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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Synthesis And Applications Of Theranostic Oligonucleotides Carrying Multiple Fluorine Atoms, Valeriy G. Metelev, Alexei A. Bogdanov Jan 2020

Synthesis And Applications Of Theranostic Oligonucleotides Carrying Multiple Fluorine Atoms, Valeriy G. Metelev, Alexei A. Bogdanov

Open Access Articles

The use of various oligonucleotide (ON) syntheses and post-synthetic strategies for targeted chemical modification enables improving their efficacy as potent modulators of gene expression levels in eukaryotic cells. However, the search still continues for new approaches designed for increasing internalization, lysosomal escape, and tissue specific delivery of ON. In this review we emphasized all aspects related to the synthesis and properties of ON derivatives carrying multifluorinated (MF) groups. These MF groups have unique physico-chemical properties because of their simultaneous hydrophobicity and lipophobicity. Such unusual combination of properties results in the overall modification of ON mode of interaction with the cells ...


Fluorescence Monitoring And Parallel Factor Analysis Of Contaminant Mixtures In Water, Nina M. Caputo Jan 2015

Fluorescence Monitoring And Parallel Factor Analysis Of Contaminant Mixtures In Water, Nina M. Caputo

Honors College

Pharmaceuticals and Personal Care Products (PPCPs) pollute our water systems regularly by entering the environment through inefficient methods of water treatment, ineffective sanitation and unregulated industrial and agricultural runoff. Currently, the most common methods of identifying PCPPs are expensive, time consuming and often require the aid of a trained expert. This project aims to further the methodology of utilizing fluorescence spectroscopy as a means of pollutant detection with a focus on contaminant mixtures. Four non-regulated EPA contaminants were fluoresced at compound specific EEM parameters and then again in two component mixtures to determine their limits of detection (LOD). The results ...


Molecular Level Interaction Of Human Fibroblast Growth Factor-1 (Hfgf-1) With Phloridzin, Rammohan Paripelly Dec 2013

Molecular Level Interaction Of Human Fibroblast Growth Factor-1 (Hfgf-1) With Phloridzin, Rammohan Paripelly

Masters Theses & Specialist Projects

Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic fibroblast growth factor, is a potent angiogenic agent, involved in the formation of new blood vessels in various tissues. hFGF-1 is regarded as a prototype of the FGF family. It serves as one of the potential targets in tumor inhibition and obesity due to its involvement in new blood vessel formation in cancerous regions and adipose tissues ...


Light-Induced Acidification By The Antiviral Agent Hypericin, Michael J. Fehr, M. A. Mccloskey, Jacob W. Petrich Feb 1995

Light-Induced Acidification By The Antiviral Agent Hypericin, Michael J. Fehr, M. A. Mccloskey, Jacob W. Petrich

Chemistry Publications

The naturally occurring polycyclic quinone hypericin possesses light-induced antiviral activity against the human immunodeficiency virus (HIV) and other closely related enveloped lentiviruses such as equine infectious anemia virus (EIAV). We have previously argued that hypericin undergoes a fast proton transfer reaction in its singlet state (J. Phys. Chem. 1994, 98, 5784). We have also presented evidence that the light-induced antiviral activity of hypericin does not depend upon the formation of singlet oxygen (Bioorg. Med. Chem. Lett. 1994, 4, 1339). It is demonstrated here that steady-state illumination of a solution containing hypericin effects a pH drop. When hypericin and an indicator ...