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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons

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Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. McDermott, Kaitlin Gallagher, Tyrone Washington 2019 University of Arkansas, Fayetteville

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many ...


Barriers And Facilitators To Use Of A Clinical Evidence Technology For Management Of Skin Problems In Primary Care: Insights From Mixed Methods, Marianne Burke PhD, Alan Rubin MD, Liliane Savard DPT, Benjamin Littenberg MD 2019 University of Vermont Dana Medical Library

Barriers And Facilitators To Use Of A Clinical Evidence Technology For Management Of Skin Problems In Primary Care: Insights From Mixed Methods, Marianne Burke Phd, Alan Rubin Md, Liliane Savard Dpt, Benjamin Littenberg Md

Larner College of Medicine Faculty Publications

Background: A previous cluster-randomized controlled trial tested the effectiveness of a clinical evidence technology (CET), VisualDx, for skin problems seen by Primary Care Providers (PCPs). Based on patient report, there was no effect on time to problem resolution or return appointments.

Objective: To explain, from the provider perspective, why the CET did not make a difference in the clinical trial and to identify barriers and facilitators to use.

Methods: Mixed methods study design. Providers from both arms completed a survey about their use of VisualDx and information-seeking during and after the trial. Active arm providers participated in interviews to explore ...


An Observational Study With The Janssen Autism Knowledge Engine (Jake((R))) In Individuals With Autism Spectrum Disorder, Seth L. Ness, Jean A. Frazier 2019 Janssen Research & Development

An Observational Study With The Janssen Autism Knowledge Engine (Jake((R))) In Individuals With Autism Spectrum Disorder, Seth L. Ness, Jean A. Frazier

Jean A. Frazier

Objective: The Janssen Autism Knowledge Engine (JAKE(R)) is a clinical research outcomes assessment system developed to more sensitively measure treatment outcomes and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE and present results from its digital phenotyping (My JAKE) and biosensor (JAKE Sense) components.

Methods: An observational, non-interventional, prospective study of JAKE in children and adults with ASD was conducted at nine sites in the United States. Feedback on JAKE usability was obtained from caregivers. JAKE Sense included electroencephalography, eye tracking, electrocardiography, electrodermal activity, facial affect analysis, and actigraphy. Caregivers of individuals with ASD reported behaviors ...


Provider Education And Rapid Antigen Detection Test Use In An Academic Pediatric Clinic, Steven Dahl 2019 Children's Mercy Hospital

Provider Education And Rapid Antigen Detection Test Use In An Academic Pediatric Clinic, Steven Dahl

Research Days

No abstract provided.


The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta 2019 Children's Mercy Hospital, Kansas City

The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta

Research Days

No abstract provided.


A Novel, Rapid, Seedless, In Situ Synthesis Method Of Shape And Size Controllable Gold Nanoparticles Using Phosphates, Kangze Liu, zhonglei He, James F. Curtin, Hugh J. Byrne, Furong Tian 2019 Technological University Dublin

A Novel, Rapid, Seedless, In Situ Synthesis Method Of Shape And Size Controllable Gold Nanoparticles Using Phosphates, Kangze Liu, Zhonglei He, James F. Curtin, Hugh J. Byrne, Furong Tian

Articles

We hereby report a novel synthesis method of size and shape controllable gold nanoparticles that is rapid, in situ and seedless. Unlike most currently employed size and shape controllable synthesis methods, it takes place in a single step under room temperature within ~15 minutes. While mixtures of gold nanospheres around 70 nm and gold nanoplates with width ranging from 100 nm to 1000 nm can be synthesized in about 15 minutes by standard synthesis method using N-2-hydroxyethylpiperazine-N-2-ethanesulphonic acid (HEPES) to reduce Au(III), gold nanoflowers or mixtures of smaller gold nanospheres and nanoplates can be synthesized with ...


Fast Adaptive Smoothing And Thresholding For Improved Activation Detection In Low-Signal Fmri, Israel Almodovar-Rivera, Ranjan Maitra 2019 University of Puerto Rico

Fast Adaptive Smoothing And Thresholding For Improved Activation Detection In Low-Signal Fmri, Israel Almodovar-Rivera, Ranjan Maitra

Ranjan Maitra

Functional Magnetic Resonance Imaging is a noninvasive tool used to study brain function. Detecting activation is challenged by many factors, and even more so in low-signal scenarios that arise in the performance of high-level cognitive tasks. We provide a fully automated and fast adaptive smoothing and thresholding (FAST) algorithm that uses smoothing and extreme value theory on correlated statistical parametric maps for thresholding. Performance on experiments spanning a range of low-signal settings is very encouraging. The methodology also performs well in a study to identify the cerebral regions that perceive only-auditory-reliable and only-visual-reliable speech stimuli as well as those that ...


Durability Of Symptomatic Responses Obtained With Adjunctive Vagus Nerve Stimulation In Treatment-Resistant Depression, Arun Kumar, Mark T. Bunker, Scott T. Aaronson, Charles R. Conway, Anthony J. Rothschild, Giacomo Mordenti, Augustus J. Rush 2019 LivaNova USA PLC

Durability Of Symptomatic Responses Obtained With Adjunctive Vagus Nerve Stimulation In Treatment-Resistant Depression, Arun Kumar, Mark T. Bunker, Scott T. Aaronson, Charles R. Conway, Anthony J. Rothschild, Giacomo Mordenti, Augustus J. Rush

Anthony J. Rothschild

Objective: To compare the durations of response achieved with adjunctive vagus nerve stimulation (VNS + TAU) vs treatment as usual (TAU) alone in treatment-resistant depression (TRD) over a 5-year period in the TRD registry.

Materials and methods: Data from 271 participants on TAU and 328 participants on VNS + TAU were analyzed. Response was defined as > /=50% decrease in baseline Montgomery-Asberg Depression Rating Scale (MADRS) score at postbaseline visit and was considered retained until the decrease was < 40%. MADRS was obtained quarterly in year 1 and biannually thereafter. Time-to-events were estimated using Kaplan-Meier method and compared using log-rank test. HR was estimated using Cox proportion hazard model.

Results: In the VNS + TAU arm, 62.5% (205/328) of participants had a first response over 5 years compared with 39.9% (108/271 ...


Bridging From Intramuscular To Limb Perfusion Delivery Of Raav: Optimization In A Non-Human Primate Study, Alisha Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-Jie Ye, Dave R. Knop, Gensheng Wang, Janet Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, Louis G. Chicoine, Jeffrey D. Chulay, Terence R. Flotte 2019 University of Massachusetts Medical School

Bridging From Intramuscular To Limb Perfusion Delivery Of Raav: Optimization In A Non-Human Primate Study, Alisha Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-Jie Ye, Dave R. Knop, Gensheng Wang, Janet Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, Louis G. Chicoine, Jeffrey D. Chulay, Terence R. Flotte

Christian Mueller

Phase 1 and phase 2 gene therapy trials using intramuscular (IM) administration of a recombinant adeno-associated virus serotype 1 (rAAV1) for replacement of serum alpha-1 antitrypsin (AAT) deficiency have shown long-term (5-year) stable transgene expression at approximately 2% to 3% of therapeutic levels, arguing for the long-term viability of this approach to gene replacement of secreted serum protein deficiencies. However, achieving these levels required 100 IM injections to deliver 135 mL of vector, and further dose escalation is limited by the scalability of direct IM injection. To further advance the dose escalation, we sought to bridge the rAAV-AAT clinical development ...


Public Health Policy: An Ethical Analysis Of Quarantine, Dina Alqahtani 2019 Duquesne University

Public Health Policy: An Ethical Analysis Of Quarantine, Dina Alqahtani

Electronic Theses and Dissertations

As a public health measure quarantine has both historical and contemporary significance both in the United States and abroad. On the surface it represents a low-cost, low-tech way in which the spread of disease can be mitigated as its core requirement is that those who may have been exposed to an infectious agent are kept away from those who have not been exposed to that agent for enough time to determine whether or not infection has been spread. This has been utilized for centuries with both limited questions and scattered, inconsistent, or impossible to achieve oversight and goals. In understanding ...


Differential Estimation Of Audiograms Using Gaussian Process Active Model Selection, Trevor Larsen 2019 Washington University in St. Louis

Differential Estimation Of Audiograms Using Gaussian Process Active Model Selection, Trevor Larsen

Engineering and Applied Science Theses & Dissertations

Classical methods for psychometric function estimation either require excessive resources to perform, as in the method of constants, or produce only a low resolution approximation of the target psychometric function, as in adaptive staircase or up-down procedures. This thesis makes two primary contributions to the estimation of the audiogram, a clinically relevant psychometric function estimated by querying a patient’s for audibility of a collection of tones. First, it covers the implementation of a Gaussian process model for learning an audiogram using another audiogram as a prior belief to speed up the learning procedure. Second, it implements a use case ...


Complex-Valued Time Series Modeling For Improved Activation Detection In Fmri Studies, Daniel W. Adrian, Ranjan Maitra, Daniel B. Rowe 2019 Grand Valley State University

Complex-Valued Time Series Modeling For Improved Activation Detection In Fmri Studies, Daniel W. Adrian, Ranjan Maitra, Daniel B. Rowe

Ranjan Maitra

A complex-valued data-based model with pth order autoregressive errors and general real/imaginary error covariance structure is proposed as an alternative to the commonly used magnitude-only data-based autoregressive model for fMRI time series. Likelihood-ratio-test-based activation statistics are derived for both models and compared for experimental and simulated data. For a dataset from a right-hand finger-tapping experiment, the activation map obtained using complex-valued modeling more clearly identifies the primary activation region (left functional central sulcus) than the magnitude-only model. Such improved accuracy in mapping the left functional central sulcus has important implications in neurosurgical planning for tumor and epilepsy patients. Additionally ...


Sex Differences In The Cerebral Bold Signal Response To Painful Heat Stimuli, Eric A. Moulton, Michael L. Keaser, Rao P. Gullapalli, Ranjan Maitra, Joel D. Greenspan 2019 University of Maryland

Sex Differences In The Cerebral Bold Signal Response To Painful Heat Stimuli, Eric A. Moulton, Michael L. Keaser, Rao P. Gullapalli, Ranjan Maitra, Joel D. Greenspan

Ranjan Maitra

There are limited data addressing the question of sex differences in pain-related cerebral processing. This study examined whether pain-related blood oxygenation level-dependent (BOLD) signal change measured with functional magnetic resonance imaging (fMRI) demonstrated sex differences, under conditions of equivalent pain perception. Twenty-eight healthy volunteers (17 women, 11 men) were subject to a fMRI scan while noxious heat stimuli were applied to the dorsum of the left foot. Significant BOLD signal modulation was observed in several nociceptive processing regions of interest (ROIs) in all subjects. There were no sex differences in the spatial extent of BOLD signal change for any ROI ...


Unplugged, Krisha Patel '21, Jonathan Gao '21, Jason Li '21 2019 Illinois Mathematics and Science Academy

Unplugged, Krisha Patel '21, Jonathan Gao '21, Jason Li '21

Student Leadership Exchange (SLX)

Technology has infiltrated every aspect of our lives. Regardless of financial conditions, most people have a cellphone in their hands at all times—usually a smartphone. TVs are installed in almost every single room in the typical American household and very often powered up with a marathon of a favorite show, playing episode after episode without pause. Kids become obsessed with the latest video game consoles and games, paying exorbitant amounts to be the first of their friends to get their hands on them. Even many parents compulsively check and post updates to a variety of social media sites throughout ...


Effectiveness Of Adaptive Utensils On Hand And Finger Range Of Motion In Individuals With Rheumatoid Arthritis, Lauren Yeager 2019 University of Tennessee at Chattanooga

Effectiveness Of Adaptive Utensils On Hand And Finger Range Of Motion In Individuals With Rheumatoid Arthritis, Lauren Yeager

Honors Theses

Individuals with Rheumatoid Arthritis (RA) often experience functional deficits that impair range of motion (ROM) in their hands and fingers. Daily tasks like opening jars and eating become more difficult and painful for individuals with RA because they lack the grip strength and adequate ROM to perform these activities. Because of this, efforts have been made to accommodate decreasing functionality due to decreased ROM. Adaptive utensils are currently being explored as a potential aid for hand and finger functional deficits. This study sought to quantify the ROM needed for individuals with RA to grip the handles of adaptive utensils of ...


Interdevice Reliability Of A-Mode Ultrasound To Measure Body Composition, Megan Bigler 2019 Utah State University

Interdevice Reliability Of A-Mode Ultrasound To Measure Body Composition, Megan Bigler

All Graduate Plan B and other Reports

A-mode ultrasound is a noninvasive and rapid method for measuring subcutaneous fat thickness and estimating body fat percentage (%BF). The validity and reliability of the BodyMetrix BX2000 A-mode ultrasound has been reported; however, the purpose of this study was to compare results from two machines to determine interdevice reliability. Ultrasound measures were repeated with two BX2000 machines at 10 body sites (chest, biceps, triceps, scapula, lower back, hip, waist, thigh, calf, axilla) on 42 males of varying age and leanness (age: 28.6 ± 11.9 y, BMI: 25.4 ± 4.6 kg/m2). The intraclass correlation coefficients ranged from ...


Evaluation Of Body Fat Prediction Equations From A Portable A-Mode Ultrasound (Bodymetrix) Compared To Bod Pod, R. Stephan Lowry 2019 Utah State University

Evaluation Of Body Fat Prediction Equations From A Portable A-Mode Ultrasound (Bodymetrix) Compared To Bod Pod, R. Stephan Lowry

All Graduate Plan B and other Reports

A-mode ultrasound is a relatively inexpensive and noninvasive way of measuring subcutaneous fat thickness and estimating body fat percentage (%BF). The BodyMetrix BX2000 A-mode ultrasound is programmed with nine different equations that can be used to estimate %BF. The purpose of this study was to compare the %BF estimation from all nine equations available for adult males in this ultrasound system to the %BF estimation from Bod Pod air displacement plethysmography. Ultrasound measures were taken at 10 body sites on 42 males of varying age (28.6 ± 11.9 y), height (182.4 ± 7.6 cm), weight (84.5 ± 16 ...


Quality Improvement: Implementing A Foot Exam To Improve Care For Patients With Diabetes Mellitus, Emily Paprocki, Ryan McDonough, Tiffany Musick, Joseph Cernich 2019 Children's Mercy Kansas City

Quality Improvement: Implementing A Foot Exam To Improve Care For Patients With Diabetes Mellitus, Emily Paprocki, Ryan Mcdonough, Tiffany Musick, Joseph Cernich

Posters

The American Diabetes Association guidelines recommend an annual foot exam in patients with type 1 and 2 diabetes who are ten years old or older and who have been diagnosed with diabetes at least five years. Quality improvement tools were used to improve the care provided to our patients by implementing an annual food exam.


Detection Of Genetic Thrombophilia (Fa V Leiden & Pt20210 Mutation) Using Genexpert Technology With Iqcp Implementation, Mariegrace Saquilayan 2019 Dominican University of California

Detection Of Genetic Thrombophilia (Fa V Leiden & Pt20210 Mutation) Using Genexpert Technology With Iqcp Implementation, Mariegrace Saquilayan

Natural Sciences and Mathematics | Clinical Laboratory Sciences Culminating Projects

Abstract

Individuals having Genetic Thrombophilia pose a higher risk of having a thrombotic event. It is crucial to determine these gene variants to prevent a possible episode of thromboembolism. With the current PCR method, it involves individual processing of DNA isolation, amplification, and detection using three (3) different instruments resulting to an increased turnaround time of 5 to 7 days and additional staff utilization. It is performed by repetitive manual sample pipetting and preparation of reagent master mixes in small vials. Results interpretations are entered manually to a worklist built initially for final verification. These processes increase the risk of ...


Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner 2019 University of Arkansas, Fayetteville

Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner

Industrial Engineering Undergraduate Honors Theses

Tuberculosis is the deadliest infectious disease in the world; it is especially rampant in underdeveloped countries because they do not have the infrastructure, technology, or funding to properly combat the infection. However, the development of portable point-of-care diagnosis machines can reverse this epidemic as they far surpass conventional laboratory identification. The question now is where to place these machines, which is a difficult decision with a lack of data. Therefore, a flexible simulation model is created to test the implementation of these machines with different countries and configurations. The simulation tests the baseline model and three proposed implementations of the ...


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