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Articles 31 - 58 of 58

Full-Text Articles in Organic Chemistry

13c Nmr Spectroscopy: Transmission Effects In 1-Phenyl-3,5-Diarylpyrazoles, Amy N. Hockstedler, Anand B. Shah, Beatrice A. Edjah, Glenda M. Duffek, Krishna D. Patel, Hadrian Mendoza, Hayley B. Arrowood, Nicole A. Brown, Saajid Z. Azhar Apr 2016

13c Nmr Spectroscopy: Transmission Effects In 1-Phenyl-3,5-Diarylpyrazoles, Amy N. Hockstedler, Anand B. Shah, Beatrice A. Edjah, Glenda M. Duffek, Krishna D. Patel, Hadrian Mendoza, Hayley B. Arrowood, Nicole A. Brown, Saajid Z. Azhar

Georgia State Undergraduate Research Conference

No abstract provided.


Comparison Of Conventional And Microwave-Assisted Synthesis Of Chemokine Receptor Type 4 (Cxcr4) Antagonists, Saniya Virani, Damilola Gbadebo, Theresa D. Gaines, Francisco Javier Garcia Apr 2016

Comparison Of Conventional And Microwave-Assisted Synthesis Of Chemokine Receptor Type 4 (Cxcr4) Antagonists, Saniya Virani, Damilola Gbadebo, Theresa D. Gaines, Francisco Javier Garcia

Georgia State Undergraduate Research Conference

No abstract provided.


Studies Towards The Synthesis Of 2,5-Disubstituted-3-Flurothiophenes Using A Tandem Directed Ortho Metallation/Nickel Catalyzed Cross-Coupling Approach, Nicholas P. Onuska, Paul Sampson, Alexander Seed Mar 2016

Studies Towards The Synthesis Of 2,5-Disubstituted-3-Flurothiophenes Using A Tandem Directed Ortho Metallation/Nickel Catalyzed Cross-Coupling Approach, Nicholas P. Onuska, Paul Sampson, Alexander Seed

Undergraduate Research Symposium

2,5-Disubstituted 3-fluorothiophene derivatives are of interest as building blocks in liquid crystal materials synthesis. This poster details the development of 2-thienyl carbamates and related compounds as flexible building blocks for the construction of 2,5-disubstituted 3-fluorothiophenes. Our approach involves oxidation of 5-substituted 2-thienyl trifluoroborates to the corresponding thienones followed by O-trapping of the corresponding enolate as the 2-thienyl carbamate. Studies aimed at the elaboration of to 2,5-disubstituted 3-fluorothiophenes using a sequential directed ortho-metalation/fluorination/Ni-catalyzed cross-coupling approach will be presented.


Total Synthesis And Derivation Of Humulones And Lupulones As Possible Biologically Active Agents, Lucas R. Sass, Kristopher V. Waynant (Mentor) Aug 2015

Total Synthesis And Derivation Of Humulones And Lupulones As Possible Biologically Active Agents, Lucas R. Sass, Kristopher V. Waynant (Mentor)

Idaho Conference on Undergraduate Research

Humulones and lupulones have affirmed themselves as key ingredients in the multi-billion dollar brewing industry. Originally exploited for their bacteriostatic properties, these compounds also exhibit high levels of biological activity against a variety of diseases. Although quantifiable, the isolation and separation of specific humulones and lupulones has proven difficult, thus establishing efficient synthetic routes will be of value to those desiring exact bittering qualities and to the pharmaceutical community. Our investigations are towards developing a synthetic route to a library of humulones, lupulones, and their derivatives as possible biologically active agents against myriad diseases. The key step in our efficient ...


Development Of A Scalable Synthesis Of Hp-Β-Cd Pluronic Polyrotaxanes, Joseph L. Skulsky, Elizabeth A. Slepko, Bradley P. Loren, David H. Thompson Aug 2015

Development Of A Scalable Synthesis Of Hp-Β-Cd Pluronic Polyrotaxanes, Joseph L. Skulsky, Elizabeth A. Slepko, Bradley P. Loren, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Polyrotaxanes are polymers that have macrocycles threaded onto them, analogous to beads threaded onto a string. These materials are used for a variety of different biomedical applications.1-3 The Thompson group has been developing 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) polyrotaxanes as therapeutics for the treatment of Niemann-Pick Type C (NPC) disease. NPC is a debilitating genetic disorder where cholesterol accumulates in the lysosomes of cells.4 Developing a scalable process is crucial for the advancement of these materials as NPC therapeutics. The goal of this project is to optimize the only protocol for the synthesis of HP-β-CD/Pluronic polyrotaxanes in order to develop ...


Analysis Of The Fabrication Conditions In Organic Field-Effect Transistors, Rachel M. Rahn, Yan Zhao, Jianguo Mei Aug 2015

Analysis Of The Fabrication Conditions In Organic Field-Effect Transistors, Rachel M. Rahn, Yan Zhao, Jianguo Mei

The Summer Undergraduate Research Fellowship (SURF) Symposium

Polymer-based organic field-effect transistors have raised substantial awareness because they enable low-cost, solution processing techniques, and have the potential to be implemented in flexible, disposable organic electronic devices. The performance of these devices is highly dependent on the processing conditions, as well as the intrinsic properties of the polymer. Processing conditions play an important role in semiconductor film formation and device performance. These factors may provide an important link between structure and performance. In this study, an empirical analysis tool, Process Scout, was applied to assess processing factors such as polymer concentration and silicon modification. This sanctioned the creation of ...


13c Nmr Spectroscopy: Transmission Effects In 3,5-Diaryl-4-Bromoisoxazoles, Beatrice Edjah, Jiyao Yu, Joseph Akinoso, Julia Dave, Hector Argueta-Gonzalez, Patrick Gaulden Apr 2015

13c Nmr Spectroscopy: Transmission Effects In 3,5-Diaryl-4-Bromoisoxazoles, Beatrice Edjah, Jiyao Yu, Joseph Akinoso, Julia Dave, Hector Argueta-Gonzalez, Patrick Gaulden

Georgia State Undergraduate Research Conference

No abstract provided.


Biphenyl-(1,2,4)-Oxadiazole Liquid Crystals, Sonia Britton, Todd Ness, Christopher E. Ruth Mar 2015

Biphenyl-(1,2,4)-Oxadiazole Liquid Crystals, Sonia Britton, Todd Ness, Christopher E. Ruth

Undergraduate Research Symposium

Biphenyl-(1,2,4)-oxadiazole Liquid Crystals

Sonia Britton, Todd Ness, Christopher E. Ruth, Robert Twieg, and Farid Fouad

The incorporation of the 1,2,4-oxadiazole entity in the core of a calamitic heterocyclic liquid crystal results in the formation of a bent geometry, known as the “banana structure”. This 135o bend angle is what many believe to be the reason for the distinct characteristics absolved from incorporation of oxadiazoles in liquid crystals. Researchers found it intriguing to incorporate oxadiazoles into liquid crystals for organic electrodes because of their charge carrier mobility, exceptional chemical and thermal stability, and high ...


Evaluation Of Antibiotic Properties Of Diarylhydrazones, Diaryl Schiff-Bases And Their Precursors, William Horton, Kristina D'Amico, Stephanie Davis, Christian Schafer, Gregory Beck, Bela Torok May 2014

Evaluation Of Antibiotic Properties Of Diarylhydrazones, Diaryl Schiff-Bases And Their Precursors, William Horton, Kristina D'Amico, Stephanie Davis, Christian Schafer, Gregory Beck, Bela Torok

UMass Center for Clinical and Translational Science Research Retreat

Parallel with the advancements in medical techniques and treatments, the microorganisms that we are constantly battling against are also evolving. Bacterial evolution is leading to an increasing number of antibiotic resistant strains of bacteria. As the bacteria evolve, the antibiotics that are currently in use to combat bacterial diseases are becoming ineffective. FDA approval of new antibacterial agents decreased drastically over the past decade. Thus the design and synthesis of new classes of antibacterial agents, possibly with structures unrelated to the current antibiotics, as the next generation antibacterial agents is highly desirable. In the current work the antimicrobial effect of ...


Design And Synthesis Of Carbocyanine Based Photosensitizers For Use In Dye-Sensitized Solar Cells, Tyler Dost Apr 2014

Design And Synthesis Of Carbocyanine Based Photosensitizers For Use In Dye-Sensitized Solar Cells, Tyler Dost

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney Apr 2014

Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney

Georgia State Undergraduate Research Conference

No abstract provided.


Hitting Pause On Organic Chemistry, Jenny B. Vu Mar 2014

Hitting Pause On Organic Chemistry, Jenny B. Vu

Interdisciplinary STEM Teaching & Learning Conference

Written procedures for performing organic chemistry experiments are replaced by visual demonstrations that allow students to watch these videos at home and/ or in the laboratory. These previously recorded demonstrations allow students to watch, pause, and rewind the video to better understand laboratory techniques.


Investigating Intermolecular Interactions In Crystalline Aspirin Using Cdft, Nicholas Turner, Tonglei Li, Mingtao Zhang Oct 2013

Investigating Intermolecular Interactions In Crystalline Aspirin Using Cdft, Nicholas Turner, Tonglei Li, Mingtao Zhang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Drugs today are widely administered in their crystalline form, namely via tablets and capsules. The crystal structure of a drug molecule affects important drug qualities such as solubility, bioavailability, shelf life, and compaction properties. In order to form a basis for crystal structure prediction, it is necessary to first understand how intermolecular interactions cause molecules to pack in certain ways. Being able to predict and perhaps even control a drug molecule’s crystal structure will lead to the development of higher quality drugs that perform more consistently. Scientists and engineers do not fully understand the reasons for a molecule assuming ...


Spectroscopic Study Of 4-Methoxychalcone And Human Serum Albumin: Binding Interaction, Rosalind Usher Mar 2013

Spectroscopic Study Of 4-Methoxychalcone And Human Serum Albumin: Binding Interaction, Rosalind Usher

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr. Mar 2013

Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.

Georgia State Undergraduate Research Conference

No abstract provided.


Synthesis And Evaluation Of Carbocyanine Dyes As Prmt Inhibitors And Imaging Agents, Amber E. Howard Mar 2013

Synthesis And Evaluation Of Carbocyanine Dyes As Prmt Inhibitors And Imaging Agents, Amber E. Howard

Georgia State Undergraduate Research Conference

No abstract provided.


Nanoparticles In Biomedicine: Delivery And Sensing, Vincent Rotello Jan 2013

Nanoparticles In Biomedicine: Delivery And Sensing, Vincent Rotello

UMass Center for Clinical and Translational Science Seminar Series

This lecture by Dr. Vincent Rotello will present his lab's recent research in the areas of therapeutics and diagnostics using gold nanoparticles.


Establishment Of An Efficient Method For The Synthesis Of Srh, An Important Molecule In Bacterial Quorum Sensing, Emily Showell-Rouse, Ruoyi Liu Apr 2012

Establishment Of An Efficient Method For The Synthesis Of Srh, An Important Molecule In Bacterial Quorum Sensing, Emily Showell-Rouse, Ruoyi Liu

Creative Activity and Research Day - CARD

Quorum sensing (QS) is a process of bacterial communication that regulates the expression of virulence genes in many bacteria. The study of QS, could lead to new treatments for bacterial diseases. Interspecies bacterial communication utilizes the signaling molecule autoinducer-2 (AI-2). The LuxS enzyme converts S-ribosyl-L-homocysteine (SRH) into 4(S),5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2. LuxS inhibitors could prevent QS by halting conversion of SRH. We have developed an efficient synthesis of SRH from D-ribose and L-homocystine. This procedure provides us with both a supply of SRH for biochemical assays and a foundation for the synthesis of SRH ...


Enantioselective Biotransformation Of Prochiral Ketone Via Daucus Carota, Ryan Smith, Charlie Knox, Elizabeth Davis Apr 2012

Enantioselective Biotransformation Of Prochiral Ketone Via Daucus Carota, Ryan Smith, Charlie Knox, Elizabeth Davis

Undergraduate Research Conference

Biotransformations of prochiral ketones can be performed using plant cells. The benefits of using plant cells include low cost, environmentally sound procedures compared to conventional chemical processes, and the stereospecific nature of the reaction.1,2 Benzofuran-2-yl methyl ketone was reduced to (- )-benzofuran-2-yl-ethanol after incubation with carrots in water. The reaction was enantioselective in that it produced the S-isomer as indicated by optical activity. Currently, attempts to isolate the carrot enzyme and antimicrobial studies of the (-)-benzofuran-2-yl-ethanol product are underway.


Predicting Homo And Lumo Energy Gaps For Organic Semi-Conductor: A Theoretical Study, Padtaya Pukpayat Apr 2011

Predicting Homo And Lumo Energy Gaps For Organic Semi-Conductor: A Theoretical Study, Padtaya Pukpayat

Festival of Communities: UG Symposium (Posters)

This poster presents a theoretical approach for characterizing the electronic properties of novel electron-deficient organic semiconductors containing variety of electron donor substituents. In treating these compounds, the following questions will be addressed: What effects to the bandgap will each substituent have? Will any of the substituents lower the band gap to the desired range for solar cell applications(<2.0eV)? Can we use the current, inexpensive and tractable computational methods as a predictive tool for guiding future experimental design of organic based solar cells, rather than depending solely on experimental procedures?


Energy Densification Via Hydrothermal Carbonization, Keri Noack Apr 2011

Energy Densification Via Hydrothermal Carbonization, Keri Noack

Festival of Communities: UG Symposium (Posters)

A process called hydrothermal carbonization (HTC), also known as wet torrefaction involves treatment of raw biomass in hot, pressurized water. HTC of woody biomass has been shown to significantly increase the energy density of the feedstock, producing a biochar, similar to coal, having up to 40% higher calorific energy content. Feedstocks investigated include Tahoe chips, Pinion/Juniper chips, Rice hulls, and Corn Stover pellets pre-treated at 215 °C, 255 °C, and 295 °C. Chemical analyses were conducted on the gaseous, aqueous, and solid HTC products. Energy contents of the solid biochar products were measured by calorimetry, and mass balances were ...


Spectroscopic (Ir, Nmr, Uv-Vis), Theoretical Study And Optical Properties Of 9,10-Dihydrobenzo(A)Pyrene-7(8h)-One And 7, 8, 9, 10-Tetrahydrobenzo(A)Pyrene, Mireya Martinez Apr 2011

Spectroscopic (Ir, Nmr, Uv-Vis), Theoretical Study And Optical Properties Of 9,10-Dihydrobenzo(A)Pyrene-7(8h)-One And 7, 8, 9, 10-Tetrahydrobenzo(A)Pyrene, Mireya Martinez

Undergraduate Research Conference

Polycyclic aromatic hydrocarbons (PAHs) are organic molecules found in the environment. The PAHs are formed from incomplete combustion, are found in diesel exhaust particles, grilled foods, gas burners, emission from wood, and cigarette smoke. These compounds are known to be carcinogenic and mutagenic1,2. Spectroscopic studies were performed on two PAHs, 9,10- dihydrobenzo(a) pyrene-7(8H)-one and 7,8,9,10- tetrahydrobenzo(a)pyrene, which helped to characterize them. Also, a theoretical infrared study was done on 9,10-H2BaP, a scaling factor was found for a simulated infrared spectrum.


Nvrec Subtask 1.1: Pre-Treatment Of Lignocellulosic Biomass, Amber Broch, Kent Hoekman, Larry Felix, Rick Purcell, Curt Robbins, Wei Yan Aug 2010

Nvrec Subtask 1.1: Pre-Treatment Of Lignocellulosic Biomass, Amber Broch, Kent Hoekman, Larry Felix, Rick Purcell, Curt Robbins, Wei Yan

Nevada Renewable Energy Consortium Meeting

The second annual Nevada Renewable Energy Consortium meeting took place at UNLV on August 20. The meeting focused on the current three NVREC program areas: Solar, Biomass and Geothermal. Presentations were made by participating entities and a poster session followed.


Nvrec Subtask 1.2: Thermal Treatment Of Biomass, Curtis Robbins, Eric Ceniceros, Kent Hoekman, Richard Jasoni Aug 2010

Nvrec Subtask 1.2: Thermal Treatment Of Biomass, Curtis Robbins, Eric Ceniceros, Kent Hoekman, Richard Jasoni

Nevada Renewable Energy Consortium Meeting

The second annual Nevada Renewable Energy Consortium meeting took place at UNLV on August 20. The meeting focused on the current three NVREC program areas: Solar, Biomass and Geothermal. Presentations were made by participating entities and a poster session followed.


Synthesis Of Bis-Styrylbenzene Derivatives Via Wittig-Horner Reaction, Joseph K. Wray, Tae Soo Jo, Pradip K. Browmik Aug 2010

Synthesis Of Bis-Styrylbenzene Derivatives Via Wittig-Horner Reaction, Joseph K. Wray, Tae Soo Jo, Pradip K. Browmik

Undergraduate Research Opportunities Program (UROP)

Alzheimer’s Disease is now one of the most common diseases affecting the elderly population. Recently, bis-styrylbenzene derivatives have been shown to reduce the formation of Beta-amyloid plaques in the brain which are profoundly correlated with this disease. Finding new biologically active compounds which can reduce or prevent Alzheimer’s Disease has drawn much attention over the past few decades. Georg Wittig, Nobel Prize Winner in Chemistry, 1979.


Biodiesel: Tomorrow's Fuel, Today's Solution, Roberto J. Molina, Racheal A. Persuad Mar 2009

Biodiesel: Tomorrow's Fuel, Today's Solution, Roberto J. Molina, Racheal A. Persuad

Undergraduate Research Conference

Study of physical and chemical properties of biodiesel fuels derived from poultry and plant fats.


Spectroscopic Studies Of Fluoranthene And 3-Nitrofluoranthene, Matthew Parks Mar 2009

Spectroscopic Studies Of Fluoranthene And 3-Nitrofluoranthene, Matthew Parks

Undergraduate Research Conference

Polycyclic aromatic hydrocarbons (PAHs) are known byproducts of anthropogenic sources including incomplete combustion of fossil fuels. They are known to be teratogenic, mutagenic and carcinogenic. This study investigated the spectral properties of fluoranthene and 3- nitrofluoranthene using NMR, UV-Vis and infrared techniques. The acquisition of spectral data provides a means to identify these compounds in mixtures and can be used which to develop model formulae for quantitation. A 2-D NMR method (HMQC ) was used for assigning 13C peaks. The infrared spectrum for 3-nitrofluoranthene showed characteristic strong absorption peaks at 1323 and 1516 cm-1 assigned to symmetric/asymmetric nitro stretches, respectively ...


Stereospecific Enzyme Isolation From Carrots, Jacqueline Greer, Eileen Rigsby Mar 2009

Stereospecific Enzyme Isolation From Carrots, Jacqueline Greer, Eileen Rigsby

Undergraduate Research Conference

No abstract provided.