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Multidisciplinary Education And Research In Biomathematics For Solving Global Challenges, Padmanabhan Seshaiyer 2019 George Mason University

Multidisciplinary Education And Research In Biomathematics For Solving Global Challenges, Padmanabhan Seshaiyer

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Managing Intracranial Hemorrhage In Patients With A Durable Continuous Flow Left Ventricular Assist Device, Godly Jack, Phil Barker, Ryan Searcy, Jason N. Katz 2019 University of North Carolina, Chapel Hill

Managing Intracranial Hemorrhage In Patients With A Durable Continuous Flow Left Ventricular Assist Device, Godly Jack, Phil Barker, Ryan Searcy, Jason N. Katz

The VAD Journal

Background: While intracranial hemorrhage (ICH) is a known complication of left ventricular assist device (LVAD) support, and is associated with high morbidity and mortality, optimal care pathways have neither been elucidated nor reported. We describe management of LVAD patients following ICH, with a focus on anticoagulation, operative interventions, care team designation, complications, and outcomes.

Methods: We retrospectively reviewed all durable continuous-flow LVAD implantations at our academic medical center from January 2007 to July 2018. Patients who experienced ICH after LVAD were identified. We defined baseline and ICH characteristics, medical and surgical interventions, care teams, and outcomes including death, device thrombosis ...


Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg 2019 University of Massachusetts Medical School

Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg

Robert J. Goldberg

Background: To examine the impact of cardiac- and noncardiac-related conditions on the risk of hospital complications and 7- and 30-day rehospitalizations in older adult patients with an acute myocardial infarction (AMI).

Methods and Results: The study population consisted of 3863 adults aged 65 years and older hospitalized with AMI in Worcester, Massachusetts, during six annual periods between 2001 and 2011. Individuals were categorized into four groups based on the presence of 11 previously diagnosed cardiac and noncardiac conditions. The median age of the study population was 79 years and 49% were men. Twenty-eight percent of patients had two or less ...


Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg 2019 University of Massachusetts Medical School

Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg

Jerry H. Gurwitz

Background: To examine the impact of cardiac- and noncardiac-related conditions on the risk of hospital complications and 7- and 30-day rehospitalizations in older adult patients with an acute myocardial infarction (AMI).

Methods and Results: The study population consisted of 3863 adults aged 65 years and older hospitalized with AMI in Worcester, Massachusetts, during six annual periods between 2001 and 2011. Individuals were categorized into four groups based on the presence of 11 previously diagnosed cardiac and noncardiac conditions. The median age of the study population was 79 years and 49% were men. Twenty-eight percent of patients had two or less ...


Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. McManus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane 2019 University of Massachusetts Medical School

Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. Mcmanus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane

Jennifer Tjia

Background: Nursing home residents with atrial fibrillation are at high risk for ischemic stroke and bleeding events. The most recent national estimate (2004) indicated less than one third of this high-risk population was anticoagulated. Whether direct-acting oral anticoagulant ( DOAC ) use has disseminated into nursing homes and increased anticoagulant use is unknown.

Methods and Results: A repeated cross-sectional design was used to estimate the point prevalence of oral anticoagulant use on July 1 and December 31 of calendar years 2011 to 2016 among Medicare fee-for-service beneficiaries with atrial fibrillation residing in long-stay nursing homes. Nursing home residence was determined using Minimum ...


Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. McManus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane 2019 University of Massachusetts Medical School

Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. Mcmanus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane

David D. McManus

Background: Nursing home residents with atrial fibrillation are at high risk for ischemic stroke and bleeding events. The most recent national estimate (2004) indicated less than one third of this high-risk population was anticoagulated. Whether direct-acting oral anticoagulant ( DOAC ) use has disseminated into nursing homes and increased anticoagulant use is unknown.

Methods and Results: A repeated cross-sectional design was used to estimate the point prevalence of oral anticoagulant use on July 1 and December 31 of calendar years 2011 to 2016 among Medicare fee-for-service beneficiaries with atrial fibrillation residing in long-stay nursing homes. Nursing home residence was determined using Minimum ...


Navigating A Difficult Transition In Pulmonary Arterial Hypertension: A Clinical Case Study, Tina Hyman, Michael Salinero, Francisco Javier Jimenez-Carcamo, Margarita Pallares, Maribel Matos 2019 South Miami Hospital

Navigating A Difficult Transition In Pulmonary Arterial Hypertension: A Clinical Case Study, Tina Hyman, Michael Salinero, Francisco Javier Jimenez-Carcamo, Margarita Pallares, Maribel Matos

Nursing & Health Sciences Research Journal

Over the past 20 years, Pulmonary Arterial Hypertension (PAH) patients and providers have seen an increase in options to treat PAH. Currently, there are choices for the delivery of medications approved to treat patients with PAH where at one point the only option was intravenous (IV) therapy. This case study details the transition from IV Epoprostenol to oral Treprostinil for the treatment of a 53 year old female diagnosed with severe Pulmonary Arterial Hypertension whose quality of life became unbearable by the IV medication delivery route. This patient was a synchronized swimmer in her youth and her passion for water ...


Identifying The Enzyme Involved In Vacuolar Atpase Acetylation During Doxorubicin-Induced Cardiotoxicity, Rebecca Dang, Tianqing Peng 2019 The University of Western Ontario

Identifying The Enzyme Involved In Vacuolar Atpase Acetylation During Doxorubicin-Induced Cardiotoxicity, Rebecca Dang, Tianqing Peng

Western Research Forum

Doxorubicin is an established anticancer medication infamous for its bright colouration and extremely toxic side effects. Emerging studies support that the imbalance between acetylation and deacetylation disrupts the autophagic flux leading to doxorubicin-induced cardiotoxicity. Vacuolar ATPases are a family of electrogenic proton pumps present on the lysosomal membrane that create an acidic environment for proteases to degrade proteins. Our preliminary study found that acetylated Vacuolar ATPase subunit V0 D1 levels increased in doxorubicin-injected mouse hearts. However, it is unknown how acetylation of subunit V0 D1 is modulated and whether this modification plays a role in doxorubicin-induced cardiotoxicity.

The ...


Design And Preliminary Findings From A New Electronic Cohort Embedded In The Framingham Heart Study, David D. McManus, Ludovic Trinquart, Emelia J. Benjamin, Emily S. Manders, Kelsey Fusco, Lindsey S. Jung, Nicole L. Spartano, Vik Kheterpal, Christopher Nowak, Mayank Sardana, Joanne M. Murabito 2019 University of Massachusetts Medical School

Design And Preliminary Findings From A New Electronic Cohort Embedded In The Framingham Heart Study, David D. Mcmanus, Ludovic Trinquart, Emelia J. Benjamin, Emily S. Manders, Kelsey Fusco, Lindsey S. Jung, Nicole L. Spartano, Vik Kheterpal, Christopher Nowak, Mayank Sardana, Joanne M. Murabito

David D. McManus

BACKGROUND: New models of scalable population-based data collection that integrate digital and mobile health (mHealth) data are necessary.

OBJECTIVE: The aim of this study was to describe a cardiovascular digital and mHealth electronic cohort (e-cohort) embedded in a traditional longitudinal cohort study, the Framingham Heart Study (FHS).

METHODS: We invited eligible and consenting FHS Generation 3 and Omni participants to download the electronic Framingham Heart Study (eFHS) app onto their mobile phones and co-deployed a digital blood pressure (BP) cuff. Thereafter, participants were also offered a smartwatch (Apple Watch). Participants are invited to complete surveys through the eFHS app, to ...


Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study, Darae Ko, Mark D. Benson, Debby Ngo, Qiong Yang, Martin G. Larson, Thomas J. Wang, Ludovic Trinquart, David D. McManus, Steven A. Lubitz, Patrick T. Ellinor, Ramachandran S. Vasan, Robert E. Gerszten, Emelia J. Benjamin, Honghuang Lin 2019 Boston University

Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study, Darae Ko, Mark D. Benson, Debby Ngo, Qiong Yang, Martin G. Larson, Thomas J. Wang, Ludovic Trinquart, David D. Mcmanus, Steven A. Lubitz, Patrick T. Ellinor, Ramachandran S. Vasan, Robert E. Gerszten, Emelia J. Benjamin, Honghuang Lin

David D. McManus

Background: Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins.

Methods and Results: We performed proteomics assays among participants from the Framingham Heart Study Offspring attending their fifth examination. Plasma protein levels (n=1373) were measured by the SOMAscan proteomic profiling platform. We used robust inference for the Cox proportional hazards model to relate each protein level with incident AF. In addition, we examined the association between AF-related genetic loci and levels of proteins associated with AF. Our study included 1885 participants (mean age 55+/-10 years, 54% women) who had proteomic profiles measured. A ...


A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe 2019 CUNY School of Public Health

A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe

Dissertations and Theses

Cardiovascular disease is the leading cause of death worldwide. Coronary Artery Disease (CAD) accounts for the majority of those deaths. Observational studies have identified risk factors that have been helpful in lowering the death rate, including hypertension, high cholesterol, diabetes, smoking, physical inactivity and poor diet. The effects of these risk factors on CAD remain unclear. To clarify the effect of three amino acids, alanine, glutamine, and glycine on CAD I applied a two sample Mendelian randomization analysis to extensively genotyped observational data. In a sample with up to 184,000 individuals and approximately 60,000 controls, SNPs that reached ...


Wake Forest University Long-Term Follow-Up Of Type 2 Myocardial Infarction: The Wake-Up T2mi Registry, Hanumantha R. Jogu, Waqas Qureshi 2019 Wake Forest University

Wake Forest University Long-Term Follow-Up Of Type 2 Myocardial Infarction: The Wake-Up T2mi Registry, Hanumantha R. Jogu, Waqas Qureshi

Open Access Articles

BACKGROUND: The Wake-Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short- and long-term outcomes in this high-risk, understudied population.

METHODS: From 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% ( > 40 ng/L) and meeting our inclusion criteria. Data of at ...


Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg 2019 University of Massachusetts Medical School

Impact Of Cardiac- And Noncardiac-Related Conditions On Adverse Outcomes In Patients Hospitalized With Acute Myocardial Infarction, Mayra Tisminetzky, Jerry H. Gurwitz, Ruben Miozzo, Joel M. Gore, Darleen M. Lessard, Jorge L. Yarzebski, Robert J. Goldberg

Open Access Articles

Background: To examine the impact of cardiac- and noncardiac-related conditions on the risk of hospital complications and 7- and 30-day rehospitalizations in older adult patients with an acute myocardial infarction (AMI).

Methods and Results: The study population consisted of 3863 adults aged 65 years and older hospitalized with AMI in Worcester, Massachusetts, during six annual periods between 2001 and 2011. Individuals were categorized into four groups based on the presence of 11 previously diagnosed cardiac and noncardiac conditions. The median age of the study population was 79 years and 49% were men. Twenty-eight percent of patients had two or less ...


The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control, Belinda Akakpo Maxwell 2019 University of San Diego

The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control, Belinda Akakpo Maxwell

Doctor of Nursing Practice Final Manuscripts

The Roles of an Evidence-Based Weight Management Protocol in Hypertension Control

Abstract

Purpose: The purpose of this project is to evaluate the impact of a healthcare provider-led protocol for patients with hypertension (HTN) and weight loss needs to improve weight control, cardiovascular risk and quality of life.

Background: Evidence shows that a 1.2-kg weight loss can reduce systolic blood pressure (SBP) by 3.8mmHg. Thus, a 10kg (22lbs) weight loss is likely to yield a SBP decrease of as much as 32mmHg. Such results would positively impact quality of life and costs. The simple approach of instructing patients to ...


Detection Of Bleeding Events In Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach, Rumeng Li, Baotian Hu, Feifan Liu, Weisong Liu, Francesca Cunningham, David D. McManus, Hong Yu 2019 University of Massachusetts Amherst

Detection Of Bleeding Events In Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach, Rumeng Li, Baotian Hu, Feifan Liu, Weisong Liu, Francesca Cunningham, David D. Mcmanus, Hong Yu

David D. McManus

BACKGROUND: Bleeding events are common and critical and may cause significant morbidity and mortality. High incidences of bleeding events are associated with cardiovascular disease in patients on anticoagulant therapy. Prompt and accurate detection of bleeding events is essential to prevent serious consequences. As bleeding events are often described in clinical notes, automatic detection of bleeding events from electronic health record (EHR) notes may improve drug-safety surveillance and pharmacovigilance.

OBJECTIVE: We aimed to develop a natural language processing (NLP) system to automatically classify whether an EHR note sentence contains a bleeding event.

METHODS: We expert annotated 878 EHR notes (76,577 ...


The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta 2019 Children's Mercy Hospital, Kansas City

The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta

Research Days

No abstract provided.


Elevated Beta-Hydroxybutyric Acid With No Ketoacidosis In Type 2 Diabetic Patients Using Sodium-Glucose Cotransporter-2 Inhibitors, Simant Singh Thapa, Amos Lal, Abdulkadir Omer, Nitin Trivedi 2019 Saint Vincent Hospital

Elevated Beta-Hydroxybutyric Acid With No Ketoacidosis In Type 2 Diabetic Patients Using Sodium-Glucose Cotransporter-2 Inhibitors, Simant Singh Thapa, Amos Lal, Abdulkadir Omer, Nitin Trivedi

Open Access Articles

SGLT2 inhibitor (SGLT2i) class of medications are known to cause to euglycemic diabetic ketoacidosis (euDKA) as reported in the article by Lin et al. in your esteemed publication about this entity being reported for the first time in Taiwanese population.We wish to share the findings from our center to further expand the spectrum of findings associated with SGLT2i therapy.


Health Literacy Screening To Increase Antihypertensive Medication Adherence, Boyann Bonjean 2019 Valparaiso University

Health Literacy Screening To Increase Antihypertensive Medication Adherence, Boyann Bonjean

Evidence-Based Practice Project Reports

Hypertension contributes to the risk of developing cardiovascular disease (CVD), stroke, heart attack, and chronic kidney disease (CKD) (Abegaz et al., 2016; Weir, 2014; Whelton et al., 2017). Evidence indicates that 30 to 50% of people who are prescribed antihypertensive medication therapy are nonadherent (Hedna et al., 2015). Non-adherence to antihypertensive medications is a major contributor to hypertension treatment failure (Al Ghurair et al., 2012; Hu, 2016; Whelton et al., 2017). Evidence has shown that low health literacy may impact antihypertensive therapy (Slade, 2017). The purpose of this EBP project was to provide an organizational change by implementing a health ...


Developing A Community-Based Screening And Referral Mechanism For Atrial Fibrillation In Low Resource Settings: “Smartphone Monitoring For Atrial Fibrillation In Real-Time – India (Smart-India)”, Apurv Soni, Nisha Fahey, Harshil Patel, Kandarp Talati, Anna Handorf, John A. Bostrom, Shyamsundar Raihatha, Ravi Shah, Sunil Karna, Robert J. Goldberg, Jeroan J. Allison, Ki Chon, Somashekhar M. Nimbalkar, David D. McManus 2019 University of Massachusetts Medical School

Developing A Community-Based Screening And Referral Mechanism For Atrial Fibrillation In Low Resource Settings: “Smartphone Monitoring For Atrial Fibrillation In Real-Time – India (Smart-India)”, Apurv Soni, Nisha Fahey, Harshil Patel, Kandarp Talati, Anna Handorf, John A. Bostrom, Shyamsundar Raihatha, Ravi Shah, Sunil Karna, Robert J. Goldberg, Jeroan J. Allison, Ki Chon, Somashekhar M. Nimbalkar, David D. Mcmanus

Apurv Soni

BACKGROUND: Atrial fibrillation (AF), the world’s most common arrhythmia, often goes undetected and untreated in low-resource communities, including India. Moreover, AF is an important risk factor for stroke, which plagues an estimated 1.6 million Indians annually. As such, early detection of AF and management of high-risk patients is critically important to decrease stroke burden in individuals with AF.

OBJECTIVE: The objectives of this study are to evaluate the age- and sex-stratified epidemiology of AF in Anand District, Gujarat India; characterize the profile of individuals who are diagnosed with AF; and determine the performance of two mobile technologies for ...


High Burden Of Unrecognized Atrial Fibrillation In Rural India: An Innovative Community-Based Cross-Sectional Screening Program, Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael S. Chin, John Stephen Sullivan, Shyamsundar Raithatha, Robert J. Goldberg, Somashekhar Nimbalkar, Jeroan J. Allison, Sunil Thanvi, David D. McManus 2019 University of Massachusetts Medical School

High Burden Of Unrecognized Atrial Fibrillation In Rural India: An Innovative Community-Based Cross-Sectional Screening Program, Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael S. Chin, John Stephen Sullivan, Shyamsundar Raithatha, Robert J. Goldberg, Somashekhar Nimbalkar, Jeroan J. Allison, Sunil Thanvi, David D. Mcmanus

Apurv Soni

BACKGROUND: Atrial fibrillation, the world's most common arrhythmia, is a leading risk factor for stroke, a disease striking nearly 1.6 million Indians annually. Early detection and management of atrial fibrillation is a promising opportunity to prevent stroke but widespread screening programs in limited resource settings using conventional methods is difficult and costly.

OBJECTIVE: The objective of this study is to screen people for atrial fibrillation in rural western India using a US Food and Drug Administration-approved single-lead electrocardiography device, Alivecor.

METHODS: Residents from 6 villages in Anand District, Gujarat, India, comprised the base population. After obtaining informed consent ...


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