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1,255 Full-Text Articles 2,768 Authors 119,135 Downloads 122 Institutions

All Articles in Developmental Biology

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1,255 full-text articles. Page 1 of 49.

Modeling Collective Migration Of Neural Crest Cells With A Cucker-Smale Velocity Alignment Process, Claire Evensen 2019 Illinois State University

Modeling Collective Migration Of Neural Crest Cells With A Cucker-Smale Velocity Alignment Process, Claire Evensen

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, Indrajit Sahu, Padma P. Nanaware, Minal Mane, Saim Wasi Mulla, Soumen Roy, Prasanna Venkatraman 2019 Technion - Israel Institute of Technology

Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, Indrajit Sahu, Padma P. Nanaware, Minal Mane, Saim Wasi Mulla, Soumen Roy, Prasanna Venkatraman

Open Access Articles

PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function remains unknown. To address this issue, we induced PSMD10(Gankyrin) overexpression in HEK293 cells and the resultant large-scale changes in gene expression profile were analyzed. We constituted networks from microarray data of these differentially expressed genes and carried out extensive topological analyses. The overrecurring yet consistent theme that appeared throughout analysis using varied network metrics is that all genes and interactions identified as important would be involved in neurogenesis ...


Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Benard, Michael M. Francis, Michele L. Lemons 2019 University of Massachusetts Medical School

Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Benard, Michael M. Francis, Michele L. Lemons

Open Access Articles

Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show alpha integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of alpha integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination ...


Pax9 Is Required For Cardiovascular Development And Interacts With Tbx1 In The Pharyngeal Endoderm To Control 4(Th) Pharyngeal Arch Artery Morphogenesis, Helen M. Phillips, Rene Maehr, Simon D. Bamforth 2019 Newcastle University

Pax9 Is Required For Cardiovascular Development And Interacts With Tbx1 In The Pharyngeal Endoderm To Control 4(Th) Pharyngeal Arch Artery Morphogenesis, Helen M. Phillips, Rene Maehr, Simon D. Bamforth

Open Access Articles

Developmental defects affecting the heart and aortic arch arteries are a significant phenotype observed in 22q11 deletion syndrome patients and are caused by a microdeletion on chromosome 22q11. TBX1, one of the deleted genes, is expressed throughout the pharyngeal arches and is considered a key gene, when mutated, for the arch artery defects. Pax9 is expressed in the pharyngeal endoderm and is downregulated in Tbx1 mutant mice. We show here that Pax9 deficient mice are born with complex cardiovascular malformations affecting the outflow tract and aortic arch arteries with failure of the 3(rd) and 4(th) pharyngeal arch arteries ...


Tale And Nf-Y Co-Occupancy Marks Enhancers Of Developmental Control Genes During Zygotic Genome Activation In Zebrafish, William J. Stanney III, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, Charles G. Sagerstrom 2019 University of Massachusetts Medical School

Tale And Nf-Y Co-Occupancy Marks Enhancers Of Developmental Control Genes During Zygotic Genome Activation In Zebrafish, William J. Stanney Iii, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, Charles G. Sagerstrom

University of Massachusetts Medical School Faculty Publications

Animal embryogenesis is initiated by maternal factors, but zygotic genome activation (ZGA) shifts control to the embryo at early blastula stages. ZGA is thought to be mediated by specialized maternally deposited transcription factors (TFs), but here we demonstrate that NF-Y and TALE – TFs with known later roles in embryogenesis – co-occupy unique genomic elements at zebrafish ZGA. We show that these elements are selectively associated with early-expressed genes involved in transcriptional regulation and possess enhancer activity in vivo. In contrast, we find that elements individually occupied by either NF-Y or TALE are associated with genes acting later in development – such that ...


Knocking Out A Negative Regulator Of Hedgehog Signaling Blocks Differentiation Of Cells Into Neurons, Danielle Margaret Spice, Gregory M. Kelly Ph.D. 2019 Western University

Knocking Out A Negative Regulator Of Hedgehog Signaling Blocks Differentiation Of Cells Into Neurons, Danielle Margaret Spice, Gregory M. Kelly Ph.D.

Western Research Forum

Hedgehog (Hh) signaling, one of many different protein signaling pathways found in mammals, is vital in many stage of neural development. A major negative regulator of Hh signaling is a protein known as Suppressor of Fused (SUFU), which acts to sequester the full length Gli transcription factors, proteins that can turn genes on and off, in the cytoplasm or facilitates its conversion to a repressive form. The P19 embryonal carcinoma cell line is a model of hind-brain neuronal differentiation and the involvement of Hh signaling, in particular the role of SUFU in this process has yet to be explored. We ...


Smooth Muscle Cell-Specific Tmem16a Deletion Does Not Alter Ca2+ Signaling, Uterine Contraction, Gestation Length Or Litter Size In Micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, Ronghua ZhuGe 2019 University of Massachusetts Medical School

Smooth Muscle Cell-Specific Tmem16a Deletion Does Not Alter Ca2+ Signaling, Uterine Contraction, Gestation Length Or Litter Size In Micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, Ronghua Zhuge

Program in Molecular Medicine Publications and Presentations

Ion channels in myometrial cells play critical roles in spontaneous and agonist-induced uterine contraction during the menstrual cycle, pregnancy maintenance and parturition; thus identifying the genes of ion channels in these cells and determining their roles are essential to understanding the biology of reproduction. Previous studies with in vitro functional and pharmacological approaches have produced controversial results regarding the presence and role of TMEM16A Ca2+-activated Cl- channels in myometrial cells. To unambiguously determine the function of this channel in these cells, we employed a genetic approach by using smooth muscle cell-specific TMEM16A deletion (i.e. TMEM16ASMKO) mice. We found ...


Slit1a Rescue: Role Of Slit1a, Hss1a, Barresi Lab, Smith College 2019 Smith College

Slit1a Rescue: Role Of Slit1a, Hss1a, Barresi Lab, Smith College

Role of slit1a

No abstract provided.


Slit1a Rescue: Role Of Slit1a, Wt, Barresi Lab, Smith College 2019 Smith College

Slit1a Rescue: Role Of Slit1a, Wt, Barresi Lab, Smith College

Role of slit1a

No abstract provided.


Slit1a Rescue: Role Of Slit1a, Non-Hss1ayot, Barresi Lab, Smith College 2019 Smith College

Slit1a Rescue: Role Of Slit1a, Non-Hss1ayot, Barresi Lab, Smith College

Role of slit1a

No abstract provided.


Slit1a Rescue: Role Of Slit1a, Hss1ayot, Barresi Lab, Smith College 2019 Smith College

Slit1a Rescue: Role Of Slit1a, Hss1ayot, Barresi Lab, Smith College

Role of slit1a

No abstract provided.


Glial Bridge Development: 24 Hpf, Barresi Lab, Smith College 2019 Smith College

Glial Bridge Development: 24 Hpf, Barresi Lab, Smith College

Glial Bridge

No abstract provided.


Glial Bridge Development: 22 Hpf, Barresi Lab, Smith College 2019 Smith College

Glial Bridge Development: 22 Hpf, Barresi Lab, Smith College

Glial Bridge

No abstract provided.


Glial Bridge Development: 28 Hpf, Barresi Lab, Smith College 2019 Smith College

Glial Bridge Development: 28 Hpf, Barresi Lab, Smith College

Glial Bridge

No abstract provided.


Glial Bridge Development: 26 Hpf, Barresi Lab, Smith College 2019 Smith College

Glial Bridge Development: 26 Hpf, Barresi Lab, Smith College

Glial Bridge

No abstract provided.


Glial Bridge Development: 30 Hpf, Barresi Lab, Smith College 2019 Smith College

Glial Bridge Development: 30 Hpf, Barresi Lab, Smith College

Glial Bridge

No abstract provided.


Validation Experiment: Wild Type, Raw, At, Barresi Lab, Smith College 2019 Smith College

Validation Experiment: Wild Type, Raw, At, Barresi Lab, Smith College

Validation Experiment

No abstract provided.


Validation Experiment: Wild Type, Psi, Barresi Lab, Smith College 2019 Smith College

Validation Experiment: Wild Type, Psi, Barresi Lab, Smith College

Validation Experiment

No abstract provided.


Validation Experiment: You-Too, Probability, Barresi Lab, Smith College 2019 Smith College

Validation Experiment: You-Too, Probability, Barresi Lab, Smith College

Validation Experiment

No abstract provided.


Validation Experiment: Wild Type, Raw, Gfap, Barresi Lab, Smith College 2019 Smith College

Validation Experiment: Wild Type, Raw, Gfap, Barresi Lab, Smith College

Validation Experiment

No abstract provided.


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