Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

206,554 Full-Text Articles 255,735 Authors 37,629,645 Downloads 413 Institutions

All Articles in Life Sciences

Faceted Search

206,554 full-text articles. Page 3 of 5269.

Health Behaviors Of Athletic Trainers, Zachary K. Winkelmann, Maura E. Shea, Kelcey C. Granger, Lindsey E. Eberman, Kenneth E. Games 2019 University of South Carolina

Health Behaviors Of Athletic Trainers, Zachary K. Winkelmann, Maura E. Shea, Kelcey C. Granger, Lindsey E. Eberman, Kenneth E. Games

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Purpose: Health behaviors, such as diet, tobacco, and physical activity, may serve to prevent disease and promote wellness throughout the population including athletic trainers (AT). Good health behaviors act as disease prevention measures to decrease prevalence of pathologies. Hours of sleep, substance use, nutritional intake, and physical activity are behaviors that may impact the health of athletic trainers (AT). The objective of the study was to describe health behaviors of ATs in comparison to the general population and recommended behaviors. Methods: We used a cross-sectional, web-based survey of clinically practicing ATs recruited from the National Athletic Trainers’ Association member database ...


Determining The Effectiveness Of Core Strengthening Exercise Therapies In Treating Nonspecific Low Back Pain: A Critically Appraised Topic, Amanda King, Andrea Cripps 2019 Bowling Green State University

Determining The Effectiveness Of Core Strengthening Exercise Therapies In Treating Nonspecific Low Back Pain: A Critically Appraised Topic, Amanda King, Andrea Cripps

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO: Nonspecific low back pain is a condition which impacts athletes of all calibers and sports. It has been found that a total of 68% of top athletes from multiple sports have been affected by nonspecific low back pain at some point in their career. Clinicians have discussed that tight hamstrings and weak core muscles are a major cause of nonspecific low back pain. A myriad of program exist to reduce nonspecific low back pain caused from hamstring tightness, however a standardized rehabilitation protocol for strengthening the core muscles to reduce nonspecific low back pain is not as well ...


Bmp Signaling Mediates Glioma Stem Cell Quiescence And Confers Treatment Resistance In Glioblastoma., Rohit Sachdeva, Megan Wu, Kevin C Johnson, Hyunsoo Kim, Angela Celebre, Uswa Shahzad, Maya Srikanth Graham, John A Kessler, Jeffrey Chuang, Jason Karamchandani, Markus Bredel, Roel G W Verhaak, Sunit Das 2019 The Jackson Laboratory

Bmp Signaling Mediates Glioma Stem Cell Quiescence And Confers Treatment Resistance In Glioblastoma., Rohit Sachdeva, Megan Wu, Kevin C Johnson, Hyunsoo Kim, Angela Celebre, Uswa Shahzad, Maya Srikanth Graham, John A Kessler, Jeffrey Chuang, Jason Karamchandani, Markus Bredel, Roel G W Verhaak, Sunit Das

Faculty Research 2019

Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth factor-β (TGF-β) superfamily, which has been found to play an integral role in the maintenance of stem cell homeostasis within multiple stem cell systems, as a mediator of stem-like cells in glioblastoma. We find that BMP and TGF-β signaling define divergent molecular and functional identities in glioblastoma, and mark relatively quiescent and proliferative GSCs, respectively ...


A Belmont Report For Animals?, Hope Ferdowsian, L. Syd M. Johnson, Jane Johnson, Andrew Fenton, Adam Shriver, John Gluck 2019 University of Pennsylvania

A Belmont Report For Animals?, Hope Ferdowsian, L. Syd M. Johnson, Jane Johnson, Andrew Fenton, Adam Shriver, John Gluck

John P. Gluck, PhD

Human and animal research both operate within established standards. In the United States, criticism of the human research environment and recorded abuses of human research subjects served as the impetus for the establishment of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, and the resulting Belmont Report. The Belmont Report established key ethical principles to which human research should adhere: respect for autonomy, obligations to beneficence and justice, and special protections for vulnerable individuals and populations. While current guidelines appropriately aim to protect the individual interests of human participants in research, no similar, comprehensive ...


Patients’ Perception Of Childbirth According To The Delivery Method: The Experience In Our Clinic, Camelia Alexandroaia, Romina-Marina Sima, Oana-Denisa Bălălău, Gabriel-Octavian Olaru, Liana Pleş 2019 Valparaiso University

Patients’ Perception Of Childbirth According To The Delivery Method: The Experience In Our Clinic, Camelia Alexandroaia, Romina-Marina Sima, Oana-Denisa Bălălău, Gabriel-Octavian Olaru, Liana Pleş

Journal of Mind and Medical Sciences

Introduction: The aim of this study is to identify the way in which childbirth in general, and the delivery method in particular, influenced the maternal psychosocial status and the perception upon birth during postpartum. Material and method: We conducted a cohort type 2 prospective study. We included patients who had given birth at “Bucur” Maternity of Hospital “St. John” Bucharest from the 1st of January 2017 until the 1st of January 2018. Results: The majority of the patients (21.05%) who chose to give birth vaginally assigned the maximum degree (10) to the difficulty of birth. The patients who gave ...


What Do Faculties Specializing In Brain And Neural Sciences Think About, And How Do They Approach, Brain-Friendly Teaching-Learning In Iran?, Sahar Ghanbari, Fariba Haghani, Malahat Akbarfahimi 2019 Valparaiso University

What Do Faculties Specializing In Brain And Neural Sciences Think About, And How Do They Approach, Brain-Friendly Teaching-Learning In Iran?, Sahar Ghanbari, Fariba Haghani, Malahat Akbarfahimi

Journal of Mind and Medical Sciences

Objective: to investigate the perspectives and experiences of the faculties specializing in brain and neural sciences regarding brain-friendly teaching-learning in Iran. Methods: 17 faculties from 5 universities were selected by purposive sampling (2018). In-depth semi-structured interviews with directed content analysis were used. Results: 31 sub-subcategories, 10 subcategories, and 4 categories were formed according to the “General teaching model”. “Mentorship” was a newly added category. Conclusions: A neuro-educational approach that consider the roles of the learner’s brain uniqueness, executive function facilitation, and the valence system are important to learning. Such learning can be facilitated through cognitive load considerations, repetition, deep ...


Molecular Phylogeny Implemented In An Introductory Plant Classification Course, Chao Cai, Jo Ann Banks 2019 Purdue University

Molecular Phylogeny Implemented In An Introductory Plant Classification Course, Chao Cai, Jo Ann Banks

Libraries Faculty and Staff Presentations

Plant classification is one of the core components in undergraduate programs related to plant sciences. Traditionally plant classification courses primarily introduce morphology-based taxonomy because of practical needs in the field. However, the publication of new plant classification systems by Angiosperm Phylogeny Group (APG) using molecular phylogeny methods leads to the trends of using molecular evidence (DNA barcode) for plant identification. In our introductory plant classification course, we included a two-week module (lectures and labs) to introduce key concepts and fundamental skills in molecular phylogeny. Week 1 included concepts of evolutionary tree thinking, data mining in NCBI using BLAST search, and ...


The Land Of Meat And Potatoes? Exploring Ireland’S Vegan And Vegetarian Foodscape, Corey Lee Wrenn 2019 University of Kent at Canterbury

The Land Of Meat And Potatoes? Exploring Ireland’S Vegan And Vegetarian Foodscape, Corey Lee Wrenn

Corey Lee Wrenn, PhD

While it would not be accurate to suggest that Ireland is a hub of veganism or vegetarianism, too often it is written off as inherently unsympathetic to the ethics of plant-based eating and anti-speciesist politics. While it is true that Irish culture is historically tied to speciesism and its economy is especially dependent upon “meat” and dairy production, Ireland’s relationship with other animals is complex and sometimes forgiving. This essay seeks to bring shape to the Irish vegan ethic, one that can be traced along its history of animism, agrarianism, ascendency, adaptation, and activism. From its pagan roots to ...


Loss Of Scribble Confers Cisplatin Resistance During Nsclc Chemotherapy Via Nox2/Ros And Nrf2/Pd-L1 Signaling, Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li Ph.D., Jingya Zhao, Xin Zhang, Lixing Zhan 2019 Molloy College

Loss Of Scribble Confers Cisplatin Resistance During Nsclc Chemotherapy Via Nox2/Ros And Nrf2/Pd-L1 Signaling, Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li Ph.D., Jingya Zhao, Xin Zhang, Lixing Zhan

Li Li

Background: Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it is unknown whether and how Scribble is involved in the cisplatin-related cell death and the underlying mechanism of Scribble in response to chemotherapies and in the process of oxidative stress in NSCLC. Methods: We used two independent cohorts of NSCLC samples derived from patients treated with platinumcontaining chemotherapy and xenograft modeling in vivo. We analyzed the correlation between Scribble and Nox2 or Nrf2/PD-L1 both ...


The Question Of Animal Awareness, Francoise Wemelsfelder 2019 Instituut voor Theoretische Biologie

The Question Of Animal Awareness, Francoise Wemelsfelder

Françoise Wemelsfelder, PhD

The problem of animal awareness lies at the interface of science and philosophy. As a starting point for the study of phenomena such as awareness, mind, consciousness, etc., we hardly have any reference other than our own human experience and in the context of a nondualistic ontology this can be justified. In philosophy and psychology it appears to be very difficult to give direct operational definitions of terms such as consciousness, etc. So we might expect this to be even more difficult in the study of animals. A detailed knowledge of animals and their behaviour is necessary in order to ...


Animal Boredom: Is A Scientific Study Of The Subjective Experiences Of Animals Possible?, Françoise Wemelsfelder 2019 Instituut voor Theoretische Biologie

Animal Boredom: Is A Scientific Study Of The Subjective Experiences Of Animals Possible?, Françoise Wemelsfelder

Françoise Wemelsfelder, PhD

The aim of this paper is to explore the relationship between different meta-scientific frameworks and the science of animal welfare. Animal Boredom 117 During the past few years, I have become more and more convinced that the great difficulty science has in studying subjective experience in its objects, might be related to the denial of any role to subjective experience in the observer as an interpretational guide. Can a quality in the world around us be observed, when this same quality is deliberately excluded from the process of observing?

As a practical example for the discussion described above, the phenomenon ...


Xenobiotics, Toxic Compounds, Mutagens And Carcinogens Substances. Classification And Regulatory Challenges. Ksenobiotyki, Substancje Toksyczne, Mutagenne I Kancerogenne. Klasyfikacja I Aspekty Prawne, Zbigniew Dobrzański, Bogusław Buszewski, Sebastian Opaliński, Roman Kołacz, Jacek A. Koziel 2019 Uniwersytet Przyrodniczy we Wrocławiu

Xenobiotics, Toxic Compounds, Mutagens And Carcinogens Substances. Classification And Regulatory Challenges. Ksenobiotyki, Substancje Toksyczne, Mutagenne I Kancerogenne. Klasyfikacja I Aspekty Prawne, Zbigniew Dobrzański, Bogusław Buszewski, Sebastian Opaliński, Roman Kołacz, Jacek A. Koziel

Jacek A. Koziel

A review, with. 54 refs., of legal aspects of using chem. substances in the environment and foods.

Dokonano przeglądu literatury naukowej i omówiono akty prawne dotyczące ksenobiotyków, substancji toksycznych, mutagennych i kancerogennych. Podano klasyfikacje tych substancji wg ECHA (UE), IARC (WHO) oraz ATSDR i OSHA (USA). Przytoczono liczne akty prawne (dyrektywy, ustawy, rozporządzenia) dotyczące rejestracji, oceny, udzielania zezwoleń i stosowanych ograniczeń w zakresie chemikaliów (REACH) i utworzenia Europejskiej Agencji Chemikaliów, w sprawie wprowadzania klasyfikacji, oznakowania i pakowania substancji i mieszanin chemicznych (CLP). Omówiono problematykę substancji chemicznych, ich mieszanin oraz czynników lub procesów technologicznych o działaniu rakotwórczym lub mutagennym w środowisku ...


Description Of The Adult Female Of Diplocentrus Lachua (Scorpiones: Scorpionidae: Diplocentrinae) From Northeastern Alta Verapaz, Guatemala, Rony E. Trujillo, Luis F. de Armas, Carlos A. Gaitán 2019 Marshall University

Description Of The Adult Female Of Diplocentrus Lachua (Scorpiones: Scorpionidae: Diplocentrinae) From Northeastern Alta Verapaz, Guatemala, Rony E. Trujillo, Luis F. De Armas, Carlos A. Gaitán

Euscorpius

The female of the scorpion Diplocentrus lachua Armas, Trujillo & Agreda, 2011 is herein described, on the basis of a single specimen collected at Parque Nacional Laguna Lachuá, Alta Verapaz Department, Guatemala, type locality for this species. An emended diagnosis is provided and the known distribution of all described Guatemalan Diplocentrus species is graphically presented.


Progress Report Ii: Fabrication Of Nanopores In Silicon Nitride Membrane Using Self-Assembly Of Ps-B-Pmma: Nanopore Pattern Transfer To The Si Substrate, Kodai Watanabe, Unnati Joshi, Hiromichi Yamamoto 2019 Hokkaido University

Progress Report Ii: Fabrication Of Nanopores In Silicon Nitride Membrane Using Self-Assembly Of Ps-B-Pmma: Nanopore Pattern Transfer To The Si Substrate, Kodai Watanabe, Unnati Joshi, Hiromichi Yamamoto

Protocols and Reports

The asymmetric PS(46k)-b-PMMA(21k) film was spin-coated on a neutral brush layer grafted onto a Spin-On-Glass (SOG) layer on the aluminum oxide layer on a Si substrate. An aluminum oxide layer was used as a hard mask. The PS-b-PMMA film was annealed at 190 degree C under vacuum for 3 days, so that the ~20 nm diameter nanopores in the film was successfully prepared as a result of self-assembly. The nanopores in the PS-b-PMMA film were able to be transferred to the Si substrate by CF4 etching through the SOG and aluminum oxide layers, although the etching was ...


Early-Life Dna Methylation Profiles Are Indicative Of Age-Related Transcriptome Changes., Niran Hadad, Dustin R Masser, Laura Blanco-Berdugo, David R Stanford, Willard M Freeman 2019 The Jackson Laboratory

Early-Life Dna Methylation Profiles Are Indicative Of Age-Related Transcriptome Changes., Niran Hadad, Dustin R Masser, Laura Blanco-Berdugo, David R Stanford, Willard M Freeman

Faculty Research 2019

BACKGROUND: Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prevented by anti-aging interventions, but the relationship of altered methylation to gene expression is poorly understood.

RESULTS: Paired analysis of the hippocampal methylome and transcriptome with aging of male and female mice demonstrates that age-related differences in methylation and gene expression are anti-correlated within gene bodies and enhancers. Altered promoter methylation with aging was found to be generally un-related to ...


Panel 3 Paper 3.2: Nature, Agriculture And Rural Resilience: Interdependencies Between Natural Protected Areas And Rural Landscapes In Satoyama/Satoumi In Japan, Maya N. Ishizawa 2019 University of Tsukuba

Panel 3 Paper 3.2: Nature, Agriculture And Rural Resilience: Interdependencies Between Natural Protected Areas And Rural Landscapes In Satoyama/Satoumi In Japan, Maya N. Ishizawa

Rural Heritage - Landscapes and Beyond / PATRIMOINE RURAL: Paysages et au-delà

The Capacity Building Workshops on Nature-Culture Linkages in Heritage Conservation (CBWNCL), held at the University of Tsukuba in Japan, gather Asia-Pacific heritage professionals with the aim of creating a platform of mutual-learning and exchange between the culture and nature sectors. In the first workshop on Agricultural Landscapes, from 14 case studies, 5 showed natural protected areas in tense relations with their rural landscape surroundings. However, these agricultural landscapes are essential for protecting natural values, as they form part of their larger ecosystems. In the second workshop on Sacred Landscapes, from 16 case studies, 5 case studies were also agricultural landscapes ...


Incorporating New Technologies Into Toxicity Testing And Risk Assessment: Moving From 21st Century Vision To A Data-Driven Framework, Russell S. Thomas, Martin A. Philbert, Scott Auerbach, Barbara A. Wetmore, Michael J. Devito, Ila Cote, J. Craig Rowlands, Maurice Whelan, Sean M. Hays, Melvin E. Andersen, M.E. (Bette) Meek, Lawrence W. Reiter, Jason C. Lambert, Harvey J. Clewell III, Martin L. Stephens, Q. Jay Zhao, Scott C. Wesselkamper, Lynn Flowers, Edward W. Carney, Tim P. Pastoor, Dan D. Petersen, Carole L. Yauk, Andy Nong 2019 The Hamner Institutes for Health Sciences

Incorporating New Technologies Into Toxicity Testing And Risk Assessment: Moving From 21st Century Vision To A Data-Driven Framework, Russell S. Thomas, Martin A. Philbert, Scott Auerbach, Barbara A. Wetmore, Michael J. Devito, Ila Cote, J. Craig Rowlands, Maurice Whelan, Sean M. Hays, Melvin E. Andersen, M.E. (Bette) Meek, Lawrence W. Reiter, Jason C. Lambert, Harvey J. Clewell Iii, Martin L. Stephens, Q. Jay Zhao, Scott C. Wesselkamper, Lynn Flowers, Edward W. Carney, Tim P. Pastoor, Dan D. Petersen, Carole L. Yauk, Andy Nong

Martin Stephens, PhD

Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into a data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric. The first tier of the framework integrates data from high-throughput in vitro assays, in vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, and exposure modeling. The in vitro assays are used to separate chemicals based on their relative selectivity in interacting with biological targets and identify the concentration at which these interactions ...


Evidence-Based Toxicology For The 21st Century: Opportunities And Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle III, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo 2019 Johns Hopkins University

Evidence-Based Toxicology For The 21st Century: Opportunities And Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle Iii, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo

Martin Stephens, PhD

The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on “Evidence-based Toxicology for the 21st Century: Opportunities and Challenges” in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathwaybased testing methods consistent with the 2007 National Research Council report on “Toxicity Testing in the 21st Century” as well as to adopt a governance structure and work processes to move that ...


Beyond The 3rs: Expanding The Use Of Human-Relevant Replacement Methods In Biomedical Research, Kathrin Herrmann, Francesca Pistollato, Martin L. Stephens 2019 Johns Hopkins Bloomberg School of Public Health

Beyond The 3rs: Expanding The Use Of Human-Relevant Replacement Methods In Biomedical Research, Kathrin Herrmann, Francesca Pistollato, Martin L. Stephens

Martin Stephens, PhD

This year marks the 60th anniversary of Russell and Burch’s pioneering book, The Principles of Humane Experimental Technique. Their 3Rs framework has helped to inspire humane and scientific progress in experimental technique. However, it is time to update its strategic application. The 21st century has already seen the development of promising, high-tech non-animal models, such as organs-on-a-chip and computational approaches that, in our view, will replace animals as the default option in biomedical experimentation. How fast this transition will take place will depend on the pace at which these new models are optimized to reflect the biology of humans ...


Adaptation Of The Systematic Review Framework To The Assessment Of Toxicological Test Methods: Challenges And Lessons Learned With The Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob de Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun 2019 Johns Hopkins Bloomberg School of Public Health

Adaptation Of The Systematic Review Framework To The Assessment Of Toxicological Test Methods: Challenges And Lessons Learned With The Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob De Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun

Martin Stephens, PhD

Systematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant scientific evidence. This methodology has been used to advantage in clinical medicine, and is being adapted for use in other disciplines. Although some applications to toxicology have been explored, especially for hazard identification, the present preparatory study is, to our knowledge, the first attempt to adapt it to the assessment of toxicological test methods. As our test case, we chose the zebrafish embryotoxicity test (ZET) for developmental toxicity and its mammalian counterpart, the standard mammalian prenatal development toxicity study, focusing the ...


Digital Commons powered by bepress