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Medicinal-Pharmaceutical Chemistry Commons

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Organic chemistry

Theses/Dissertations

2006

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Synthesis Of Natural Compounds In Echinacea , Jaehoon Bae Jan 2006

Synthesis Of Natural Compounds In Echinacea , Jaehoon Bae

Retrospective Theses and Dissertations

In this dissertation, we have investigated the direct and efficient synthetic route to biologically active natural products. Chapter 1 describes the synthesis of some of the natural compounds in Echinacea. Several main constituents of the plant Echinacea have been synthesized for the first time. We have developed a direct and flexible route to amides and ketones in Echinacea. The synthesized natural products have been used for standard samples for the biological studies. Chapter 2 describes the new tandem strategy to construct bicyclic systems by a Diels-Alder/ene reaction and its application for the synthesis of Isoligularone. During this tandem reaction ...