Open Access. Powered by Scholars. Published by Universities.®

Veterinary Medicine Commons

Open Access. Powered by Scholars. Published by Universities.®

10,848 Full-Text Articles 16,043 Authors 1,651,439 Downloads 78 Institutions

All Articles in Veterinary Medicine

Faceted Search

10,848 full-text articles. Page 1 of 185.

Systematic Review Protocol: The Effects Of Glucocorticoids On Selected Hemodynamic And Biochemical Parameters In Dogs And Cats, Jessica Ward, Allison Masters, Annette O'Connor 2019 Iowa State University

Systematic Review Protocol: The Effects Of Glucocorticoids On Selected Hemodynamic And Biochemical Parameters In Dogs And Cats, Jessica Ward, Allison Masters, Annette O'Connor

Jessica Ward

Objective: The objective of this scoping review is to define the scope of literature pertaining to the effects of glucocorticoids in dogs or cats on selected parameters that may affect cardiac function or fluid balance (blood glucose, blood pressure, sodium and potassium levels, echocardiographic or invasive hemodynamic indices, or indicators of volume status). It is our intention that after evaluating the available literature, we will then make a determination of the potential to conduct a systematic review and meta-analysis of the relevant literature for specific interventions.


Pharmacokinetics Of Fentanyl Citrate And Norfentanyl In Holstein Calves And Effect Of Analytical Performances On Fentanyl Parameter Estimation, Joe Smith, Johann F. Coetzee, Isaac W. G. Fisher, David J. Borts, Jonathan P. Mochel 2019 Iowa State University

Pharmacokinetics Of Fentanyl Citrate And Norfentanyl In Holstein Calves And Effect Of Analytical Performances On Fentanyl Parameter Estimation, Joe Smith, Johann F. Coetzee, Isaac W. G. Fisher, David J. Borts, Jonathan P. Mochel

Jonathan Mochel

This study describes the pharmacokinetics of intravenously administered (i.v.) fentanyl citrate, and its primary metabolite norfentanyl in Holstein calves. Eight calves (58.6 ± 2.2 kg), aged 3–4 weeks, were administered fentanyl citrate at a single dose of 5.0 μg/kg i.v. Blood samples were collected from 0 to 24 hr. Plasma (nor)fentanyl concentrations were determined using liquid chromatography with mass spectrometry and a lower limit of quantification (LLOQ) of 0.03 ng/ml. To explore the effect of analytical performance on fentanyl parameter estimation, the noncompartmental pharmacokinetic analysis was then repeated with a hypothetical ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Jonathan Mochel

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Joe Smith

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Lionel Sebbag

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Rachel A. Allbaugh

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


A Pilot Study Of The Effects Of Mycoplasma Ovipneumoniae Exposure On Domestic Lamb Growth And Performance, Thomas E. Besser, Jessica Levy, Melissa Ackerman, Danielle Nelson, Kezia Manlove, Kathleen A. Potter, Jan Busboom, Margaret Benson 2019 Washington State University

A Pilot Study Of The Effects Of Mycoplasma Ovipneumoniae Exposure On Domestic Lamb Growth And Performance, Thomas E. Besser, Jessica Levy, Melissa Ackerman, Danielle Nelson, Kezia Manlove, Kathleen A. Potter, Jan Busboom, Margaret Benson

Kezia Manlove

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. In order to assess the effects of M. ovipneumoniae on lamb performance, we generated a cohort of lambs free of M. ovipneumoniae by segregation of test negative ewes after lambing, then compared the growth and carcass quality traits of M. ovipneumoniae-free and -colonized lambs from weaning to harvest. Some signs of respiratory disease ...


Geospatial Analysis Of Rickettsial Species, Amy Frank 2019 University of Arkansas, Fayetteville

Geospatial Analysis Of Rickettsial Species, Amy Frank

Entomology Undergraduate Honors Theses

Rickettsia species are obligate intracellular, arthropod-borne bacteria with a potential to cause multiple diseases including Rocky Mountain spotted fever (RMSF). Fleas, mites, and ticks serve as vectors for Rickettsia, but ticks are the primary vector of interest. RMSF and other rickettsial diseases have continued to gain importance in both human and veterinary medicine as RMSF is the most common tick-borne disease within the United States according to the Lyme and Tick-Borne Disease Research Center. A statewide citizen science project was utilized to determine the prevalence of Spotted Fever Group (SFG) Rickettsia in Arkansas. This project yielded results in 64 of ...


Evaluation Of Casein Hydrolysate As An Alternative Dry-Off Treatment And Milk Quality Management Tool In Dairy Cows, Justine Elena Britten 2019 Utah State University

Evaluation Of Casein Hydrolysate As An Alternative Dry-Off Treatment And Milk Quality Management Tool In Dairy Cows, Justine Elena Britten

All Graduate Theses and Dissertations

Mastitis, an infection of the mammary gland, is the most common and expensive animal health problem for the dairy industry and affects every dairy farm to some degree. This disease complex is painful for dairy cows, increases the on-farm use of antibiotics, presents a threat to milk quality and is a waste of time, money and milk production. Each year, the dairy industry loses as much as a billion dollars to mastitis.

Many cows will experience mastitis at least once during a lactation cycle and some animals will develop recurring mastitis episodes in a single mammary quarter. These mastitic quarters ...


Nontarget Effects Of Bt Corn On Pathogenic And Toxigenic Fungi, Gary P. Munkvold, Walter G. Hyde, Richard L. Hellmich 2019 Iowa State University

Nontarget Effects Of Bt Corn On Pathogenic And Toxigenic Fungi, Gary P. Munkvold, Walter G. Hyde, Richard L. Hellmich

Richard L Hellmich

There may be nontarget effects of transgenic corn hybrids, positive and negative, on fungi that interact with the targeted pests. What are the effects of Bt corn on fungi that are associated with corn plants and their insect pests?


Veterinary Considerations For The Theoretical Resurrection Of Extinct Species, K. M. Feye, Joseph S. Smith, Lionel Sebbag, A. E. Hohman, Sreemoyee Acharya, Benjamin K. Schneider, J. T. Tucker, Lucia A. Cherep, B. R. Nordeng, A. L. Richardson, Meghan C. Gage, Diou Luo, Denusha Shrestha, Patricia Izbicki, Emir Malovic, M. A. Jefferson, Sireesha Manne, Pongrat Jaisil, Naveen Kondru, Nyzil Massey, Brandon S. Klinedinst, Steve A. Carlson 2019 Iowa State University

Veterinary Considerations For The Theoretical Resurrection Of Extinct Species, K. M. Feye, Joseph S. Smith, Lionel Sebbag, A. E. Hohman, Sreemoyee Acharya, Benjamin K. Schneider, J. T. Tucker, Lucia A. Cherep, B. R. Nordeng, A. L. Richardson, Meghan C. Gage, Diou Luo, Denusha Shrestha, Patricia Izbicki, Emir Malovic, M. A. Jefferson, Sireesha Manne, Pongrat Jaisil, Naveen Kondru, Nyzil Massey, Brandon S. Klinedinst, Steve A. Carlson

Lionel Sebbag

The de-extinction of the dinosaur is a dubious possibility but its consideration brings forth some issues that are at least worthy of scientific discussion. In this review, we discuss two distinct issues that have implications for a de-extinct species such as a dinosaur: the ability, or lack thereof, to safely sedate a rare and potentially fractious animal capable of harming the veterinary staff tasked with its care; and, disease risks associated with a species that has been extinct for millions of years. To identify potential sedatives, comparative pharmacology will be needed to uncover the links between receptor pharmacology and the ...


Veterinary Considerations For The Theoretical Resurrection Of Extinct Species, K. M. Feye, Joseph S. Smith, Lionel Sebbag, A. E. Hohman, Sreemoyee Acharya, Benjamin K. Schneider, J. T. Tucker, Lucia A. Cherep, B. R. Nordeng, A. L. Richardson, Meghan C. Gage, Diou Luo, Denusha Shrestha, Patricia Izbicki, Emir Malovic, M. A. Jefferson, Sireesha Manne, Pongrat Jaisil, Naveen Kondru, Nyzil Massey, Brandon S. Klinedinst, Steve A. Carlson 2019 Iowa State University

Veterinary Considerations For The Theoretical Resurrection Of Extinct Species, K. M. Feye, Joseph S. Smith, Lionel Sebbag, A. E. Hohman, Sreemoyee Acharya, Benjamin K. Schneider, J. T. Tucker, Lucia A. Cherep, B. R. Nordeng, A. L. Richardson, Meghan C. Gage, Diou Luo, Denusha Shrestha, Patricia Izbicki, Emir Malovic, M. A. Jefferson, Sireesha Manne, Pongrat Jaisil, Naveen Kondru, Nyzil Massey, Brandon S. Klinedinst, Steve A. Carlson

Joe Smith

The de-extinction of the dinosaur is a dubious possibility but its consideration brings forth some issues that are at least worthy of scientific discussion. In this review, we discuss two distinct issues that have implications for a de-extinct species such as a dinosaur: the ability, or lack thereof, to safely sedate a rare and potentially fractious animal capable of harming the veterinary staff tasked with its care; and, disease risks associated with a species that has been extinct for millions of years. To identify potential sedatives, comparative pharmacology will be needed to uncover the links between receptor pharmacology and the ...


Rapid Communication: A Comparison Of Cardiac Lesions And Heart Weights From Market Pigs That Did And Did Not Die During Transport To One Ontario Abattoir, Kathy Zurbrigg, Tony van Dreumel, Max F. Rothschild, David Alves, Robert M. Friendship, Terri L. O’Sullivan 2019 University of Guelph

Rapid Communication: A Comparison Of Cardiac Lesions And Heart Weights From Market Pigs That Did And Did Not Die During Transport To One Ontario Abattoir, Kathy Zurbrigg, Tony Van Dreumel, Max F. Rothschild, David Alves, Robert M. Friendship, Terri L. O’Sullivan

Max Rothschild

In-transit losses of market hogs represent a small proportion of all market-weight pigs shipped in a year. This suggests that individual pig factors may be a significant cause of in-transit losses along with more traditionally considered environmental and transport factors. An investigation was performed to determine whether cardiac pathology and heart weights were associated with pigs that did or did not die during transport to an abattoir. The hearts from 70 pigs that died in-transit to one Ontario abattoir and 388 pigs that arrived alive were collected and examined. Hearts from pigs that died during transport demonstrated greater frequencies of ...


Immunomodulatory Effects Of Heat Stress And Lipopolysaccharide On The Bursal Transcriptome In Two Distinct Chicken Lines, Melissa S. Monson, Angelica Van Goor, Christopher M. Ashwell, Michael E. Persia, Max F. Rothschild, Carl J. Schmidt, Susan J. Lamont 2019 Iowa State University

Immunomodulatory Effects Of Heat Stress And Lipopolysaccharide On The Bursal Transcriptome In Two Distinct Chicken Lines, Melissa S. Monson, Angelica Van Goor, Christopher M. Ashwell, Michael E. Persia, Max F. Rothschild, Carl J. Schmidt, Susan J. Lamont

Max Rothschild

Background: Exposure to heat stress suppresses poultry immune responses, which can increase susceptibility to infectious diseases and, thereby, intensify the negative effects of heat on poultry welfare and performance. Identifying genes and pathways that are affected by high temperatures, especially heat-induced changes in immune responses, could provide targets to improve disease resistance in chickens. This study utilized RNAsequencing (RNA-seq) to investigate transcriptome responses in the bursa of Fabricius, a primary immune tissue, after exposure to acute heat stress and/or subcutaneous immune stimulation with lipopolysaccharide (LPS) in a 2 × 2 factorial design: Thermoneutral + Saline, Heat + Saline, Thermoneutral + LPS and Heat ...


Genome-Wide Association Studies Of Inflammatory Bowel Disease In German Shepherd Dogs, Atiyeh Peiravan, Francesca Bertolini, Max Rothschild, Kenneth W. Simpson, Albert E. Jergens, Karin Allenspach, Dirk Werling 2019 University of London, North Mymms

Genome-Wide Association Studies Of Inflammatory Bowel Disease In German Shepherd Dogs, Atiyeh Peiravan, Francesca Bertolini, Max Rothschild, Kenneth W. Simpson, Albert E. Jergens, Karin Allenspach, Dirk Werling

Max Rothschild

Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal microbiota and environmental factors in genetically susceptible individuals. Although IBD can affect any breed, German shepherd dogs (GSD) in the UK are at increased risk of developing the disease. Based on previous evidence, the aim of the present study was to identify single nucleotide polymorphisms (SNPs), which may confer genetic susceptibility or resistance to IBD using a genome-wide association study (GWAS). Genomic DNA was extracted from EDTA blood or saliva samples of 96 cases and 98 controls. Genotyping of cases ...


Identification Of A Nth-Like Gene Encoding An Endonuclease Iii In Campylobacter Jejuni, Lei Dai, Jing Xia, Orhan Sahin, Qijing Zhang 2019 Iowa State University

Identification Of A Nth-Like Gene Encoding An Endonuclease Iii In Campylobacter Jejuni, Lei Dai, Jing Xia, Orhan Sahin, Qijing Zhang

Veterinary Microbiology and Preventive Medicine Publications

Campylobacter jejuni is a leading cause of foodborne illnesses worldwide. As a microaerobic pathogen, C. jejuni is subjected to DNA damages caused by various stresses such as reactive oxygen species (ROS) and UV radiations. The base excision repair (BER) system plays an important role in preventing mutations associated with oxidative DNA damage, but the system remains poorly characterized in Campylobacter. In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of ...


Comparison Of Immunohistochemistry Methods For Visualization Of Middle Eastern Respiratory Viral Antigen, Elena Carlos 2019 Kansas State University Libraries

Comparison Of Immunohistochemistry Methods For Visualization Of Middle Eastern Respiratory Viral Antigen, Elena Carlos

Kansas State University Undergraduate Research Conference

Middle Eastern respiratory syndrome (MERS), caused by MERS coronavirus (MERS-CoV) first appeared in Saudi Arabia in 2012. Although there have been less than 2,400 cases reported, the case fatality rate is 35%. Dromedary camels are the known host animal for the virus. However, they are difficult to manage experimental animals. In a recent study, alpacas proved to be a suitable experimental animal to further characterize MERS-CoV infection. Our work is part of a wider project focused on studying the efficacy of MERS-CoV antigen and RNA labeling in infected alpaca tissues, when these tissues are preserved in novel modular alcohol ...


Assessing The Nutritional Value Of Black Soldier Fly Larvae (Hermetia Illucens) Used For Reptile Foods, Kimberly L. Boykin 2019 Louisiana State University and Agricultural and Mechanical College

Assessing The Nutritional Value Of Black Soldier Fly Larvae (Hermetia Illucens) Used For Reptile Foods, Kimberly L. Boykin

LSU Master's Theses

Black soldier fly (BSF) larvae have been studied extensively in animal feed production, but there is limited research for non-production species, such as reptiles, despite their popularity as a calcium-rich feeder insect. The goals of this thesis were to determine the nutritive value of BSF larvae for a lizard species and as an ingredient in a diet formulated for snakes.

BSF larvae are deficient in fat soluble vitamins (A, D, and E). Using vitamin A as a test nutrient, several factors were identified that affect the success and consistency of gut loading. Based on the results, the following gut loading ...


Evaluation Of Responses To Vaccination Of Angus Cattle For Four Viruses That Contribute To Bovine Respiratory Disease Complex, L. M. Kramer, M. S. Mayes, E. Fritz-Waters, J. L. Williams, E. D. Downey, R. G. Tait Jr., A. Woolums, C. Chase, J. M. Reecy 2019 Iowa State University

Evaluation Of Responses To Vaccination Of Angus Cattle For Four Viruses That Contribute To Bovine Respiratory Disease Complex, L. M. Kramer, M. S. Mayes, E. Fritz-Waters, J. L. Williams, E. D. Downey, R. G. Tait Jr., A. Woolums, C. Chase, J. M. Reecy

James M Reecy

While vaccination is an effective measure in reducing the risk of bovine respiratory disease complex (BRDC) in cattle, BRDC losses remain significant. Increasing the efficacy of vaccination depends on elucidating the protective immune response to different antigens included in vaccines, determining the best timing for vaccination and understanding the impact of the age of calf on vaccination. This study measured the serum antibodies present in calves following vaccination against four viruses commonly associated with BRDC: bovine viral diarrhea virus 1 and 2 (BVDV1 and BVDV2), bovine respiratory syncytial virus (BRSV), and bovine herpesvirus (BHV1). Serum antibody titers were measured in ...


Digital Commons powered by bepress