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An Update On Gestational Diabetes, Jamie L. Amero, Jennifer L. Bauer, Sarah M. Webb, Ryan A. Fischer, Lindsey A. Hallman, Sandra L. Hrometz 2019 Ohio Northern University

An Update On Gestational Diabetes, Jamie L. Amero, Jennifer L. Bauer, Sarah M. Webb, Ryan A. Fischer, Lindsey A. Hallman, Sandra L. Hrometz

Pharmacy and Wellness Review

Gestational diabetes is a concern for a large number of pregnant women due to the potential for long-term complications for both the mother and the fetus. With the increasing prevalence of obesity and diabetes in the general public, the number of pregnant women with undiagnosed type 2 diabetes mellitus has also increased. In order to adequately educate their patients, it is important for pharmacists to be aware of the general practices of treating gestational diabetes. This review will highlight recent updates to initial screening, the criteria for diagnosing gestational diabetes, and current management strategies.


Pediatric Poisoning: Overview, Treatment, And Prevention, Margaret Rowland, Taylor Gauthier, Kaitlin Sanders, Caitlin Swann, David Bright 2019 Ohio Northern University

Pediatric Poisoning: Overview, Treatment, And Prevention, Margaret Rowland, Taylor Gauthier, Kaitlin Sanders, Caitlin Swann, David Bright

Pharmacy and Wellness Review

Pediatric poisoning remains a common and preventable occurrence in the United States. Every year, prescription and over-the-counter medications account for a significant portion of documented poison exposures. Frequent causes of overdose in children include improper medication storage and caregiver or physician dosing error. As easily accessible medication experts, pharmacists have an opportunity to counsel patients in an effort to decrease these preventable poisoning cases. Because children frequently ingest products prescribed for adult use, pharmacist should relay safety considerations to all patients, regardless of age. This article provides a general review of toxicity concerns, discusses clinical implications of common medications resulting ...


Healthy People 2020: Identifying Roles For Pharmacists In Public Health, Ellen Hazelet, Aisha Oliver, Katherine Salay, Breanne Rizzo, Alison L. Huet, Natalie DiPietro 2019 Ohio Northern University

Healthy People 2020: Identifying Roles For Pharmacists In Public Health, Ellen Hazelet, Aisha Oliver, Katherine Salay, Breanne Rizzo, Alison L. Huet, Natalie Dipietro

Pharmacy and Wellness Review

Healthy People, sponsored by the United States Department of Health and Human Services, utilizes evidence-based medicine to create objectives addressing significant preventable health issues. The vision of Healthy People is to improve the quality and length of life free from preventable disease, disability, injury and death. Based on objectives outlined by Healthy People 2020 (HP 2020) pharmacists can play a role in public awareness, collaborate with other health care professionals and help achieve goals set forth by HP 2020. Based on the expertise and accessibility of the pharmacist, pharmacists can impact nine of the 13 new focus areas pf HP ...


Will New Mrsa Guidelines Make A Difference In Clinical Outcomes? A Comparison Of United States And United Kingdom Guidelines And Outcomes, Kelly Fargo, Erica Schoenberger, Kristen Thatcher, Lindsey Hallman, Andrew Roecker, Tarek Mahfouz 2019 Ohio Northern University

Will New Mrsa Guidelines Make A Difference In Clinical Outcomes? A Comparison Of United States And United Kingdom Guidelines And Outcomes, Kelly Fargo, Erica Schoenberger, Kristen Thatcher, Lindsey Hallman, Andrew Roecker, Tarek Mahfouz

Pharmacy and Wellness Review

As of February 2011, the Infectious Disease Society of America (IDSA) published the first guidelines assessing the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. S. aureus is present in the environment and is also located on the skin's surface. MRSA can cause a variety of clinical syndromes presenting with different symptoms that vary with the type and stage of the infection. MRSA is also classified into community-acquired MRSA (CA-MRSA) and hospital-acquired (HA-MRSA), both of which possess different treatment options and strategies. Due to the complex treatment of MRSA, as well the concern over the development of resistance, suggested treatment ...


Letter To The Editor, Olivia Hiddleson 2019 Ohio Northern University

Letter To The Editor, Olivia Hiddleson

Pharmacy and Wellness Review

No abstract provided.


Pharmacy Colleges: A Highly Controversial Test, Tana M. Peterman, Brieann Miller 2019 Ohio Northern University

Pharmacy Colleges: A Highly Controversial Test, Tana M. Peterman, Brieann Miller

Pharmacy and Wellness Review

As substance abuse continues to be problematic on college campuses across the United States, pharmacy colleges in particular are faced with the challenge of deterring drug abuse among their students. Many pharmacy schools are considering the adoption of student drug -screening policies in hopes of discouraging abuse, directing impaired students to treatment, and, ultimately, protecting the public. However, these policies are being met with apprehension in regards to added costs, Fourth Amendment rights violations, and privacy concerns. Drug-screening policies continue to be an issue of deliberation for pharmacy colleges, requiring much consideration and care.


The Importance Of Early Diagnosis And Treatment Of Postpartum Depression, Sarah E. Drake, Alison L. Huet, Tana M. Peterman, Jamie L. Drees, Robert D. Raiff 2019 Ohio Northern University

The Importance Of Early Diagnosis And Treatment Of Postpartum Depression, Sarah E. Drake, Alison L. Huet, Tana M. Peterman, Jamie L. Drees, Robert D. Raiff

Pharmacy and Wellness Review

Postpartum depression (PPD) is a major depressive episode following childbirth that can have serious consequences affecting the family. Consequences range from marital problems and issues with child development to maternal suicide and infantcide. Depression in mothers can lead to cognitive and social impairment in the child as well as paternal postpartum depression in the father. Due to the severity of these problems, it is important to diagnose and treat mothers as soon as possible. There are several symptoms that are evident in mothers suffering from PPD that lead to diagnosis. Symptoms are similar to those of major depressive episodes, but ...


A Novel Approach To Treating Alzheimer's Disease, Kristen Quertinmount, Breanne Rizzo, Caitlin Swann, Lindsey Coram, Mary Klein, Whitney N. Detillion 2019 Ohio Northern University

A Novel Approach To Treating Alzheimer's Disease, Kristen Quertinmount, Breanne Rizzo, Caitlin Swann, Lindsey Coram, Mary Klein, Whitney N. Detillion

Pharmacy and Wellness Review

No abstract provided.


Prescription Drug Abuse: The Pharmacist's Occupational Hazard, Brieann J. Miller, Cynthia C. Nguyen, Joshua P. Stevens, Nicholas J. Edmonds, Ryan W. Naseman, Michael M. Milks 2019 Ohio Northern University

Prescription Drug Abuse: The Pharmacist's Occupational Hazard, Brieann J. Miller, Cynthia C. Nguyen, Joshua P. Stevens, Nicholas J. Edmonds, Ryan W. Naseman, Michael M. Milks

Pharmacy and Wellness Review

Prescription drug abuse within the profession of pharmacy is a rising threat that must be addressed. While familiarity of drugs, work-related stress, family history and enabling may contribute to addiction disorders, chemical impairment by the pharmacist can posse serious risks to patient care. Help is available for the struggling pharmacist in the form of treatment facilities and support networks for recovery.


Use Of Gastric Bypass Surgery For The Treatment Of Type 2 Diabetes Mellitus, Kaitlin A. Sanders, Jenna L. Schaffner, Leslie M. Hart, Whitney N. Detillion, Anne Gentry 2019 Ohio Northern University

Use Of Gastric Bypass Surgery For The Treatment Of Type 2 Diabetes Mellitus, Kaitlin A. Sanders, Jenna L. Schaffner, Leslie M. Hart, Whitney N. Detillion, Anne Gentry

Pharmacy and Wellness Review

Over the past decade, the incidence of type 2 diabetes mellitus (T2DM) has increased significantly. Evidence has shown that a clear association exists between obesity and diabetes development. This association has inspired researchers to explore bariatric surgery as an option for diabetes management and possible disease reversal. Improvement of T2DM using Roux-En-Y gastric bypass (RYGB) is thought to result from from a combination of weight loss, decreased caloric intake, hormonal changes and rearrangement of the gastrointestinal anatomy. Positive outcomes resulting from the procedure include decreased mortality rates, normalization of HbA1c levels, decreased dependence on diabetic medications, and increased insulin sensitivity ...


An Update On Exenatide And Liraglutide For Type 2 Diabetes Mellitus, Sarah M. Webb, Lacey A. Shumate, Ashley M. Overy, Ashley E. Lehnert, Monica A. Weisenberger, David R. Bright, Whitney N. Detillion 2019 Ohio Northern University

An Update On Exenatide And Liraglutide For Type 2 Diabetes Mellitus, Sarah M. Webb, Lacey A. Shumate, Ashley M. Overy, Ashley E. Lehnert, Monica A. Weisenberger, David R. Bright, Whitney N. Detillion

Pharmacy and Wellness Review

No abstract provided.


A Review Of Rivaroxaban, An Oral Anticoagulant, Lindsey A. Hallman, Chad A. Rounds, Rebecca A. Carey, Nicole R. Hume, Ryan W. Naseman, Karen L. Kier 2019 Ohio Northern University

A Review Of Rivaroxaban, An Oral Anticoagulant, Lindsey A. Hallman, Chad A. Rounds, Rebecca A. Carey, Nicole R. Hume, Ryan W. Naseman, Karen L. Kier

Pharmacy and Wellness Review

No abstract provided.


A New Horizon: Emergency Department Pharmacy Practice, Amanda C. McDavid 2019 Ohio Northern University

A New Horizon: Emergency Department Pharmacy Practice, Amanda C. Mcdavid

Pharmacy and Wellness Review

No abstract provided.


The Role Of Using Formative Assessments In Problem-Based Learning: A Health Sciences Education Perspective, Kristi W. Kelley, Julaine M. Fowlin, Andrew A. Tawfik, Max C. Anderson 2019 Auburn University

The Role Of Using Formative Assessments In Problem-Based Learning: A Health Sciences Education Perspective, Kristi W. Kelley, Julaine M. Fowlin, Andrew A. Tawfik, Max C. Anderson

Interdisciplinary Journal of Problem-Based Learning

Practitioners in the field of pharmacy are often confronted with ill-structured problems. Specifically, pharmacists are tasked with making patient-specific recommendations that are both safe and effective, which requires combining knowledge from the biomedical, behavioral, and pharmaceutical sciences. Given the dynamic nature of pharmacy as a profession, the field has begun to explore learning strategies that go beyond mere content coverage to strategies that better support higher-order learning outcomes. One of these approaches is problem-based learning (PBL). While studies have focused on how to support PBL to improve learning outcomes, the role of assessment is often overlooked. Further exploration is thus ...


Edb-Fn Targeted Peptide–Drug Conjugates For Use Against Prostate Cancer, Shang Eun Park, Kiumars Shamloo, Timothy A. Kristedja, Shaban Darwish, Marco Bisoffi, Keykavous Parang, Rakesh Tiwari 2019 Chapman University

Edb-Fn Targeted Peptide–Drug Conjugates For Use Against Prostate Cancer, Shang Eun Park, Kiumars Shamloo, Timothy A. Kristedja, Shaban Darwish, Marco Bisoffi, Keykavous Parang, Rakesh Tiwari

Pharmacy Faculty Articles and Research

Prostate cancer (PCa) is the most common malignancy in men and is the leading cause of cancer-related male mortality. A disulfide cyclic peptide ligand [CTVRTSADC] 1 has been previously found to target extra domain B of fibronectin (EDB-FN) in the extracellular matrix that can dierentiate aggressive PCa from benign prostatic hyperplasia. We synthesized and optimized the stability of ligand 1 by amide cyclization to obtain [KTVRTSADE] 8 using Fmoc/tBu solid-phase chemistry. Optimized targeting ligand 8 was found to be stable in phosphate buered saline (PBS, pH 6.5, 7.0, and 7.5) and under redox conditions, with a ...


Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex, Tyler D. Dexter, Daniel Palmer, Amy C. Reichelt, Anita Taksokhan, Lisa M. Saksida, Tim J. Bussey 2019 Western University

Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex, Tyler D. Dexter, Daniel Palmer, Amy C. Reichelt, Anita Taksokhan, Lisa M. Saksida, Tim J. Bussey

Western Research Forum

Attention is the cognitive processing that facilitates the ability to target and attend to relevant environmental stimuli, while filtering out irrelevant or distracting stimuli. Control over selective attention is theorized to be dependent on organized neural communication that stems from the medial prefrontal cortex (mPFC). To evaluate selective and sustained attention, mice were trained on the novel touchscreen rodent continuous performance task (rCPT), a task designed to emulate the human CPT. In the rodent version, images are continuously presented on a touchscreen, where mice have been trained to selectively respond to one image type while suppressing responses to all others ...


Molecular Recognition Of M1-Linked Ubiquitin Chains By Native And Phosphorylated Uban Domains, Lina Herhaus, Henry van den Bedem, Sean Teng, Innokentiy Maslennikov, Soichi Wakatsuki, Ivan Dikic, Simin Rahighi 2019 Goethe University

Molecular Recognition Of M1-Linked Ubiquitin Chains By Native And Phosphorylated Uban Domains, Lina Herhaus, Henry Van Den Bedem, Sean Teng, Innokentiy Maslennikov, Soichi Wakatsuki, Ivan Dikic, Simin Rahighi

Pharmacy Faculty Articles and Research

Although the Ub-binding domain in ABIN proteins and NEMO (UBAN) is highly conserved, UBAN-containing proteins exhibit different Ub-binding properties, resulting in their diverse biological roles. Post-translational modifications further control UBAN domain specificity for poly-Ub chains. However, precisely, how the UBAN domain structurally confers such functional diversity remains poorly understood. Here we report crystal structures of ABIN-1 alone and in complex with one or two M1-linked di-Ub chains. ABIN-1 UBAN forms a homo-dimer that provides two symmetrical Ub-binding sites on either side of the coiled-coil structure. Moreover, crystal structures of ABIN1 UBAN in complex with di-Ub chains reveal a concentration-dependency of ...


Effect Of Crohn’S Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine, Brian D. Chapron 2019 Kansas City Children's Mercy

Effect Of Crohn’S Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine, Brian D. Chapron

Research Days

No abstract provided.


Characterization Of The Relative Contribution Of Cyp2d6 And Cyp3a4 To The Metabolism Of Pimozide, Brian D. Chapron 2019 Kansas City Children's Mercy

Characterization Of The Relative Contribution Of Cyp2d6 And Cyp3a4 To The Metabolism Of Pimozide, Brian D. Chapron

Research Days

No abstract provided.


Improving Physician Office Quality Measures By Evaluating Statin Prescribing In Type 2 Diabetic Patients, Choniece Phillips, Kathleen Dawson, Lindsay Roberts, Jamie McConaha, Megan Bookser 2019 Duquesne University

Improving Physician Office Quality Measures By Evaluating Statin Prescribing In Type 2 Diabetic Patients, Choniece Phillips, Kathleen Dawson, Lindsay Roberts, Jamie Mcconaha, Megan Bookser

Undergraduate Research and Scholarship Symposium

Abstract

Objective

The focus of this study was to evaluate the impact of pharmacist’ intervention on quality metrics focusing on patients with a diagnosis of diabetes mellitus type II (T2DM) not currently prescribed statin therapy.

Methods

This retrospective cohort investigational study was conducted in four lowest performing office locations of a nineteen regional primary care physician group practice. Inclusion criteria were diagnosis of T2DM without active statin therapy. Data was excluded from analysis for patients younger than age 40 or older than age 75, or if the most recent LDL documented was less than 70 mg/dL. Recommendations for initiation ...


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