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Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2011

Issue Briefs

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Re-Engineering Drug Discovery And Development, Garret A. Fitzgerald Oct 2011

Re-Engineering Drug Discovery And Development, Garret A. Fitzgerald

Issue Briefs

The rate of new drug approvals in the US has remained essentially constant since 1950, while the costs of drug development have soared. Many commentators question the sustainability of the current model of drug development, in which large pharmaceutical companies incur markedly escalating costs to deliver the same number of products to market. This Issue Brief summarizes the problem, describes ongoing governmental efforts to influence the process, and suggests changes in regulatory science and translational medicine that may promote more successful development of safe and effective therapeutics.