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Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2014

Aminophenols

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Investigations Of Synthetic Models Of Mononuclear Nonheme Iron Dioxygenases, Michael Bittner Jul 2014

Investigations Of Synthetic Models Of Mononuclear Nonheme Iron Dioxygenases, Michael Bittner

Dissertations (2009 -)

Ring cleaving dioxygenases, such as o-aminophenol dioxygenase (APDO) and extradiol catechol dioxygenases (CatD), play an important role in human metabolism and the degradation of aromatic pollutants, yet questions still remain concerning the enzymatic mechanisms. One area of the catalytic cycle that remains controversial is the geometric and electronic structure of the intermediate formed after O2 binding to the Fe(II) centers. Synthetic model systems can be useful for studying enzyme active sites, as they are easier to modify and characterize than the enzymes themselves. However, synthetic models of APDOs have been relatively rare thus far. We prepared several monoiron ...