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4,717 full-text articles. Page 1 of 190.

Joint Annual Wellness Visit Scheduling, Rob Chamberlin, Jennifer Bliss, Andrea Lai, Paula Dougherty, Deb Swett, Logan Merrithew, Pam Stevens, Scott Williams 2019 Maine Medical Center

Joint Annual Wellness Visit Scheduling, Rob Chamberlin, Jennifer Bliss, Andrea Lai, Paula Dougherty, Deb Swett, Logan Merrithew, Pam Stevens, Scott Williams

Maine Medical Center

Problem/Impact Statement: The pharmacists in Scarborough & Westbrook Primary Care conduct Medicare Annual Wellness Visits (AWVs) with a physician. The pharmacist and physician see the patient individually. The practices achieved and sustained FY18 Joint AWV volume goals through a new process to reschedule physician-only AWVs to Joints AWVs with a pharmacist. This leads to reschedule rework and reduced time practice staff have for patient care.


Tigecycline In The Treatment Of Complicated Intra-Abdominal And Complicated Skin And Skin Structure Infections, M. L. Townsend, M. W. Pound, R. H. Drew 2019 Selected Works

Tigecycline In The Treatment Of Complicated Intra-Abdominal And Complicated Skin And Skin Structure Infections, M. L. Townsend, M. W. Pound, R. H. Drew

Melanie Pound

Tigecycline, a glycylcycline related to the tetracycline class of antibiotics, represents a new option for the treatment of complicated intra-abdominal and complicated skin and skin structure infections. It displays favorable activity in vitro against the most common causative Gram-positive, Gram-negative and anaerobic pathogens. In addition, tigecycline demonstrates activity against drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and organisms (such as Escherichia coli and Klebsiella pneumoniae) producing extended-spectrum beta-lactamases. Tigecycline lacks activity in vitro against Pseudomonas and Proteus spp. In randomized clinical trials, tigecycline administered intravenously twice daily has demonstrated efficacy similar to comparators for a variety of complicated ...


Estrogen Metabolites In Human Corpus Luteum Physiology: Differential Effects On Angiogenic Activity, Soledad Henríquez, Paulina Kohen, Xia Xu, Timothy Veenstra, Alex Muñoz, Wilder A Palomino, Jerome F Strauss, Luigi Devoto 2019 Cedarville University

Estrogen Metabolites In Human Corpus Luteum Physiology: Differential Effects On Angiogenic Activity, Soledad Henríquez, Paulina Kohen, Xia Xu, Timothy Veenstra, Alex Muñoz, Wilder A Palomino, Jerome F Strauss, Luigi Devoto

Timothy Veenstra, Ph.D.

OBJECTIVE: To determine tissue concentrations of E2, estrone, P, and estrogens metabolites (EMs) 2-methoxyestradiol, 2-methoxyestrone, 4-hydroxyestrone, and 16-ketoestradiol in corpus luteum (CL) of different ages, and after hCG administration; and to examine the effects of EMs on vascular endothelial growth factor (VEGF) secretion and angiogenic activity released by cultured luteinizing granulosa cells in the presence and absence of hCG.

DESIGN: Experimental study.

SETTING: University.

PATIENT(S): Thirty-two healthy women of reproductive age.

INTERVENTION(S): Corpus luteum was collected at the time of minilaparotomy for tubal sterilization, at varying stages of the luteal phase (LP). Late-LP CL was collected 24 hours ...


Cell Cycle-Dependent Phosphorylation Of Nucleophosmin And Its Potential Regulation By Peptidyl-Prolyl Cis/Trans Isomerase, Xuelian Zhao, Junfang Ji, Li-Rong Yu, Timothy Veenstra, Xin Wei Wang 2019 Cedarville University

Cell Cycle-Dependent Phosphorylation Of Nucleophosmin And Its Potential Regulation By Peptidyl-Prolyl Cis/Trans Isomerase, Xuelian Zhao, Junfang Ji, Li-Rong Yu, Timothy Veenstra, Xin Wei Wang

Timothy Veenstra, Ph.D.

Nucleophosmin (NPM) is a ubiquitously expressed phosphoprotein involved in many cellular processes. Phosphorylation is considered the major regulatory mechanism of the NPM protein, associated with diverse cellular events. In this study, we characterized the phosphorylation status of several physiological phosphorylation sites of NPM, especially the newly confirmed


Integrated Proteotranscriptomics Of Breast Cancer Reveals Globally Increased Protein-Mrna Concordance Associated With Subtypes And Survival, Wei Tang, Ming Zhou, Tiffany H Dorsey, DaRue A Prieto, Xin W Wang, Eytan Ruppin, Timothy Veenstra, Stefan Ambs 2019 Cedarville University

Integrated Proteotranscriptomics Of Breast Cancer Reveals Globally Increased Protein-Mrna Concordance Associated With Subtypes And Survival, Wei Tang, Ming Zhou, Tiffany H Dorsey, Darue A Prieto, Xin W Wang, Eytan Ruppin, Timothy Veenstra, Stefan Ambs

Timothy Veenstra, Ph.D.

BACKGROUND: Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

METHODS: We applied a quantitative liquid chromatography/mass spectrometry-based proteome analysis using an untargeted approach and analyzed protein extracts from 65 breast tumors and 53 adjacent non-cancerous tissues. Additional gene expression data from Affymetrix Gene Chip Human Gene ST Arrays were ...


Complex Acylation Of Angiotensin Ii By N-Hydroxysulfosuccinimide Linked Biotin Reagents, Q. Liu, A. Lam, A. Kathuria 2019 Selected Works

Complex Acylation Of Angiotensin Ii By N-Hydroxysulfosuccinimide Linked Biotin Reagents, Q. Liu, A. Lam, A. Kathuria

Qinfeng Liu

N-Hydroxysulfosuccinimide-linked biotins (sulfoNHS-biotins) are water soluble biotin tags commonly used to conjugate a biotin moiety to proteins by rapid N-acylation of primary amines. Unexpected O-acylation by sulfoNHSbiotin on tyrosine of Angiotensin II (Ag-II) and an acylation on third site unable to characterize were identified by LC-MS in addition to the expected N-acylation on the N-terminal of Ag-II. The N-acylation only undergoes incomplete hydrolysis in 0.1% formic acid not at pH 7.2 and 8.0, while two unexpected acylation hydrolyze at both conditions, but their hydrolysis in 0.1% formic acid was much more rapid. Dithiothreitol treatment selectively catalyzed ...


Sipuleucel-T (Provenge®): Therapeutic Use And Financial Implications, Courtney Porter, Joshua Ilenin, Lisa Berni, Ashley Overy, Karen L. Kier 2019 Ohio Northern University

Sipuleucel-T (Provenge®): Therapeutic Use And Financial Implications, Courtney Porter, Joshua Ilenin, Lisa Berni, Ashley Overy, Karen L. Kier

Pharmacy and Wellness Review

Although mortality rates have been declining, prostate cancer accounts for a large percentage of cancer diagnoses around the world. Sipuleucel-T (Provenge®), an autologous cellular immunotherapy targeted against the antigen expressed in most prostate cancers, has been shown to increase the median survival rate of castration-resistant prostate cancer. Even so, the therapeutic risks and benefits, as well as financial implications, all currently play a role in the governmental decision to reimburse for this new therapy.


An Update On Gestational Diabetes, Jamie L. Amero, Jennifer L. Bauer, Sarah M. Webb, Ryan A. Fischer, Lindsey A. Hallman, Sandra L. Hrometz 2019 Ohio Northern University

An Update On Gestational Diabetes, Jamie L. Amero, Jennifer L. Bauer, Sarah M. Webb, Ryan A. Fischer, Lindsey A. Hallman, Sandra L. Hrometz

Pharmacy and Wellness Review

Gestational diabetes is a concern for a large number of pregnant women due to the potential for long-term complications for both the mother and the fetus. With the increasing prevalence of obesity and diabetes in the general public, the number of pregnant women with undiagnosed type 2 diabetes mellitus has also increased. In order to adequately educate their patients, it is important for pharmacists to be aware of the general practices of treating gestational diabetes. This review will highlight recent updates to initial screening, the criteria for diagnosing gestational diabetes, and current management strategies.


Treatment Options For Seasonal Affective Disorder, Lauren D. Bajbus, Amanda M. Meyer, Kristen M. Quertinmont, Sarah E. Drake, Alison L. Huet, Shane Martin 2019 Ohio Northern University

Treatment Options For Seasonal Affective Disorder, Lauren D. Bajbus, Amanda M. Meyer, Kristen M. Quertinmont, Sarah E. Drake, Alison L. Huet, Shane Martin

Pharmacy and Wellness Review

Many patients who have undiagnosed Seasonal Affective Disorder (SAD) may come into the pharmacy to try to self-treat their symptoms with over-the-counter and herbal drugs. Often, patients don't recognize their symptoms as a true depressive disorder since they are not constant. The pharmacist has the opportunity to talk to these patients, educate them on the disease state and explain that they do have options, both pharmacologic and non-pharmacologic. It also is important for pharmacists to point out any interactions that the herbal or over-the-counter medications may have with other medications and to refer patients to their physician for further ...


The Pharmacogenetics Of Opioid Pain Management, MaryAnne Ventura, Lauren Desko, Kimberly Gathers, Ashley Overy, David Kisor 2019 Ohio Northern University

The Pharmacogenetics Of Opioid Pain Management, Maryanne Ventura, Lauren Desko, Kimberly Gathers, Ashley Overy, David Kisor

Pharmacy and Wellness Review

High rates of interpatient variability in drug metabolism and drug response for nearly all medications lead to the hypothesis that assessment of an individual patient's genotype with respect to their ability metabolize certain drugs can be a useful tool in predicting a patient's responsiveness to certain medications. Evaluating patients using pharmacogenomics as a basis for assessment could allow pharmacists to decide which treatment options would be most efficacious in a given patient and, thereby, have significant impact in the clinical setting. This holds true especially in the case of prodrugs, which require in vivo activation to an active ...


Pediatric Poisoning: Overview, Treatment, And Prevention, Margaret Rowland, Taylor Gauthier, Kaitlin Sanders, Caitlin Swann, David Bright 2019 Ohio Northern University

Pediatric Poisoning: Overview, Treatment, And Prevention, Margaret Rowland, Taylor Gauthier, Kaitlin Sanders, Caitlin Swann, David Bright

Pharmacy and Wellness Review

Pediatric poisoning remains a common and preventable occurrence in the United States. Every year, prescription and over-the-counter medications account for a significant portion of documented poison exposures. Frequent causes of overdose in children include improper medication storage and caregiver or physician dosing error. As easily accessible medication experts, pharmacists have an opportunity to counsel patients in an effort to decrease these preventable poisoning cases. Because children frequently ingest products prescribed for adult use, pharmacist should relay safety considerations to all patients, regardless of age. This article provides a general review of toxicity concerns, discusses clinical implications of common medications resulting ...


Healthy People 2020: Identifying Roles For Pharmacists In Public Health, Ellen Hazelet, Aisha Oliver, Katherine Salay, Breanne Rizzo, Alison L. Huet, Natalie DiPietro 2019 Ohio Northern University

Healthy People 2020: Identifying Roles For Pharmacists In Public Health, Ellen Hazelet, Aisha Oliver, Katherine Salay, Breanne Rizzo, Alison L. Huet, Natalie Dipietro

Pharmacy and Wellness Review

Healthy People, sponsored by the United States Department of Health and Human Services, utilizes evidence-based medicine to create objectives addressing significant preventable health issues. The vision of Healthy People is to improve the quality and length of life free from preventable disease, disability, injury and death. Based on objectives outlined by Healthy People 2020 (HP 2020) pharmacists can play a role in public awareness, collaborate with other health care professionals and help achieve goals set forth by HP 2020. Based on the expertise and accessibility of the pharmacist, pharmacists can impact nine of the 13 new focus areas pf HP ...


Prescription Drug Manufacturer Attempts To Prevent Abuse Of Controlled Substances, Amanda R. Hoersten, Nathaniel Hedrick, Lacey Shumate, H. Paige Stewart, Caitlin Swann, Michael Milks 2019 Ohio Northern University

Prescription Drug Manufacturer Attempts To Prevent Abuse Of Controlled Substances, Amanda R. Hoersten, Nathaniel Hedrick, Lacey Shumate, H. Paige Stewart, Caitlin Swann, Michael Milks

Pharmacy and Wellness Review

In the United States, prescription drug abuse is on the rise. This trend has impacted the makers of OxyContin®, as well as the manufacturers of other controlled substances,to reevaluate how they formulate their products, resulting in medications, that are more difficult to abuse. These abuse-deterrent formulations utilize physical, chemical and aversion barriers, specific delivery systems, and prodrug technology to prevent abuse. Additionally, some manufacturers have implemented the use of risk-management campaigns and education programs, to reduce the misuse of their products. Working together with prescription drug manufacturers, pharmacists play an important role in preventing abuse and educating patients on ...


Will New Mrsa Guidelines Make A Difference In Clinical Outcomes? A Comparison Of United States And United Kingdom Guidelines And Outcomes, Kelly Fargo, Erica Schoenberger, Kristen Thatcher, Lindsey Hallman, Andrew Roecker, Tarek Mahfouz 2019 Ohio Northern University

Will New Mrsa Guidelines Make A Difference In Clinical Outcomes? A Comparison Of United States And United Kingdom Guidelines And Outcomes, Kelly Fargo, Erica Schoenberger, Kristen Thatcher, Lindsey Hallman, Andrew Roecker, Tarek Mahfouz

Pharmacy and Wellness Review

As of February 2011, the Infectious Disease Society of America (IDSA) published the first guidelines assessing the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. S. aureus is present in the environment and is also located on the skin's surface. MRSA can cause a variety of clinical syndromes presenting with different symptoms that vary with the type and stage of the infection. MRSA is also classified into community-acquired MRSA (CA-MRSA) and hospital-acquired (HA-MRSA), both of which possess different treatment options and strategies. Due to the complex treatment of MRSA, as well the concern over the development of resistance, suggested treatment ...


Letter To The Editor, Olivia Hiddleson 2019 Ohio Northern University

Letter To The Editor, Olivia Hiddleson

Pharmacy and Wellness Review

No abstract provided.


Pharmacy Colleges: A Highly Controversial Test, Tana M. Peterman, Brieann Miller 2019 Ohio Northern University

Pharmacy Colleges: A Highly Controversial Test, Tana M. Peterman, Brieann Miller

Pharmacy and Wellness Review

As substance abuse continues to be problematic on college campuses across the United States, pharmacy colleges in particular are faced with the challenge of deterring drug abuse among their students. Many pharmacy schools are considering the adoption of student drug -screening policies in hopes of discouraging abuse, directing impaired students to treatment, and, ultimately, protecting the public. However, these policies are being met with apprehension in regards to added costs, Fourth Amendment rights violations, and privacy concerns. Drug-screening policies continue to be an issue of deliberation for pharmacy colleges, requiring much consideration and care.


Pharmacotherapeutic Study Of Antiretroviral Therapy For Hiv/Aids Patients At The Federal Medical Centre, Owo, Ondo State, Nigeria, Isiaka Adebowale Ayeni Pharm., Adelanwa Oludele Itiola Prof, Tajudeen Temitayo Adebayo Dr. 2019 Department of Pharmaceutical Services, Federal Medical Centre, Owo, Nigeria

Pharmacotherapeutic Study Of Antiretroviral Therapy For Hiv/Aids Patients At The Federal Medical Centre, Owo, Ondo State, Nigeria, Isiaka Adebowale Ayeni Pharm., Adelanwa Oludele Itiola Prof, Tajudeen Temitayo Adebayo Dr.

Library Philosophy and Practice (e-journal)

A 6-12 months retrospective study is made of HAART utilization in cases of HIV/AIDS patients at Federal Medical Centre, Owo, Nigeria. The objective to evaluate the rational pharmacotherapeutic approach to the management of the retroviral disease. Sixty two (62) antiretroviral drug-naive HIV/AIDS patients, which comprise of (19) 30.65% males with a mean age of 37.15±8.55 years and (43) 69.35% females with a mean age of 35.68±9.75 years case files are reviewed. The data used for this study was extracted from the clinical records of the Hospital. Sixty six percent of ...


Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali 2019 The University of Texas at Tyler

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva Handihaler, Advair Diskus, and Pulmicort Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available DPIs by means of ...


Osteoarthritis: Natural Supplements For Joint Health, Katherine Salay, Kimberly Gathers, Lindsey McClish, Lisa Vranekovic, Kristen Seaman, Ryan W. Naseman 2019 Ohio Northern University

Osteoarthritis: Natural Supplements For Joint Health, Katherine Salay, Kimberly Gathers, Lindsey Mcclish, Lisa Vranekovic, Kristen Seaman, Ryan W. Naseman

Pharmacy and Wellness Review

An estimated 46 million adults in the U.S. are affected by arthritis, with osteoarthritis (OA) being the most common. Due to the limited pharmacologic therapy available to treat this condition, many patients are turning to dietary supplements to relieve their symptoms. Some of the most popular supplements available for the treatment of OA are glucosamine, chrondroitin and methylsulfonylmethane (MSM), but many less studied products are also available. Due to limited evidence of efficacy, it is difficult to make a strong recommendation for any of these products; however, pharmacists must be able to educate the patients that choose to use ...


The Importance Of Early Diagnosis And Treatment Of Postpartum Depression, Sarah E. Drake, Alison L. Huet, Tana M. Peterman, Jamie L. Drees, Robert D. Raiff 2019 Ohio Northern University

The Importance Of Early Diagnosis And Treatment Of Postpartum Depression, Sarah E. Drake, Alison L. Huet, Tana M. Peterman, Jamie L. Drees, Robert D. Raiff

Pharmacy and Wellness Review

Postpartum depression (PPD) is a major depressive episode following childbirth that can have serious consequences affecting the family. Consequences range from marital problems and issues with child development to maternal suicide and infantcide. Depression in mothers can lead to cognitive and social impairment in the child as well as paternal postpartum depression in the father. Due to the severity of these problems, it is important to diagnose and treat mothers as soon as possible. There are several symptoms that are evident in mothers suffering from PPD that lead to diagnosis. Symptoms are similar to those of major depressive episodes, but ...


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