Open Access. Powered by Scholars. Published by Universities.®

Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2016

Anti-bacterial activity

Articles 1 - 1 of 1

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Novel Class Of Bi(Iii) Hydroxamato Complexes: Synthesis, Urease Inhibitory Activity And Activity Against H. Pylori., Donal M. Keogan, Brendan Twamley, Deirdre Fitzgerald-Hughes, Darren M. Griffith Jul 2016

Novel Class Of Bi(Iii) Hydroxamato Complexes: Synthesis, Urease Inhibitory Activity And Activity Against H. Pylori., Donal M. Keogan, Brendan Twamley, Deirdre Fitzgerald-Hughes, Darren M. Griffith

Chemistry Articles

Reaction of Bi(NO3)3 with benzohydroxamic acid (Bha) and salicylhydroxamic acid (Sha) gives the novel Bi(iii) complexes [Bi2(Bha-1H)2(μ-Bha-1H)2(η(2)-NO3)2] () and [Bi6(CH3OH)2(η(1)-NO3)2(η(2)-NO3)(OH2)2(Sha-1H)12](NO3)2 (). X-ray crystal structure of reveals two hydroxamato coordination modes; bidentate bridging (O, O') and bidentate non-bridging (O, O') and of reveals one coordination mode; bidentate bridging (O, O'). , specifically designed to and demonstrated to inhibit the activity of urease, exhibits excellent antibacterial activity against three strains of Helicobacter pylori with MIC ≥ 16 μg mL(-1).