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Children Shouldn't Play With Dead Things, Sarah Adcock 2019 Washington University in St. Louis

Children Shouldn't Play With Dead Things, Sarah Adcock

Graduate School of Art Theses

I view my creative process as alchemy, the transformation of materials through experimentation. I use wax as a material that transcends its historical use as a sculptural process for casting and instead, use it for its transmutable qualities to inform content. Because of its plasticity and duality as fragile and resilient, wax is symbolically submissive and assertive. By applying heat, wax can be molded and formed into new shapes. Once it cools, wax reverts back to its natural state; solid and impermeable. I use objects to explore desires of origin and life. Transitional objects, the first “me not me” possession ...


Topography Study Of Fixa: Generation Of A Lipid Anchored Molecular Ruler With Attached Inhibitor, Nickolas P. Buchanan 2019 Philadelphia College of Osteopathic Medicine

Topography Study Of Fixa: Generation Of A Lipid Anchored Molecular Ruler With Attached Inhibitor, Nickolas P. Buchanan

PCOM Biomedical Studies Student Scholarship

Blood coagulation, an important hemostatic property, is directed through activation of proteolytic enzymes known as serine proteases to generate a fibrin plug. Using multiple proteases allows for localized and precise regulation of blood coagulation within the circulatory system. Factor IX, a serine protease, is a key activator in the coagulation cascade by activating Factor X. For activation of FX to occur, FIXa must be in proper conformation on the platelet surface with cofactor FVIIIa to increase enzymatic abilities of FIXa a billion-fold. Current research looks at structure and function of FIXa yet neglects structural plasticity on the membrane, with function ...


Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte 2019 Olivet Nazarene University

Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte

Honors Program Projects

Hexavalent chromium, or Cr(VI), is a potent oxidizer and known carcinogen, that is found at varying levels in the water sources of more than 200 million Americans. However, the exact mechanism of carcinogenicity remains unknown, and though the government currently regulates total chromium levels, they have yet to determine a permissible exposure limit for Cr(VI). Moreover, there is currently no preventative treatment for Cr(VI). Because of Cr(VI)’s strong oxidative power, we hypothesized that it causes DNA mutation and cell death via oxidation and that antioxidants could prevent this from occurring. To test this, we first ...


The Role Of Il-6 In Osteogenic And Neurogenic Differentiation Potentials Of Dental Pulp Stem Cells (Dpscs), YongTae Park, Xiaoxing Kou, Songtao Shi 2019 University of Pennsylvania

The Role Of Il-6 In Osteogenic And Neurogenic Differentiation Potentials Of Dental Pulp Stem Cells (Dpscs), Yongtae Park, Xiaoxing Kou, Songtao Shi

Dental Theses

Introduction: Interleukin 6 (IL-6) is a pleiotropic soluble mediator which is involved with many different parts of inflammatory processes. Studies have shown that there is a significantly higher concentration of IL-6 in inflamed pulp tissues when compared to healthy pulp tissues. However, there are no comprehensive studies on how IL-6 can interact with dental pulp stem cells (DPSCs) from healthy (H-DPSCs) and inflamed pulp tissues (I-DPSCs) and how it can affect the differentiation potential of DPSCs. Therefore, I hypothesized that IL-6 can promote osteogenesis while inhibiting neurogenesis from DPSCs. The aims of this study were to investigate the baseline differences ...


Obat Sembuhkan Total Wasir Stadium 3 Dan 4 Paling Manjur, rama sinta 2019 University of South Carolina - Beaufort

Obat Sembuhkan Total Wasir Stadium 3 Dan 4 Paling Manjur, Rama Sinta

rama sinta

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Ambeien Saat Hamil 7 Bulan, benjolan diluar 2019 University of South Carolina - Beaufort

Ambeien Saat Hamil 7 Bulan, Benjolan Diluar

benjolan diluar

ambeien saat hamil 7 bulan
Konsultasi Hbungi CS Kami (Call / SMS / WhatsApp) 081903433675


Https://wellnesstrials.org/Keto-Rapid-Max-Pure/, DavidRow DavidRow 2019 University of South Carolina - Beaufort

Https://wellnesstrials.org/Keto-Rapid-Max-Pure/, Davidrow Davidrow

DavidRow DavidRow

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Bodycontouring.Jpg, albert morelock 2019 University of California, San Francisco

Bodycontouring.Jpg, Albert Morelock

albert morelock

Keto Life >>Do not drink your calories. Know water and watch the sodium content on other drinks even these people do donrrrt you have calories. Drinks loaded with calories don't have a nutritional value and deliver more energy than system can use at an occasion. This simply means they turn you into fat!
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Using Marginal Structural Models To Control For Time-Dependent Confounding And Detect Effect Modification In A Randomized Control Trial With A Time-Varying Exposure, Non-Adherence And Missing Data, Elizabeth A. Lancet 2019 CUNY School of Public Health

Using Marginal Structural Models To Control For Time-Dependent Confounding And Detect Effect Modification In A Randomized Control Trial With A Time-Varying Exposure, Non-Adherence And Missing Data, Elizabeth A. Lancet

Dissertations and Theses

Background: Unlike traditional regression used in the Intention to Treat (ITT) approach, Marginal Structural Models (MSM) can account for joint effects of baseline and subsequent treatments as well as the presence of time-dependent confounding influenced by prior treatment and selection bias due to censoring. In addition, MSMs have been theorized to be able to assist investigators in determining the overall benefit of a drug in the total population as they are able to provide a summary effect size across all strata of an effect modifier which cannot be done via tradition regression techniques. The overall goal of this dissertation is ...


Reply To Om Shannon Et Al, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson 2019 Edith Cowan University

Reply To Om Shannon Et Al, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson

ECU Publications Post 2013

No abstract provided.


The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori 2019 Edith Cowan University

The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori

ECU Publications Post 2013

Background

Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus.

Aims

(i) To examine the effects of alcohol consumed as red wine on plasma SPM in men and women with Type 2 diabetes in a randomised controlled trial and (ii) compare baseline plasma ...


Biomarkers In Patients With Mucopolysaccharidosis Type Ii And Iv., Honoka Fujitsuka, Kazuki Sawamoto, Hira Peracha, Robert W. Mason, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu 2019 Nemours/Alfred I. duPont Hospital for Children; Gifu University

Biomarkers In Patients With Mucopolysaccharidosis Type Ii And Iv., Honoka Fujitsuka, Kazuki Sawamoto, Hira Peracha, Robert W. Mason, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Glycosaminoglycans (GAGs), dermatan sulfate (DS), heparan sulfate (HS), and keratan sulfate (KS), are the primary biomarkers in patients with mucopolysaccharidoses (MPS); however, little is known about other biomarkers. To explore potential biomarkers and their correlation with GAGs, blood samples were collected from 46 MPS II patients, 34 MPS IVA patients, and 5 MPS IVB patients. We evaluated the levels of 8 pro-inflammatory factors (EGF, IL-1β, IL-6, MIP-1α, TNF-α, MMP-1, MMP-2, and MMP-9), collagen type II, and DS, HS (HS0S, HSNS), and KS (mono-sulfated, di-sulfated) in blood. Eight biomarkers measured were significantly elevated in untreated MPS II patients, compared with those ...


Glycine Supplementation Extends Lifespan Of Male And Female Mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, Randy Strong 2019 The Jackson Laboratory

Glycine Supplementation Extends Lifespan Of Male And Female Mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, Randy Strong

Faculty Research 2019

Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%-6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycine-supplemented females were lighter than controls, but there was no effect on weight in males. End-of-life necropsies suggested that glycine-treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine-supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI-1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late-life diseases.


Effects Of Igf-1 Isoforms On Muscle Growth And Sarcopenia., Francesca Ascenzi, Laura Barberi, Gabriella Dobrowolny, Aline Villa Nova Bacurau, Carmine Nicoletti, Emanuele Rizzuto, Nadia Rosenthal, Bianca Maria Scicchitano, Antonio Musarò 2019 The Jackson Laboratory

Effects Of Igf-1 Isoforms On Muscle Growth And Sarcopenia., Francesca Ascenzi, Laura Barberi, Gabriella Dobrowolny, Aline Villa Nova Bacurau, Carmine Nicoletti, Emanuele Rizzuto, Nadia Rosenthal, Bianca Maria Scicchitano, Antonio Musarò

Faculty Research 2019

The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels of inflammatory mediators. Thus, factors that increase muscle mass and promote anabolic pathways might be of therapeutic benefit to counteract sarcopenia. Among these, the insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb ...


Exploring The Main Effects Of Patient Activation And Provider Support For Patient Self-Management On Patient Portal Use, Linda Anne Greenspan 2019 CUNY Graduate School of Public Health and Health Policy

Exploring The Main Effects Of Patient Activation And Provider Support For Patient Self-Management On Patient Portal Use, Linda Anne Greenspan

Dissertations and Theses

Objectives:

This dissertation was designed to: (1) explore variations in clinicians’ views about patient self-management, (2) explore variation in patient activation and (3) explore variation in patients’ and their primary care physicians’ characteristics in the use of a patient portal and the main effects of patient activation and primary care physician support for patient self-management on portal use in an understudied closed multi-specialty ambulatory center. The main hypothesis is that primary care physician support for patient self-management will be an effect modifier on the association between patient activation and patient portal use.

Setting:

The New York Hotel Trades Council and ...


Missed Shots: Increasing Flu Vaccine Documentation Utilizing A Clinical Reminder In A Student Health Clinic, Noelle Simms 2019 University of San Diego

Missed Shots: Increasing Flu Vaccine Documentation Utilizing A Clinical Reminder In A Student Health Clinic, Noelle Simms

Doctor of Nursing Practice Final Manuscripts

Objectives: The primary purpose of this evidence-based practice project is to increase influenza vaccination documentation in the student health setting utilizing a standardized clinical reminder.

Participants: 1,337 undergraduate and graduate students at a private university is Southern California.

Methods: A clinical reminder template was created and added to the intake form in the electronic medical record. The medical assistants complete the template with the patient. The provider then orders the vaccine or educates the patient based on the documented refusal reason.

Results: During the 10-week implementation period there was a 46% increase from baseline in flu vaccine documentation at ...


Comprehensive Sleep Apnea Screening In Veterans With Posttraumatic Stress Disorder, Richard W. Schulz 2019 University of San Diego

Comprehensive Sleep Apnea Screening In Veterans With Posttraumatic Stress Disorder, Richard W. Schulz

Doctor of Nursing Practice Final Manuscripts

Objectives: Recent studies have shown a higher prevalence of sleep apnea in veterans with Posttraumatic Stress Disorder (PTSD). It is estimated that 69 to 83% of veterans have Obstructive Sleep Apnea (OSA) while 80 to 90% are undiagnosed or untreated. Untreated OSA can lead to severe chronic medical conditions as well as impairment of neurocognitive and fear extinction processing potentially decreasing responsiveness to trauma focused therapy. Despite the widespread dissemination of knowledge regarding the negative effects of OSA, many veterans are not screened. The goal of this project is to increase the rate of identifying veterans who are high-risk for ...


The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control, Belinda Akakpo Maxwell 2019 University of San Diego

The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control, Belinda Akakpo Maxwell

Doctor of Nursing Practice Final Manuscripts

The Roles of an Evidence-Based Weight Management Protocol in Hypertension Control

Abstract

Purpose: The purpose of this project is to evaluate the impact of a healthcare provider-led protocol for patients with hypertension (HTN) and weight loss needs to improve weight control, cardiovascular risk and quality of life.

Background: Evidence shows that a 1.2-kg weight loss can reduce systolic blood pressure (SBP) by 3.8mmHg. Thus, a 10kg (22lbs) weight loss is likely to yield a SBP decrease of as much as 32mmHg. Such results would positively impact quality of life and costs. The simple approach of instructing patients to ...


Telephone Follow Up For Obstetrical Triage, Ann Grimshaw 2019 University of San Diego

Telephone Follow Up For Obstetrical Triage, Ann Grimshaw

Doctor of Nursing Practice Final Manuscripts

TELEPHONE FOLLOW UP FOR OBSTETRICAL TRIAGE VISITS

Ann Grimshaw, RN, MSN, CNS

Clinical Nurse Specialist

Doctorate of Nursing Practice, Student

University of San Diego, School of Nursing

San Diego, CA

Purpose: To reduce a patient’s knowledge deficit related to plan of care after an unscheduled obstetric triage through follow up phone calls.

Rationale and Background: Up to 75% women during their pregnancy will present to an unscheduled visit in obstetrical triage with questions about their own health and the health of their unborn newborn. The majority of these visits will result in discharge from obstetrical triage prior to delivery ...


Herpes Zostervaccine To The Homebound Elderly: Prevention, Protection, And Access To Care, Serena Arts 2019 University of San Diego

Herpes Zostervaccine To The Homebound Elderly: Prevention, Protection, And Access To Care, Serena Arts

Doctor of Nursing Practice Final Manuscripts

Herpes Zoster Vaccine to the Homebound Elderly: Prevention, Protection, and Access to Care

Purpose: To increase the administration rate of the Herpes Zoster (Hz) vaccine Zostavax by 10% for persons 65 years and older in a home-based primary care practice, utilizing Medicare part D.

Background: Persons in the United States (US) age 40 years and older show a 99% positive serology for Varicella, which causes Hz decades later. Zostavax has been shown to decease Hz by 51% and post-herpetic neuralgia by 67%.

Brief Description: The goal of Healthy People 2020 is to increase the vaccination rates of persons 65 years ...


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