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Development Of A Unique Student Pharmacist Internship In A Primary Care Provider System, Norman E. Fenn III, Natalie R. Gadbois, Gwen J. Seamon, Shannon L. Castek, Kimberly S. Plake 2019 University of Texas at Tyler

Development Of A Unique Student Pharmacist Internship In A Primary Care Provider System, Norman E. Fenn Iii, Natalie R. Gadbois, Gwen J. Seamon, Shannon L. Castek, Kimberly S. Plake

Pharmacy Faculty Publications and Presentations

Purpose: To describe a unique pharmacy intern program in a group of federally qualified health center (FQHC) outpatient primary care provider clinics. Summary: A pharmacy intern program was created at the North Central Nursing Clinics in Indiana, a group of four FQHC outpatient primary care provider facilities. Intern-performed tasks included: Prior authorization (PA) requests, medication assistance program (MAP) applications, sample procurement and inventory, and contraceptive devices for implantation inventory management. Interns interacted with clinic administration, nurse practitioners, and medical staff to complete their assigned responsibilities. Over a one-year period, the interns completed documentation on more than 2000 charts during a ...


Sunscreen Efficacy By Chemical Composition And Its Effect On Aquatic Life, Taylor Yates 2019 Rappahannock Community College

Sunscreen Efficacy By Chemical Composition And Its Effect On Aquatic Life, Taylor Yates

Student Writing

Sunscreen provides protection against skin cancer by reducing UV exposure to the skin. Active ingredients come in two basic forms, chemical and mineral; ongoing research indicates that some active ingredients in sunscreen are harmful to marine life. This study is an analysis of chemical and mineral SPF 30 sunscreens to determine which provides the highest efficacy for skin protection while also providing the lowest toxicity to aquatic organisms. Sunscreen efficacy was tested by exposing photoreactive chemical paper applied with chemical and mineral sunscreens to the sun. Results of the photo effect paper trial showed a wide variation in the efficacy ...


Case Presentation On Congestive Heart Failure And Pulmonary Edema, Tetiana Soloviova, Denise Aris 2019 CUNY New York City College of Technology

Case Presentation On Congestive Heart Failure And Pulmonary Edema, Tetiana Soloviova, Denise Aris

Publications and Research

No abstract provided.


Jane Miller's Portfolio, Jane Miller 2019 Duquesne University

Jane Miller's Portfolio, Jane Miller

Honors College Portfolios

The portfolio that I am presenting is a collection of work and experiences that represent who I am as a motivated individual and a hard-working student.

As a whole, my portfolio provides evidence that I am able to reach my professional goal of becoming a diligent pharmacist because it demonstrates that I am able to achieve my maximum potential of a balanced, motivated individual, even when I am given large amounts of responsibility.


The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, Chloé Elizabeth LeBegue 2019 University of South Carolina

The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, Chloé Elizabeth Lebegue

Senior Theses

Phenylketonuria, now known as phenylalanine hydroxylase (PAH) deficiency, is a genetic disorder of metabolism affecting approximately one in every 15,000 infants born in the United States. Patients have nonfunctional PAH enzyme secondary to one or more genetic mutations. The enzyme deficit results in destructive supraphysiologic blood phenylalanine levels upon consumption of the essential dietary amino acid phenylalanine. Current standards of care mitigate signs and symptoms of the disorder, but do not approach a cure. The methods for creating a prototype pharmabiotic as an innovative treatment strategy for PAH deficiency are described herein.

DNA molecular cloning techniques were utilized to ...


The Impact Of Concomitant Empiric Cefepime On Patient Outcomes Of Methicillin-Resistant Staphylococcus Aureus Bloodstream Infections Treated With Vancomycin, Evan J. Zasowski, Trang D. Trinh, Safana M. Atwan, Marina Merzlyakova, Abdalhamid M. Langf, Sahil Bhatia, Michael J. Rybak 2019 Touro University California

The Impact Of Concomitant Empiric Cefepime On Patient Outcomes Of Methicillin-Resistant Staphylococcus Aureus Bloodstream Infections Treated With Vancomycin, Evan J. Zasowski, Trang D. Trinh, Safana M. Atwan, Marina Merzlyakova, Abdalhamid M. Langf, Sahil Bhatia, Michael J. Rybak

College of Pharmacy (TUC) Publications and Research

Background: Data suggest that vancomycin + β-lactam combinations improve clearance of methicillin-resistant Staphylococcus aureus(MRSA) bloodstream infections (BSIs). However, it is unclear which specific β-lactams confer benefit. This analysis evaluates the impact of concomitant empiric cefepime on outcomes of MRSA BSIs treated with vancomycin.

Methods: Retrospective cohort study of adults with MRSA BSI from 2006 to 2017. Vancomycin + cefepime therapy was defined as ≥24 hours of cefepime during the first 72 hours of vancomycin. The primary outcome was microbiologic failure, defined as BSI duration ≥7 days and/or 60-day recurrence. Multivariable logistic regression was used to evaluate the association between vancomycin ...


Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, John F. Greden, Anthony J. Rothschild 2019 University of Michigan-Ann Arbor

Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, John F. Greden, Anthony J. Rothschild

Open Access Articles

Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were limited in scope. Outpatients (N=1167) diagnosed with MDD and with a patient- or clinician-reported inadequate response to at least one antidepressant were enrolled in the Genomics Used to Improve DEpression Decisions (GUIDED) trial - a rater- and patient-blind randomized controlled trial. Patients were randomized to treatment as usual (TAU) or a pharmacogenomics-guided intervention arm in which clinicians had access to a pharmacogenomic test report to inform medication selections (guided-care). Medications were considered congruent ('use ...


Evaluation Of An Empiric Vancomycin Dosing Nomogram In Achieving Goal Steady-State Trough Concentrations In Obese Adults Weighing At Least 100 Kilograms, S. W. Johnson, R. D. Bowers, A. A. Cooper, C. L. Wente, D. Wilson 2019 Selected Works

Evaluation Of An Empiric Vancomycin Dosing Nomogram In Achieving Goal Steady-State Trough Concentrations In Obese Adults Weighing At Least 100 Kilograms, S. W. Johnson, R. D. Bowers, A. A. Cooper, C. L. Wente, D. Wilson

April Cooper

No abstract provided.


Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey 2019 University of Newcastle-upon-Tyne

Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey

Jarrod Bailey, PhD

There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and ...


The Use Of Aerosolized Ribavirin In Respiratory Syncytial Virus Lower Respiratory Tract Infections In Adult Immunocompromised Patients: A Systematic Review, Lisa M. Avery, Charles Hoffmann, Karen M. Whalen 2019 St. John Fisher College

The Use Of Aerosolized Ribavirin In Respiratory Syncytial Virus Lower Respiratory Tract Infections In Adult Immunocompromised Patients: A Systematic Review, Lisa M. Avery, Charles Hoffmann, Karen M. Whalen

Pharmacy Faculty/Staff Publications

Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug costs remain a challenge for patient management. The purpose of this systematic review is to summarize the efficacy and adverse event profile of RBV AER for the treatment of hospitalized RSV LRTI in immunocompromised adult patients. Methods: A Medline/PubMed, Embase, Google Scholar, Clinicaltrials.gov, and Cochrane Library database search was conducted from 1966 to January 2019 for the use of RBV AER. Search strategy: [(ribavirin ...


Using An "Escape Room" Toolbox Approach To Enhance Pharmacology Education, Melinda Hermanns, Belinda Deal, Ann M. C, Shawn Hillhouse, J. Brian Opella, Casey Faigle, Robert H. Campbell IV 2019 The University of Texas at Tyler

Using An "Escape Room" Toolbox Approach To Enhance Pharmacology Education, Melinda Hermanns, Belinda Deal, Ann M. C, Shawn Hillhouse, J. Brian Opella, Casey Faigle, Robert H. Campbell Iv

Barbara Haas

Background: Faculty are encouraged to use a variety of teaching/learning strategies to engage nursing students. While simulation and games are now common, there were no reports in the nursing literature using an “escape room” concept. Escape rooms use an entertainment approach as teams engage in critical thinking to solve puzzles and find clues to escape a room. In the classroom setting, this concept is modified to solve a mystery by finding various objects through a series of puzzles to locate clues. Some of these games involve finding numerical clues to open locks on a box, such as a toolbox ...


Associations Between Dietary Intake Of Fruits And Vegetables In Relation To Urinary Estrogen Dna Adduct Ratio, K. W. Reding, M. Zahid, E. Cavalieri, E. G. Rogan, B. S. Raccor, C. Atkinson, M. Yong, K. M. Newton, J. W. Lampe 2019 Selected Works

Associations Between Dietary Intake Of Fruits And Vegetables In Relation To Urinary Estrogen Dna Adduct Ratio, K. W. Reding, M. Zahid, E. Cavalieri, E. G. Rogan, B. S. Raccor, C. Atkinson, M. Yong, K. M. Newton, J. W. Lampe

Brianne S. Raccor

No abstract provided.


Comparison Of Pharmaceutical Calculations Learning Outcomes Achieved Within A Traditional Lecture Or Flipped Classroom Andragogy, H. Glenn Anderson Jr., Lisa Frazier, Stephanie L. Anderson, Robert B. Stanton, Chris Gillette, Kim Broedel-Zaugg, Kevin W. Yingling 2019 Marshall University

Comparison Of Pharmaceutical Calculations Learning Outcomes Achieved Within A Traditional Lecture Or Flipped Classroom Andragogy, H. Glenn Anderson Jr., Lisa Frazier, Stephanie L. Anderson, Robert B. Stanton, Chris Gillette, Kim Broedel-Zaugg, Kevin W. Yingling

Kim Broedel-Zaugg

Objective. To compare learning outcomes achieved from a pharmaceutical calculations course taught in a traditional lecture (lecture model) and a flipped classroom (flipped model).

Methods. Students were randomly assigned to the lecture model and the flipped model. Course instructors, content, assessments, and instructional time for both models were equivalent. Overall group performance and pass rates on a standardized assessment (Pcalc OSCE) were compared at six weeks and at six months post-course completion.

Results. Student mean exam scores in the flipped model were higher than those in the lecture model at six weeks and six months later. Significantly more students passed ...


Weight Gain In Patients With Hiv Infection Who Are Virologically Suppressed On Antiretroviral Therapy And Switch To Integrase Inhibitor Containing Regimens, Matty Zimmerman, Jason Schafer, PharmD, MPH, BCPS, BCIDP, AAHIVP 2019 Thomas Jefferson University

Weight Gain In Patients With Hiv Infection Who Are Virologically Suppressed On Antiretroviral Therapy And Switch To Integrase Inhibitor Containing Regimens, Matty Zimmerman, Jason Schafer, Pharmd, Mph, Bcps, Bcidp, Aahivp

College of Pharmacy Posters

Objective

To determine the prevalence and extent of weight gain among virologically suppressed PLWH whose antiretroviral therapy (ART) has been switched to an integrase inhibitor (INSTI) containing regimen.


Safety And Efficacy Of Very High Dose Furosemide Continuous Infusions, Jessica Wilczynski, PharmD, Matthew Decaro, MD, FACC, FACP, Gregary Marhefka, MD, FACC, FACP, Brandi Thoma, PharmD, BCPS, BCCP, Susan Varghese, PharmD, BCPS, Ryan Watson, MD, Ilya Danelich, PharmD, BCPS, BCCP 2019 Thomas Jefferson University

Safety And Efficacy Of Very High Dose Furosemide Continuous Infusions, Jessica Wilczynski, Pharmd, Matthew Decaro, Md, Facc, Facp, Gregary Marhefka, Md, Facc, Facp, Brandi Thoma, Pharmd, Bcps, Bccp, Susan Varghese, Pharmd, Bcps, Ryan Watson, Md, Ilya Danelich, Pharmd, Bcps, Bccp

Division of Cardiology Posters

  • Fluid overload is treated with loop diuretics in patients with heart failure and in patients with acute kidney injury1,2
  • There are sparse data regarding use of very high dose continuous loop diuretic infusions. In some studies, very high doses were only used in outlying patients (maximum160 mg/hour)3, 4
  • The use of very high dose furosemide continuous infusions at Thomas Jefferson University Hospital is a rare practice. These infusions range in dose from 40-240 mg/hour, with no limitation on the duration
  • The purpose of this study is to examine the efficacy and safety of very high dose ...


Purification And Characterization Of A Nonspecific Lipid Transfer Protein 1 (Nsltp1) From Ajwain (Trachyspermum Ammi) Seeds, Meshal Nazeer, Humera Waheed, Maria Saeed, Saman Yousuf ali, M. Iqbal Choudhary, Zaheer Ul-Haq, Aftab Ahmed 2019 Chapman University

Purification And Characterization Of A Nonspecific Lipid Transfer Protein 1 (Nsltp1) From Ajwain (Trachyspermum Ammi) Seeds, Meshal Nazeer, Humera Waheed, Maria Saeed, Saman Yousuf Ali, M. Iqbal Choudhary, Zaheer Ul-Haq, Aftab Ahmed

Pharmacy Faculty Articles and Research

Ajwain (Trachyspermum ammi) belongs to the family Umbelliferae, is commonly used in traditional, and folk medicine due to its carminative, stimulant, antiseptic, diuretic, antihypertensive, and hepatoprotective activities. Non-specific lipid transfer proteins (nsLTPs) reported from various plants are known to be involved in transferring lipids between membranes and in plants defense response. Here, we describe the complete primary structure of a monomeric non-specific lipid transfer protein 1 (nsLTP1), with molecular weight of 9.66 kDa, from ajwain seeds. The nsLTP1 has been purified by combination of chromatographic techniques, and further characterized by mass spectrometry, and Edman degradation. The ajwain nsLTP1 is ...


Systematic Literature Review Of Quetiapine For The Treatment Of Psychosis In Patients With Parkinsonism, Jack J. Chen, Henry Hua, Lilian Massihi, Ivan Portillo, Azita Alipour, William Ondo, Khashayar Dashtipour 2019 American University of Health Sciences

Systematic Literature Review Of Quetiapine For The Treatment Of Psychosis In Patients With Parkinsonism, Jack J. Chen, Henry Hua, Lilian Massihi, Ivan Portillo, Azita Alipour, William Ondo, Khashayar Dashtipour

Library Articles and Research

Objective:

The purpose of this article was to determine the efficacy and tolerability of quetiapine compared with placebo or other interventions for psychosis in parkinsonism.

Methods:

Participants with a diagnosis of parkinsonism participated in randomized controlled trials (RCTs) investigating the efficacy and tolerability of quetiapine for psychotic symptoms within a defined follow-up period. The authors conducted searches on PubMed, Cochrane Controlled Register of Trials, and EMBASE for articles published from January 1991 to October 2017. Study methodology and patient- and treatment-level data were independently extracted and summarized by using descriptive statistics. Studies underwent quality assessment for risk of bias.

Results ...


The Impact Of Naloxone Training And Education In The Community, Tom Davis, Krista Brooks, Saleena Brownell, Kayley Humann, Carla Williams 2019 Southwestern Oklahoma State University

The Impact Of Naloxone Training And Education In The Community, Tom Davis, Krista Brooks, Saleena Brownell, Kayley Humann, Carla Williams

Faculty Articles & Research

The issue of opioid overdose has become a national crisis and is receiving a lot of attention in the media. In the state of Oklahoma, 388 people died from opioid overdose in 2017. Nationally, there were over 47,600 opioid-related drug overdose deaths in 2017.


Medication Therapy Management: Empowering The Patient, Aimee Henderson, Krista Brooks, Jordyn Richey, Victoria Thompson 2019 Southwestern Oklahoma State University

Medication Therapy Management: Empowering The Patient, Aimee Henderson, Krista Brooks, Jordyn Richey, Victoria Thompson

Faculty Articles & Research

Medication Therapy Management provides the community with many benefits. In order to demonstrate the importance, we used pharmacist surveys to convey how often MTM is utilized, pharmacists perspectives on service utilization and challenges, and goals and expectations of the outcomes of MTM services.


Evaluating Naloxone Access And Prescribing Requirements In The Opioid Epidemic Across The United States, Krista Brooks, Tom Davis, Khoa Nguyen, Ngan-Dinh Nguyen, Tashrique Rahman, Lucero Villa 2019 Southwestern Oklahoma State University

Evaluating Naloxone Access And Prescribing Requirements In The Opioid Epidemic Across The United States, Krista Brooks, Tom Davis, Khoa Nguyen, Ngan-Dinh Nguyen, Tashrique Rahman, Lucero Villa

Faculty Articles & Research

  • Deaths related to opioid overdose has been an increasing problem in the United States
  • Deaths related to opioid overdoses can be prevented by the use of naloxone which reverses the effects of opioids
  • Approaches to promote naloxone access have been described by federal agencies, including the Substance Abuse and Mental Health Services Administration


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