Open Access. Powered by Scholars. Published by Universities.®

Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 7 of 7

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Preparation Of Polymeric Materials From Bio-Renewable Sources, Jason Douglas Smith Feb 2018

Preparation Of Polymeric Materials From Bio-Renewable Sources, Jason Douglas Smith

Theses and Dissertations

The focus of this project was to develop methodologies for the preparation of novel polymeric materials from bio-renewable sources. In order to complete this task we needed (a) unfettered access to bio-based materials and ways to convert them to value needed chemicals, as well as, (b) reaction protocols that would allow greater diversity during the synthesis of polymeric compounds so as to affect the properties of these materials.

Our research group has a background in converting plant-based materials like cellulose into value added chemicals employing catalytic reactions. The polymerization of these monomers was then conducted utilizing the Baylis-Hillman reaction. The ...


Assessment Of Purification Methods For The Removal Of Endotoxins From Polymers Generated By E. Coli, Jason R. Pauldine May 2016

Assessment Of Purification Methods For The Removal Of Endotoxins From Polymers Generated By E. Coli, Jason R. Pauldine

Honors Theses

In the medical field, specialty polymers have great potential to meet the demands for bioabsorbable materials as base materials for new technologies. Targeted drug delivery, scaffolds for stem cell growth and intraoperative hemostasis are just a few of the many potential applications for these polymers. Bacterially derived polymers, which are known to be biocompatible, often contain harmful endotoxins. Removal of these endotoxins is necessary to create a safe biocompatible product that meets the FDA requirements on endotoxin limits for implants. This study examines the effectiveness of methanol and sodium hydroxide purification of Clear Coli™ developed by Lucigen and on LSBJ ...


Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy Jan 2015

Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy

Doctoral Dissertations

Supramolecular nanoassemblies capable of reducing non-specific interactions with biological macromolecules, such as proteins, are of great importance for various biological applications especially for targeted drug delivery therapeutics. Recently, zwitterionic materials have been shown to reduce non-specific interactions with biomolecules, owing both to their charge neutrality and their ability to form strong hydration layer around zwitterions via electrostatic interactions. This dissertation focuses on design, synthesis, thorough characterization, and applications of zwitterionic amphiphilic dendrimers and polymeric materials. Firstly, A new triazole-based zwitterionic moiety was conceived and incorporated as the hydrophilic functionality in facially amphiphilic dendrons. Self-assembly characteristics and the structural and functional ...


Poly(Ethylene Glycol)-Based Backbones With High Peptide Loading Capacities., Aoife O'Connor, Jean-Noel Marsat, Annachiara Mitrugno, Tom Flahive, Niamh Moran, David Brayden, Marc Devocelle Oct 2014

Poly(Ethylene Glycol)-Based Backbones With High Peptide Loading Capacities., Aoife O'Connor, Jean-Noel Marsat, Annachiara Mitrugno, Tom Flahive, Niamh Moran, David Brayden, Marc Devocelle

Chemistry Articles

Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a ...


Polymers Used In Medicine: Common Types And Benefits Of Drug Delivery Systems, Camille Andrews Jan 2012

Polymers Used In Medicine: Common Types And Benefits Of Drug Delivery Systems, Camille Andrews

Natural Sciences Poster Sessions

This poster describes the common types and benefits of drug delivery systems.


Controlled Assembly Of Rodlike Viruses With Polymers, T. Li, L. Wu, N. Suthiwangcharoen, M. A. Bruckman, D. Cash, J. S. Hudson, Soumitra Ghoshroy, Qian Wang Jan 2009

Controlled Assembly Of Rodlike Viruses With Polymers, T. Li, L. Wu, N. Suthiwangcharoen, M. A. Bruckman, D. Cash, J. S. Hudson, Soumitra Ghoshroy, Qian Wang

Faculty Publications

A practical method to assemble rodlike tobacco mosaic virus and bacteriophage M13 with polymers was developed, which afforded a 3D core–shell composite with morphological control.


Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch Jan 2008

Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch

Doctoral

Much is known about the electronic, vibrational and steric effects resulting from the addition of differing organic functional groups as side chains, to the parent conjugated polymer. However the same cannot be said about the substitution of constituents of the polymer backbone itself. To this end a study is presented here which systematically studies the effects of naphthalene and anthracene substitution of the properties of poly phenylene vinylene (PPV) derivative conjugated polymers. The synthesis by the Witting-Horner reaction of derivatives is presented whereby the phenylene units of the PPV structure are methodically substituted by naphthylene and anthrylene units to form ...