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Progress In Controlling Healthcare Associated Infections: A Historical Perspective, Richard Wenzel, MD 2011 Former President, International Society for Infectious Diseases

Progress In Controlling Healthcare Associated Infections: A Historical Perspective, Richard Wenzel, Md

Building the Chain of Safety: Stakeholders Summit

Richard P. Wenzel, MD, MSc, is professor and former chairman of the Department of Internal Medicine at the Medical College of Virginia, Virginia Commonwealth University, in Richmond, Virginia (1995-2009). From 2003-2008, he was President of MCV Physicians, the clinical practice plan for over 600 physicians, and Senior Associate Dean for Clinical Affairs.

For eight years (1992 to 2000), he was a member of the editorial board of The New England Journal of Medicine, and, in September 2001, became the journal’s first Editor-at-Large, a position he still holds. He is the prolific author of over 500 publications, the editor of ...


The State Of Safety, John Combes, MD 2011 Senior Vice President, American Hospital Association

The State Of Safety, John Combes, Md

Building the Chain of Safety: Stakeholders Summit

John Combes, MD, is a Senior Vice President at the American Hospital Association (AHA) and the President of the Center for Healthcare Governance (CHG), an AHA affiliate organization. CHG is a dynamic community of board members, executives and thought leaders dedicated to advancing excellence, innovation and accountability in healthcare governance through education, tool development and research. Dr. Combes also serves as Senior Fellow at the Hospital Research and Education Trust (HRET), and in that role focuses on quality and leadership issues in Patient Safety, End of Life Care and Clinical Performance Improvement.

Dr. Combes received his medical degree from Cornell ...


The Effect Of Mannose-6-Phosphate On Recovery After Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson 2011 Univ. Malaya

The Effect Of Mannose-6-Phosphate On Recovery After Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson

Wei Cheong Ngeow

We have determined the effect of applying Mannose-6-Phosphate (M6P), a scar reducing agent, to a site of sciatic nerve repair. In anaesthetised C57-Black-6 mice, the left sciatic nerve was sectioned and repaired using 4 epineurial sutures. Either 100 mu l of 600 mM Mannose-6-Phosphate (29 animals), or 100 mu l of phosphate buffered saline as a placebo control (29 animals), was injected into and around the nerve repair site. A further group acted as sham-operated controls. After 6 or 12 weeks of recovery the extent of regeneration was assessed electrophysiologically and the percentage area of collagen staining at the repair ...


Design And Methods For A Randomized Clinical Trial Comparing Three Outreach Efforts To Improve Screening Mammography Adherence, Mary E. Costanza, Roger S. Luckmann, Mary Jo White, Milagros C. Rosal, Caroline Cranos, George W. Reed, Robin E. Clark, Susan Sama, Robert A. Yood 2011 University of Massachusetts Medical School

Design And Methods For A Randomized Clinical Trial Comparing Three Outreach Efforts To Improve Screening Mammography Adherence, Mary E. Costanza, Roger S. Luckmann, Mary Jo White, Milagros C. Rosal, Caroline Cranos, George W. Reed, Robin E. Clark, Susan Sama, Robert A. Yood

Center for Health Policy and Research (CHPR) Publications

BACKGROUND: Despite the demonstrated need to increase screening mammography utilization and strong evidence that mail and telephone outreach to women can increase screening, most managed care organizations have not adopted comprehensive outreach programs. The uncertainty about optimum strategies and cost effectiveness have retarded widespread acceptance. While 70% of women report getting a mammogram within the prior 2 years, repeat mammography rates are less than 50%. This 5-year study is conducted though a Central Massachusetts healthcare plan and affiliated clinic. All women have adequate health insurance to cover the test.

METHODS/DESIGN: This randomized study compares 3 arms: reminder letter alone ...


Patterns And Mechanisms Of Ancestral Histone Protein Inheritance In Budding Yeast, Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J. Rando, Fred van Leeuwen 2011 University of Massachusetts Medical School

Patterns And Mechanisms Of Ancestral Histone Protein Inheritance In Budding Yeast, Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor Van Welsem, Nir Friedman, Oliver J. Rando, Fred Van Leeuwen

Open Access Articles

Replicating chromatin involves disruption of histone-DNA contacts and subsequent reassembly of maternal histones on the new daughter genomes. In bulk, maternal histones are randomly segregated to the two daughters, but little is known about the fine details of this process: do maternal histones re-assemble at preferred locations or close to their original loci? Here, we use a recently developed method for swapping epitope tags to measure the disposition of ancestral histone H3 across the yeast genome over six generations. We find that ancestral H3 is preferentially retained at the 5' ends of most genes, with strongest retention at long, poorly ...


A 5'-Uridine Amplifies Mirna/Mirna* Asymmetry In Drosophila By Promoting Rna-Induced Silencing Complex Formation, Herve Seitz, Jogender S. Tushir, Phillip D. Zamore 2011 University of Massachusetts Medical School

A 5'-Uridine Amplifies Mirna/Mirna* Asymmetry In Drosophila By Promoting Rna-Induced Silencing Complex Formation, Herve Seitz, Jogender S. Tushir, Phillip D. Zamore

Open Access Articles

BACKGROUND: MicroRNA (miRNA) are diverse in sequence and have a single known sequence bias: they tend to start with uridine (U).

RESULTS: Our analyses of fly, worm and mouse miRNA sequence data reveal that the 5'-U is recognized after miRNA production. Only one of the two strands can be assembled into Argonaute protein from a single miRNA/miRNA* molecule: in fly embryo lysate, a 5'-U promotes miRNA loading while decreasing the loading of the miRNA*.

CONCLUSION: We suggest that recognition of the 5'-U enhances Argonaute loading by a mechanism distinct from its contribution to weakening base pairing ...


Community-Based Knowledge Translation: Unexplored Opportunities, Anita Kothari, Rebecca Armstrong 2011 The University of Western Ontario

Community-Based Knowledge Translation: Unexplored Opportunities, Anita Kothari, Rebecca Armstrong

Anita Kothari

BACKGROUND: Knowledge translation is an interactive process of knowledge exchange between health researchers and knowledge users. Given that the health system is broad in scope, it is important to reflect on how definitions and applications of knowledge translation might differ by setting and focus. Community-based organizations and their practitioners share common characteristics related to their setting, the evidence used in this setting, and anticipated outcomes that are not, in our experience, satisfactorily reflected in current knowledge translation approaches, frameworks, or tools.

DISCUSSION: Community-based organizations face a distinctive set of challenges and concerns related to engaging in the knowledge translation process ...


Gynaecomastia; Management With Liposuction And Glandular Excision, Stanley Ominde Khainga, Ronald Wasike, P. K. Biribwa 2011 University of Nairobi

Gynaecomastia; Management With Liposuction And Glandular Excision, Stanley Ominde Khainga, Ronald Wasike, P. K. Biribwa

General Surgery, East Africa

Gynaecomastia is caused by an increase in ductal tissue, stroma and fat in the male breast. Frequently it occurs at the time of hormonal changes during infancy, adolescence and old age. Galen, introduced the term gynaecomastia in the second century AD and surgical excision was first described by Pauli of Aegina in the seventh AD (1,2). Ultrasound assisted liposuction and surgical excision of glandular tissue through an inferior circumareolar incision is currently the best mode of treatment. In this study seven patients varying from the ages 17-45 years were operated on using this technique at the Aga Khan University ...


International Evidence On Medical Spending., Robert D. Lieberthal, PhD 2011 School of Population Health, Thomas Jefferson University

International Evidence On Medical Spending., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the Casualty Actuarial Society 2011 Seminar on Reinsurance, Philadelphia, PA.

Handouts are also available at: http://www.casact.org/education/reinsure/2011/handouts/C17-Lieberthal.pdf

the audio is available at: http://www.casact.org/education/reinsure/2011/audio/C17.mp3

and it is associated with the paper: http://jdc.jefferson.edu/healthpolicyfaculty/45/

23 PowerPoint slides.


Prevalence Of Physical Inactivity And Barriers To Physical Activity Among Obese Attendants At A Community Health-Care Center In Karachi, Pakistan., Nafisa Samir, Sadia Mahmud, Ali Khan Khuwaja 2011 Aga Khan University

Prevalence Of Physical Inactivity And Barriers To Physical Activity Among Obese Attendants At A Community Health-Care Center In Karachi, Pakistan., Nafisa Samir, Sadia Mahmud, Ali Khan Khuwaja

Department of Family Medicine

Background: Overweight and obesity are significant public health problems worldwide with serious health consequences. With increasing urbanization and modernization there has been an increase in prevalence of obesity that is attributed to reduced levels of physical activity (PA). However, little is known about the prevalence of physical inactivity and factors that prohibit physical activity among Pakistani population. This cross-sectional study is aimed at estimating the prevalence of physical inactivity, and determining associated barriers in obese attendants accompanying Patients coming to a Community Health Center in Karachi, Pakistan.
Findings: PA was assessed by using international physical activity questionnaire (IPAQ). Barriers to ...


Three-Dimensional Photographic Evaluation Of Immediate Soft Tissue Changes Following Rapid Maxillary Expansion, Nathan Granillo 2011 Virginia Commonwealth University

Three-Dimensional Photographic Evaluation Of Immediate Soft Tissue Changes Following Rapid Maxillary Expansion, Nathan Granillo

Theses and Dissertations

The skeletal and dental changes associated with rapid maxillary expansion (RME) are well documented. Effects on the soft tissues and the potential impact on facial esthetics have not been well researched. The purpose of this study was to evaluate immediate changes in facial soft tissues as a result of RME by comparing threedimensional digital photogrammetric images before and after RME treatment. The 3dMDface System was used to obtain photographic images of 21 patients (mean age = 11.8 years) before and after RME treatment for transverse maxillary deficiency. A control group of 13 patients (mean age = 12.7 years) also had ...


The Effects Of Low Protein During Gestation On Mouse Pancreas Development And Beta Cell Regeneration, Aaron R. Cox 2011 The University of Western Ontario

The Effects Of Low Protein During Gestation On Mouse Pancreas Development And Beta Cell Regeneration, Aaron R. Cox

Electronic Thesis and Dissertation Repository

Effects of a low protein (LP) diet during gestation on the metabolism of rat offspring have been well characterized and leads to glucose intolerance in adulthood. It is unknown how LP impacts endocrine pancreas development in the mouse, or whether this affects future β-cell plasticity. Streptozotocin (STZ) – induced β-cell injury has been demonstrated to be followed by β-cell regeneration in young animals, but the mechanism(s) of regeneration are not clear. Our objective was to characterize a mouse model of maternal LP, in addition to identifying factors that contribute to the long term development of glucose intolerance and the mechanism ...


Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman 2011 The University of Western Ontario

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Robarts Imaging Publications

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate ...


Spearheading Health Information Literacy In The Community: Librarians As Leaders, Irena Bond, Carolyn Friel, Monina Lahoz 2011 Massachusetts College of Pharmacy and Health Sciences

Spearheading Health Information Literacy In The Community: Librarians As Leaders, Irena Bond, Carolyn Friel, Monina Lahoz

National Network of Libraries of Medicine New England Region (NNLM NER) Repository

This paper describes a multi-institutional educational program that brings community organizations and libraries together with the goal of developing health information literacy skills in elementary school children aged 11 to 12 years. The primary goal of the program was to improve the ability of elementary school students to find, use, and apply quality health information from specific resource within the National Library of Medicine website. Five institutions in Worcester, Massachusetts, namely the Massachusetts College of Pharmacy and Health Sciences, the Worcester Art Museum, the Worcester Public Library, the Worcester Department of Public Health, and a Worcester inner city elementary school ...


A Traditional Chinese Medicine Versus Western Combination Therapy In The Treatment Of Rheumatoid Arthritis: Two-Stage Study Protocol For A Randomized Controlled Trial, C Zhang, M Jiang, Aiping Lu 2011 Hong Kong Baptist University

A Traditional Chinese Medicine Versus Western Combination Therapy In The Treatment Of Rheumatoid Arthritis: Two-Stage Study Protocol For A Randomized Controlled Trial, C Zhang, M Jiang, Aiping Lu

Professor LU, Aiping

No abstract provided.


Trial Of The University Assistance Program For Alcohol Use Among Mandated Students, Hortensia Amaro (1950-), Marilyn Ahl, Atsushi Matsumoto, Guillermo Prado, Christina Mulé, Amaura Kemmerer, Mary E. Larimer, Dale A. Masi, Philomena Mantella 2011 Northeastern University

Trial Of The University Assistance Program For Alcohol Use Among Mandated Students, Hortensia Amaro (1950-), Marilyn Ahl, Atsushi Matsumoto, Guillermo Prado, Christina Mulé, Amaura Kemmerer, Mary E. Larimer, Dale A. Masi, Philomena Mantella

Hortensia Amaro

Objective:The aim of this study was to investigate the effectiveness of a brief intervention for mandated students in the context of the University Assistance Program, a Student Assistance Program developed and modeled after workplace Employee Assistance Programs. Method:Participants were 265 (196 males and 69 females) judicially mandated college students enrolled in a large, urban university in the northeast United States. All participants were sanctioned by the university's judicial office for an alcohol- or drug-related violation. Participants were randomized to one of two intervention conditions (the University Assistance Program or services as usual) and were assessed at baseline ...


Brief Screening For Co-Occurring Disorders Among Women Entering Substance Abuse Treatment, Alisa K. Lincoln, Jane M. Liebschutz, Miriam Chernoff, Dana Nguyen, Hortensia Amaro (1950-) 2011 Boston University

Brief Screening For Co-Occurring Disorders Among Women Entering Substance Abuse Treatment, Alisa K. Lincoln, Jane M. Liebschutz, Miriam Chernoff, Dana Nguyen, Hortensia Amaro (1950-)

Hortensia Amaro

BackgroundDespite the importance of identifying co-occurring psychiatric disorders in substance abuse treatment programs, there are few appropriate and validated instruments available to substance abuse treatment staff to conduct brief screen for these conditions. This paper describes the development, implementation and validation of a brief screening instrument for mental health diagnoses and trauma among a diverse sample of Black, Hispanic and White women in substance abuse treatment. With input from clinicians and consumers, we adapted longer existing validated instruments into a 14 question screen covering demographics, mental health symptoms and physical and sexual violence exposure. All women entering treatment (methadone, residential ...


The Nida Brain Disease Paradigm: History, Resistance And Spinoffs, David T. Courtwright 2011 University of North Florida

The Nida Brain Disease Paradigm: History, Resistance And Spinoffs, David T. Courtwright

David T. Courtwright

This article examines ‘the NIDA paradigm’, the theory that addiction is a chronic, relapsing brain disease characterized by loss of control over drug taking. I critically review the official history of the National Institute on Drug Abuse (NIDA) paradigm and analyze the sources of resistance to it. I argue that, even though the theory remains contested, it has yielded important insights in other fields, including my own discipline of history.


Mr. Atod’S Wild Ride: What Do Alcohol, Tobacco, And Other Drugs Have In Common?, David T. Courtwright 2011 University of North Florida

Mr. Atod’S Wild Ride: What Do Alcohol, Tobacco, And Other Drugs Have In Common?, David T. Courtwright

David T. Courtwright

All researchers agree that individuals can become intoxicated by and dependent on alcohol, tobacco, and other psychoactive drugs. But they have disagreed over whether, and to what extent, drug pathologies comprise a unitary medical problem. Most critically, does addiction have a biological common denominator? Consensus on this question has shifted back and forth. In the late nineteenth and early twentieth centuries, physicians often studied and treated various drug addictions together, working under the “inebriety” paradigm. By the mid-twentieth century the inebriety paradigm had collapsed. Tobacco and alcohol had split off, both in the medical research community and in western popular ...


U.S. Cultural Involvement And Its Association With Co-Occurring Substance Abuse And Sexual Risk Behaviors Among Youth In The Dominican Republic, Elián P. Cabrera-Nguyen, Juan B. Peña 2011 Washington University in St. Louis

U.S. Cultural Involvement And Its Association With Co-Occurring Substance Abuse And Sexual Risk Behaviors Among Youth In The Dominican Republic, Elián P. Cabrera-Nguyen, Juan B. Peña

Elián P. Cabrera-Nguyen

We examined the relationship of US cultural involvement with substance abuse and sexual risk behavior profiles from our nationally representative sample of public high school students in the Dominican Republic. Using a novel methodological approach to control for selection bias, we examined explanations for the so-called Latino or Hispanic immigrant paradox. A latent class regression analysis with manifest and latent covariates found that US cultural involvement indicators were independent and robust predictors of increased risk of co-ocurring substance abuse and sexual risk behaviors. Implications for prevention efforts targeting risk behaviors among Latino/a adolescents in the US and abroad are ...


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