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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett May 2017

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no ...


A Potential Improved Anti-Hiv Drug: Using A Bivalent Design To Increase Specificity And Potency, Theo Koelsch Jan 2017

A Potential Improved Anti-Hiv Drug: Using A Bivalent Design To Increase Specificity And Potency, Theo Koelsch

Undergraduate Honors Theses

In this thesis, the synthesis of a potentially improved HIV entry inhibitor is presented. HIV has infected millions of people, and yet there is no fully effective treatment for the infection and the subsequent, high mortality disease AIDS. This is due in large part to the virus’s rapid development of resistance to any drug used to treat the infection. The best way to combat this is to use multiple drugs with different inhibition targets and so prevent the virus from developing resistance. In order to contribute to the effective treatment of HIV infection, it is therefore important to develop ...