Open Access. Powered by Scholars. Published by Universities.®

Social and Behavioral Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2009

Purdue University

Alcohol; breast cancer risk factor; EGF receptor; matrix metalloprotease

Articles 1 - 1 of 1

Full-Text Articles in Social and Behavioral Sciences

Egfr May Couple Moderate Alcohol Consumption To Increased Breast Cancer Risk, Christopher P. Mill, Julia Chester, David J. Riese Ii Oct 2009

Egfr May Couple Moderate Alcohol Consumption To Increased Breast Cancer Risk, Christopher P. Mill, Julia Chester, David J. Riese Ii

Department of Psychological Sciences Faculty Publications

Alcohol consumption is an established risk factor for breast cancer. Nonetheless, the mechanism by which alcohol contributes to breast tumor initiation or progression has yet to be definitively established. Studies using cultured human tumor cell lines have identified signaling molecules that may contribute to the effects of alcohol, including reactive oxygen species and other ethanol metabolites, matrix metalloproteases, the ErbB2/Her2/Neu receptor tyrosine kinase, cytoplasmic protein kinases, adenylate cyclase, E-cadherins, estrogen receptor, and a variety of transcription factors. Emerging data suggest that the epidermal growth factor receptor (EGFR) tyrosine kinase may contribute to breast cancer genesis and progression. Here ...