann

Faculty Publications -- Chemistry Department

Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy measurements that provide direct experimental evidence for the ozonide and establish its propensity for the solution-vapor interface. Theoretical calculations support these findings, showing that water stabilizes the ozonide and lowers the energy of the transition state at neutral pH. Kinetic experiments confirm the dominance of the heterogeneous oxidation route established by this precursor at ...


Soft Robotic Actuators, Filip Ilievski, Xin Chen, Aaron D. Mazzeo, George M. Whitesides, Robert F. Shepherd, Ramses V. Martinez, Won Jae Choi, Sen Wai Kwok, Stephen A. Morin, Adam Stokes, Zhihong Nie 2017 Santa Clara, CA

Soft Robotic Actuators, Filip Ilievski, Xin Chen, Aaron D. Mazzeo, George M. Whitesides, Robert F. Shepherd, Ramses V. Martinez, Won Jae Choi, Sen Wai Kwok, Stephen A. Morin, Adam Stokes, Zhihong Nie

Faculty Publications -- Chemistry Department

A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.


Resolving The Cofactor-Binding Site In The Proline Biosynthetic Enzyme Human Pyrroline-5-Carboxylate Reductase 1, Emily M. Christensen, Sagar M. Patel, David A. Korasick, Ashley C. Campbell, Kurt L. Krause, Donald F. Becker, John J. Tanner 2017 University of Missouri

Resolving The Cofactor-Binding Site In The Proline Biosynthetic Enzyme Human Pyrroline-5-Carboxylate Reductase 1, Emily M. Christensen, Sagar M. Patel, David A. Korasick, Ashley C. Campbell, Kurt L. Krause, Donald F. Becker, John J. Tanner

Faculty Publications -- Chemistry Department

Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [?]1-pyrroline-5-carboxylate (P5C) to proline. Mutations in the PYCR1 gene alter mitochondrial function and cause the connective tissue disorder cutis laxa. Furthermore, PYCR1 is overexpressed in multiple cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that PYCR1 is a potential cancer target. However, inhibitor development has been stymied by limited mechanistic details for the enzyme, particularly in light of a previous crystallographic study that placed the cofactor-binding site in the C-terminal domain rather than the anticipated Rossmann fold of the N-terminal domain. To ...


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