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Full-Text Articles in Organic Chemistry

#44 - Introducing Biocatalysis In An Undergraduate Teaching Laboratory Using A Cyclopropanation Reaction, Sarah Youngblood Nov 2019

#44 - Introducing Biocatalysis In An Undergraduate Teaching Laboratory Using A Cyclopropanation Reaction, Sarah Youngblood

Georgia Undergraduate Research Conference (GURC)

Introducing Biocatalysis in an Undergraduate Teaching Laboratory Using a Cyclopropanation Reaction

Sarah Youngblood

Faculty Sponsor: Gopeekrishnan Sreenilayam

Biocatalysis is the use of enzymes and proteins to perform chemical transformations. Enzymes and proteins are increasingly used in organic reactions due to excellent chemo-, regio- and stereo- selectivity, environmental sustainability, milder reaction conditions, improved productivity, simplified work-streams and greater economical saving potential. The purpose of this project is to design a biocatalysis experiment that we can incorporate into an undergraduate organic chemistry teaching laboratory. In recent years, there have been a number of studies reported regarding the use of heme containing proteins ...


Photoswitchable Self-Complementary Hydrogen Bond Arrays, Suendues Noori, James A. Wisner Jun 2019

Photoswitchable Self-Complementary Hydrogen Bond Arrays, Suendues Noori, James A. Wisner

Western Research Forum

Background: Photochromism is the reversible transformation of a chemical material to another form by the absorption of electromagnetic radiation (light), where the two metastable forms have distinct absorption spectra and other properties. Photochromism in materials allows for the switching of their function solely based on irradiation with light. Polymers are used frequently as the building blocks for materials as they are versatile, multifunctional, can carry charge and be processed by solution-based deposition methods. Supramolecular polymers share the same definition as polymers with the exception that they are held together by reversible and directional non-covalent interactions such as hydrogen bonds. Synthesizing ...


Heavy-Atom Tunneling In The Planar Bond Shifting Of [16]Annulene, Philip Lampkin, Jon Shezaf Apr 2019

Heavy-Atom Tunneling In The Planar Bond Shifting Of [16]Annulene, Philip Lampkin, Jon Shezaf

Creative Activity and Research Day - CARD

Mid-sized annulenes are known to undergo rapid π-bond shifting. Given that heavy­atom tunneling plays a role in planar bond shifting of cyclobutadiene, we computationally explored the contribution of heavy­ atom tunneling to the planar bond shifting in the major (CTCTCTCT) and minor (CTCTTCTT) isomers of [16]annulene. (U)M06-2X/cc-pVDZ calculations yield bond-shifting barriers of ca. 10 kcal/mol. The results also reveal extremely narrow barrier widths, suggesting a high probability of tunneling for these bond-shifting reactions. Rate constants were calculated using canonical variational transition state theory (CVT) as well as with small curvature tunneling (SCT) contributions, via direct ...


Forming Carbon-Carbon Bonds Via Photo-Oxidation, Joseph Pesa, John Rowley Apr 2019

Forming Carbon-Carbon Bonds Via Photo-Oxidation, Joseph Pesa, John Rowley

Carroll College Student Undergraduate Research Festival

1-(2-thienyl)-pyrene has been viewed to form a carbon-carbon bond when oxidized. We investigated a palladium catalyzed reaction leading to the dimerization of a furan. However, ostensibly a similar reaction can occur in the absence of palladium but the presence of a photocurrent substantial enough to push an electron to an excited state, leaving a hole in it’s previous orbital. After this occurs, this molecule can find another of the same nature and complete the desired carbon-carbon bond. In creating this bond, we will have synthesized a “solar fuel” that can store energy in a stable bond using ...


Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage Apr 2019

Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage

Scholar Week 2016 - present

The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.


Synthesis And Optimization Of Novel Poly-(Β-Amino Ester) Polymer For Gene-Delivery, Maria Montes Apr 2019

Synthesis And Optimization Of Novel Poly-(Β-Amino Ester) Polymer For Gene-Delivery, Maria Montes

Kansas State University Undergraduate Research Conference

Gene delivery is one of the most promising methods to treat multiple diseases through the alteration of a genetic code to enhance or inhibit gene expression (NIH). The potential for gene delivery to be used as a treatment for cancerous cells is the beginning for advanced personalized healthcare. Current methods for cancer are costly, nonspecific, and come with major side effects that lowers quality of life in cancer patients. Previous studies have demonstrated Poly-(β-amino ester) (PBAE) to be biodegradable, non-toxic, and capable to deliver payloads in a targeted manner. For this study, PBAE was synthesized and characterized by Nuclear ...


Copper Binding Of Heterocyclic Compounds Is Vital For Novel Drugs Against Gram-Positive Bacteria, Azriel Minjarez-Almeida Apr 2019

Copper Binding Of Heterocyclic Compounds Is Vital For Novel Drugs Against Gram-Positive Bacteria, Azriel Minjarez-Almeida

Kansas State University Undergraduate Research Conference

Azzy Minjarez1, Man Zhang1, Anjana Delpe-Acharige1, Kayla Eschliman1, Olaf Kutsch2, Stefan H. Bossmann1

1: Department of Chemistry, Kansas State University

2: Department of Medicine, University of Alabama at Birmingham

Copper Binding of Heterocyclic Compounds Is Vital For Novel Drugs Against Resistant Gram-positive Bacteria

Multidrug resistant bacteria are capable of developing resistance to a majority of available antibiotics making them an imminent threat. Thus, synthesizing novel drug candidates is vital. The average adult contains 50-80 mg of copper within the body, which assist the immune system. Efflux pumps of bacterial cells are the primary defense mechanism, which recognize and remove copper ...


Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel Mar 2019

Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel

Student Research and Creative Activity Fair

Previous work in our lab has found diphenyl ether benzylamines showed a successful response with a micromolar concentration of our lead compound to treat the deadly Trypanosamiosis rhodesience. Furthermore, mammalian cell lines saw promising resistance towards damages. The goal of this study was to synthesize a diphenyl thio benzylamine variant. This variant was more active toward T. b. rhodesience but showed more toxicity to both rat 10 (IC50 mM) and human cell lines (HFF, HC-04, U-2 OS, and HEK293). The selectivity index (ratio of toxicity to activity in the same concentration units (SI)) varied from 55 ...


An In Vitro Study On Skin Protection Across The Uv Spectra, Cheyenne Boone Nov 2018

An In Vitro Study On Skin Protection Across The Uv Spectra, Cheyenne Boone

Posters-at-the-Capitol

Skin cancer is the number one cancer in the United States. Lack of awareness of how harmful UV radiation is could be the cause of the over two million cases reported since 2012. It appears that there is not a lot information on the active ingredients used in sunscreens. Some of the compounds have been linked to birth defects, hormone disruptions, and the bleaching of coral reefs. Samples of commonly used sunscreens (both sprays and creams), cosmetic foundation, essential oils, lotions, and three pure organic actives were tested at specific concentrations and ran through a UV spectrometer. The results have ...


Examining The Effects Of Amino And Thiolate Ligands On The Reactivity And Selectivity Of Palladium On Carbon In Hydrogenation Reactions, Eric Liu, Christina Li Aug 2018

Examining The Effects Of Amino And Thiolate Ligands On The Reactivity And Selectivity Of Palladium On Carbon In Hydrogenation Reactions, Eric Liu, Christina Li

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heterogeneous catalysts are used widely by chemical and energy industries because they show high reactivity but often suffer from lack of selectivity. On the other hand, ligands are commonly used in homogeneous catalysts to control the reactivity and selectivity; however, the effects of the ligands on the steric and electronic properties of heterogeneous catalysts are less understood. We examine the effects of four different ligands: 1-adamantanethiol, 1-adamantylamine, 1-dodecanethiol, and 1-dodecylamine, for the commercial hydrogenation catalyst palladium on carbon. Hydrogenation reactions are used as a screening tool to see the behavior that the different catalysts exhibit in the presence of unsaturated ...


Thienoisatin Oligomers As N-Type Molecular Semiconductors, Natalie M. Kadlubowski, Xuyi Luo, Jianguo Mei Aug 2018

Thienoisatin Oligomers As N-Type Molecular Semiconductors, Natalie M. Kadlubowski, Xuyi Luo, Jianguo Mei

The Summer Undergraduate Research Fellowship (SURF) Symposium

Organic field effect transistors (OFETs) offer many advantages compared to traditional inorganic transistors, such as flexibility and solution processability. In this study we design and synthesize two thienoisatin-based organic semiconducting small molecules, then investigate their electronic properties in n-type OFETs. To introduce n-type charge transport, electron-withdrawing dicarbonitrile moieties were installed on thienoisoindigo and bis-thienoisatin molecules, which led to a quinoidal conjugation on thienoisoindigo, while maintaining an aromatic conjugation on the bis-thienoisatin. Following the syntheses, the molecules were characterized to determine highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels via cyclic voltammetry, as well as any potential ...


Rearrangements Of Fluorinated Cyclopropylamines As A Novel Approach Toward Fluoroalkene-Based Peptidomimetics, Igor Mezentsev, Vera Zaborova Jun 2018

Rearrangements Of Fluorinated Cyclopropylamines As A Novel Approach Toward Fluoroalkene-Based Peptidomimetics, Igor Mezentsev, Vera Zaborova

The International Student Science Fair 2018

"Organofluorine molecules have been widely applied in various research fields because of the unique properties of fluorine atoms. One type of fluorinated compounds is fluoroalkene-based peptidomimetics which are structurally similar to amide-containing compounds. They have been prepared to improve the pharmaceutical properties such as bioactivity, target specificity, and metabolic stability of the bioactive amides.

We suggested a new way of synthesizing fluoroalkene-based peptidomimetics through 2-fluoro-2-halocyclopropylamines, which provides an effective way toward fluoroalkene-based peptidomimetics with increased functional group tolerance and possibility of convergent synthesis."


Reduction Of Nitro-Compounds By Iron Pentacarbonyl - New Approach To Drug Precursors, Alexander Sharipov, Maria Vladimirovna Galkina Jun 2018

Reduction Of Nitro-Compounds By Iron Pentacarbonyl - New Approach To Drug Precursors, Alexander Sharipov, Maria Vladimirovna Galkina

The International Student Science Fair 2018

Reduction of nitro compounds lies at the center of most of the major areas of modern chemical industry, such as pharmacy and dye manufacturing. The precursors in these industrial processes predominantly possess multiple functional groups, including those highly susceptible to reduction by most of the currently used reducing agents. Therefore, the non-selective methods of reduction of precursors result in the loss of such functional groups. Furthermore, common reducing agents can potentially trigger the undesired intramolecular interactions between the substrate molecules and in turn make it impossible to obtain the end product. The rising demand for a cheap and efficient approach ...


Rearrangements Of Fluorinated Cyclopropylamines As A Novel Approach Toward Fluoroalkene-Based Peptidomimetics, Igor Mezentsev, Vera Zaborova Jun 2018

Rearrangements Of Fluorinated Cyclopropylamines As A Novel Approach Toward Fluoroalkene-Based Peptidomimetics, Igor Mezentsev, Vera Zaborova

The International Student Science Fair 2018

Organofluorine molecules have been widely applied in various research fields because of the unique properties of fluorine atoms. One type of fluorinated compounds is fluoroalkene-based peptidomimetics which are structurally similar to amide-containing compounds. They have been prepared to improve the pharmaceutical properties such as bioactivity, target specificity, and metabolic stability of the bioactive amides.

We suggested a new way of synthesizing fluoroalkene-based peptidomimetics through 2-fluoro-2-halocyclopropylamines, which provides an effective way toward fluoroalkene-based peptidomimetics with increased functional group tolerance and possibility of convergent synthesis.


New Reactions Of Strained Allyl Silacycles, Elizabeth Cummins May 2018

New Reactions Of Strained Allyl Silacycles, Elizabeth Cummins

Graduate Student Symposium

Ring-strained allylsilanes exhibit both electrophilic and nucleophilic characteristics, allowing for simultaneous activation and allylation of carbonyl compounds. Results are presented describing an optimized synthesis of certain allylsilacyclobutanes and their use in several selective carbon-carbon bond forming reactions.


A Chimeric Nucleobase - Phenylazo Derivative As An Intrinsic Nucleobase Quencher, Gyeongsu Park, Timothy Martin-Chan, Amer El Samm, Robert H.E. Hudson Mar 2018

A Chimeric Nucleobase - Phenylazo Derivative As An Intrinsic Nucleobase Quencher, Gyeongsu Park, Timothy Martin-Chan, Amer El Samm, Robert H.E. Hudson

Western Research Forum

Molecular beacons are important bioanalytical probes which are most often

constructed from a single-stranded oligonucleotide which has been labeled at

opposite termini with a fluorophore and a quencher. When the fluorophore and

quencher are in close proximity, no fluorescence is observed due to FRET

(Fluorescence Resonance Energy Transfer). DABCYL (4-dimethylaminoazobenzene-

4'-carboxylic acid) has been used as a quencher in the molecular beacon to absorbs

excitation energy from a fluorophore and to dissipate the energy as heat. However,

DABCYL is unable to form a base-pair and is conventionally placed as an overhanging

residue. This produces a derivative wherein the chromophore ...


Investigation Of The Exraction Processes And Performance Properties Of Kudzu Fibers, Bahrum Prang Rocky, Virginia Wimberley Jan 2018

Investigation Of The Exraction Processes And Performance Properties Of Kudzu Fibers, Bahrum Prang Rocky, Virginia Wimberley

International Textile and Apparel Association (ITAA) Annual Conference Proceedings

While kudzu was introduced into the Southeastern United states for soil erosion and increase of land fertility, the plant has become unmanageable and is rapidly spreading to Canada. Japanese traditional craftsmen extract long, white fibers by labor intensive practices not feasible for 21st century commercial fiber production. This research investigated extraction by boiling, retting or fermentation, enzymatic combinations, and mild chemical processes. Two types of fibers were resultant- soft fibers and compact woody fibers. These fibers types were assessed for microscopic visual appearance, elemental analysis using EDAX SEM, and tensile strengths for the four extraction processes. In all extraction cases ...


Tunable Copper Complexes For Sustainable Photocatalysis, David Kline Nov 2017

Tunable Copper Complexes For Sustainable Photocatalysis, David Kline

Posters-at-the-Capitol

Photoredox catalysis has direct applications in sustainable chemistry and thus an immense impact on our environment. With the ability to harness energy directly from the sun to catalyze useful chemical reactions, photocatalysts can help to eliminate the need for harsh reaction conditions and reduce generation of hazardous chemical waste. Photocatalysts based on Earth-abundant metals such as copper have recently emerged as sustainable alternatives to rare-earth metals including iridium and ruthenium, which are no longer required for many photocatalyzed chemical transformations.


Synthesis Of Healable Organic Semiconductor Through Dioxaborolane Bond, Junchen Liu, William W. Mcnutt, Jianguo Mei Aug 2017

Synthesis Of Healable Organic Semiconductor Through Dioxaborolane Bond, Junchen Liu, William W. Mcnutt, Jianguo Mei

The Summer Undergraduate Research Fellowship (SURF) Symposium

The field of organic semiconductors have gained enormous attention the past few decades. Organic materials offer numerous advantages over their inorganic counterparts. Recently a number of works have demonstrated organic semiconductors with healable properties. We aim to investigate the healable ability of an organic semiconductor by mimicking a vitrimer system through the reversible dioxaborolane bond. Vitrimers are polymers with reversible crosslink system. It has been reported that the use of the borane-oxygen bond as the crosslink showed good mechanical performance. The electrical properties will be inspected for the vitrimer-like polymer. In this report we describe a Diketopyrrolopyrrole base polymer incorporating ...


Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks May 2017

Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks

Graduate Student Symposium

Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we are working towards a substrate bound structure of sortase A from Streptococcus pneumoniae (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable substrate analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme to recognize ...


An Investigation Of The Kinetics And Equilibrium Chemistry Of Cold-Brew Coffee: Caffeine And Chlorogenic Acid Concentrations As A Function Of Roasting Temperature And Grind Size, Niny Z. Rao, Phd, Megan Fuller, Phd, Nicholas Parenti, Samantha Ryder, Nelly Setchie Tchato Apr 2017

An Investigation Of The Kinetics And Equilibrium Chemistry Of Cold-Brew Coffee: Caffeine And Chlorogenic Acid Concentrations As A Function Of Roasting Temperature And Grind Size, Niny Z. Rao, Phd, Megan Fuller, Phd, Nicholas Parenti, Samantha Ryder, Nelly Setchie Tchato

CSHLA Scholar Day

Abstract:

Recently, both small and large commercial coffee brewers have begun offering cold-brew coffee drinks to customers with the claims that these cold-water extracts contain fewer bitter acids due to brewing conditions (Toddy website, 2016) while still retaining the flavor profile. Dunkin Donuts’ website suggests that the cold-water and long brewing times allow the coffee to reach “... its purest form.” With very little research existent on the chemistry of cold brew coffee consumers are left to the marketing strategies of Starbucks and other companies regarding the contents of cold-brew coffee. This research analyzes the caffeine and chlorogenic acid (3-CGA) content ...


Synthesis Of Cyanine Dyes And Their Use As Duplex Dna Photocleavage Agents, Hector Argueta-Gonzalez Apr 2017

Synthesis Of Cyanine Dyes And Their Use As Duplex Dna Photocleavage Agents, Hector Argueta-Gonzalez

Georgia State Undergraduate Research Conference

No abstract provided.


Synthesis Of 1-Phenyl-3,5-Diaryl-4-Bromopyrazoles, 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromopyrazoles, And 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromoisoxazoles., Keren Antoine, Anne K. Jean, Roseleen Almenord, Sierra A. Fleming, Titilope Akinwe, Paula Garzon, Julio C. Falcon Apr 2017

Synthesis Of 1-Phenyl-3,5-Diaryl-4-Bromopyrazoles, 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromopyrazoles, And 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromoisoxazoles., Keren Antoine, Anne K. Jean, Roseleen Almenord, Sierra A. Fleming, Titilope Akinwe, Paula Garzon, Julio C. Falcon

Georgia State Undergraduate Research Conference

No abstract provided.


Spectrofluorometric Analysis Of Bisphenol-A In Drinking Water Bottles, Jeff Brochetti Apr 2017

Spectrofluorometric Analysis Of Bisphenol-A In Drinking Water Bottles, Jeff Brochetti

Student Scholar Showcase

Spectrofluorometric Analysis of Bisphenol-A in Drinking Water Bottles

Bisphenol-A (BPA) is of environmental concern due to its ability to act as an endocrine disruptor in humans and many other animals. In the food industry, BPA is widely used in the production of plastic bottles and plastic liners in aluminum cans. Over time, trace amounts of BPA can leach from the container and into the contents inside. A new method of testing for trace amount of BPA involved the formation of an inclusion complex with ß-Cyclodextrin. With the formation of the inclusion complex, it becomes much easier to analyze low concentrations ...


Stable Isotope Chemistry In Titan Haze Aerosol, Allison Wold Mar 2017

Stable Isotope Chemistry In Titan Haze Aerosol, Allison Wold

Research in the Capitol

Titan, a moon of Saturn, has a thick atmosphere made up of nitrogen and a few percent methane, with a surface pressure of 1.5x that of Earth. Titan’s atmosphere is believed to be that similar to that of early Earth before the rise of O2. One significant source of information on the history and evolution of the atmosphere is the measurement of stable isotopes of elements in the molecules of major gases such as nitrogen, methane, and higher order hydrocarbons. The fractionation associated with the formation of Titan aerosol analogs are explored in the laboratory as a function ...


One-Pot Dialkylation Of Cycloalkanones And Their Ring-Closing Metathesis To Make Bridged Bicyclic Compounds, Dylan Sacenti, Ashley Yoon, Nathan Behrens Mar 2017

One-Pot Dialkylation Of Cycloalkanones And Their Ring-Closing Metathesis To Make Bridged Bicyclic Compounds, Dylan Sacenti, Ashley Yoon, Nathan Behrens

Seaver College Research And Scholarly Achievement Symposium

No abstract provided.


Could O-Aminoquinones Of Estrogen Metabolites Serve As Platforms For Redox Cycling?, Rachel Miller Mar 2017

Could O-Aminoquinones Of Estrogen Metabolites Serve As Platforms For Redox Cycling?, Rachel Miller

Student Research and Creative Activity Fair

The metabolism of estrogen can lead to the formation of two isomeric o-quinones, estrogen-2,3-quinone (E-2,3-Q) and estrogen-3,4-Q (E-3,4-Q). The more reactive E-3,4-Q is genotoxic and can damage DNA by forming apurinic sites; whereas, E-2,3-Q does not form apurinic sites. Estrogen quinones may also be involved in redox cycling to produce reactive oxygen species (ROS), which is another genotoxic pathway. What is not yet clear, is why E-3,4-Q would undergo redox cycling while the non-carcinogenic E-2,3-Q would not. Nitrogen nucleophiles react with the E-3,4-Q at the 1-position. With DNA bases as the ...


Synthesis Of Small Molecule Anti-Trypanosomal Drugs, Samuel Anderson Mar 2017

Synthesis Of Small Molecule Anti-Trypanosomal Drugs, Samuel Anderson

Student Research and Creative Activity Fair

Demand for novel chemotherapeutic agents that treat Human African Trypanosomaiasis (HAT) persists. A series of compounds sharing a 3,4’diphephyl ether skeleton were prepared for a structure activity relationship (SAR) study evaluating antitrypansomal drug candidates. Trypanocidal assays performed in vitro by the Swiss Tropical and Public Health Institute identified a lead with an IC50 of 1.35 μg/mL analogous to a compound previously made in our laboratory. A slight improvement in activity (10%) was observed when changing the molecular substitution pattern from 4,4’ to 3,3’; however, the result is equivocal. Furthermore, in vitro test results demonstrated ...


Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch Mar 2017

Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch

Student Research and Creative Activity Fair

Phosphatidylinositol 3-kinases (PI3Ks) and their related pathways are reputed targets for drug-based anticancer therapies. Mutations in PI3K genes, expression, and pathways are frequent among multiple cancer types. Four isoforms of PI3Ks exist: α, β, γ, & δ and studies have identified several ligands for each isoform which are capable of serving as inhibitory therapeutic compounds. However, the biochemical efficacy of these molecules varies and the isoform selectivity is not well understood. In this study, we applied in silico docking methods and free energy calculation methods to estimate the binding of reported PI3K ligands against 5 PI3K structures: PI3Kα (PBD ID: 2RD0 ...


Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright Apr 2016

Microwave Assisted Synthesis Of Tri-Substituted Pyridazine Exploration, Austin Wright

Georgia Southern University Research Symposium

Pyridazines are nitrogen-containing compounds that have been found to show a number of pharmaceutical applications. They exhibit antimicrobial, antifungal, and antibacterial properties to name a few. In particular: 3,4,6-triphenylpyridazine derivatives are known to possess anticancer properties. The purpose of this project is to synthesize tri-substituted pyridazine derivatives using microwave-assisted reactions, and to check its biological applications. Microwave synthesis will help shorten reaction times and produce high, efficient yields. Various catalysts, bases, reaction times, and temperatures will be explored to study the scope of the reactions.