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Organic Chemistry Commons

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Articles 1 - 4 of 4

Full-Text Articles in Organic Chemistry

Interrogating Metabolism In Brain Cancer, Travis Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth Gammon, Frederick F. Lang, Amy B. Heimberger, Pratip Bhattacharya Dec 2015

Interrogating Metabolism In Brain Cancer, Travis Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth Gammon, Frederick F. Lang, Amy B. Heimberger, Pratip Bhattacharya

Nicholas Whiting

Many existing and emerging techniques of interrogating metabolism in brain cancer are at an early stage of development. A few clinical trials that employ these techniques are in progress in patients with brain cancer to establish the clinical efficacy of these techniques. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy.


Binding-Induced, Turn-On Fluorescence Of The Egfr/Erbb Kinase Inhibitor, Lapatinib, James N. Wilson Mar 2015

Binding-Induced, Turn-On Fluorescence Of The Egfr/Erbb Kinase Inhibitor, Lapatinib, James N. Wilson

James N Wilson

We report the photophysical properties, binding-induced turn-on emission, and fluorescence imaging of the cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor. Lapatinib, a type II, i.e. inactive state, inhibitor that targets the ATP binding pocket of the EGFR family of receptor tyrosine kinases. DFT calculations predict that the 6-furanylquinazoline core of lapatinib should exhibit an excited state with charge transfer character and an S0 to S1 transition energy of 3.4 eV. Absorption confirms an optical tran- sition in the near UV to violet, while fluorescence spectroscopy shows that photoemission is highly sensi- tive to solvent polarity ...


Parallel Text Immersion, Daniel P. Becker Ph.D. Dec 2011

Parallel Text Immersion, Daniel P. Becker Ph.D.

Daniel P. Becker

A new method of teaching foreign languages to beginning, intermediate, and advancing foreign language students is proposed involving reading out loud passages, chapters, and entire works of literature that are familiar to the student through required pre-reading in the students’ mother tongue. Testing is proposed to evaluate the success of the method.


Pyrene Labeled Poly(Aryl Ether) Monodendrons: Synthesis, Characterization, Diffusion Coefficients, And Photophysical Studies, James Hanson, Jeanne Riley, Sibel Alkan, Wajiha Khan, Wyatt Murphy, Aidi Chen, Michael Shapiro Dec 2000

Pyrene Labeled Poly(Aryl Ether) Monodendrons: Synthesis, Characterization, Diffusion Coefficients, And Photophysical Studies, James Hanson, Jeanne Riley, Sibel Alkan, Wajiha Khan, Wyatt Murphy, Aidi Chen, Michael Shapiro

Wyatt Murphy

Four generations of poly(aryl ether) monodendrons labeled with pyrene at the focus were synthesized and characterized by a combination of NMR, size-exclusion chromatography with light scattering detection (SEC-LS), and electronic spectroscopy. The monodendrons were then studied by magnetic resonance and fluorescence techniques. Translational diffusion coefficients in THF-d8, acetonitrile-d3, and cyclohexane-d12 were measured by Pulsed-Field-Gradient NMR and ranged from 2.2 x 10-5 cm2/sec for methoxypyrene in acetonitrile to 3.4 x 10-6 cm2/sec for the fourth generation monodendron in THF. Molecular radii were calculated from the diffusion coefficients by the Stokes-Einstein equation. In THF, the radii increased ...