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The Association Between Different Clinical Methods For Evaluating Lower Extremity Muscular Function, Roger Olen Kollock Jr. 2011 Old Dominion University

The Association Between Different Clinical Methods For Evaluating Lower Extremity Muscular Function, Roger Olen Kollock Jr.

Human Movement Sciences Theses & Dissertations

Insufficient muscular strength at the hip and thigh may increase an athlete's susceptibility to lower extremity injuries. In an attempt to reduce this risk, researchers have proposed lower limb strength testing within preparticipation physical examinations (PPE) and return-to-play (RTP) evaluations. However, because of cost, mobility, and or set-up time, some methods are not feasible in certain settings. Since methodological approaches between methods can vary, having different contraction modes and testing parameters, substitution of one method for another may not be valid. Therefore, the purpose of this study is three-fold: a) to determine the association between isometric and isokinetic contraction ...


Magnetic Scanometric Dna Microarray Detection Of Methyl Tertiary Butyl Ether Degrading Bacteria For Environmental Monitoring, Mei-Lin Chan, Gerardo Jaramillo, Krassimira R. Hristova, David A. Horsley 2011 University of California - Davis

Magnetic Scanometric Dna Microarray Detection Of Methyl Tertiary Butyl Ether Degrading Bacteria For Environmental Monitoring, Mei-Lin Chan, Gerardo Jaramillo, Krassimira R. Hristova, David A. Horsley

Biological Sciences Faculty Research and Publications

A magnetoresistive biosensing platform based on a single magnetic tunnel junction (MTJ) scanning probe and DNA microarrays labeled with magnetic particles has been developed to provide an inexpensive, sensitive and reliable detection of DNA. The biosensing platform was demonstrated on a DNA microarray assay for quantifying bacteria capable of degrading methyl tertiary butyl ether (MTBE), where concentrations as low as 10 pM were detectable. Synthetic probe bacterial DNA was immobilized on a microarray glass slide surface, hybridized with the 48 base pair long biotinylated target DNA and subsequently incubated with streptavidin-coated 2.8 μm diameter magnetic particles. The biosensing platform ...


A Field Evaluation Of A Trap For Invasive American Bullfrogs, Nathan P. Snow, Gary W. Witmer 2011 Michigan State University

A Field Evaluation Of A Trap For Invasive American Bullfrogs, Nathan P. Snow, Gary W. Witmer

USDA National Wildlife Research Center - Staff Publications

Native to the eastern United States, American bullfrogs (Rana catesbeiana [Lithobates catesbeianus]) have been introduced in many countries throughout the world. There have been relatively few effective and efficient control methods developed to manage bullfrogs. Particularly in the Hawaiian Islands, Pacific coast of North America, and Japan, finding effective methods for controlling invasive bullfrogs is needed with special emphasis on low impacts for sensitive native species. We conducted a field study to examine the efficacy of a newly designed live trap for capturing invasive bullfrogs. We found that our trap was successful at capturing bullfrogs because we captured up to ...


The Effects Of Seagrass Species And Trophic Interactions In Experimental Seagrass Communities, Althea F. P. Moore 2011 College of William and Mary - Virginia Institute of Marine Science

The Effects Of Seagrass Species And Trophic Interactions In Experimental Seagrass Communities, Althea F. P. Moore

Dissertations, Theses, and Masters Projects

No abstract provided.


Understanding The Origins, Dispersal, And Evolution Of Bonamia Species (Phylum Haplosporidia) Based On Genetic Analyses Of Ribosomal Rna Gene Regions, Kristina M. Hill 2011 College of William and Mary - Virginia Institute of Marine Science

Understanding The Origins, Dispersal, And Evolution Of Bonamia Species (Phylum Haplosporidia) Based On Genetic Analyses Of Ribosomal Rna Gene Regions, Kristina M. Hill

Dissertations, Theses, and Masters Projects

No abstract provided.


Basic Concepts In Forest Valuation And Investment Analysis: Edition 3.0, Steven H. Bullard, Thomas J. Straka 2011 Stephen F. Austin State University, Arthur Temple College of Forestry and Agriculture

Basic Concepts In Forest Valuation And Investment Analysis: Edition 3.0, Steven H. Bullard, Thomas J. Straka

Faculty Publications

This book was originally intended to supplement lectures in forestry economics at the undergraduate level. It’s currently used for that purpose in ‘Forest Resource Economics’ courses at several universities. The book is also intended, however, to serve as a basic reference for foresters with experience in valuation and investment analysis concepts and methods. It has proven to be a valuable resource in forest valuation and investment analysis workshops for practicing foresters, landowners, and others interested in forestry investments.


Deep-Pelagic (0-3000m) Fish Assemblage Structure Over The Mid-Atlantic Ridge In The Area Of The Charlie-Gibbs Fracture Zone, April B. Cook 2011 College of William and Mary - Virginia Institute of Marine Science

Deep-Pelagic (0-3000m) Fish Assemblage Structure Over The Mid-Atlantic Ridge In The Area Of The Charlie-Gibbs Fracture Zone, April B. Cook

Dissertations, Theses, and Masters Projects

Only a miniscule fraction of the world’s largest volume of living space, the ocean’s mid-water biome, has ever been sampled. As part of the International Census of Marine Life field project Mid-Atlantic Ridge Ecosystems (MAR-ECO), a discrete-depth trawling survey was conducted in 2009 aboard the NOAA ship Henry B. Bigelow to examine the pelagic faunal assemblage structure and distribution over the Charlie-Gibbs Fracture Zone (CGFZ) of the northern Mid-Atlantic Ridge. This is the first MAR-ECO project aimed specifically at describing diel vertical migration as a distributional phenomenon. Discrete-depth sampling from 0-3000 m was conducted during both day and ...


Searching For The Seed Plant Ethylene Pathway In A Basal Plant Lineage: A Genomic Approach, Ashley R. DeCarme 2011 College of William & Mary - Arts & Sciences

Searching For The Seed Plant Ethylene Pathway In A Basal Plant Lineage: A Genomic Approach, Ashley R. Decarme

Dissertations, Theses, and Masters Projects

No abstract provided.


A Landscape Perspective On Bird Beak Deformity: An Epizootic Of Unknown Etiology, Rachelle McLaughlin, Shaily Menon 2011 Grand Valley State University

A Landscape Perspective On Bird Beak Deformity: An Epizootic Of Unknown Etiology, Rachelle Mclaughlin, Shaily Menon

Student Summer Scholars Manuscripts

Although birds with beak deformities have been documented throughout the literature, the recent spike in occurrences in certain regions has caused concern in the scientific community. A major concern relates to the role of contaminants and environmental degradation in causing or exacerbating this epizootic. This study used spatial and statistical analyses to examine the problem from a landscape perspective. The objectives of this study were to 1) locate and compile a database of known bird beak occurrences, 2) conduct a preliminary assessment of the environmental correlates of this epizootic in order to identify patterns, and 3) make recommendations that could ...


Collagen Matrices As An Improved Model For In Vitro Study Of Live Cells Using Raman Microspectroscopy, Franck Bonnier, Peter Knief, Aidan Meade, Jennifer Dorney, Kunal Bhattacharya, Fiona Lyng, Hugh Byrne 2011 Technological University Dublin

Collagen Matrices As An Improved Model For In Vitro Study Of Live Cells Using Raman Microspectroscopy, Franck Bonnier, Peter Knief, Aidan Meade, Jennifer Dorney, Kunal Bhattacharya, Fiona Lyng, Hugh Byrne

Conference papers

Due to its high lateral resolution, Raman microspectrsocopy is rapidly becoming an accepted technique for the subcellular imaging of single cells. Although the potential of the technique has frequently been demonstrated, many improvements have still to be realised to enhance the relevancy of the data collected. Although often employed, chemical fixation of cells can cause modifications to the molecular composition and therefore influence the observations made. However, the weak contribution of water to Raman spectra offers the potential to study live cells cultured in vitro using an immersion lens, giving the possibility to record highly specific spectra from cells in ...


Collagen Binding Proteins In Helicobacter Pylori, Carmel Cremin 2011 Technological University Dublin

Collagen Binding Proteins In Helicobacter Pylori, Carmel Cremin

Masters

Helicobacter pylori is a human pathogen and the causative agent of chronic gastritis, peptic ulcer and gastric malignancies. A number of H. pylori virulence factors have been described including, CagA, VacA, neutrophil activating protein, and expression of receptors for binding to extracellular matrix proteins (adhesins). H. pylori interacts with extracellular matrix (ECM) proteins such as collagen IV, laminin, vitronectin and fibronectin, that can be exposed due to loss of integrity of the gastric epithelial cell layer. These interactions may be important in the pathogenesis of the organism. This study examines the interaction of H. pylori with collagen IV in an ...


Role Of Vascular Endothelial Growth Factor, Placental Growth Factor And Cytokines On Outer Blood Retinal Barrier Breakdown., Sangeetha Sukumaran 2011 Technological University Dublin

Role Of Vascular Endothelial Growth Factor, Placental Growth Factor And Cytokines On Outer Blood Retinal Barrier Breakdown., Sangeetha Sukumaran

Masters

The aim of this thesis was to investigate the effect of the VEGF family of growth factors and
cytokines TNF- α and IL-1β on oBRB function. The human RPE line ARPE-19 was
employed as an in vitro model of the oBRB. Two-Dimensional gel electrophoresis was
employed to study the effect of growth factors on the RPE proteome. The barrier properties of
the oBRB were evaluated by expression of the TJ proteins occludin or Zo-1, or claudins-1, 2,
3 and 4, determined by western blotting analysis. Claudins 2, 3 and 4 were found to be
significantly up-regulated by TNF-α, while interleukin ...


Application Of Response Surface Methodology For Studying The Influence Of Hydrothermal Processing On The Phytochemical Constituents Of Irish Edible Brown Seaweed, Sabrina Cox 2011 Technological University Dublin

Application Of Response Surface Methodology For Studying The Influence Of Hydrothermal Processing On The Phytochemical Constituents Of Irish Edible Brown Seaweed, Sabrina Cox

Articles

We used response surface methodology to investigate the effect of time and temperature of hydrothermal processing (blanching) on the phytochemical content, texture and colour of a semi-dried brown seaweed ( Himanthalia elongata ). A central composite design was employed with a hydrothermal processing time of 10 – 30 min and temperature of 60 – 90 ° C. Predicted models were found to be signifi cant for total phenolic content, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, total fl avonoids, total condensed tannins, texture and colour. The predicted values for each of the responses were in good agreement with experimental values. Processing time had the most signifi cant ...


The Effect Of Untreated And Enzyme-Treated Commercial Dairy Powders On The Growth And Adhesion Of Streptococcus Mutans, Rachel Halpin, D.B. Brady, E.D. O’Riordan, M. O’Sullivan 2011 Technological University Dublin

The Effect Of Untreated And Enzyme-Treated Commercial Dairy Powders On The Growth And Adhesion Of Streptococcus Mutans, Rachel Halpin, D.B. Brady, E.D. O’Riordan, M. O’Sullivan

Articles

Dental caries is a common bacterial infection, but the progression of this disease can be delayed by preventing initial attachment of cariogenic bacteria such as Streptococcus mutans to tooth surfaces. This study firstly compares the effect of untreated (UT) and enzyme-treated (ET) dairy powders on the adherence of S. mutans to hydroxylapatite (HA), an analogue of tooth enamel. A fluorescence-based method was used to quantify adherence of S. mutans to HA both in the presence (S-HA) and absence (PBS-HA) of saliva. Secondly, binding of proteins present in the test materials to HA was quantified using bicinchonic acid assays and SDS-PAGE ...


Synthesis, Evaluation And Structural Studies Of Antiproliferative Tubulin-Targeting Azetidin-2-Ones, Niamh O'Boyle, Lisa M. Greene, Orla Bergin, Jean-Baptiste Fichet, Thomas McCabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan 2011 Technological University Dublin

Synthesis, Evaluation And Structural Studies Of Antiproliferative Tubulin-Targeting Azetidin-2-Ones, Niamh O'Boyle, Lisa M. Greene, Orla Bergin, Jean-Baptiste Fichet, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan

Articles

A series of azetidin-2-ones substituted at positions 2, 3 and 4 of the azetidinone ring scaffold were synthesised and evaluated for antiproliferative, cytotoxic and tubulin binding activity. In these compounds, the cis double bond of the vascular targeting agent combretastatin A-4 is replaced with the azetidinone ring in order to enhance the antiproliferative effects displayed by combretastatin A-4 and prevent the cis/trans isomerization that is associated with inactivation of combretastatin A-4. The series of azetidinones was synthetically accessible via the Staudinger and Reformatsky reactions. Of a diverse range of heterocyclic derivatives, 3-(2-thienyl) analogue 28 and 3-(3-thienyl) analogue ...


Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Niall O. Keely, Andrew JS Knox, Thomas McCabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan 2011 Technological University Dublin

Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Niall O. Keely, Andrew Js Knox, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan

Articles

The structure-activity relationships of antiproliferative β-lactams, focusing on modifications at the 4-position of the β-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger and Reformatsky reactions. The antiproliferative activity was assessed in MCF-7 cells, where the 4-(4-ethoxy)phenyl substituted compound 26 displayed the most potent activity with an IC50 value of 0.22 μM. The mechanism of action was demonstrated to be by inhibition of tubulin. Cell exposure to combretastatin A-4 and 26 led to arrest of MCF-7 cells in the G2/M phase of the cell cycle and induction of apoptosis ...


Nano-Enhanced Food Contact Materials And The In Vitro Toxicity To Human Intestinal Cells Of Nano-Zno At Low Dose, Gordon Chambers, Niall Ó Claonadh, Alan Casey, Clement Higginbotham, Sean Lyons, Sanchali Mukherjee 2011 Technological University Dublin

Nano-Enhanced Food Contact Materials And The In Vitro Toxicity To Human Intestinal Cells Of Nano-Zno At Low Dose, Gordon Chambers, Niall Ó Claonadh, Alan Casey, Clement Higginbotham, Sean Lyons, Sanchali Mukherjee

Articles

Nano Zinc Oxide (nZnO) has been shown to display antimicrobial effects which have lead to its application in a number of areas such as antimicrobial surface coatings, anti bacterial wound dressings and more recently in polymer composite systems for use in food contact materials. Concerns have been raised due to the incorporation of nanoparticles in food packaging stemming from the possibility of repeated low dose direct exposure, through ingestion, primarily due to degradation and nanoparticle leaching from the polymer composite. To address these concerns, composites consisting of nZnO and polyethylene were formed using twin screw extrusion to mimic commercial methods ...


Modelling The Effect Of Asparaginase In Reducing Acrylamide Formation In Biscuits, Monica Anese, Barbara Quarta, Jesus Maria Frias 2011 University of Udine

Modelling The Effect Of Asparaginase In Reducing Acrylamide Formation In Biscuits, Monica Anese, Barbara Quarta, Jesus Maria Frias

Articles

The influence of asparaginase on acrylamide formation, as well as colour development, in short dough biscuits was studied. In particular, asparaginase concentration, incubation time and temperature were changed according to an experimental design. As acrylamide formation was found to vary significantly between biscuits obtained by using the same ingredients and process, a mixed effect model was used to model variation of acrylamide concentration. By contrast a fixed effect model was used for colour polynomial analysis. Within the range of study, the overall results allowed the best conditions for minimising acrylamide formation to be found. It can be suggested that acrylamide ...


Application Of Principal Component And Hierarchical Cluster Analysis To Classify Different Spices Based On In Vitro Antioxidant Activity And Individual Polyphenolic Antioxidant Compounds, M. Hossain, A. Patras, Catherine Barry-Ryan, Ana Belen Martin-Diana, N. Brunton 2011 Technological University Dublin

Application Of Principal Component And Hierarchical Cluster Analysis To Classify Different Spices Based On In Vitro Antioxidant Activity And Individual Polyphenolic Antioxidant Compounds, M. Hossain, A. Patras, Catherine Barry-Ryan, Ana Belen Martin-Diana, N. Brunton

Articles

This study investigated the variations in antioxidant profiles between spices using pattern recognition tools; classification was achieved based on the results of global antioxidant activity assays (2,2-diphenyl-1-picrylhydrazyl [DPPH], oxygen radical absorbance capacity [ORAC], ferric reducing antioxidant power [FRAP], microsomal lipid peroxidation [MLP] and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) [ABTS]), levels of different polyphenolic compounds (gallic acid [GA], carnosol [CAR], carnosic acid [CRA], caffeic acid [CA], rosmarinic acid [RA], luteolin-7-O-glucoside [LOG], apigenin-7-O-glucoside [APOG] and total phenols [TP]) of spices namely rosemary, oregano, marjoram, sage, basil, thyme, fennel, celery, cumin and parsley, commonly consumed in Ireland were analyzed. Rosemary showed the ...


Phenolic Composition, Antioxidant Capacity And Antibacterial Activity Of Selected Irish Brassica Vegetables, Amit Jaiswal, Gaurav Rajauria, Nissreen Abu-Ghannam, Shilpi Gupta 2011 Technological University Dublin

Phenolic Composition, Antioxidant Capacity And Antibacterial Activity Of Selected Irish Brassica Vegetables, Amit Jaiswal, Gaurav Rajauria, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

Vegetables belonging to the Brassicaceae family are rich in polyphenols, flavonoids and glucosinolates, and their hydrolysis products, which may have antibacterial, antioxidant and anticancer properties. In the present study, phenolic composition, antibacterial activity and antioxidant capacity of selected Brassica vegetables, including York cabbage, Brussels sprouts, broccoli and white cabbage were evaluated after extraction with aqueous methanol. Results obtained showed that York cabbage extract had the highest total phenolic content, which was 33.5, followed by 23.6, 20.4 and 18.4 mg GAE/g of dried weight (dw) of the extracts for broccoli, Brussels sprouts and white cabbage, respectively ...


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