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Medicinal-Pharmaceutical Chemistry Commons

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Articles 1 - 4 of 4

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Lysosome Triggered Near-Infrared Fluorescence Imaging Of Cellular Trafficking Processes In Real Time., Marco Grossi, Marina Morgunova, Shane Cheung, Dimitri Scholz, Emer Conroy, Marta Terrile, Angela Panarella, Jeremy C. Simpson, William M. Gallagher, Donal F. O'Shea Mar 2016

Lysosome Triggered Near-Infrared Fluorescence Imaging Of Cellular Trafficking Processes In Real Time., Marco Grossi, Marina Morgunova, Shane Cheung, Dimitri Scholz, Emer Conroy, Marta Terrile, Angela Panarella, Jeremy C. Simpson, William M. Gallagher, Donal F. O'Shea

Chemistry Articles

Bioresponsive NIR-fluorophores offer the possibility for continual visualization of dynamic cellular processes with added potential for direct translation to in vivo imaging. Here we show the design, synthesis and lysosome-responsive emission properties of a new NIR fluorophore. The NIR fluorescent probe design differs from typical amine functionalized lysosomotropic stains with off/on fluorescence switching controlled by a reversible phenol/phenolate interconversion. Emission from the probe is shown to be highly selective for the lysosomes in co-imaging experiments using a HeLa cell line expressing the lysosomal-associated membrane protein 1 fused to green fluorescent protein. The responsive probe is capable of real-time ...


Synthesis And Characterization Of Imidazolium Salt Derivatives For Anti-Tumor Activity, Ryan W. Pearce Jan 2015

Synthesis And Characterization Of Imidazolium Salt Derivatives For Anti-Tumor Activity, Ryan W. Pearce

Williams Honors College, Honors Research Projects

Several aldehydes (butanal, pentanal, hexanal, 4-hydroxybenzaldehyde) were reacted with 1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (1) to produce novel C2 substituted imidazolium salts for the potential use against non-small cell lung cancer in humans. Compounds 2-(1-hydroxypentyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (3) and 2-(1-hydroxyhexyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (5) were successfully synthesized with structures supported by NMR and mass spectrometry. Characterization by 1H NMR showed evidence of 1 in both compounds. The tumor cell growth inhibition of 3 against non-small cell lung cancer lines NCI-A549, NCI-H460, HCC827, and NCI-H1975 was tested and found to be comparable ...


Discrimination Of Colon Cancer Stem Cells Using Noncanonical Amino Acid, X. Duan, H. Li, Hexin Chen, Qian Wang Jan 2012

Discrimination Of Colon Cancer Stem Cells Using Noncanonical Amino Acid, X. Duan, H. Li, Hexin Chen, Qian Wang

Faculty Publications

Cancer stem cells (CSCs) may be responsible for tumor recurrence. Metabolic labelling of newly synthesized proteins with non-canonical amino acids allows us to discriminate CSCs in mixed populations due to the quiescent nature of these cells.


A Novel Anti-Cancer Bifunctional Platinum Drug Candidate With Dual Dna Binding And Histone Deacetylase Inhibitory Activity., Darren Griffith, Maria P. Morgan, Celine J. Marmion Nov 2009

A Novel Anti-Cancer Bifunctional Platinum Drug Candidate With Dual Dna Binding And Histone Deacetylase Inhibitory Activity., Darren Griffith, Maria P. Morgan, Celine J. Marmion

Chemistry Articles

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.