Amphiphilic Peptides For Efficient Sirna Delivery, 2019 Chapman University
Amphiphilic Peptides For Efficient Sirna Delivery, Saghar Mozaffari, Emira Bousoik, Farideh Amirrad, Robert Lamboy, Melissa Coyle, Ryley Hall, Abdulaziz Alasmari, Parvin Mahdipoor, Keykavous Parang, Hamidreza Montazeri Aliabadi
Pharmacy Faculty Articles and Research
A number of amphiphilic cyclic peptides—[FR]4, [WR]5, and [WK]5—containing hydrophobic and positively-charged amino acids were synthesized by Fmoc/tBu solid-phase peptide methods and evaluated for their efficiency in intracellular delivery of siRNA to triple-negative breast cancer cell lines, MDA-MB-231 and MDA-MB-468, in the presence and absence of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). Among the peptides, [WR]5, which contains alternate tryptophan (W) and arginine (R) residues, was found to be the most efficient in the delivery of siRNA by improving the delivery by more than 3-fold when compared to other synthesized cyclic peptides that were not efficient ...
Application Of Beers Criteria And A Brown Bag Event To Increase Prescribing Safety In Older Adults, 2019 Valparaiso University
Application Of Beers Criteria And A Brown Bag Event To Increase Prescribing Safety In Older Adults, Kristen Garza
Evidence-Based Practice Project Reports
With older adults making up about 14.5% of the U.S. population, polypharmacy may be an unintended consequence of adhering to clinical practice guidelines (Kim & Luck Parish, 2017). Effective polypharmacy interventions are needed in the primary care setting to increase prescribing safety and lower the risk of adverse drug events among older adults. The application of the Beers criteria, in conjunction with a brown bag medication reconciliation event, was initiated as focused interventions for a private primary practice without electronic health records. Outcomes included medication reduction, identification of possible inappropriate medication, decrease of medication dosages, and identification of duplicate ...
Investigations Of Novel Strategies To Treat Bacterial Infection And Development Of New Reaction Methodology, Shane Philippi
Theses and Dissertations
Quorum Sensing (QS), a form of bacteria communication mediated through chemical signaling, was investigated in the bacterial pathogen Pseudomonas aeruginosa. QS has the ability to regulate when a bacterial pathogen is infective or benign. LasR is the main regulator in this system and is also the receptor targeted for inhibition. A Structure Activity Relationship was produced for the system along with the binding pocket being explored.
A new reaction methodology was developed inspired by the Haloform reaction. The reaction was optimized based on solvent, stoichiometry, and conditions. Changing the initial electrophile and the reagent nucleophile created the scope of the ...
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, 2019 University of New Mexico - Main Campus
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin
Nanoscience and Microsystems ETDs
Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The ...
Extended Infusions Of Meropenem For Febrile Neutropenia, 2019 Butler University
Extended Infusions Of Meropenem For Febrile Neutropenia, Daniel J. Przybylski, Pharmd, David J. Reeves, Pharmd, Bcop
Background: Neutropenic fever is an oncologic emergency that requires quick intervention with anti-pseudomonal beta-lactam antibiotics, such as meropenem. Previous literature suggests that extended infusions of beta-lactam antibiotics may improve clinical outcomes. To date, there are 3 prior studies utilizing an extended infusion beta-lactam in this population; however, there is only one previous study investigating the use of extended infusion meropenem in patients with febrile neutropenia.
Objective: To describe the outcomes of eight patients receiving extended infusions of meropenem for the treatment of febrile neutropenia.
Methods: A retrospective chart review was completed including adult patients admitted to a community teaching hospital ...
Synthesis And Antiproliferative Activities Of Conjugates Of Paclitaxel And Camptothecin With A Cyclic Cell-Penetrating Peptide, Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Tiwari
Pharmacy Faculty Articles and Research
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one lysine to enable the conjugation with the anticancer drugs. Paclitaxel (PTX) was functionalized with an esterification reaction at the C20 hydroxyl group of PTX with glutaric anhydride and conjugated with the cyclic peptide [W(WR)4K(bAla)] in DMF to obtain the peptide-drug conjugate PTX1. Furthermore, camptothecin (CPT) was modified at the C(20)-hydroxyl group through the reaction with triphosgene. Then, it was ...
Eis Inhibitors, 2019 University of Kentucky
Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
Pharmaceutical Sciences Faculty Patents
Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
Sex Hormones And Vascular Function, 2019 Selected Works
Sex Hormones And Vascular Function, M. Bowling, S. Oparil, F. Hage, R. H. Hilgers, D. Xing
No abstract provided.
Decreased Edhf-Mediated Relaxation Is A Major Mechanism In Endothelial Dysfunction In Resistance Arteries In Aged Mice On Prolonged High- Fat Sucrose Diet, S. M. Dunn, R. H. Hilgers, K. C. Das
No abstract provided.
Surface-Controlled Dissolution Rates: A Case Study Of Nanoceria In Carboxylic Acid Solutions, 2019 University of Kentucky
Surface-Controlled Dissolution Rates: A Case Study Of Nanoceria In Carboxylic Acid Solutions, Eric A. Grulke, Matthew J. Beck, Robert A. Yokel, Jason M. Unrine, Uschi M. Graham, Matthew L. Hancock
Chemical and Materials Engineering Faculty Publications
Nanoparticle dissolution in local milieu can affect their ecotoxicity and therapeutic applications. For example, carboxylic acid release from plant roots can solubilize nanoceria in the rhizosphere, affecting cerium uptake in plants. Nanoparticle dispersions were dialyzed against ten carboxylic acid solutions for up to 30 weeks; the membrane passed cerium-ligand complexes but not nanoceria. Dispersion and solution samples were analyzed for cerium by inductively coupled plasma mass spectrometry (ICP-MS). Particle size and shape distributions were measured by transmission electron microscopy (TEM). Nanoceria dissolved in all carboxylic acid solutions, leading to cascades of progressively smaller nanoparticles and producing soluble products. The dissolution ...
Effective Nebulization Of Interferon-Γ Using A Novel Vibrating Mesh., 2019 Aerogen, Galway
Effective Nebulization Of Interferon-Γ Using A Novel Vibrating Mesh., Louise Sweeney, Alice P. Mccloskey, Gerard Higgins, Joanne M. Ramsey, Sally-Ann Cryan, Ronan Macloughlin
School of Pharmacy Articles
BACKGROUND: Interferon gamma (IFN-γ) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and management of respiratory diseases such as tuberculosis and pulmonary fibrosis. As with all large biomolecules, clinical translation is dependent on effective delivery to the disease site and delivery of IFN-γ as an aerosol offers a logical means of drug targeting. Effective localization is often hampered by instability and a lack of safe and efficient delivery systems. The present study sought to determine how effectively IFN-γ can be nebulized using two types of vibrating mesh nebulizer, each with differing mesh architectures, and ...
A Randomized, Controlled Trial On The Effects Of Almonds On Lipoprotein Response To A Higher Carbohydrate, Lower Fat Diet In Men And Women With Abdominal Adiposity., Paul T. Williams, Nathalie Bergeron, Sally Chiu, Ronald M. Krauss
College of Pharmacy (TUC) Publications and Research
BACKGROUND: Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small, dense low-density lipoprotein (LDL) particles that is associated with abdominal adiposity and high carbohydrate intake. The objective of the present study was to test whether substitution of almonds for other foods attenuates carbohydrate-induced increases in small, dense LDL in individuals with increased abdominal adiposity.
METHODS: This was a randomized cross-over study of three 3wk diets, separated by 2wk washouts: a higher-carbohydrate (CHO) reference diet (CHO
RESULTS: Relative to ...
Jackrabbits Script And Scope, 2019 South Dakota State University
Jackrabbits Script And Scope, College Of Pharmacy And Allied Health Professions
Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)
[Page] 4 Hoch Professorship
[Page] 7 Lansink Takes Lead
[Page] 8 Innovation Pharmacy
[Page] 12 MPH Student Michael Dunn
[Page] 14 MLS White Coat
[Page] 16 Alumnus of the Year
[Page] 18 Van Riper Wins
[Page] 19 Shaw Honored
[Page] 20 Scholarship Recipients
[Page] 22 Paying it Forward
[Page] 23 Remembering Struggles
[Page] 24 Student News
[Page] 25 2018 Highlights
[Page] 29 Asessing Student Readiness
[Page] 30 Raina Joins Department
[Page] 31 The Opioid Crisis
[Page] 32 Donor Listing
[Page] 34 SDSU Foundation
Pharmacy Newsletter : April 2019, 2019 Aga Kahn University Hospital
Pharmacy Newsletter : April 2019, Pharmacy Department
- New Dosing Recommendations for Safe Use of Colistin
- Fournier’s Gangrene reported with SGLT2 Inhibitors for Diabetes
- Drug Use : The Three Dosage form of Fosfomycin
- Losartan, An Effective Alternative Approach in Managing Marfan Syndrome
- Pediatric Dose Calculation when no Pediatric Dose Available?
Development Of A Unique Student Pharmacist Internship In A Primary Care Provider System, 2019 University of Texas at Tyler
Development Of A Unique Student Pharmacist Internship In A Primary Care Provider System, Norman E. Fenn Iii, Natalie R. Gadbois, Gwen J. Seamon, Shannon L. Castek, Kimberly S. Plake
Pharmacy Faculty Publications and Presentations
Purpose: To describe a unique pharmacy intern program in a group of federally qualified health center (FQHC) outpatient primary care provider clinics. Summary: A pharmacy intern program was created at the North Central Nursing Clinics in Indiana, a group of four FQHC outpatient primary care provider facilities. Intern-performed tasks included: Prior authorization (PA) requests, medication assistance program (MAP) applications, sample procurement and inventory, and contraceptive devices for implantation inventory management. Interns interacted with clinic administration, nurse practitioners, and medical staff to complete their assigned responsibilities. Over a one-year period, the interns completed documentation on more than 2000 charts during a ...
Sunscreen Efficacy By Chemical Composition And Its Effect On Aquatic Life, 2019 Rappahannock Community College
Sunscreen Efficacy By Chemical Composition And Its Effect On Aquatic Life, Taylor Yates
Sunscreen provides protection against skin cancer by reducing UV exposure to the skin. Active ingredients come in two basic forms, chemical and mineral; ongoing research indicates that some active ingredients in sunscreen are harmful to marine life. This study is an analysis of chemical and mineral SPF 30 sunscreens to determine which provides the highest efficacy for skin protection while also providing the lowest toxicity to aquatic organisms. Sunscreen efficacy was tested by exposing photoreactive chemical paper applied with chemical and mineral sunscreens to the sun. Results of the photo effect paper trial showed a wide variation in the efficacy ...
Case Presentation On Congestive Heart Failure And Pulmonary Edema, 2019 CUNY New York City College of Technology
Case Presentation On Congestive Heart Failure And Pulmonary Edema, Tetiana Soloviova, Denise Aris
Publications and Research
No abstract provided.
Jane Miller's Portfolio, 2019 Duquesne University
Jane Miller's Portfolio, Jane Miller
Honors College Portfolios
The portfolio that I am presenting is a collection of work and experiences that represent who I am as a motivated individual and a hard-working student.
As a whole, my portfolio provides evidence that I am able to reach my professional goal of becoming a diligent pharmacist because it demonstrates that I am able to achieve my maximum potential of a balanced, motivated individual, even when I am given large amounts of responsibility.
The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, 2019 University of South Carolina
The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, Chloé Elizabeth Lebegue
Phenylketonuria, now known as phenylalanine hydroxylase (PAH) deficiency, is a genetic disorder of metabolism affecting approximately one in every 15,000 infants born in the United States. Patients have nonfunctional PAH enzyme secondary to one or more genetic mutations. The enzyme deficit results in destructive supraphysiologic blood phenylalanine levels upon consumption of the essential dietary amino acid phenylalanine. Current standards of care mitigate signs and symptoms of the disorder, but do not approach a cure. The methods for creating a prototype pharmabiotic as an innovative treatment strategy for PAH deficiency are described herein.
DNA molecular cloning techniques were utilized to ...
Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, 2019 University of Michigan-Ann Arbor
Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, John F. Greden, Anthony J. Rothschild
Open Access Articles
Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were limited in scope. Outpatients (N=1167) diagnosed with MDD and with a patient- or clinician-reported inadequate response to at least one antidepressant were enrolled in the Genomics Used to Improve DEpression Decisions (GUIDED) trial - a rater- and patient-blind randomized controlled trial. Patients were randomized to treatment as usual (TAU) or a pharmacogenomics-guided intervention arm in which clinicians had access to a pharmacogenomic test report to inform medication selections (guided-care). Medications were considered congruent ('use ...