Open Access. Powered by Scholars. Published by Universities.®

Organic Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 2 of 2

Full-Text Articles in Organic Chemistry

Data Mining Of Protein Databases, Christopher Assi Jul 2012

Data Mining Of Protein Databases, Christopher Assi

Computer Science and Engineering: Theses, Dissertations, and Student Research

Data mining of protein databases poses special challenges because many protein databases are non-relational whereas most data mining and machine learning algorithms assume the input data to be a relational database. Protein databases are non-relational mainly because they often contain set data types. We developed new data mining algorithms that can restructure non-relational protein databases so that they become relational and amenable for various data mining and machine learning tools. We applied the new restructuring algorithms to a pancreatic protein database. After the restructuring, we also applied two classification methods, such as decision tree and SVM classifiers and compared their ...


Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague Apr 2012

Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague

Senior Theses and Projects

Previous research within the Curran group has demonstrated that ferrocene may be used as an organometallic constraint to induce the formation of α-helices in short peptides which traditionally possess undefined conformations. Through strategic placement of lysine residues at the i and i+3 positions within the peptide, such a constraint was accomplished via the crosslinking of the lysine side chains to ferrocene dicarboxylic acid chloride in solution phase synthesis. The aim of this work was to develop a method for solid phase peptide synthesis (SPPS) for the synthesis of these ferrocene-constrained helices. In particular, we seek to develop a method ...