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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Poly(Ethylene Glycol)-Based Peptidomimetic "Pegtide" Of Oligo-Arginine Allows For Efficient Sirna Transfection And Gene Inhibition., Alan Hibbitts, Aoife M O'Connor, Joanna Mccarthy, Éanna B Forde, Gary Hessman, Caitriona M O'Driscoll, Sally-Ann Cryan, Marc Devocelle Jun 2019

Poly(Ethylene Glycol)-Based Peptidomimetic "Pegtide" Of Oligo-Arginine Allows For Efficient Sirna Transfection And Gene Inhibition., Alan Hibbitts, Aoife M O'Connor, Joanna Mccarthy, Éanna B Forde, Gary Hessman, Caitriona M O'Driscoll, Sally-Ann Cryan, Marc Devocelle

Chemistry Articles

While a wide range of experimental and commercial transfection reagents are currently available, persistent problems remain regarding their suitability for continued development. These include the transfection efficiency for difficult-to-transfect cell types and the risks of decreased cell viability that may arise from any transfection that does occur. Therefore, research is now turning toward alternative molecules that improve the toxicity profile of the gene delivery vector (GDV), while maintaining the transfection efficiency. Among them, cell-penetrating peptides, such as octa-arginine, have shown significant potential as GDVs. Their pharmacokinetic and pharmacodynamic properties can be enhanced through peptidomimetic conversion, whereby a peptide is modified ...


Nonlinear Optical Measurements Of Bf2–Aza Dipyrromethene Fluorophores., Fryad Z. Henari, Donal F. O'Shea, Dan Wu Apr 2019

Nonlinear Optical Measurements Of Bf2–Aza Dipyrromethene Fluorophores., Fryad Z. Henari, Donal F. O'Shea, Dan Wu

Chemistry Articles

Nonlinear absorption coefficient and the nonlinear refractive index of a series of BF2 aza dipyrromethene chromophores in tetrahydrofuran (THF) solutions were measured using the Z-scan technique with a low power continuous wave laser at 633 nm. Acquired data illustrated that the process involved in nonlinear absorption is reverse saturation absorption. The excited state absorption cross sections for all complexes were calculated and a pump and probe technique was used to record the triplet absorption spectrum. The band gap of the triplet state was estimated from this spectral data and the optical limiting behavior was demonstrated for each derivative.


Qualitative And Quantitative Ethnobotanical Study Of The Pangkhua Community In Bilaichari Upazilla, Rangamati District, Bangladesh., Mohammad O. Faruque, Gang Feng, Md Na Khan, James W. Barlow, Umme R. Ankhi, Sheng Hu, M Kamaruzzaman, Shaikh B. Uddin, Xuebo Hu Feb 2019

Qualitative And Quantitative Ethnobotanical Study Of The Pangkhua Community In Bilaichari Upazilla, Rangamati District, Bangladesh., Mohammad O. Faruque, Gang Feng, Md Na Khan, James W. Barlow, Umme R. Ankhi, Sheng Hu, M Kamaruzzaman, Shaikh B. Uddin, Xuebo Hu

Chemistry Articles

BACKGROUND: The present study documents the ethnomedicinal knowledge among the traditional healers of the Pangkhua indigenous community of Bangladesh. The documented data from this area was quantitatively analyzed for the first time. We aimed to record ethnomedicinal information from both the traditional healers and also the elderly men and women of the community, in order to compile and document all available information concerning plant use and preserve it for the coming generations. We aimed to compare how already known species are used compared to elsewhere and particularly to highlight new ethnomedicinal plant species alongside their therapeutic use(s).

METHODS: All ...


Rgd Conjugated Cell Uptake Off To On Responsive Nir-Aza Fluorophores: Applications Toward Intraoperative Fluorescence Guided Surgery, Dan Wu, Harrison C. Daly, Marco Grossi, Emer Conroy, Bo Li, William M. Gallagher, Robert Elmes, Donal F. O'Shea Jan 2019

Rgd Conjugated Cell Uptake Off To On Responsive Nir-Aza Fluorophores: Applications Toward Intraoperative Fluorescence Guided Surgery, Dan Wu, Harrison C. Daly, Marco Grossi, Emer Conroy, Bo Li, William M. Gallagher, Robert Elmes, Donal F. O'Shea

Chemistry Articles

The use of NIR-fluorescence imaging to demarcate tumour boundaries for real-time guidance of their surgical resection has a huge untapped potential. However, fluorescence imaging using molecular fluorophores, even with a targeting biomolecule attached, has a major shortcoming of signal interference from non-specific background fluorescence outside the region of interest. This poor selectivity necessitates prolonged time delays to allow clearance of background fluorophore and retention within the tumour prior to image acquisition. In this report, an innovative approach to overcome this issue is described in which cancer targeted off to on bio-responsive NIRfluorophores are utilised to switch-on first within the tumour ...