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Medicinal-Pharmaceutical Chemistry Commons

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Chemistry

1994

Articles 1 - 2 of 2

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Synthetic Approaches To Huperzine A , Danette René Vines Jan 1994

Synthetic Approaches To Huperzine A , Danette René Vines

Retrospective Theses and Dissertations

The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease. As life expectancy increases, identifying and synthesizing drugs which treat cognitive dysfunction becomes a primary health objective;This study was undertaken to synthesize huperzine A, and to offer a direct route to improved analogs of huperzine A. A bicyclic amino ketone for the synthesis of huperzine A was prepared in six steps. The conjugate addition of metallated alkylpyridines afforded a direct route ...


Synthesis, Structure Features And Application Of Pro-Azaphsphatranes As Catalysts And Strong Non-Ionic Bases In Organic Synthesis , Jiansheng Tang Jan 1994

Synthesis, Structure Features And Application Of Pro-Azaphsphatranes As Catalysts And Strong Non-Ionic Bases In Organic Synthesis , Jiansheng Tang

Retrospective Theses and Dissertations

This dissertation describes the development of pro-azaphosphatranes ZP(MeNCH[subscript]2CH[subscript]2)[subscript]3N as versatile useful materials in organic synthesis;Pro-imidophosphatranes MeN= P(MeNCH[subscript]2CH[subscript]2)[subscript]3N and PhN= P(MeNCH[subscript]2CH[subscript]2)[subscript]3N, their corresponding acyclic analogues MeN= P(NMe[subscript]2)[subscript]3 and PhN= P(NMe[subscript]2)[subscript]3, and their conjugate acids as well as the conjugate acid of the commercially available non-ionic base P[subscript]4-t-Bu (i.e. t-BuN=P (N=P(NMe[subscript]2)[subscript]3][subscript]3) have been synthesized. Equilibria measured by [superscript ...