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Preventing Osteosarcoma Progression With Small Molecular Inhibitors Targeting Macrophage Migration Inhibitory Factor : Cd74 Interaction, Sana Farooki 2019 Children's Mercy Hospital

Preventing Osteosarcoma Progression With Small Molecular Inhibitors Targeting Macrophage Migration Inhibitory Factor : Cd74 Interaction, Sana Farooki

Research Days

No abstract provided.


Umccts Newsletter, May 2019, UMass Center for Clinical and Translational Science 2019 University of Massachusetts Medical School

Umccts Newsletter, May 2019, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the May 2019 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Developing A Community-Based Screening And Referral Mechanism For Atrial Fibrillation In Low Resource Settings: “Smartphone Monitoring For Atrial Fibrillation In Real-Time – India (Smart-India)”, Apurv Soni, Nisha Fahey, Harshil Patel, Kandarp Talati, Anna Handorf, John A. Bostrom, Shyamsundar Raihatha, Ravi Shah, Sunil Karna, Robert J. Goldberg, Jeroan J. Allison, Ki Chon, Somashekhar M. Nimbalkar, David D. McManus 2019 University of Massachusetts Medical School

Developing A Community-Based Screening And Referral Mechanism For Atrial Fibrillation In Low Resource Settings: “Smartphone Monitoring For Atrial Fibrillation In Real-Time – India (Smart-India)”, Apurv Soni, Nisha Fahey, Harshil Patel, Kandarp Talati, Anna Handorf, John A. Bostrom, Shyamsundar Raihatha, Ravi Shah, Sunil Karna, Robert J. Goldberg, Jeroan J. Allison, Ki Chon, Somashekhar M. Nimbalkar, David D. Mcmanus

Apurv Soni

BACKGROUND: Atrial fibrillation (AF), the world’s most common arrhythmia, often goes undetected and untreated in low-resource communities, including India. Moreover, AF is an important risk factor for stroke, which plagues an estimated 1.6 million Indians annually. As such, early detection of AF and management of high-risk patients is critically important to decrease stroke burden in individuals with AF.

OBJECTIVE: The objectives of this study are to evaluate the age- and sex-stratified epidemiology of AF in Anand District, Gujarat India; characterize the profile of individuals who are diagnosed with AF; and determine the performance of two mobile technologies for ...


High Burden Of Unrecognized Atrial Fibrillation In Rural India: An Innovative Community-Based Cross-Sectional Screening Program, Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael S. Chin, John Stephen Sullivan, Shyamsundar Raithatha, Robert J. Goldberg, Somashekhar Nimbalkar, Jeroan J. Allison, Sunil Thanvi, David D. McManus 2019 University of Massachusetts Medical School

High Burden Of Unrecognized Atrial Fibrillation In Rural India: An Innovative Community-Based Cross-Sectional Screening Program, Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael S. Chin, John Stephen Sullivan, Shyamsundar Raithatha, Robert J. Goldberg, Somashekhar Nimbalkar, Jeroan J. Allison, Sunil Thanvi, David D. Mcmanus

Apurv Soni

BACKGROUND: Atrial fibrillation, the world's most common arrhythmia, is a leading risk factor for stroke, a disease striking nearly 1.6 million Indians annually. Early detection and management of atrial fibrillation is a promising opportunity to prevent stroke but widespread screening programs in limited resource settings using conventional methods is difficult and costly.

OBJECTIVE: The objective of this study is to screen people for atrial fibrillation in rural western India using a US Food and Drug Administration-approved single-lead electrocardiography device, Alivecor.

METHODS: Residents from 6 villages in Anand District, Gujarat, India, comprised the base population. After obtaining informed consent ...


Education Mitigates The Relationship Of Stress And Mental Disorders Among Rural Indian Women, Nisha Fahey, Apurv Soni, Jeroan J. Allison, Jagdish Vankar, Anusha Prabhakaran, Tiffany A. Moore Simas, Nancy Byatt, Ajay Phatak, Eileen O'Keefe, Somashekhar Nimbalkar 2019 Des Moines University

Education Mitigates The Relationship Of Stress And Mental Disorders Among Rural Indian Women, Nisha Fahey, Apurv Soni, Jeroan J. Allison, Jagdish Vankar, Anusha Prabhakaran, Tiffany A. Moore Simas, Nancy Byatt, Ajay Phatak, Eileen O'Keefe, Somashekhar Nimbalkar

Apurv Soni

BACKGROUND: Common mental disorders (CMD) are a constellation of mental health conditions that include depression, anxiety, and other related nonpsychotic affective disorders. Qualitative explanatory models of mental health among reproductive-aged women in India reveal that distress is strongly associated with CMD. The relationship of perceived stress and CMD might be attenuated or exacerbated based on an individual's sociodemographic characteristics.

OBJECTIVES: To screen for Common Mental Disorders (CMD) among reproductive-aged women from rural western India and explore how the relationship between perceived stress and CMD screening status varies by sociodemographic characteristics.

METHODS: Cross-sectional survey of 700 women from rural Gujarat ...


Identification Of Relationships Between Patients Through Elements In A Data Warehouse Using The Familial, Associational, And Incidental Relationship (Fair) Initiative: A Pilot Study, Thomas M. English, Rebecca L. Kinney, Michael A. Davis, Ariana Kamberi, Wayne Chan, Rajani S. Sadasivam, Thomas K. Houston 2019 University of Massachusetts Medical School

Identification Of Relationships Between Patients Through Elements In A Data Warehouse Using The Familial, Associational, And Incidental Relationship (Fair) Initiative: A Pilot Study, Thomas M. English, Rebecca L. Kinney, Michael A. Davis, Ariana Kamberi, Wayne Chan, Rajani S. Sadasivam, Thomas K. Houston

Rajani S. Sadasivam

BACKGROUND: Over the last several years there has been widespread development of medical data warehouses. Current data warehouses focus on individual cases, but lack the ability to identify family members that could be used for dyadic or familial research. Currently, the patient's family history in the medical record is the only documentation we have to understand the health status and social habits of their family members. Identifying familial linkages in a phenotypic data warehouse can be valuable in cohort identification and in beginning to understand the interactions of diseases among families.

OBJECTIVE: The goal of the Familial, Associational, and ...


21st Century Clinical Trials: Rethinking Best Practices Challenges And Opportunities, William E Truog 2019 Children's Mercy Hospital

21st Century Clinical Trials: Rethinking Best Practices Challenges And Opportunities, William E Truog

Presentations

Panel discussion at the Pediatric Academic Societies 2019 annual meeting.


Mutant P53 Depletion By Natural Compounds, Mohamed A.A. Alalem, Sana Farooki, Tomoo Iwakuma 2019 Children's Mercy Hospital

Mutant P53 Depletion By Natural Compounds, Mohamed A.A. Alalem, Sana Farooki, Tomoo Iwakuma

Presentations

The goal of this research project is to identify and characterize potentially novel antineoplastic agents that could specifically degrade conformational mutP53 protein in cancer cells. We concluded that treatment of cancer cells with curcumin or PLINH compounds inhibit proliferation of cancer cells in a DNAJA1-misfolded mutp5-dependent manner. Delineation of the exact mechanism through which curcumin and PLINH exert their anti-cancer effects could pave the way for promising novel preventive and therapeutic modalities for cancer.


Religiosity And Patient Engagement In Their Healthcare Among Hospital Survivors Of An Acute Coronary Syndrome, Hawa Ozien Abu, David D. McManus, Catarina I. Kiefe, Robert J. Goldberg 2019 University of Massachusetts Medical School

Religiosity And Patient Engagement In Their Healthcare Among Hospital Survivors Of An Acute Coronary Syndrome, Hawa Ozien Abu, David D. Mcmanus, Catarina I. Kiefe, Robert J. Goldberg

David D. McManus

Background: Optimum management after an Acute Coronary Syndrome (ACS) requires considerable patient engagement/activation. Religious practices permeate people's lives and may influence engagement in their healthcare. Little is known about the relationship between religiosity and patient activation in hospital survivors of an ACS.

Methods: We recruited patients hospitalized for an ACS at six medical centers in Central Massachusetts and Georgia (2011-2013). Participants self-reported three measures of religiosity - strength and comfort from religion, making petition prayers, and awareness of intercessory prayers for health. Patient activation was assessed using the 6-item Patient Activation Measure (PAM-6). We categorized participants as either having ...


The All Of Us Research Program: Engaging The Community For The Future Of Health, Mara M. Epstein, Kathleen M. Mazor, Joann L. Wagner, Peggy Preusse, Candace LeBlanc, Brenda Valenti, Lawrence D. Garber 2019 University of Massachusetts Medical School

The All Of Us Research Program: Engaging The Community For The Future Of Health, Mara M. Epstein, Kathleen M. Mazor, Joann L. Wagner, Peggy Preusse, Candace Leblanc, Brenda Valenti, Lawrence D. Garber

Lawrence D. Garber

The All of Us Research Program (AoURP), funded by the National Institutes of Health, is an ambitious ten-year effort to enroll over one million participants across the country. The AoURP is a key part of the Precision Medicine Initiative and seeks to build a national cohort collecting self-reported health data, medical record data, biospecimen samples and physical measurements to accelerate precision medicine. Precision Medicine is an emerging approach for healthcare treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Researchers at the Meyers Primary Care Institute and the University of Massachusetts Medical ...


Engaging Emergency Department Patients In The Creation Of A Shared Decision-­Making Tool Regarding Ct Scanning In Kidney Stones: Challenges To Traditional Stakeholder Engagement, Elizabeth M. Schoenfeld, Connor J. Houghton, Pooja P. Patel, Leonora Merwin, Kathleen M. Mazor, Erik Hess, Charles Scales, Maggie Breslin, Peter K. Lindenauer 2019 University of Massachusetts Medical School

Engaging Emergency Department Patients In The Creation Of A Shared Decision-­Making Tool Regarding Ct Scanning In Kidney Stones: Challenges To Traditional Stakeholder Engagement, Elizabeth M. Schoenfeld, Connor J. Houghton, Pooja P. Patel, Leonora Merwin, Kathleen M. Mazor, Erik Hess, Charles Scales, Maggie Breslin, Peter K. Lindenauer

Kathleen M. Mazor

Background: Every year approximately 2 million patients are seen in US EDs for suspected renal colic, and the majority receive CT scans. The objective of our study was to develop a stakeholder-informed conversation aid to help clinicians use SDM regarding CT scanning in patients with suspected renal colic.

Methods: Using a published decision aid development framework, and under the direction of a multi-disciplinary Steering Committee, we engaged a diverse set of stakeholders via qualitative methods. EM clinicians, urologists, radiologists, researchers, and emergency department patients participated in focus groups and semi-structured interviews. All groups were recorded, transcribed, and analyzed in an ...


The All Of Us Research Program: Engaging The Community For The Future Of Health, Mara M. Epstein, Kathleen M. Mazor, Joann L. Wagner, Peggy Preusse, Candace LeBlanc, Brenda Valenti, Lawrence D. Garber 2019 University of Massachusetts Medical School

The All Of Us Research Program: Engaging The Community For The Future Of Health, Mara M. Epstein, Kathleen M. Mazor, Joann L. Wagner, Peggy Preusse, Candace Leblanc, Brenda Valenti, Lawrence D. Garber

Kathleen M. Mazor

The All of Us Research Program (AoURP), funded by the National Institutes of Health, is an ambitious ten-year effort to enroll over one million participants across the country. The AoURP is a key part of the Precision Medicine Initiative and seeks to build a national cohort collecting self-reported health data, medical record data, biospecimen samples and physical measurements to accelerate precision medicine. Precision Medicine is an emerging approach for healthcare treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Researchers at the Meyers Primary Care Institute and the University of Massachusetts Medical ...


Umccts Newsletter, April 2019, UMass Center for Clinical and Translational Science 2019 University of Massachusetts Medical School

Umccts Newsletter, April 2019, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the April 2019 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Quantification Of Contrast-Enhanced Ultrasound, Joseph Pathoulas 2019 College of Saint Benedict/Saint John's University

Quantification Of Contrast-Enhanced Ultrasound, Joseph Pathoulas

All College Thesis Program, 2016-present

The aim of this experiment was to investigate the effect of manipulating ultrasound scanner settings on time-intensity curve parameters in a tube perfusion phantom system using contrast-enhanced ultrasound imaging. Imaging was performed using a Philips LOGIQ E9 ultrasound scanner equipped with a C1-6VN transducer and utilized two different microbubble contrast agents: Definity and Lumason. The ultrasound scanner settings manipulated included: gain, dynamic range, and frequency. Additionally, relative microbubble concentration, microbubble type, and perfusion flow rate were manipulated. Four time-intensity curve parameters (time to peak, area under curve, gradient, peak intensity) were measured from linearized pixel data. Time to peak was ...


Electroencephalogram As A Diagnostic Tool In Acquired Brain Injury, Michael Zarra 2019 Trinity College

Electroencephalogram As A Diagnostic Tool In Acquired Brain Injury, Michael Zarra

Senior Theses and Projects

The ability of electroencephalogram (EEG) to be used as a diagnostic device for acquired brain injuries (ABI) has been conceptualized previously. Averaged event-related potentials (ERP) derived from an EEG are suitable as markers of dysfunction however, distinctive properties in the frequency domain have not been established previously. In the present study, we examined pre- existing EEG signal data of healthy adults (HA), mild ABI (mABI), and severe ABI (sABI) human groups. Through Fourier analysis performed in MATLAB, we found that individuals in our sample population (n=80) were able to be categorized into their respective group based on common neuronal ...


Abstracts From The 25th Annual Health Care Systems Research Network Conference, April 8–10, 2019, Portland, Oregon, 2019 Aurora Health Care

Abstracts From The 25th Annual Health Care Systems Research Network Conference, April 8–10, 2019, Portland, Oregon

Journal of Patient-Centered Research and Reviews

The Health Care Systems Research Network (HCSRN) is made up of nonprofit health systems with embedded research departments whose scientists are dedicated to public domain research. The network’s annual conference serves as a forum for research teams to disseminate study findings, stimulate new collaborations, and share insights about conducting research in real-world care settings. Abstracts accepted for presentation at HCSRN 2019 are published in this supplement of Journal of Patient-Centered Research and Reviews, the official scientific journal of the conference.


Talking To Children About Their Terminal Disease And Ultimate Death, Alyssa Nesbitt 2019 Wayne State University School of Medicine

Talking To Children About Their Terminal Disease And Ultimate Death, Alyssa Nesbitt

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Kreicbergs U, Valdimarsdóttir U, Onelöv E, Henter J, Steineck G. Talking about death with children who have severe malignant disease. New Eng J Med. 2004;351(12):1175-1186. doi: 10.1056/nejmoa040366.


Outcomes Of Robotic-Assisted Laparoscopic Prostatectomy Versus Open Prostatectomy In Surgical Intervention Of Localized Prostate Cancer, Hojun Lee, Brandon Ahlgren 2019 Wayne State University School of Medicine

Outcomes Of Robotic-Assisted Laparoscopic Prostatectomy Versus Open Prostatectomy In Surgical Intervention Of Localized Prostate Cancer, Hojun Lee, Brandon Ahlgren

Clinical Research in Practice: The Journal of Team Hippocrates

An informed consent conversation regarding robotic-assisted laparoscopic prostatectomy versus open prostatectomy in patients with localized prostate cancer.


Evidence Doesn’T Change Prescribing Patterns…So What Does?, Ali Rida, Anthony Brooks 2019 Beaumont Wayne Family Medicine Residency Program

Evidence Doesn’T Change Prescribing Patterns…So What Does?, Ali Rida, Anthony Brooks

Clinical Research in Practice: The Journal of Team Hippocrates

The authors write in support of critical analysis of clinical research, as a corrective to the physician's urge to "do something" even when no evidence of benefit exists.


Health Promotion Practice And The Road Ahead: Addressing Enduring Gaps And Encouraging Greater Practice-To-Research Translation, Amanda Birnbaum, Mark D. Rivera 2019 Montclair State University

Health Promotion Practice And The Road Ahead: Addressing Enduring Gaps And Encouraging Greater Practice-To-Research Translation, Amanda Birnbaum, Mark D. Rivera

Amanda Birnbaum

A decade ago, Lancaster and Roe described four critical gaps (i.e., communications, accessibility, credibility, and expectations) between research and practice in health education and health promotion that formed the framework for this department. Despite considerable attention and some progress, these gaps persist and are barriers to interaction and translation between health promotion and health education research and practice. Looking to the next several years as the new Associate Editors for this department, we renew the department’s commitment toward addressing these enduring gaps around which we frame new questions and invite continued dialogue.


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