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Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2011

Analog Synthesis

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

The Synthesis And Biological Evaluation Of Tamandarin B Analogs, Kenneth Lassen May 2011

The Synthesis And Biological Evaluation Of Tamandarin B Analogs, Kenneth Lassen

Publicly Accessible Penn Dissertations

The tamandarin and didemnins are a class of cyclodepsipeptides that have shown a wide range of biological activity. The didemnins have demonstrated antitumor, antiviral and immunosuppressive activity at low nano- and femtomolar levels. Didemnin B was the first marine natural product to enter clinical trials in humans in the United States. The structures of tamandarins A and B were reported in 2000 and possess almost identical structure and biological activity to didemnin B. These compounds have shown impressive biological activity and some progress has been made in establishing structure-activity relationships. However, their molecular mechanism of action is still unclear. The ...