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Full-Text Articles in Organic Chemistry

#44 - Introducing Biocatalysis In An Undergraduate Teaching Laboratory Using A Cyclopropanation Reaction, Sarah Youngblood Nov 2019

#44 - Introducing Biocatalysis In An Undergraduate Teaching Laboratory Using A Cyclopropanation Reaction, Sarah Youngblood

Georgia Undergraduate Research Conference (GURC)

Introducing Biocatalysis in an Undergraduate Teaching Laboratory Using a Cyclopropanation Reaction

Sarah Youngblood

Faculty Sponsor: Gopeekrishnan Sreenilayam

Biocatalysis is the use of enzymes and proteins to perform chemical transformations. Enzymes and proteins are increasingly used in organic reactions due to excellent chemo-, regio- and stereo- selectivity, environmental sustainability, milder reaction conditions, improved productivity, simplified work-streams and greater economical saving potential. The purpose of this project is to design a biocatalysis experiment that we can incorporate into an undergraduate organic chemistry teaching laboratory. In recent years, there have been a number of studies reported regarding the use of heme containing proteins ...


A Chimeric Nucleobase - Phenylazo Derivative As An Intrinsic Nucleobase Quencher, Gyeongsu Park, Timothy Martin-Chan, Amer El Samm, Robert H.E. Hudson Mar 2018

A Chimeric Nucleobase - Phenylazo Derivative As An Intrinsic Nucleobase Quencher, Gyeongsu Park, Timothy Martin-Chan, Amer El Samm, Robert H.E. Hudson

Western Research Forum

Molecular beacons are important bioanalytical probes which are most often

constructed from a single-stranded oligonucleotide which has been labeled at

opposite termini with a fluorophore and a quencher. When the fluorophore and

quencher are in close proximity, no fluorescence is observed due to FRET

(Fluorescence Resonance Energy Transfer). DABCYL (4-dimethylaminoazobenzene-

4'-carboxylic acid) has been used as a quencher in the molecular beacon to absorbs

excitation energy from a fluorophore and to dissipate the energy as heat. However,

DABCYL is unable to form a base-pair and is conventionally placed as an overhanging

residue. This produces a derivative wherein the chromophore ...


Investigation Of The Exraction Processes And Performance Properties Of Kudzu Fibers, Bahrum Prang Rocky, Virginia Wimberley Jan 2018

Investigation Of The Exraction Processes And Performance Properties Of Kudzu Fibers, Bahrum Prang Rocky, Virginia Wimberley

International Textile and Apparel Association (ITAA) Annual Conference Proceedings

While kudzu was introduced into the Southeastern United states for soil erosion and increase of land fertility, the plant has become unmanageable and is rapidly spreading to Canada. Japanese traditional craftsmen extract long, white fibers by labor intensive practices not feasible for 21st century commercial fiber production. This research investigated extraction by boiling, retting or fermentation, enzymatic combinations, and mild chemical processes. Two types of fibers were resultant- soft fibers and compact woody fibers. These fibers types were assessed for microscopic visual appearance, elemental analysis using EDAX SEM, and tensile strengths for the four extraction processes. In all extraction cases ...


Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks May 2017

Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks

Graduate Student Symposium

Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we are working towards a substrate bound structure of sortase A from Streptococcus pneumoniae (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable substrate analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme to recognize ...


Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch Mar 2017

Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch

Student Research and Creative Activity Fair

Phosphatidylinositol 3-kinases (PI3Ks) and their related pathways are reputed targets for drug-based anticancer therapies. Mutations in PI3K genes, expression, and pathways are frequent among multiple cancer types. Four isoforms of PI3Ks exist: α, β, γ, & δ and studies have identified several ligands for each isoform which are capable of serving as inhibitory therapeutic compounds. However, the biochemical efficacy of these molecules varies and the isoform selectivity is not well understood. In this study, we applied in silico docking methods and free energy calculation methods to estimate the binding of reported PI3K ligands against 5 PI3K structures: PI3Kα (PBD ID: 2RD0 ...


Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr. Mar 2013

Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.

Georgia State Undergraduate Research Conference

No abstract provided.


Biodiesel: Tomorrow's Fuel, Today's Solution, Roberto J. Molina, Racheal A. Persuad Mar 2009

Biodiesel: Tomorrow's Fuel, Today's Solution, Roberto J. Molina, Racheal A. Persuad

Undergraduate Research Conference

Study of physical and chemical properties of biodiesel fuels derived from poultry and plant fats.