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Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Analytical, Diagnostic and Therapeutic Techniques and Equipment

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, Limin Wang Dec 2010

Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, Limin Wang

Publicly Accessible Penn Dissertations

Malignant tumors can be detected with high sensitivity and specificity by imaging their increased metabolic rate for glucose, amino acids and fatty acids. Positron emission tomography (PET) with glucose analog [18F]FDG, which utilizes increased glucose metabolism, has become a routine clinical test for diagnosis, staging and restaging a variety of cancers. Despite the tremendous success of PET-FDG, there are some well-known limitations of [18F]FDG such as high cerebral uptake, uptake in inflammatory tissues, high excretion through urinary tract and low or negligent uptake in certain type of tumors. Decades of nuclear medicine research have lead to development of ...