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848 full-text articles. Page 30 of 33.

Word Find, Allison Marsh 2012 University of South Carolina - Columbia

Word Find, Allison Marsh

Handouts

No abstract provided.


It’S My Body: The Biomedical Ethics Of Cell And Organ Harvest, Christina Perri 2012 Providence College

It’S My Body: The Biomedical Ethics Of Cell And Organ Harvest, Christina Perri

Common Reading Essay Contest Winners

First Place


The Injustice Of Ignorance, Nicholas Tavares 2012 Providence College

The Injustice Of Ignorance, Nicholas Tavares

Common Reading Essay Contest Winners

Third Place (tie)


Pursuing Medawar’S Challenge For Full Replacement, Martin Stephens 2012 The Humane Society of the United States

Pursuing Medawar’S Challenge For Full Replacement, Martin Stephens

Experimentation Collection

In 1969, Nobel Prize-winning scientist Peter Medawar predicted that scientific innovation would someday fully replace the use of animals in biomedical research. Medawar correctly forecast the leveling off and subsequent decline in animal use in the last quarter of the 20th century – a period of remarkable innovation in the life sciences. A 2007 report by the U.S. National Academy of Sciences, Toxicity Testing in the 21st Century, proposed a strategy that is likely to replace all routine animal use in toxicology with innovative methods within one to two decades. Replacing animal use throughout biomedical research is more challenging given ...


Does Immunocontraception In Feral Horses (Equus Caballus) Extend Reproductive Cycling Beyond The Normal Breeding Season?, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein 2012 Virginia Polytechnic Institute and State University

Does Immunocontraception In Feral Horses (Equus Caballus) Extend Reproductive Cycling Beyond The Normal Breeding Season?, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein

Cassandra M.V. Nuñez

Although the physiological effects of immunocontraceptive treatment with porcine zona pellucida (PZP) have been well studied, little is known about PZP’s effects on the scheduling of reproductive cycling. Recent behavioral research has suggested that recipients of PZP extend the receptive breeding period into what is normally the non-breeding season. To determine if this is the case, we compiled foaling data from wild horses (Equus caballus) living on Shackleford Banks, North Carolina for 4 years pre- and 8 years post-contraception management with PZP (pre-contraception, n = 65 births from 45 mares; post-contraception, n = 97 births from 46 mares). Gestation lasts approximately ...


Biology Department Newsletter, No.2, Sacred Heart University 2012 Sacred Heart University

Biology Department Newsletter, No.2, Sacred Heart University

Biology Newsletter

No abstract provided.


A Roadmap For The Development Of Alternative (Non-Animal) Methods For Systemic Toxicity Testing, David Basketter, Harvey Clewell, Ian Kimber, Annamaria Rossi, Bas Blaauboer, Robert Burrier, Mardas Daneshian, Chantra Eskes, Alan Goldberg, Nina Hasiwa, Sebastian Hoffmann, Joanna Jaworska, Thomas B. Knudsen, Robert Landsiedel, Marcel Leist, Paul Locke, Gavin Maxwell, James McKim, Emily McVey, Gladys Ouédraogo, Grace Patlewicz, Olavi Pelkonen, Erwin Roggen, Costanza Rovida, Irmela Ruhdel, Michael Schwarz, Andreas Schepky, Greet Schoeters, Nigel Skinner, Kerstin Trentz, Marian Turner, Philippe Vanparys, James Yager, Joanne Zurlo, Thomas Hartung 2012 DABMEB Consultancy Ltd

A Roadmap For The Development Of Alternative (Non-Animal) Methods For Systemic Toxicity Testing, David Basketter, Harvey Clewell, Ian Kimber, Annamaria Rossi, Bas Blaauboer, Robert Burrier, Mardas Daneshian, Chantra Eskes, Alan Goldberg, Nina Hasiwa, Sebastian Hoffmann, Joanna Jaworska, Thomas B. Knudsen, Robert Landsiedel, Marcel Leist, Paul Locke, Gavin Maxwell, James Mckim, Emily Mcvey, Gladys Ouédraogo, Grace Patlewicz, Olavi Pelkonen, Erwin Roggen, Costanza Rovida, Irmela Ruhdel, Michael Schwarz, Andreas Schepky, Greet Schoeters, Nigel Skinner, Kerstin Trentz, Marian Turner, Philippe Vanparys, James Yager, Joanne Zurlo, Thomas Hartung

Biomedical Research and Alternative Methods Collection

Systemic toxicity testing forms the cornerstone for the safety evaluation of substances. Pressures to move from traditional animal models to novel technologies arise from various concerns, including: the need to evaluate large numbers of previously untested chemicals and new products (such as nanoparticles or cell therapies), the limited predictivity of traditional tests for human health effects, duration and costs of current approaches, and animal welfare considerations. The latter holds especially true in the context of the scheduled 2013 marketing ban on cosmetic ingredients tested for systemic toxicity. Based on a major analysis of the status of alternative methods (Adler et ...


Implementation Of Systematic Reviews In Efsa Scientific Outputs Workflow, Annette M. O'Connor, Gabor Lövei, J. Eales, Geoff K. Frampton, J. Glanville, Andrew S. Pullin, Jan M. Sargeant 2012 Iowa State University

Implementation Of Systematic Reviews In Efsa Scientific Outputs Workflow, Annette M. O'Connor, Gabor Lövei, J. Eales, Geoff K. Frampton, J. Glanville, Andrew S. Pullin, Jan M. Sargeant

Veterinary Diagnostic and Production Animal Medicine Reports

Systematic reviews (SR) are an evidence synthesis approach that provides robust and transparent answers to clearly formulated questions. Originally developed for use in clinical practice, SRs have wider applicability, including food and feed safety risk assessment. EFSA has implemented the use of SRs, and this document contributes to the further development of this in-house capacity. Since the publication of the document “Application of Systematic Review Methodology to Food and Feed Safety Assessments to Support Decision Making”, which mainly focuses on interventions and exposures (PECO/PICO), little has changed in this arena. Fast increasing fields of application include chemical and environmental ...


Detection Of Dichloromethane With A Bioluminescent (Lux) Bacterial Bioreporter, Nicholas Lopes, Shawn Hawkins, Patricia Jegier, Fu-Min Menn, Gary Sayler, Steven Ripp 2011 University of Tennessee - Knoxville

Detection Of Dichloromethane With A Bioluminescent (Lux) Bacterial Bioreporter, Nicholas Lopes, Shawn Hawkins, Patricia Jegier, Fu-Min Menn, Gary Sayler, Steven Ripp

Steven Ripp

The focus of this research effort was to develop an autonomous, inducible, lux-based bioluminescent bioreporter for the real-time detection of dichloromethane. Dichloromethane (DCM), also known as methylene chloride, is a volatile organic compound and one of the most commonly used halogenated solvents in the U.S., with applications ranging from grease and paint stripping to aerosol propellants and pharmaceutical tablet coatings. Predictably, it is released into the environment where it contaminates air and water resources. Due to its classification as a probable human carcinogen, hepatic toxin, and central nervous system effector, DCM must be carefully monitored and controlled. Methods for ...


Biochemical Conversion Of Acid-Pretreated Water Hyacinth (Eichhornia Crassipes) To Alcohol Using Pichia Stipitis Ncim3497, Sandip S. Magdum, Sandeep M. More, Aiyaj A. Nadaf 2011 Pune university

Biochemical Conversion Of Acid-Pretreated Water Hyacinth (Eichhornia Crassipes) To Alcohol Using Pichia Stipitis Ncim3497, Sandip S. Magdum, Sandeep M. More, Aiyaj A. Nadaf

Sandip S. Magdum

Cleaning and removal of water hyacinth from lakes and various historical places government spends lacks of rupees per year. High rate of propagation and easy availability, water-hyacinth could be used as a renewable carbon source for alcohol (fuel ethanol) production. Water-hyacinth’s (Eichhornia crassipes) hemicellulose acid hydrolysate has been utilized as a substrate for alcohol production using Pichia stipitis NCIM3497. Acid hydrolysis were carried out by using (1% v/v) sulfuric acid. Perhydrolysate was detoxified, boiled and overlimed up to pH 10.0 with NaOH to produce acid hydrolysate. Acid hydrolysate had higher fermentability than perhydrolysate. Freshly prepared acid hydrolysate ...


Environmental Issues For The 21st Century And Their Impact On Human Health, Richard B. Philp 2011 University of Western Ontario

Environmental Issues For The 21st Century And Their Impact On Human Health, Richard B. Philp

Richard B. Philp

This book (see contents attached) is now available from the author on CD


Dietary Calcium Induced Cytological And Biochemical Changes In Thyroid, Amar K. Chandra, Haimanti Goswami, Pallav Sengupta 2011 University of Calcutta

Dietary Calcium Induced Cytological And Biochemical Changes In Thyroid, Amar K. Chandra, Haimanti Goswami, Pallav Sengupta

Pallav Sengupta, PhD

Certain epidemiological studies revealed correlation between hard water consumption (with high calcium) and thyroid size of the population, though the possible alterations in thyroid physiology upon calcium exposure are still inconclusive. Adult male Wistar strain rats were subjected to calcium treatment at the doses of 0.5g%, 1.0g% and 1.5g% calcium chloride (CaCl2) for 60 days. The parameters studied were -thyroid gland weight, histopathology, histomorphometry; thyroid peroxidase (TPO), 5'- deiodinase I (DI), sodium-potassium adenosine triphosphatase (Na+-K+-ATPase) activities; serum total and free thyroxine (tT4, fT4), total and free triiodothyronine (tT3, fT3), thyroid stimulating hormone (TSH) levels. Enlargement ...


Hands-On Labs (Hol): Using Technology And Web-Based Resources To Transform A Traditional Lab-Based Biology Course Into A Distance Learning (Dl) Hybrid Course, Across Schools At Pace University., Erica Kipp 2011 Pace University, Dyson College of Arts and Sciences

Hands-On Labs (Hol): Using Technology And Web-Based Resources To Transform A Traditional Lab-Based Biology Course Into A Distance Learning (Dl) Hybrid Course, Across Schools At Pace University., Erica Kipp

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.


Aqueous Micellar Gels Of Multiresponsive Hydrophilic Aba Linear Triblock Copolymers, Jeremiah Wallace Woodcock 2011 University of Tennessee, Knoxville

Aqueous Micellar Gels Of Multiresponsive Hydrophilic Aba Linear Triblock Copolymers, Jeremiah Wallace Woodcock

Doctoral Dissertations

This dissertation presents the synthesis of a series of well-defined multiresponsive hydrophilic ABA linear triblock copolymers and the study of their aqueous micellar gels. By incorporating a small amount of stimuli-responsive groups into thermosensitive outer blocks of ABA triblock copolymers, the lower critical solution temperatures (LCST) of thermosensitive blocks can be modified by external stimuli. Consequently, the sol-gel transition temperatures (Tsol-gel) of their aqueous solutions can be altered.

Chapter 1 describes the synthesis and solution behavior of a series of thermo- and light-sensitive triblock copolymers, poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate)-b-poly(ethylene oxide)-b ...


Harnessing Opportunities In Non-Animal Asthma Research For A 21st-Century Science, Gemma L. Buckland 2011 Humane Society International

Harnessing Opportunities In Non-Animal Asthma Research For A 21st-Century Science, Gemma L. Buckland

Experimentation Collection

The incidence of asthma is on the increase and calls for research are growing, yet asthma is a disease that scientists are still trying to come to grips with. Asthma research has relied heavily on animal use; however, in light of increasingly robust in vitro and computational models and the need to more fully incorporate the ‘Three Rs’ principles of Replacement, Reduction and Refinement, is it time to reassess the asthma research paradigm? Progress in non-animal research techniques is reaching a level where commitment and integration are necessary. Many scientists believe that progress in this field rests on linking disciplines ...


Mcnamara 2011 Mpmicro - Multi-Probe Microscopy (10/31/2011), George McNamara 2011 M.D. Anderson Cancer Center

Mcnamara 2011 Mpmicro - Multi-Probe Microscopy (10/31/2011), George Mcnamara

George McNamara

Multi-Probe Microscopy is an ~1500 page Word document summarizing what I know and/or found interesting in light microscopy, fluorescence microscopy and digital image analysis, from 1995-2005. Very little has been updated since 2005.


Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller 2011 University of Tennessee - Knoxville

Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller

Howard K. Plummer III

Human lung cancer cell lines are widely used to test anticancer drugs. These in-vitro tests, however, preclude the detection of responses to paracrine factors from surrounding stroma. We have cocultured pulmonary fibroblasts CCD-19Lu, from a healthy donor, or HLF-A, from a patient with epidermoid carcinoma of the lung, with two human pulmonary adenocarcinoma cell lines to test the hypothesis that the fibroblasts stimulate the growth of the tumor cells. Both fibroblast cell lines significantly increased the proliferation of the pulmonary adenocarcinoma cell lines in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assays, with HLF-A fibroblasts yielding the most pronounced responses ...


Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer, Madhu Dhar, Maria Cekanova, Hildegard Schuller 2011 University of Tennessee - Knoxville

Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer, Madhu Dhar, Maria Cekanova, Hildegard Schuller

Howard K. Plummer III

BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six ...


Significance Of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer, Amy L. Han 2011 The University of Texas Graduate School of Biomedical Sciences at Houston

Significance Of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer, Amy L. Han

UT GSBS Dissertations and Theses (Open Access)

The progression of hormone responsive to hormone refractory prostate cancer poses a major clinical challenge in the successful treatment of prostate cancer. The hormone refractory prostate cancer cells exhibit resistance not only to castrate levels of testosterone, but also to other therapeutic modalities and hence become lethal. Currently, there is no effective treatment available for managing this cancer. These observations underscore the urgency to investigate mechanism(s) that contribute to the progression of hormone-responsive to hormone-refractory prostate cancer and to target them for improved clinical outcomes.

Tissue transglutaminase (TG2) is a multifunctional pro-inflammatory protein involved in diverse physiological processes such ...


Forward Osmosis Bag: Ground Testing The Prospect Of Using Alternative Water Sources For Drinking Water, Michaela Marie Brant, Ariella Yendler, Mona Hammoudeh, Michael T. Flynn 2011 California Polytechnic State University - San Luis Obispo

Forward Osmosis Bag: Ground Testing The Prospect Of Using Alternative Water Sources For Drinking Water, Michaela Marie Brant, Ariella Yendler, Mona Hammoudeh, Michael T. Flynn

STAR (STEM Teacher and Researcher) Presentations

On the STS-135 Space Shuttle mission, to be launched July 8, 2011, a forward osmosis bag (FOB) study will be conducted. At NASA Ames this summer, the ground truth testing is being conducted for results comparisons. The FOB technology is derived from a commercial product, the X-Pack water filter. Forward osmosis operates by utilizing an established concentration gradient across a semi-permeable membrane to move water molecules from one side of the membrane to the other. This concept is exploited to harvest drinking water from grey water sources such as urine, sea water, or vehicle water. In this experiment, potassium chloride ...


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