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Social and Behavioral Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2009

University of Massachusetts Amherst

Geert De Vries

Articles 1 - 2 of 2

Full-Text Articles in Social and Behavioral Sciences

The Epigenetics Of Sex Differences In The Brain, Geert De Vries, M. M. Mccarthy, A. P. Auger, T. L. Bale, G. A. Dunn, N. G. Forger, E. K. Murray, B. M. Nugent, J. M. Schwarz, M. E. Wilson Oct 2009

The Epigenetics Of Sex Differences In The Brain, Geert De Vries, M. M. Mccarthy, A. P. Auger, T. L. Bale, G. A. Dunn, N. G. Forger, E. K. Murray, B. M. Nugent, J. M. Schwarz, M. E. Wilson

Geert De Vries

Epigenetic changes in the nervous system are emerging as a critical component of enduring effects induced by early life experience, hormonal exposure, trauma and injury, or learning and memory. Sex differences in the brain are largely determined by steroid hormone exposure during a perinatal sensitive period that alters subsequent hormonal and nonhormonal responses throughout the lifespan. Steroid receptors are members of a nuclear receptor transcription factor superfamily and recruit multiple proteins that possess enzymatic activity relevant to epigenetic changes such as acetylation and methylation. Thus steroid hormones are uniquely poised to exert epigenetic effects on the developing nervous system to ...


Epigenetic Control Of Sexual Differentiation Of The Bed Nucleus Of The Stria Terminalis, Geert De Vries, E. K. Murray, A. Hien, N. G. Forger Sep 2009

Epigenetic Control Of Sexual Differentiation Of The Bed Nucleus Of The Stria Terminalis, Geert De Vries, E. K. Murray, A. Hien, N. G. Forger

Geert De Vries

The principal nucleus of the bed nucleus of the stria terminalis (BNSTp) is larger in volume and contains more cells in male than female mice. These sex differences depend on testosterone and arise from a higher rate of cell death during early postnatal life in females. There is a delay of several days between the testosterone surge at birth and sexually dimorphic cell death in the BNSTp, suggesting that epigenetic mechanisms may be involved. We tested the hypothesis that chromatin remodeling plays a role in sexual differentiation of the BNSTp by manipulating the balance between histone acetylation and deacetylation using ...