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Medicinal-Pharmaceutical Chemistry Commons

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2011

Functionalization

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Nir-Emissive Polymersomal Markers For Molecular-Level Detection Of Metastasis, Wei Qi Aug 2011

Nir-Emissive Polymersomal Markers For Molecular-Level Detection Of Metastasis, Wei Qi

Publicly Accessible Penn Dissertations

Noninvasive imaging technologies, capable of visualizing early carcinoma or dormant or latent metastatic tumor cells and evaluating the efficacy of cancer therapies are becoming increasingly important. In this thesis, NIR-emissive polymersomes are engineered for optimal cellular uptake to enable fluorescence-based tumor targeting. A series of benzothiadiazole conjugated porphyrin oligomers with high emission dipole strength and exceptional large quantum yields in the NIR region are synthesized for optimized emissive output would be greatly enhanced. Furthermore, this thesis established for the first time a class of universal chemistry modification methods to directly attach antibody to polymersomes surface with very high antibody coupling ...