Natural Selection On Epas1 (Hif2Α) Associated With Low Hemoglobin Concentration In Tibetan Highlanders, 2010 Case Western Reserve University
Natural Selection On Epas1 (Hif2Α) Associated With Low Hemoglobin Concentration In Tibetan Highlanders, Cynthia M. Beall, Gianpiero L. Cavalleri, Libin Deng, Robert C. Elston, Yang Gao, Jo Knight, Chaohua Li, Jiang Chuan Li, Yu Liang, Mark Mccormack, Hugh E. Montgomery, Hao Pan, Peter A. Robbins, Kevin V. Shianna, Siu Cheung Tam, Ngodup Tsering, Krishna Veeramah, Wei Wang, Puchung Wangdui, Michael E. Weale, Yaomin Xu, Zhe Xu, Ling Yang, M Justin Zaman, Changqing Zeng, Li Zhang, Xianglong Zhang, Pingcuo Zhaxi, Yong Tang Zheng
Molecular and Cellular Therapeutics Articles
By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We employed genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders of the Tibetan Plateau (3200-3500m) with closely related lowland Han revealed a genome-wide significant divergence across eight SNPs located near EPAS1. This gene encodes the transcription factor HIF2α, which stimulates production of red blood cells and thus increases the concentration of hemoglobin in blood. Second, in a separate cohort ...
Poisonous Rangeland Plants In San Luis Obispo County, 2010 California Polytechnic State University - San Luis Obispo
Poisonous Rangeland Plants In San Luis Obispo County, Sara Litten, Amanda Ou
Poisonous Rangeland Plants in San Luis Obispo County is a comprehensive educational guide to rangeland plants that are toxic to domestic livestock. This guide begins with an exploration of how the biological systems are affected by the poisonous plant toxins. The biochemistry behind these toxins is included in the discussion. Next, reference material for fourteen plants that inhabit San Luis Obispo County is provided. This information includes specific toxins found in poisonous plants, affected animals, symptoms of poisoning, stages of growth, lethal dose, and distribution of the plant in California. This section of the guide is filled with helpful photos ...
Analysis Of Anthropogenic Effects On Topsoil Throughout The California Polytechnic State University Campus In San Luis Obispo, 2010 California Polytechnic State University, San Luis Obispo
Analysis Of Anthropogenic Effects On Topsoil Throughout The California Polytechnic State University Campus In San Luis Obispo, Brooke L. Hamilton
Earth and Soil Sciences
Soils reflect the health of a landscape, and in many cases carry the burden of anthropogenic activity, continually changing in characteristics such as pH, soil texture, soil structure, carbon:nitrogen ratios (C:N), and chemical composition. In a study sampling six different soils on the California Polytechnic State University campus in San Luis Obispo, these five soil characteristics were tested for and the results were determined. Soil samples consist of the top 5-10 cm of soil profiles, with sample sites varying according to degree of human contact; the locations the samples were taken from are as follows: (1) Walters Creek ...
Effects Of Atmospheric Non-Thermal Plasma On Invasion Of Colorectal Cancer Cells., 2010 The University of Tennessee
Effects Of Atmospheric Non-Thermal Plasma On Invasion Of Colorectal Cancer Cells., Seung Baek, Chul-Ho Kim, S Kwon, K Lee, S Jun, Philip Rack
Seung J Baek
No abstract provided.
Comparative Transcriptional Study Of The Effects Of High Intracellular Zinc On Prostate Carcinoma Cells, 2010 Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Comparative Transcriptional Study Of The Effects Of High Intracellular Zinc On Prostate Carcinoma Cells, Wong Pooi Fong
Wong Pooi Fong
The normally high concentration of zinc in normal prostate gland is significantly reduced in malignant prostate tissues, but its precise role in prostate tumorigenesis remains unclear. The present study investigates the growth and transcriptional responses of LNCaP prostate cancer cells to prolonged high Zn(2+) treatment. Restoration of high intracellular Zn(2+) to LNCaP cells significantly reduced the cell proliferation rate by 42.2 +/- 7.4% at the exponential growth phase and the efficiency of colony formation on soft agar by 87.2 +/- 2.5% at week 5 post-treatment. At least 161 LNCaP cell genes responded to the high intracellular ...
The C1 Domain In Cancer Signaling Molecules: Regulation By Lipids And Protein-Protein Interactions, 2010 University of Pennsylvania
The C1 Domain In Cancer Signaling Molecules: Regulation By Lipids And Protein-Protein Interactions, Hongbin Wang
Publicly Accessible Penn Dissertations
Cysteine-rich (C1) domains, present in PKC isozymes, Chimaerins, RasGRPs, PKDs, Munc13s, DGKs, and MRCKs, can bind the diacylglycerol (DAG) second messenger. In the present thesis research, I demonstrated that p23/Tmp21 acts as a C1-domain docking protein that mediates perinuclear translocation of beta2-chimaerin. Glu227 and Leu248 in the beta2-chimaerin C1-domain are crucial for binding p23/Tmp21 and perinuclear targeting. Isolated C1-domains from individual PKC isozymes or RasGRP1 differentially interact with p23/Tmp21. PKCepsilon interacts with p23/Tmp21 specifically via its C1b domain, however this association is lost in response to phorbol esters. These results demonstrate that p23/Tmp21 acts as ...
Molecular And Structural Insights Into Nuclear Hormone Receptor Repression Mediated By The Corepressor Ncor, 2010 University of Pennsylvania
Molecular And Structural Insights Into Nuclear Hormone Receptor Repression Mediated By The Corepressor Ncor, Caroline A. Murphy
Publicly Accessible Penn Dissertations
Nuclear hormone receptors comprise a large family of ligand-sensitive transcription factors that can directly bind and regulate target genes to affect various physiological processes including development, differentiation, circadian rhythm and metabolism. Classically, activation of transcription by nuclear receptors (NRs) is due to a ligandinduced switch from corepressor- to coactivator-bound states. Highly analogous corepressors including NCoR and SMRT facilitate repression by NR via recruitment and activation of the histone deacetylase HDAC3. Liver X Receptor (LXR) is an NR that functions to regulate diverse physiological processes including cholesterol metabolism, lipid homeostasis, immunity and inflammation. Selective modulators of LXR to specifically target pathways ...
Improved Plasma Stability And Sustained Release Profile Of Gemcitabine Via Polypeptide Conjugation, 2010 Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Improved Plasma Stability And Sustained Release Profile Of Gemcitabine Via Polypeptide Conjugation, Kiew Lik Voon, Cheong Soon Keng, Khalifah Sidik
Kiew Lik Voon
To enhance the stability of the anticancer drug gemcitabine (2'-deoxy-2',2'-difluorocytidine), it was conjugated to poly-L-glutamic acid (PG-H) via a carbodiimide reaction. The synthesised poly-L-glutamic acid-gemcitabine (PG-G) was purified and characterised by using SDS-PAGE to estimate its molecular weight, HPLC to determine its purity and degree of drug loading, and NMR to elucidate the structure. In vitro aqueous hydrolytic studies showed that the gemcitabine release from the polymeric drug conjugate was pH dependent, and that the conjugation to PG-H improved its stability in human plasma. The release of the bound gemcitabine from PG-G in plasma was mediated by ...
Xenoestrogen-Specific Mechanisms Of Developmental Reprogramming Correlate With Gene Expression And Tumor Development, 2010 University of Texas Graduate School of Biomedical Sciences at Houston
Xenoestrogen-Specific Mechanisms Of Developmental Reprogramming Correlate With Gene Expression And Tumor Development, Kristen L. Greathouse
UT GSBS Dissertations and Theses (Open Access)
Environmental exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental reprogramming. We have shown that neonatal exposure to the xenoestrogen diethylstilbestrol (DES) can developmentally reprogram the reproductive tract in genetically susceptible Eker rats giving rise to complete penetrance of uterine leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the mechanism that is responsible for the developmental reprogramming of gene expression was through ...
The Role Of Camkii Binding Nmdars In Synaptic Plasticity And Memory, 2010 University of Iowa
The Role Of Camkii Binding Nmdars In Synaptic Plasticity And Memory, Robert Francis Dallapiazza
Theses and Dissertations
Our memories are fundamental components of who we are as individuals. They influence almost every aspect of our lives such as our decisions, our personalities, our emotions, and our purpose in life. Diseases that affect memory have devastating impacts on the individuals who bear them. Imagine not being able to recall pleasant memories or even the faces of close family members. It's important to understand the biology of memory formation not only because it's an intriguing scientific question, but because of its consequences when these processes are lost. N-methyl-D-aspartate-type glutamate receptors (NMDARs) and calcium/calmodulin-dependent kinase II (CaMKII ...
Quantifying Legacy Effects Of Managed Disturbance On Sagebrush Steppe Resilience And Diversity, 2010 Utah State University
Quantifying Legacy Effects Of Managed Disturbance On Sagebrush Steppe Resilience And Diversity, Julie Ripplinger
All Graduate Theses and Dissertations
Land-use legacies can affect landscapes for decades to millennia. A long history of shrub management exists in the sagebrush steppe of the Intermountain West where shrub-removal treatments, a type of managed disturbance, have been implemented for over 50 years to reduce sagebrush cover. The assumption behind managed disturbances is that they will increase forage for domestic livestock and improve wildlife habitat. However, the long-term effects of managed disturbance on plant community composition and diversity are not well understood. We investigated the legacy effects of three common types of managed disturbance (chemical, fire, and mechanical treatments) on plant community diversity and ...
Generalized Concentration Addition Predicts Joint Effects Of Aryl Hydrocarbon Receptor Agonists With Partial Agonists And Competitive Antagonists, Gregory J. Howard, Jennifer J. Schlezinger, Mark E. Hahn, Thomas F. Webster
Faculty and Staff Publications By Year
Background: Predicting the expected outcome of a combination exposure is critical to risk assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxinlike chemicals is a special case of the method of concentration addition. However, the TEF method assumes that individual agents are full aryl hydrocarbon receptor (AhR) agonists with parallel dose–response curves, whereas many mixtures include partial agonists.
Objectives: We assessed the ability of generalized concentration addition (GCA) to predict effects of combinations of full AhR agonists with partial agonists or competitive antagonists.
Methods: We measured activation of AhR-dependent gene expression in H1G1.1c3 ...
Effects Of Long-Term Pioglitazone Treatment On Peripheral And Central Markers Of Aging, 2010 University of Kentucky
Effects Of Long-Term Pioglitazone Treatment On Peripheral And Central Markers Of Aging, Eric M. Blalock, Jeremiah T. Phelps, Tristano Pancani, James L. Searcy, Katie L. Anderson, John C. Gant, Jelena Popovic, Margarita G. Avdiushko, Don A. Cohen, Kuey-Chu Chen, Nada M. Porter, Olivier Thibault
Pharmacology and Nutritional Sciences Faculty Publications
BACKGROUND: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. While TZD's actions in AD models help to elucidate the mechanisms underlying their potentially beneficial effects in AD patients, little is known about the functional consequences of TZDs in animal models of normal aging. Because aging is a common risk factor for both ...
Pesticide Safety: A Photonovel, 2010 Western Kentucky University
Pesticide Safety: A Photonovel, M. Susan Jones
M. Susan Jones
No abstract provided.
A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, 2010 Old Dominion University
A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, Jacqueline Florette Jackson
Health Services Research Dissertations
Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern Africa, Egypt, Saudi Arabia, Yemen and Madagascar, proving it to be a virus able to invade ecologically diverse regions (Gaff, 2007). The potential introduction of Rift Valley fever into the United States suggests the potential for human infection and major economic disruption. It is important to understand the role environmental variables have played in historical outbreaks ...
Adaptivearc And The Future Of The Energy Industry, 2010 California Polytechnic State University, San Luis Obispo
Adaptivearc And The Future Of The Energy Industry, Trevor Chase
Earth and Soil Sciences
No abstract provided.
Stem Cells And Germ Cells: Microrna And Gene Expression Signatures, 2010 University of Guelph
Stem Cells And Germ Cells: Microrna And Gene Expression Signatures, Paul Dyce, Derek Toms, Julang Li
Paul W. Dyce
The study of primordial germ cell development in vivo is hampered by their low numbers and inaccessibility. Recent research has shown the ability of embryonic and adult stem cells to differentiate into primordial germ cells and more mature gametes and this generation of germ cells in vitro may be an attractive model for their study. One of the biggest challenges facing in vitro differentiation of stem cells into primordial germ cells is the lack of markers to clearly distinguish the two. As both cell types originate early in embryonic development they share many pluripotent markers such as OCT4, VASA, FRAGILIS ...
The Economics Of Water Utilization: Tools And Applications, 2010 Western Kentucky University
The Economics Of Water Utilization: Tools And Applications, Matt Bogard
Given worldwide problems of access to safe potable water, this presentation examines how tools of economics can aid in drafting appropriate mitigating policies. Utilizing partial equilibrium analysis, it demonstrates the role that prices play in social coordination and then applies the framework to real world examples. In addition it examines Pigouvian Taxation and Coasean Bargaining as two classic methods for dealing with externalities in the context of water pollution. Second-best solutions such as tradable permits and metered pricing by public utilities are discussed. This presentation concludes by examining the issues and challenges that policy makers face when trying to implement ...
Palm Oil Tocotrienol Fractions Restore Endothelium Dependent Relaxation In Aortic Rings Of Streptozotocin-Induced Diabetic And Spontaneously Hypertensive Rats, 2010 Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Palm Oil Tocotrienol Fractions Restore Endothelium Dependent Relaxation In Aortic Rings Of Streptozotocin-Induced Diabetic And Spontaneously Hypertensive Rats, Dharmani Devi A/P Murugan
Dharmani Devi A/P Murugan
Diabetes and hypertension are closely associated with impaired endothelial function. Studies have demonstrated that regular consumption of edible palm oil may reverse endothelial dysfunction. The present study investigates the effect of palm oil fractions: tocotrienol rich fraction (TRF), alpha-tocopherol and refined palm olein (vitamin E free fraction) on the vascular relaxation responses in the aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats (SHR). We hypothesize that the TRF and alpha-tocopherol fractions are able to improve endothelial function in both diabetic and hypertensive rat aortic tissue. A 1,1-diphenyl picryl hydrazyl assay was performed on the various palm oil fractions ...
A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, 2010 Louisiana State Univ. Law Center
A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, Michael J. Malinowski
Michael J. Malinowski
This article addresses the impact of integration of academia, industry, and government on the public nature of research. The article concludes that, while the integration has benefited science immensely, regulatory measures should be taken to restore the public nature of research in an age of integration.