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Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara 2019 Southern Methodist University

Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara

Biological Sciences Theses and Dissertations

Multidrug resistance (MDR) is a major cause of chemotherapy failure. Overexpression of ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two well-studied drug transporters which are associated with MDR. These two transporters also act as a major functional unit of the blood brain barrier to protect the brain from xenobiotics and toxins. Lack of clinically approved P-gp and BCRP inhibitors renders chemotherapy treatments of many MDR cancers ineffective and obstructs drug uptake into the brain.

Using computational methods, we have identified new compounds that inhibit P-gp (Brewer et al., Mol. Pharmacol. 2014). Several of these ...


Exploring The Usage Of Found Objects In Art Therapy For Bereavement: A Literature Review, Bridget Bogan 2019 Lesley University

Exploring The Usage Of Found Objects In Art Therapy For Bereavement: A Literature Review, Bridget Bogan

Expressive Therapies Capstone Theses

Bereavement is a multifaceted, evolving, and intensely individual experience. Moving away from a linear theoretical framework towards a constructivist theoretical model promotes the healing properties of self-narrative while incorporating the story of the loss of a loved one. Most important to bereaved individuals, as indicated by current research on the topics of death, grief, and bereavement are memory keeping, meaning making, and continued bonds with the deceased. These common themes have remained consistent since the Victorian age.

Traditional mourning jewelry represents a form of memorialization and continued bonds with the dead. Alternative forms of art using found objects belonging to ...


A Literature Review On Substance Related Grief And Expressive Art Therapy Support Groups, Holly N. St. Cyr 2019 Lesley University

A Literature Review On Substance Related Grief And Expressive Art Therapy Support Groups, Holly N. St. Cyr

Expressive Therapies Capstone Theses

In the year of 2017, 18.7 million Americans aged 18 years or older were reported to have a substance use disorder and the pervasiveness of substance related deaths escalated (McCance- Katz, 2017). Researchers have examined how grief experienced by substance users and their loved ones is often disenfranchised by social stigmatization, loss of support, and feelings of regret, blame, humiliation, and shame. According to Valentine, Bauld, and Walter, (2016) “bereavement following a drug or alcohol related death has been largely neglected in research and service provision, despite its global prevalence and potentially devastating consequences for those concerned,” (p. 283 ...


The Study Of Neurological Response In Art Therapy And Trauma: A Literature Review, Kristin Weber 2019 Lesley University

The Study Of Neurological Response In Art Therapy And Trauma: A Literature Review, Kristin Weber

Expressive Therapies Capstone Theses

This review will focus on neurological research and art therapy practice to consider benefits of the integration of science and the creative therapies. These topics will be addressed through a trauma informed theoretical lens, focusing on Post-Traumatic Stress Disorder and Traumatic Brain Injury diagnoses in the US military veteran population. Arts-based, qualitative, and quantitative research were correlated within this review to discover links between neurology and art therapy’s unique impact on trauma, and the outcome of combining these practices. The conclusions found that, with limited research connecting these two fields, there is a possibility for enhanced trauma treatment through ...


A Literature Review Of Nature-Based Expressive Arts Therapy For Bereaved Children, Wendy Dalton 2019 Lesley University

A Literature Review Of Nature-Based Expressive Arts Therapy For Bereaved Children, Wendy Dalton

Expressive Therapies Capstone Theses

There is a need for increased visibility of child bereavement to expand research in and accessibility of developmentally appropriate supports, which views the child holistically and within their biopsychosocial context. Worden’s (1996) formative work with child bereavement resulting in the "tasks" of child bereavement was the first and most recent study of its scale and kind. This marked an affirming of grief as normative response to death and occurring throughout the developmental lifespan. This work also highlights the need for additional inquiry to expand and deepen understanding of child bereavement. A growing body of research suggests that ecotherapy and ...


Breathing Life Into Life: A Literature Review Supporting Body-Based Interventions In The Treatment Of Trauma, Andrea Werbalowksy 2019 Lesley University

Breathing Life Into Life: A Literature Review Supporting Body-Based Interventions In The Treatment Of Trauma, Andrea Werbalowksy

Expressive Therapies Capstone Theses

In the recent turn toward a more trauma-informed practice of mental health counseling, a glaring gap remains between the research validating that trauma is a somatic experience and the continued privileging of cognitive and behaviorist interventions commonly used to treat trauma. In an effort to explore this gap, this paper presents a literature review inquiry into the neurophysiological and overall life effects trauma can have on the people who experience it. The review further explores how Stephen Porges’s Polyvagal Theory elucidates the benefits of using body-based therapeutic interventions in the treatment of trauma. The inquiry investigates the wide gap ...


A Laughing Matter: Transforming Trauma Through Therapeutic Humor And Expressive Arts Therapy, Alison M. Landoni 2019 Lesley University

A Laughing Matter: Transforming Trauma Through Therapeutic Humor And Expressive Arts Therapy, Alison M. Landoni

Expressive Therapies Capstone Theses

Humor and trauma share two characteristics: they are both perspectival in nature and hold incongruity at their core, however, their impacts are profoundly different for the perceiver. As humor and laughter open one’s psyche and invite positive social exchanges, trauma produces more dissociative, dysregulated and dysfunctional interactions. While fundamental to interpersonal experiences, there has been limited research about the use of humor and laughter as essential tools within the mental health therapeutic alliance. Neurological research and case studies have shown that humor and laughter can have hormonal, physiological and psychological benefits. Due to the perspectival nature of humor and ...


Integrating Digital App Technologies Within Traditional Expressive Arts Therapy For Children And Adolescents, Sarah Storjohann 2019 Lesley University

Integrating Digital App Technologies Within Traditional Expressive Arts Therapy For Children And Adolescents, Sarah Storjohann

Expressive Therapies Capstone Theses

In recent years, technology in the form of digital applications (apps) has emerged as a fundamental aspect of everyday life as well as a practical, convenient, and inexpensive tool for artistic self-expression, most notably amongst children and adolescents. Ninety-eight percent of U.S. households currently possess some form of mobile device (Rideout, 2017), with an estimated 95% of U.S. teenagers ages 13 to 17 owning a Smartphone (Anderson & Jiang, 2018). As digital natives, children and adolescents are more likely to identify with and connect to these arts-based methods. Clinician perspective concerning digital integration varies across a wide spectrum. Through a critical review of the existing literature, this research investigated the current state of digital app technology within the field of Expressive Arts Therapies, as well as potential benefits and drawbacks to the integration of this artistic media. Expressive Arts Therapy is predicated on the multimodal nature of artistic forms. Modality-specific apps within art, music, and dance therapy disciplines have garnered encouraging findings; however, no authentic multimodal digital app currently exists. This research explored the intermodal possibilities of both singular modality apps as well as those quantitatively examined in other mental-health related fields. Additionally ...


“There Was Something Magical About This Group”: Building Cohesion In A Psychiatric Hospital, Mariah L. Logan 2019 Lesley University

“There Was Something Magical About This Group”: Building Cohesion In A Psychiatric Hospital, Mariah L. Logan

Expressive Therapies Capstone Theses

This capstone details the development and implementation of Hope Notes, an expressive arts therapy intervention used in a private psychiatric hospital setting. Hope Notes was carried out in the group setting with adolescent and adult clients in a partial-hospitalization or inpatient hospitalization with a range of diagnoses and symptoms including, but not limited to, depression, anxiety, bipolar disorder, schizophrenia, trauma disorders including post-traumatic stress, and obsessive-compulsive disorder with symptoms of delusions, hallucinations, suicidality and homicidally. Using expressive arts therapy the clients worked together to collaboratively discuss, create, design, and build an art piece intended to increase group cohesion and connection ...


Beyond Regression: An Investigation Of Art Material Choice For Children With Trauma, Natalie Lane 2019 Lesley University

Beyond Regression: An Investigation Of Art Material Choice For Children With Trauma, Natalie Lane

Expressive Therapies Capstone Theses

Choice in art materials and the artistic process are arguably two of the primary facets of how art making can be therapeutic. The purpose of the present inquiry was to investigate the impacts of art material choice in children who have experienced trauma. Using the expressive therapies continuum (ETC) as a foundation for choosing art materials in a therapeutic context, this inquiry sought to introduce art materials in the kinesthetic/sensory component of the ETC (e.g., clay, paint, large paint brushes, etc.). As a mediating consideration, this inquiry articulated the responsibilities and obligations that the art therapist possesses in ...


Promoting Resilience In Economically Disadvantaged Adolescents Through School-Based Expressive Arts Groups, Bailey Knox 2019 Lesley University

Promoting Resilience In Economically Disadvantaged Adolescents Through School-Based Expressive Arts Groups, Bailey Knox

Expressive Therapies Capstone Theses

Since 2013, the majority of students served by the public school system in the United States have been considered “low-income” by the federal government. The stressors associated with low socioeconomic status significantly increase risk for social, emotional and behavioral challenges at all age levels, but can be particularly damaging to adolescents coping with heightened stress levels related to the intense multi-dimensional changes that define this developmental period. As the correlation between economic disadvantage and negative socio-emotional and academic outcomes is increasingly evidenced, schools have begun to recognize their responsibility for providing preventative mental health care to high-risk students. Over the ...


Moving Blind Spots: Cultural Bias In The Movement Repertoire Of Dance/Movement Therapists, Ebony Nichols 2019 Lesley University

Moving Blind Spots: Cultural Bias In The Movement Repertoire Of Dance/Movement Therapists, Ebony Nichols

Expressive Therapies Capstone Theses

This thesis explores the need for cultural diversity in the field of dance/movement therapy and the impact of unconscious bias as it relates to cultural rhythmic patterns, movement styles, and music choices in therapeutic practice. This literature review examines the historical context that has contributed to the field of dance/movement therapy while outlining cultural competency and ethical considerations in practice as it relates to cultural and/or race identity. Common themes are summarized notating the effects of oppression, bias, and trauma on populations of statistically marginalized communities with specific emphases on African American cultural identity. With consideration toward ...


Dance/Movement Therapy As A Tool To Improve Social Skills In Children And Adolescents With Autism Spectrum Disorder: A Literature Review, Holly Berlandy 2019 Lesley University

Dance/Movement Therapy As A Tool To Improve Social Skills In Children And Adolescents With Autism Spectrum Disorder: A Literature Review, Holly Berlandy

Expressive Therapies Capstone Theses

Abstract

Autism spectrum disorder is a neurodevelopmental disorder diagnosed by the presence of social communication and interaction deficits present in their day to day. The deficits present in this disorder appear within the first three years of life and lead to problems with connecting and interacting with other individuals including their own family members. As a result, children and adolescents with Autism spectrum disorder often experience negative self-image and lack the proper skills to interact with others. Autism spectrum disorder is becoming more commonly diagnosed and yet there remains a gap in interventions and treatment due to the individualized appearance ...


Music Therapy Assisted Childbirth In The United States: A Critical Literature Review, Sydney Mohr 2019 Lesley University

Music Therapy Assisted Childbirth In The United States: A Critical Literature Review, Sydney Mohr

Expressive Therapies Capstone Theses

Music therapy assisted childbirth is an approach of music therapy in which a licensed and credentialed professional utilizes music therapy interventions to address a variety of goals during childbirth. There is a lack of literature and missing knowledge on the topic, associated with an increased rate in traumatic birth cases, mothers with post-traumatic stress disorder, and postpartum anxiety and depression. The literature review provides a summary of the historical context of feminist theory and feminism, as well as brief descriptions of music therapy, guided imagery and music, and familiar music interventions. One of the primary goals of this type of ...


Expressive Mindfulness: A Trauma-Sensitive Expressive Arts Therapy Group Method, Meghan Daly 2019 Lesley University

Expressive Mindfulness: A Trauma-Sensitive Expressive Arts Therapy Group Method, Meghan Daly

Expressive Therapies Capstone Theses

Mindfulness and expressive arts therapy are both supportive of directing attention in a manner that promotes integration and function of a person. In this paper, a trauma-sensitive method was created for use in a day treatment setting for adults with severe and persistent mental illness (SPMI). This method utilized expressive movement, visual art making with three different materials, and creative writing to encourage mindful, non-judgmental acceptance of the present moment; a sense of relaxation; and an overall increase in quality of life. During development of the method arts-based research informed the choice of materials, music, and structure of the group ...


Considering Art Therapy For Adults With Fear Of Cancer Recurrence (Fcr): A Literature Review, Max Roberts 2019 Lesley University

Considering Art Therapy For Adults With Fear Of Cancer Recurrence (Fcr): A Literature Review, Max Roberts

Expressive Therapies Capstone Theses

Fear of cancer recurrence (FCR) is a major problem for many cancer survivors. As cancer treatments improve and more people are surviving cancer, FCR will likely become a larger problem in general for the healthcare system. Art therapists working with cancer survivors need to be prepared for addressing FCR as they are likely to encounter this clinical issue. A literature search was conducted and no research investigating art therapy specifically for FCR was found, indicating there is currently no empirically supported approach to art therapy for FCR. Mindfulness and acceptance-based therapies appear to be efficacious for reducing effects of FCR ...


Patterned Sensory Enhancement-Based Interventions In An Acute Rehabilitation Setting: Development Of A Method, Lionel Cheong 2019 Lesley University

Patterned Sensory Enhancement-Based Interventions In An Acute Rehabilitation Setting: Development Of A Method, Lionel Cheong

Expressive Therapies Capstone Theses

Constraint-induced therapy (CIT) or Constraint-induced movement therapy (CIMT) is used in rehabilitation to improve upper extremity function in patients who suffer from brain injuries, such as stroke or cerebral palsy. By engaging in repetitive exercises and increasing the use of the affect area of the upper extremity, the brain develops a change in neural pathways that helps recover the use of limbs by these patients. Unfortunately, one of the main limitations of CIT is the low compliance with patients involved in CIT, due to the stopping of use of compensation strategies, and the intensity and duration of the treatment, especially ...


“Do I Need Exercise?” A Qualitative Study On Factors Affecting Leisure-Time Physical Activity In India, Shalini Garg, V Raman Kutty 2019 SCTIMST

“Do I Need Exercise?” A Qualitative Study On Factors Affecting Leisure-Time Physical Activity In India, Shalini Garg, V Raman Kutty

The Qualitative Report

Physical activity can reduce the risk of premature mortality from various chronic diseases. Previous research in Kerala, India indicates several barriers which can impact physical activity levels. Perceptions about the importance of health-promoting physical activity were examined among adults in Kerala and various facilitators, motivators and barriers to physical activity were identified using focus group discussions and interviews with key informants. At present, the attitude of people and health professionals is that physical activity has to be taken up when diagnosed with a disease (obesity, diabetes) and advised by a health professional. Men were more likely to start exercising after ...


Current And Upcoming Stroke Research At Baptist Health, Amy K. Starosciak 2019 Baptist Health South Florida

Current And Upcoming Stroke Research At Baptist Health, Amy K. Starosciak

Amy K. Starosciak

No abstract provided.


"Daftar Nama Obat Kutil Ampuh Di Apotik", Dina Apriana 2019 Jl. Noenoeng tisna saputra Perum Wijaya Permai 2 Blok A No. 02 Kec. Tawang Kota Tasikmalaya kode pos 46115 Jawa Barat, Indonesia

"Daftar Nama Obat Kutil Ampuh Di Apotik", Dina Apriana

Jual Herbal Propolis Brazil SM

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