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Medicinal-Pharmaceutical Chemistry Commons

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Fluorescence

1995

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Light-Induced Acidification By The Antiviral Agent Hypericin, Michael J. Fehr, M. A. Mccloskey, Jacob W. Petrich Feb 1995

Light-Induced Acidification By The Antiviral Agent Hypericin, Michael J. Fehr, M. A. Mccloskey, Jacob W. Petrich

Chemistry Publications

The naturally occurring polycyclic quinone hypericin possesses light-induced antiviral activity against the human immunodeficiency virus (HIV) and other closely related enveloped lentiviruses such as equine infectious anemia virus (EIAV). We have previously argued that hypericin undergoes a fast proton transfer reaction in its singlet state (J. Phys. Chem. 1994, 98, 5784). We have also presented evidence that the light-induced antiviral activity of hypericin does not depend upon the formation of singlet oxygen (Bioorg. Med. Chem. Lett. 1994, 4, 1339). It is demonstrated here that steady-state illumination of a solution containing hypericin effects a pH drop. When hypericin and an indicator ...