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Georgia Southern University Research Symposium

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Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright Apr 2016

Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright

Georgia Southern University Research Symposium

Pyridazines are nitrogen-containing compounds that have been found to show a number of pharmaceutical applications. They exhibit antimicrobial, antifungal, and antibacterial properties to name a few. In particular: 3,4,6-triphenylpyridazine derivatives are known to possess anticancer properties. The purpose of this project is to synthesize tri-substituted pyridazine derivatives using microwave-assisted reactions, and to check its biological applications. Microwave synthesis will help shorten reaction times and produce high, efficient yields. Various catalysts, bases, reaction times, and temperatures will be explored to study the scope of the reactions.