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Sperm Motility In Groups, Julie Simons 2019 California State University Maritime Academy

Sperm Motility In Groups, Julie Simons

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Modeling Collective Migration Of Neural Crest Cells With A Cucker-Smale Velocity Alignment Process, Claire Evensen 2019 Illinois State University

Modeling Collective Migration Of Neural Crest Cells With A Cucker-Smale Velocity Alignment Process, Claire Evensen

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, Vidya Chandrasekaran 2019 Saint Mary's College of California

Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, Vidya Chandrasekaran

Vidya Chandrasekaran

Neuronal connectivity is dependent on size and shape of the dendritic arbor. However, mechanisms controlling dendritic arborization, especially in the peripheral nervous system, are not completely understood. Previous studies have shown that bone morphogenetic proteins (BMPs) are important initiators of dendritic growth in peripheral neurons. In this study, we examined the hypothesis that post-transcriptional regulation mediated by microRNAs (miRNAs) is necessary for BMP-7-induced dendritic growth in these neurons. To examine the role of miRNAs in BMP-7-induced dendritic growth, microarray analyses was used to profile miRNA expression in cultured sympathetic neurons from the superior cervical ganglia of embryonic day 21 rat ...


Immediate-Early Genes And Delayed Primary Response Genes Regulated By Nmu In Skbr3 Her-2 Positive Breast Cancer Cell Line, Jessica Murphy, Sweta Rani 2019 Waterford Institute of Technology

Immediate-Early Genes And Delayed Primary Response Genes Regulated By Nmu In Skbr3 Her-2 Positive Breast Cancer Cell Line, Jessica Murphy, Sweta Rani

Sure-J: Science Undergraduate Research Journal

Background
Breast cancer is a heterogeneous disease that consists of varying genetic, cellular and molecular subtypes with unique characteristics. Due to the multiple subtypes and molecular markers of breast cancer, successful clinical treatment is hampered by the lack of reliable biomarkers. HER2-positive breast cancer is an aggressive subtype associated with poor patient prognosis. Although survival rates have dramatically increased due to the development of Trastuzumab in 1997, many patients develop a resistance to this therapeutic treatment and relapse over time. Rani et al. (2014), have associated the acquirement of resistance to HER2-treatment with Neuromedin U, but the mechanisms by which ...


Endoglin Protein Interactome Profiling Identifies Trim21 And Galectin-3 As New Binding Partners, Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla 2019 CSIC & CIBERER

Endoglin Protein Interactome Profiling Identifies Trim21 And Galectin-3 As New Binding Partners, Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla

Papers in Veterinary and Biomedical Science

Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause herediatry hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectase, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, sEng), proteolytically released from the membrane-bound protein, has been observed in several inflammation-related pathological conditions and appears to contribute to endothelial dysfunction and cancer development through unknown mechanisms. Membrane-bound endoglin is an auxiliary component of the TGF-B receptor complex and ...


9th Annual Postdoctoral Science Symposium, University of Texas MD Anderson Cancer Center PostDoctoral Association 2019 The Texas Medical Center Library

9th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

MD Anderson Cancer Center Postdoctoral Association Annual Postdoctoral Science Symposium Abstracts

The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011.

The APSS provides a professional venue for postdoctoral scientists to develop, clarify, and refine their research as a result of formal reviews and critiques of faculty and other postdoctoral scientists. Additionally, attendees discuss current research on a broad range of subjects while promoting academic interactions and enrichment and developing new collaborations.


Fagin: Synteny-Based Phylostratigraphy And Finer Classification Of Young Genes, Zebulun Arendsee, Jing Li, Urminder Singh, Priyanka Bhandary, Arun Seetharam, Eve Syrkin Wurtele 2019 Iowa State University

Fagin: Synteny-Based Phylostratigraphy And Finer Classification Of Young Genes, Zebulun Arendsee, Jing Li, Urminder Singh, Priyanka Bhandary, Arun Seetharam, Eve Syrkin Wurtele

Eve Wurtele

Background: With every new genome that is sequenced, thousands of species-specific genes (orphans) are found, some originating from ultra-rapid mutations of existing genes, many others originating de novo from non-genic regions of the genome. If some of these genes survive across speciations, then extant organisms will contain a patchwork of genes whose ancestors first appeared at different times. Standard phylostratigraphy, the technique of partitioning genes by their age, is based solely on protein similarity algorithms. However, this approach relies on negative evidence ─ a failure to detect a homolog of a query gene. An alternative approach is to limit the search ...


Visualizing Multivariate Hierarchic Data Using Enhanced Radial Space-Filling Layout, Ming Jia, Ling Li, Erin Boggess, Eve Syrkin Wurtele, Julie A. Dickerson 2019 Iowa State University

Visualizing Multivariate Hierarchic Data Using Enhanced Radial Space-Filling Layout, Ming Jia, Ling Li, Erin Boggess, Eve Syrkin Wurtele, Julie A. Dickerson

Eve Wurtele

Currently, visualization tools for large ontologies (e.g., pathway and gene ontologies) result in a very flat wide tree that is difficult to fit on a single display. This paper develops the concept of using an enhanced radial space-filling (ERSF) layout to show biological ontologies efficiently. The ERSF technique represents ontology terms as circular regions in 3D. Orbital connections in a third dimension correspond to non-tree edges in the ontology that exist when an ontology term belongs to multiple categories. Biologists can use the ERSF layout to identify highly activated pathway or gene ontology categories by mapping experimental statistics such ...


Metnet: Systems Biology Tools For Arabidopsis, Eve Syrkin Wurtele, Ling Li, Dan Berleant, Dianne Cook, Julie A. Dickerson, Jing Ding, Heike Hofmann, Michael Lawrence, Eun-kyung Lee, Jie Li, Wieslawa Mentzen, Leslie Miller, Basil J. Nikolau, NIck Ransom, Yingjun Wang 2019 Iowa State University

Metnet: Systems Biology Tools For Arabidopsis, Eve Syrkin Wurtele, Ling Li, Dan Berleant, Dianne Cook, Julie A. Dickerson, Jing Ding, Heike Hofmann, Michael Lawrence, Eun-Kyung Lee, Jie Li, Wieslawa Mentzen, Leslie Miller, Basil J. Nikolau, Nick Ransom, Yingjun Wang

Eve Wurtele

MetNet (http://metnetdb.org) is an emerging open-source software platform for exploration of disparate experimental data types and regulatory and metabolic networks in the context of Arabidopsis systems biology. The MetNet platform features graph visualization, interactive displays, graph theoretic computations for determining biological distances, a unique multivariate display and statistical analysis tool, graph modeling using the open source statistical analysis language, R, and versatile text mining. The use of these tools is illustrated with data from the bio1 mutant of Arabidopsis.


Comparative Proteomics Of Rubber Latex Revealed Multiple Protein Species Of Ref/Srpp Family Respond Diversely To Ethylene Stimulation Among Different Rubber Tree Clones, Zheng Tong, Dan Wang, Yong Sun, Qian Yang, Xueru Meng, Limin Wang, Weiqiang Feng, Ling Li, Eve Syrkin Wurtele, Xuchu Wang 2019 Chinese Academy of Tropical Agricultural Sciences

Comparative Proteomics Of Rubber Latex Revealed Multiple Protein Species Of Ref/Srpp Family Respond Diversely To Ethylene Stimulation Among Different Rubber Tree Clones, Zheng Tong, Dan Wang, Yong Sun, Qian Yang, Xueru Meng, Limin Wang, Weiqiang Feng, Ling Li, Eve Syrkin Wurtele, Xuchu Wang

Eve Wurtele

Rubber elongation factor (REF) and small rubber particle protein (SRPP) are two key factors for natural rubber biosynthesis. To further understand the roles of these proteins in rubber formation, six different genes for latex abundant REF or SRPP proteins, including REF138,175,258 and SRPP117,204,243, were characterized from Hevea brasiliensis Reyan (RY) 7-33-97. Sequence analysis showed that REFs have a variable and long N-terminal, whereas SRPPs have a variable and long C-terminal beyond the REF domain, and REF258 has a β subunit of ATPase in its N-terminal. Through two-dimensional electrophoresis (2-DE), each REF/SRPP protein ...


Fagin: Synteny-Based Phylostratigraphy And Finer Classification Of Young Genes, Zebulun Arendsee, Jing Li, Urminder Singh, Priyanka Bhandary, Arun Seetharam, Eve Syrkin Wurtele 2019 Iowa State University

Fagin: Synteny-Based Phylostratigraphy And Finer Classification Of Young Genes, Zebulun Arendsee, Jing Li, Urminder Singh, Priyanka Bhandary, Arun Seetharam, Eve Syrkin Wurtele

Arun Seetharam

Background: With every new genome that is sequenced, thousands of species-specific genes (orphans) are found, some originating from ultra-rapid mutations of existing genes, many others originating de novo from non-genic regions of the genome. If some of these genes survive across speciations, then extant organisms will contain a patchwork of genes whose ancestors first appeared at different times. Standard phylostratigraphy, the technique of partitioning genes by their age, is based solely on protein similarity algorithms. However, this approach relies on negative evidence ─ a failure to detect a homolog of a query gene. An alternative approach is to limit the search ...


Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin 2019 Technological University Dublin

Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin

Articles

Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma ...


Evaluation Of Epas1 Variants For Association With Bovine Congestive Heart Failure [Version 1; Peer Review: 2 Approved], Michael P. Heaton, Adam S. Bassett, Katherine J. Whitman, Greta M. Krafsur, Sang M. Lee, Jaden M. Carlson, Halden J. Clark, Helen R. Smith, Madeline C. Pelster, Veronica Basnayake, Dale M. Grotelueschen, B. Vander Ley 2019 U.S. Meat Animal Research Center

Evaluation Of Epas1 Variants For Association With Bovine Congestive Heart Failure [Version 1; Peer Review: 2 Approved], Michael P. Heaton, Adam S. Bassett, Katherine J. Whitman, Greta M. Krafsur, Sang M. Lee, Jaden M. Carlson, Halden J. Clark, Helen R. Smith, Madeline C. Pelster, Veronica Basnayake, Dale M. Grotelueschen, B. Vander Ley

Papers in Veterinary and Biomedical Science

Background: Bovine congestive heart failure (BCHF) has become increasingly prevalent in feedlot cattle in the Western Great Plains of North America. BCHF is an untreatable complex condition involving pulmonary hypertension that culminates in right ventricular failure and death. A protein variant of hypoxia-inducible factor 2 alpha (HIF2α, encoded by the endothelial PAS domain-containing protein 1 gene, EPAS1) was previously reported to be associated with pulmonary hypertension at altitudes exceeding 2,000 m. Our aim was to evaluate EPAS1 haplotypes for association with BCHF in feedlot cattle raised at moderate altitudes (1,200 m).

Methods: Paired samples of clinical cases and ...


Diverse Repertoire Of Human Adipocyte Subtypes Develops From Transcriptionally Distinct Mesenchymal Progenitor Cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, Silvia Corvera 2019 University of Massachusetts Medical School

Diverse Repertoire Of Human Adipocyte Subtypes Develops From Transcriptionally Distinct Mesenchymal Progenitor Cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany Desouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, Silvia Corvera

Open Access Articles

Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of cells required to mediate complex functions in multicellular organisms. Despite the multiple roles of adipose tissue in maintaining systemic metabolic homeostasis, adipocytes are thought to be largely homogenous with only 2 major subtypes recognized in humans so far. Here we report the existence and characteristics of 4 distinct human adipocyte subtypes, and of their respective mesenchymal progenitors. The phenotypes of these distinct adipocyte subtypes are differentially associated with key adipose tissue functions, including thermogenesis, lipid storage, and adipokine secretion. The transcriptomic signature of "brite/beige" thermogenic adipocytes reveals mechanisms for ...


The Central Role Of The Tail In Switching Off 10s Myosin Ii Activity, Shixin Yang, Kyounghwan Lee, John L. Woodhead, Osamu Sato, Mitsuo Ikebe, Roger Craig 2019 University of Massachusetts Medical School

The Central Role Of The Tail In Switching Off 10s Myosin Ii Activity, Shixin Yang, Kyounghwan Lee, John L. Woodhead, Osamu Sato, Mitsuo Ikebe, Roger Craig

Radiology Publications and Presentations

Myosin II is a motor protein with two heads and an extended tail that plays an essential role in cell motility. Its active form is a polymer (myosin filament) that pulls on actin to generate motion. Its inactive form is a monomer with a compact structure (10S sedimentation coefficient), in which the tail is folded and the two heads interact with each other, inhibiting activity. This conformation is thought to function in cells as an energy-conserving form of the molecule suitable for storage as well as transport to sites of filament assembly. The mechanism of inhibition of the compact molecule ...


Anti-Cancer Effects Of Oleocanthal And Extra Virgin Olive Oil, Limor Goren 2019 The Graduate Center, City University of New York

Anti-Cancer Effects Of Oleocanthal And Extra Virgin Olive Oil, Limor Goren

All Dissertations, Theses, and Capstone Projects

Oleocanthal is a phenolic compound found in varying concentrations in extra virgin olive oil. Oleocanthal has been shown to be active physiologically, benefiting several diseased states by conferring anti-inflammatory and neuroprotective benefits. Recently, we and other groups have demonstrated its specific and selective toxicity toward cancer cells; however, the mechanism leading to cancer cell death is still disputed. The current study demonstrates that oleocanthal induced damage to cancer cells’ lysosomes leading to cellular toxicity in vitro. Non-cancer cells were significantly less affected. Lysosomal membrane permeabilization following oleocanthal treatment in various cell lines was assayed via three complementary methods. Additionally, we ...


Hyaluronan At The Brain-Environment Interface, Donald M. Thevalingam 2019 The Graduate Center, City University of New York

Hyaluronan At The Brain-Environment Interface, Donald M. Thevalingam

All Dissertations, Theses, and Capstone Projects

Hyaluronan (HA; Hyaluronic Acid), a primary scaffolding component of the brain extracellular matrix, serves as an integral structural component to the brain extracellular space (ECS). The fossorial African naked mole-rat (Heterocephalus glaber; NM-R), a mammal which lives in a low-oxygen environment and is capable of tolerating hypoxia and hypercapnia, has been shown to synthesize and sustain a unique high-molecular-mass variant of hyaluronan macromolecule (HMM-HA). This body of work highlights HA’s role in mediating the interplay between brain ECM composition, ECS structure, and cell viability.

Here we employ the NM-R as a unique animal model to observe the role of ...


Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, Indrajit Sahu, Padma P. Nanaware, Minal Mane, Saim Wasi Mulla, Soumen Roy, Prasanna Venkatraman 2019 Technion - Israel Institute of Technology

Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, Indrajit Sahu, Padma P. Nanaware, Minal Mane, Saim Wasi Mulla, Soumen Roy, Prasanna Venkatraman

Open Access Articles

PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function remains unknown. To address this issue, we induced PSMD10(Gankyrin) overexpression in HEK293 cells and the resultant large-scale changes in gene expression profile were analyzed. We constituted networks from microarray data of these differentially expressed genes and carried out extensive topological analyses. The overrecurring yet consistent theme that appeared throughout analysis using varied network metrics is that all genes and interactions identified as important would be involved in neurogenesis ...


5 Lipoxygenase's Role In Chondrogenesis Of The Atdc5 Cell Line, Tien My Tran 2019 Seton Hall University

5 Lipoxygenase's Role In Chondrogenesis Of The Atdc5 Cell Line, Tien My Tran

Seton Hall University Dissertations and Theses (ETDs)

5-Lipoxygenase metabolizes arachidonic acid (AA) to generate leukotrienes (LTs). Leukotrienes are very potent inflammatory mediators that can have negative effects on bone healing and cartilage tissue generation. Recent studies have shown that decreasing 5-lipoxygenase (5-LO) activity during fracture healing accelerates endochondral ossification and decreases healing time in animal fracture models, however, the roles of 5-LO in chondrogenesis is not fully investigated. In this study, we tested the hypothesis that 5-LO inhibition will increase the process of chondrogenesis. The ABT-761 is an N-hydroxyurea analog structurally similar to zileuton, which is a 5-LO enzyme inhibitor, The ATDC5 cell line which is derived ...


The Role Of Tra1 In Cellular Stress Responses In Yeast: Implications For Human Diseases, Yuwei Jiang 2019 The University of Western Ontario

The Role Of Tra1 In Cellular Stress Responses In Yeast: Implications For Human Diseases, Yuwei Jiang

Electronic Thesis and Dissertation Repository

Regulation of gene expression under stress conditions involves chromatin remodeling through post-translational modification of histones. One of these modifications, acetylation of lysine residues, regulates transcription initiation and is linked to a variety of essential cellular processes including cell cycle control, DNA repair, and importantly, activation of cellular stress response pathways. Dysregulation of histone acetylation has been observed in many stress-related diseases such as inflammatory diseases, cancer, neurodegenerative disorders, and fungal infections. Tra1 is the only essential component of both the highly conserved SAGA and NuA4 histone acetyltransferase (HAT) complexes that are responsible for acetylation of histones and other proteins. Tra1 ...


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