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Pharmacology, Toxicology and Environmental Health Commons

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Unconventional Energy, Fall/Winter 2015, Issue 31, 2019 University of Louisville

Unconventional Energy, Fall/Winter 2015, Issue 31

Sustain Magazine

No abstract provided.


Carbon Neutral, Spring/Summer 2018, Issue 38, 2019 University of Louisville

Carbon Neutral, Spring/Summer 2018, Issue 38

Sustain Magazine

No abstract provided.


Political Will, Fall/Winter 2018, Issue 37, 2019 University of Louisville

Political Will, Fall/Winter 2018, Issue 37

Sustain Magazine

No abstract provided.


Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression, Rochelle M. Hines, Matthew Khumnark, Ben Macphail, Dustine J. Hines 2019 University of Nevada, Las Vegas

Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression, Rochelle M. Hines, Matthew Khumnark, Ben Macphail, Dustine J. Hines

Psychology Faculty Publications

Route of administration is well-known to impact factors ranging from absorption and distribution, up through the subjective effects of active ingredients. Different routes of administration confer specific advantages, such as more rapid absorption resulting from intravenous injection, or increased convenience with oral administration, but a combination of both rapid and convenient delivery is highly desirable. QuickStrip™ was designed as a rapidly dissolving thin film matrix that contains active ingredients, which may be promising for rapid and convenient delivery via the oral mucosa. To assess the delivery of QuickStrip™, we administered the well-characterized active ingredient caffeine to mice and compared QuickStrip ...


Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin 2019 Technological University Dublin

Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin

Articles

Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma ...


Drug Screening For Discovery Of Broad-Spectrum Agents For Soil-Transmitted Nematodes, Elfawal A. Mostafa, Sergey N. Savinov, Raffi V. Aroian 2019 University of Massachusetts Medical School

Drug Screening For Discovery Of Broad-Spectrum Agents For Soil-Transmitted Nematodes, Elfawal A. Mostafa, Sergey N. Savinov, Raffi V. Aroian

Open Access Articles

Soil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids, are extremely common parasites, infecting 1-2 billion of the poorest people worldwide. Two benzimidazoles, albendazole and mebendazole, are currently used in STN mass drug administration, with many instances of low/reduced activity reported. New drugs against STNs are urgently needed. We tested various models for STN drug screening with the aim of identifying the most effective tactics for the discovery of potent, safe and broad-spectrum agents. We screened a 1280-compound library of approved drugs to completion against late larval/adult stages and egg/larval stages of both the human hookworm parasite Ancylostoma ...


Our Envirome, Spring/Summer 2019, Issue 40, 2019 University of Louisville

Our Envirome, Spring/Summer 2019, Issue 40

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39.3, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39.3

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39.2, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39.2

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39

Sustain Magazine

No abstract provided.


Mechanism For Apobec3g Catalytic Exclusion Of Rna And Non-Substrate Dna, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, Hiroshi Matsuo 2019 University of Minnesota

Mechanism For Apobec3g Catalytic Exclusion Of Rna And Non-Substrate Dna, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, Hiroshi Matsuo

Schiffer Lab Publications

The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recruitment of A3G to the virion; yet, A3G displays no deamination activity for cytidines in viral RNA. Here, we report NMR and molecular dynamics (MD) simulation analysis for interactions between A3Gctd and multiple substrate or non-substrate DNA and RNA, in combination with deamination assays. NMR ssDNA-binding experiments revealed that the interaction with residues in helix1 and loop1 (T201-L220) distinguishes the binding mode of ...


Screening Of Microbial Volatile Organic Compounds For Detection Of Disease In Cattle: Development Of Lab-Scale Method, Devin L. Maurer, Christine K. Ellis, Tyler C. Thacker, Somchai Rice, Jacek A. Koziel, Pauline Nol, Kurt C. VerCauteren 2019 Iowa State University

Screening Of Microbial Volatile Organic Compounds For Detection Of Disease In Cattle: Development Of Lab-Scale Method, Devin L. Maurer, Christine K. Ellis, Tyler C. Thacker, Somchai Rice, Jacek A. Koziel, Pauline Nol, Kurt C. Vercauteren

Agricultural and Biosystems Engineering Publications

The primary hurdle for diagnosis of some diseases is the long incubation required to culture and confirm the presence of bacteria. The concept of using microbial VOCs as “signature markers” could provide a faster and noninvasive diagnosis. Finding biomarkers is challenging due to the specificity required in complex matrices. The objectives of this study were to (1) build/test a lab-scale platform for screening of microbial VOCs and (2) apply it to Mycobacterium avium paratuberculosis; the vaccine strain of M. bovis Bacillus Calmette-Guérin; and M. kansasii to demonstrate detection times greater those typically required for culture. SPME-GC-MS was used for ...


Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner 2019 Purdue University

Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner

The Journal of Purdue Undergraduate Research

No abstract provided.


Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad 2019 Purdue University

Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad

The Journal of Purdue Undergraduate Research

No abstract provided.


Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis 2019 Purdue University

Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis

The Journal of Purdue Undergraduate Research

No abstract provided.


Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski 2019 Purdue University

Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski

The Journal of Purdue Undergraduate Research

No abstract provided.


Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer 2019 Purdue University

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer

The Journal of Purdue Undergraduate Research

No abstract provided.


Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms 2019 Indian Institute of Packaging, Mumbai

Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms

Journal of Applied Packaging Research

Biodegradable polymers (especially those derived from plant sources) begin their lifecycle as renewable resources, usually in the form of starch or cellulose. In this paper, the evaluation of biodegradability of cellulose-based polymer film under controlled composting conditions as per the guidelines of IS/ISO 14855 (Part-1) standard has been described. Microcrystalline cellulose (MCC) powder was taken as positive-control polymer. The apparatus used to analyse the degree and rate of biodegradation was developed indigenously. The validation of the biodegradability testing apparatus was also performed as per the prescribed test method given in IS/ISO 14855-1.


Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas 2019 University of Alberta

Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas

Office of the Provost

In addition to small for gestational age (SGA) and low birth weight at term (LBWT), critically ill cases of SGA/LBWT are significant events from outcomes and economic perspectives that require further understanding of risk factors. We aimed to assess the spatiotemporal distribution of locations where there were consistently higher numbers of critically ill SGA/LBWT (hot spots) in comparison with all SGA/LBWT and all births. We focused on Edmonton (2008-2010) and Calgary (2006-2010), Alberta, and used a geographical information system to apply emerging hot spot analysis, as a new approach for understanding SGA, LBWT, and the critically ill ...


Evaluating The Presence Of The Endocrine Disruptor 4-Nonylphenol In California Glaciers, Jonah Lay 2019 University of Redlands

Evaluating The Presence Of The Endocrine Disruptor 4-Nonylphenol In California Glaciers, Jonah Lay

MS GIS Program Major Individual Projects

The use of GIS in addressing environmental problems is evident in its application to the Sierra Nevada mountain range glaciers in California. The presence of 4-nonylphenol (4NP) in pesticides used in agriculture has led to its accumulation in California glaciers through onshore wind deposition. As an endocrine disruptor, 4NP poses a threat to human health because it can interrupt and alter physiological processes such as human development and metabolism, and lead to ovarian and prostate cancer at higher concentrations. To evaluate the mass of 4NP in the glacier, GIS analysis is conducted with considerations of wind direction, topographic features, and ...


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