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Organic Chemistry Commons

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Articles 1 - 4 of 4

Full-Text Articles in Organic Chemistry

Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright Apr 2016

Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright

Georgia Southern University Research Symposium

Pyridazines are nitrogen-containing compounds that have been found to show a number of pharmaceutical applications. They exhibit antimicrobial, antifungal, and antibacterial properties to name a few. In particular: 3,4,6-triphenylpyridazine derivatives are known to possess anticancer properties. The purpose of this project is to synthesize tri-substituted pyridazine derivatives using microwave-assisted reactions, and to check its biological applications. Microwave synthesis will help shorten reaction times and produce high, efficient yields. Various catalysts, bases, reaction times, and temperatures will be explored to study the scope of the reactions.


13c Nmr Spectroscopy: Transmission Effects In 1-Phenyl-3,5-Diarylpyrazoles, Amy N. Hockstedler, Anand B. Shah, Beatrice A. Edjah, Glenda M. Duffek, Krishna D. Patel, Hadrian Mendoza, Hayley B. Arrowood, Nicole A. Brown, Saajid Z. Azhar Apr 2016

13c Nmr Spectroscopy: Transmission Effects In 1-Phenyl-3,5-Diarylpyrazoles, Amy N. Hockstedler, Anand B. Shah, Beatrice A. Edjah, Glenda M. Duffek, Krishna D. Patel, Hadrian Mendoza, Hayley B. Arrowood, Nicole A. Brown, Saajid Z. Azhar

Georgia State Undergraduate Research Conference

No abstract provided.


Comparison Of Conventional And Microwave-Assisted Synthesis Of Chemokine Receptor Type 4 (Cxcr4) Antagonists, Saniya Virani, Damilola Gbadebo, Theresa D. Gaines, Francisco Javier Garcia Apr 2016

Comparison Of Conventional And Microwave-Assisted Synthesis Of Chemokine Receptor Type 4 (Cxcr4) Antagonists, Saniya Virani, Damilola Gbadebo, Theresa D. Gaines, Francisco Javier Garcia

Georgia State Undergraduate Research Conference

No abstract provided.


Studies Towards The Synthesis Of 2,5-Disubstituted-3-Flurothiophenes Using A Tandem Directed Ortho Metallation/Nickel Catalyzed Cross-Coupling Approach, Nicholas P. Onuska, Paul Sampson, Alexander Seed Mar 2016

Studies Towards The Synthesis Of 2,5-Disubstituted-3-Flurothiophenes Using A Tandem Directed Ortho Metallation/Nickel Catalyzed Cross-Coupling Approach, Nicholas P. Onuska, Paul Sampson, Alexander Seed

Undergraduate Research Symposium

2,5-Disubstituted 3-fluorothiophene derivatives are of interest as building blocks in liquid crystal materials synthesis. This poster details the development of 2-thienyl carbamates and related compounds as flexible building blocks for the construction of 2,5-disubstituted 3-fluorothiophenes. Our approach involves oxidation of 5-substituted 2-thienyl trifluoroborates to the corresponding thienones followed by O-trapping of the corresponding enolate as the 2-thienyl carbamate. Studies aimed at the elaboration of to 2,5-disubstituted 3-fluorothiophenes using a sequential directed ortho-metalation/fluorination/Ni-catalyzed cross-coupling approach will be presented.